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The map label for this gene is ybdR [H]

Identifier: 222109542

GI number: 222109542

Start: 332946

End: 334109

Strand: Direct

Name: ybdR [H]

Synonym: Dtpsy_0322

Alternate gene names: 222109542

Gene position: 332946-334109 (Clockwise)

Preceding gene: 222109541

Following gene: 222109548

Centisome position: 8.77

GC content: 65.38

Gene sequence:

>1164_bases
ATGAAAGCTCTCACCTACCAAGGCGCCAAGGACGTGCGCGTGGAAAACGTGCCCGACCCCGTGCTGCTCGCACAGGACGA
TGTGCTGCTGCGCGTCACCGCCACGGCCATCTGCGGCTCGGATCTGCATATCTACCGCGGAAAGATCCCTGGCATGAAGG
ACGGCGACATCCTCGGCCATGAATTCATGGGTATCGTGGAAGAGGTGGGCCCTGCAGTGACGGCGCTGCGCCCTGGTGAT
CGCGTGGTGGTGCCGTTCGTCATCGCCTGCGGATCCTGCTTCTATTGCGACAAGACCCTGTTCGCGGCCTGCGAGAACAC
CAATCCGGGACGCGGCGCCATCCTCAACAAAAAGAACGCCACCGCGGGTGCAGGGCTGTTCGGCTACAGCCACCTCTACG
GCGGTTACCCCGGCGGGCAGGCAGAATACGTGCGGGTGCCGCACGGCAACGTCGGGCCGCTGAAGGTGCCCCAGGTGCTG
AGCGACGAGCAGGTGCTTTTCCTGTCCGACATCCTGCCCACCGGCTACCAGGCGGCGGTCAATGCACAGATCGGGGCAGG
CTCTTCTGTGGCGATCTTCGGCGCGGGACCGGTGGGGCTGATGAGCGCCCTGGCGGCGCGCTTCCTGGGCGCGGAGCAGG
TCTTCATGGTGGACCACAACGAGTACCGGCTGCAGTTTGCCCAGGCCACGTACGGCGTGGTGCCCATCAACTTCGACAAG
GACGAGGACCCGGCCGAAACCATTCTCTCGGCCACGGGTGGGCACGGCGTGGACGCCACGATCGACGCCGTAGGATTCGA
GGCCAAGGGCAGCGCGCTGGAGACGGCGCTCACCGCCGTGCGGCTGGAGGGTTCCAGCGGCAAGGCGCTGCGCCAGTGCA
TCGCCGCGACGCGCCGCGGCGGAGTCCTCAGCGTGCCCGGGGTCTATGCCGGCTTCATCCACGGCTTCCTCTTCGGCGAT
GCCTTCGAGAAGGGGTTGACCTTCCGCATGGGGCAGACGCACGCGCAAAAGTACATGCCCCAGTTGCTGGAACACATCGC
CAACGGCCGCATGCGGCCGGAGGTCATCATTTCCCACCGCATGAAGCTTGCCGATGCCGCGCGCGGCTATGAAATCTTCG
AGAAGAAGGAAGAGGAGTGCCGCAAGGTGGTGTTGACGCCCTAG

Upstream 100 bases:

>100_bases
GATCGAAGCCGGCGAACCCGAAGGCATGGAAATCTGAACCCCGGCGCACAGCCCGGCGCGCCGTGCGCCCGGTGTCCCCG
GCCATTGACGGAGTGATCGC

Downstream 100 bases:

>100_bases
CGCGCTGCTACCCGCGCGTGCTGCTGCCCGCGTACGGTGAGGTCGGGCCAGGTTGGGCAGGCCACCGGCCGTCGGAGTCA
GTCATCGCCTCCCTCACGCG

Product: alcohol dehydrogenase groes domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKALTYQGAKDVRVENVPDPVLLAQDDVLLRVTATAICGSDLHIYRGKIPGMKDGDILGHEFMGIVEEVGPAVTALRPGD
RVVVPFVIACGSCFYCDKTLFAACENTNPGRGAILNKKNATAGAGLFGYSHLYGGYPGGQAEYVRVPHGNVGPLKVPQVL
SDEQVLFLSDILPTGYQAAVNAQIGAGSSVAIFGAGPVGLMSALAARFLGAEQVFMVDHNEYRLQFAQATYGVVPINFDK
DEDPAETILSATGGHGVDATIDAVGFEAKGSALETALTAVRLEGSSGKALRQCIAATRRGGVLSVPGVYAGFIHGFLFGD
AFEKGLTFRMGQTHAQKYMPQLLEHIANGRMRPEVIISHRMKLADAARGYEIFEKKEEECRKVVLTP

Sequences:

>Translated_387_residues
MKALTYQGAKDVRVENVPDPVLLAQDDVLLRVTATAICGSDLHIYRGKIPGMKDGDILGHEFMGIVEEVGPAVTALRPGD
RVVVPFVIACGSCFYCDKTLFAACENTNPGRGAILNKKNATAGAGLFGYSHLYGGYPGGQAEYVRVPHGNVGPLKVPQVL
SDEQVLFLSDILPTGYQAAVNAQIGAGSSVAIFGAGPVGLMSALAARFLGAEQVFMVDHNEYRLQFAQATYGVVPINFDK
DEDPAETILSATGGHGVDATIDAVGFEAKGSALETALTAVRLEGSSGKALRQCIAATRRGGVLSVPGVYAGFIHGFLFGD
AFEKGLTFRMGQTHAQKYMPQLLEHIANGRMRPEVIISHRMKLADAARGYEIFEKKEEECRKVVLTP
>Mature_387_residues
MKALTYQGAKDVRVENVPDPVLLAQDDVLLRVTATAICGSDLHIYRGKIPGMKDGDILGHEFMGIVEEVGPAVTALRPGD
RVVVPFVIACGSCFYCDKTLFAACENTNPGRGAILNKKNATAGAGLFGYSHLYGGYPGGQAEYVRVPHGNVGPLKVPQVL
SDEQVLFLSDILPTGYQAAVNAQIGAGSSVAIFGAGPVGLMSALAARFLGAEQVFMVDHNEYRLQFAQATYGVVPINFDK
DEDPAETILSATGGHGVDATIDAVGFEAKGSALETALTAVRLEGSSGKALRQCIAATRRGGVLSVPGVYAGFIHGFLFGD
AFEKGLTFRMGQTHAQKYMPQLLEHIANGRMRPEVIISHRMKLADAARGYEIFEKKEEECRKVVLTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=24.7933884297521, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=24.7159090909091, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI71565152, Length=389, Percent_Identity=24.6786632390745, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI71743840, Length=352, Percent_Identity=25.2840909090909, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI262073058, Length=352, Percent_Identity=25.2840909090909, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI71565154, Length=267, Percent_Identity=29.5880149812734, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI34577061, Length=242, Percent_Identity=30.1652892561983, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=242, Percent_Identity=30.1652892561983, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=68.8144329896907, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1787863, Length=391, Percent_Identity=26.3427109974425, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1790045, Length=395, Percent_Identity=27.3417721518987, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788073, Length=375, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=233, Percent_Identity=32.618025751073, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI226510992, Length=390, Percent_Identity=25.1282051282051, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082125, Length=388, Percent_Identity=24.4845360824742, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788407, Length=231, Percent_Identity=29.4372294372294, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786552, Length=261, Percent_Identity=31.4176245210728, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=396, Percent_Identity=25, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790718, Length=268, Percent_Identity=27.6119402985075, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=26.7217630853994, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=26.7955801104972, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=382, Percent_Identity=24.869109947644, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=365, Percent_Identity=26.027397260274, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=301, Percent_Identity=30.8970099667774, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=403, Percent_Identity=26.0545905707196, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=302, Percent_Identity=30.1324503311258, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=286, Percent_Identity=26.2237762237762, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=374, Percent_Identity=27.2727272727273, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737897, Length=269, Percent_Identity=29.7397769516729, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737895, Length=389, Percent_Identity=25.1928020565553, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551930, Length=316, Percent_Identity=25.9493670886076, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45550770, Length=316, Percent_Identity=25.9493670886076, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221457811, Length=316, Percent_Identity=25.9493670886076, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 41233; Mature: 41233

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTYQGAKDVRVENVPDPVLLAQDDVLLRVTATAICGSDLHIYRGKIPGMKDGDILGH
CCCCCCCCCCCCEECCCCCCEEEECCCEEEEEEEEHHCCCCCEEEECCCCCCCCCCCHHH
EFMGIVEEVGPAVTALRPGDRVVVPFVIACGSCFYCDKTLFAACENTNPGRGAILNKKNA
HHHHHHHHHCCCEEEECCCCEEEEEHHHHCCCEEEECHHHHHHCCCCCCCCCEEEECCCC
TAGAGLFGYSHLYGGYPGGQAEYVRVPHGNVGPLKVPQVLSDEQVLFLSDILPTGYQAAV
CCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCEEE
NAQIGAGSSVAIFGAGPVGLMSALAARFLGAEQVFMVDHNEYRLQFAQATYGVVPINFDK
EEECCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEEEECCC
DEDPAETILSATGGHGVDATIDAVGFEAKGSALETALTAVRLEGSSGKALRQCIAATRRG
CCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHCC
GVLSVPGVYAGFIHGFLFGDAFEKGLTFRMGQTHAQKYMPQLLEHIANGRMRPEVIISHR
CEEECCHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MKLADAARGYEIFEKKEEECRKVVLTP
HHHHHHHCCHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKALTYQGAKDVRVENVPDPVLLAQDDVLLRVTATAICGSDLHIYRGKIPGMKDGDILGH
CCCCCCCCCCCCEECCCCCCEEEECCCEEEEEEEEHHCCCCCEEEECCCCCCCCCCCHHH
EFMGIVEEVGPAVTALRPGDRVVVPFVIACGSCFYCDKTLFAACENTNPGRGAILNKKNA
HHHHHHHHHCCCEEEECCCCEEEEEHHHHCCCEEEECHHHHHHCCCCCCCCCEEEECCCC
TAGAGLFGYSHLYGGYPGGQAEYVRVPHGNVGPLKVPQVLSDEQVLFLSDILPTGYQAAV
CCCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCEEE
NAQIGAGSSVAIFGAGPVGLMSALAARFLGAEQVFMVDHNEYRLQFAQATYGVVPINFDK
EEECCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEEEECCC
DEDPAETILSATGGHGVDATIDAVGFEAKGSALETALTAVRLEGSSGKALRQCIAATRRG
CCCHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHCC
GVLSVPGVYAGFIHGFLFGDAFEKGLTFRMGQTHAQKYMPQLLEHIANGRMRPEVIISHR
CEEECCHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MKLADAARGYEIFEKKEEECRKVVLTP
HHHHHHHCCHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]