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The map label for this gene is fabG [C]

Identifier: 222109359

GI number: 222109359

Start: 155310

End: 156227

Strand: Direct

Name: fabG [C]

Synonym: Dtpsy_0138

Alternate gene names: 222109359

Gene position: 155310-156227 (Clockwise)

Preceding gene: 222109350

Following gene: 222109360

Centisome position: 4.09

GC content: 67.76

Gene sequence:

>918_bases
ATGGCGCAGAAGATGGTGCAGGACAAGGTGGTGGTGGTGACGGGGGCTGGCGGCGGCATCGGGCGCGACATGGCGCTGGC
GCTGGCCGCCGCCGGGGCCAAGGTGGTGGTGAACGACATCGGCACCTCCACCACGGGCGAAGGCACCGACGCCGGCCCCG
CGCAGAAGGTGGTCGAGGAGATCAAGGCCGCCGGCGGCCAGGCCGTGGCCAACATGGACAGCGTGGCCGAGGCCGCCGCG
GCGGGCCGCATCATCCAGTGCGCGCTGGACCACTTCGGCCGCATCGACGGCGTGGTCAACAACGCGGGCATCCTGCGCGA
CCGGTTCTTCCACAAGATGAGCCTGGACGAGTGGGACGCCGTGCTCAAGGTGCACCTGTACGGCAGTTACTACATGAGCC
GCGCGGCCGCCAACCATTTCAAGGAGCAGGAGAGCGGCGCCTTCGTGCACATGACCTCCACCTCGGGCCTGATCGGCAAC
TTCGGCCAAGCCAACTACAGCGCGGCCAAGCTGGGGCTGGTGGCGCTGTCCAAGTCCATCGCGCTGGACATGCAGCAGTT
CCACGTGCGCTCCAACTGCATCGCGCCCTTTGCGTGGAGCCGCATGATCGGCTCGATCCCCACCGACACGCCCGAGCAGC
AGGCGCGCGTGGCCAAGATCCAGCAGATGACGCCCAACAAGATCGCTCCGCTGGCCGTGTACCTGCTGTCGGACCAGGCC
AAGGACGTGAACGCCCAGGTCTTCGCCGTGCGCAACAACGAGATCTTCCTGATGAGCCAGCCGCGCCCCCTGCGCTCGGT
GCACCGCAGCGAAGGCTGGACGCCCGAGTTCATCGCTGAGCACGGCATGCCCGCGCTCAAGGCCTCGTTCGTGCCCATGG
AGCGCTCGGGCGACGTGTTCTCCTGGGATCCTGTGTGA

Upstream 100 bases:

>100_bases
GGGCCGAAGCCCGCCCTTGCGATTGCCGAATAGCGCAGGCGGCCCTTTGCCGTCATGCTCGCAGCCATTGATTTCCTATC
GCAAACAAAGGACGACAGAC

Downstream 100 bases:

>100_bases
CAGAGACAACCCCCTGAGGCGCTGCGCGCCTTCCCCCCTTCTCTCTGCGCGCTGCGCGCTACGGGAAGGGGGACGCCACC
AGCGCGGCGGGGCGGCGCGG

Product: short-chain dehydrogenase/reductase sdr

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAQKMVQDKVVVVTGAGGGIGRDMALALAAAGAKVVVNDIGTSTTGEGTDAGPAQKVVEEIKAAGGQAVANMDSVAEAAA
AGRIIQCALDHFGRIDGVVNNAGILRDRFFHKMSLDEWDAVLKVHLYGSYYMSRAAANHFKEQESGAFVHMTSTSGLIGN
FGQANYSAAKLGLVALSKSIALDMQQFHVRSNCIAPFAWSRMIGSIPTDTPEQQARVAKIQQMTPNKIAPLAVYLLSDQA
KDVNAQVFAVRNNEIFLMSQPRPLRSVHRSEGWTPEFIAEHGMPALKASFVPMERSGDVFSWDPV

Sequences:

>Translated_305_residues
MAQKMVQDKVVVVTGAGGGIGRDMALALAAAGAKVVVNDIGTSTTGEGTDAGPAQKVVEEIKAAGGQAVANMDSVAEAAA
AGRIIQCALDHFGRIDGVVNNAGILRDRFFHKMSLDEWDAVLKVHLYGSYYMSRAAANHFKEQESGAFVHMTSTSGLIGN
FGQANYSAAKLGLVALSKSIALDMQQFHVRSNCIAPFAWSRMIGSIPTDTPEQQARVAKIQQMTPNKIAPLAVYLLSDQA
KDVNAQVFAVRNNEIFLMSQPRPLRSVHRSEGWTPEFIAEHGMPALKASFVPMERSGDVFSWDPV
>Mature_304_residues
AQKMVQDKVVVVTGAGGGIGRDMALALAAAGAKVVVNDIGTSTTGEGTDAGPAQKVVEEIKAAGGQAVANMDSVAEAAAA
GRIIQCALDHFGRIDGVVNNAGILRDRFFHKMSLDEWDAVLKVHLYGSYYMSRAAANHFKEQESGAFVHMTSTSGLIGNF
GQANYSAAKLGLVALSKSIALDMQQFHVRSNCIAPFAWSRMIGSIPTDTPEQQARVAKIQQMTPNKIAPLAVYLLSDQAK
DVNAQVFAVRNNEIFLMSQPRPLRSVHRSEGWTPEFIAEHGMPALKASFVPMERSGDVFSWDPV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=271, Percent_Identity=45.0184501845018, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI15277342, Length=228, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI40254992, Length=230, Percent_Identity=29.1304347826087, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI19923817, Length=209, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI20149619, Length=201, Percent_Identity=26.865671641791, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI31542939, Length=215, Percent_Identity=30.6976744186047, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=29.6, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=28.4, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI109715829, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503817, Length=181, Percent_Identity=26.5193370165746, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224922801, Length=184, Percent_Identity=30.9782608695652, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=32.1138211382114, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082100, Length=243, Percent_Identity=28.8065843621399, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=27.1317829457364, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=28.968253968254, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=26.2948207171315, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=30.1587301587302, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=26.4227642276423, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788459, Length=260, Percent_Identity=28.0769230769231, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787526, Length=258, Percent_Identity=24.4186046511628, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789057, Length=187, Percent_Identity=30.4812834224599, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=240, Percent_Identity=44.5833333333333, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=29.8449612403101, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=28.2352941176471, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=27.9527559055118, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=215, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=25.1968503937008, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=198, Percent_Identity=29.2929292929293, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=231, Percent_Identity=27.7056277056277, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=214, Percent_Identity=24.7663551401869, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=200, Percent_Identity=24, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=217, Percent_Identity=25.3456221198157, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=220, Percent_Identity=26.3636363636364, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71997099, Length=215, Percent_Identity=28.8372093023256, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=198, Percent_Identity=28.7878787878788, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=189, Percent_Identity=26.984126984127, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=239, Percent_Identity=47.2803347280335, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.0588235294118, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859837, Length=234, Percent_Identity=43.5897435897436, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=31.6, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI23397609, Length=197, Percent_Identity=34.5177664974619, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644339, Length=189, Percent_Identity=29.1005291005291, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737361, Length=219, Percent_Identity=28.7671232876712, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24640492, Length=224, Percent_Identity=24.1071428571429, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=28.7958115183246, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281364892, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32691; Mature: 32559

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKMVQDKVVVVTGAGGGIGRDMALALAAAGAKVVVNDIGTSTTGEGTDAGPAQKVVEE
CCCHHCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
IKAAGGQAVANMDSVAEAAAAGRIIQCALDHFGRIDGVVNNAGILRDRFFHKMSLDEWDA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCHHHCE
VLKVHLYGSYYMSRAAANHFKEQESGAFVHMTSTSGLIGNFGQANYSAAKLGLVALSKSI
EEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
ALDMQQFHVRSNCIAPFAWSRMIGSIPTDTPEQQARVAKIQQMTPNKIAPLAVYLLSDQA
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
KDVNAQVFAVRNNEIFLMSQPRPLRSVHRSEGWTPEFIAEHGMPALKASFVPMERSGDVF
CCCCEEEEEEECCEEEEEECCCHHHHHHHCCCCCHHHHHHCCCCHHHHCCCCCCCCCCEE
SWDPV
ECCCC
>Mature Secondary Structure 
AQKMVQDKVVVVTGAGGGIGRDMALALAAAGAKVVVNDIGTSTTGEGTDAGPAQKVVEE
CCHHCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
IKAAGGQAVANMDSVAEAAAAGRIIQCALDHFGRIDGVVNNAGILRDRFFHKMSLDEWDA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCHHHCE
VLKVHLYGSYYMSRAAANHFKEQESGAFVHMTSTSGLIGNFGQANYSAAKLGLVALSKSI
EEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
ALDMQQFHVRSNCIAPFAWSRMIGSIPTDTPEQQARVAKIQQMTPNKIAPLAVYLLSDQA
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
KDVNAQVFAVRNNEIFLMSQPRPLRSVHRSEGWTPEFIAEHGMPALKASFVPMERSGDVF
CCCCEEEEEEECCEEEEEECCCHHHHHHHCCCCCHHHHHHCCCCHHHHCCCCCCCCCCEE
SWDPV
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]