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The map label for this gene is fdhF [H]

Identifier: 222102854

GI number: 222102854

Start: 530551

End: 532887

Strand: Direct

Name: fdhF [H]

Synonym: Avi_7586

Alternate gene names: 222102854

Gene position: 530551-532887 (Clockwise)

Preceding gene: 222102853

Following gene: 222102862

Centisome position: 83.98

GC content: 56.4

Gene sequence:

>2337_bases
ATGGCTGTTTTAAAGCCGCCTTTTTTCCTCTTTAACCTCCCATCAAAAGAAAGGCCCGCCATGGCCGACCCTATCGAGAA
CCCGGAAGCCGAAGGTCCCGCTGGTGGCTGGGGATCTGTGAAGTCGATCGCCCGTATGCTGGGCGACAACAAACCCTCAC
CGGCAATCCTTGAAACGCTTTACCGCCTGAATAAGCCTGCCGGGCTTATGTGCGTTTCCTGCGCGTGGCCAAAACCCGCA
AACTACCATCCCTTCGAGTTCTGCGAAAACGGTGCCAAGGCAACGATCTCGGACCTGACCAGCGCGCGCTGTACGCCTGA
TTTCTGGAACCGTCACACCGTGGCCGAGCTCAGGAACTGGAAAGACTATGACCTCGAACAGACCGGGCGGCTGACGCATC
CCCTTCGCTATGACGCTGGAACGGATCGCTATGTTGAGGTGACGTGGGACAAGGCCTTCTCTGACATCGGCACGACGCTG
AAATCCTTGCCGTGCGAGAGCGTCGTCTTCTACTCTTCCGGCCATGCCGGTCTTGAAGCATCCTATCTCTACGCCCTGCT
GGCGCGGGTCTTCGGCAACAACAACCTGCCCCAGAGTTCCAACATGTGCCATGAGACGACGTCAGTCGGGCTTCAGAAGG
TTATCGGCTCGCCGGTTGGCACTATTGTCTGGGAAGACCTGGAGAAGGCCGACGCATTTTTCTTTTTCGGCCAGAACCCG
GGATCGAACAGTCCGCGCTTCCTTCACCCATTGCAGGAGGCCAAGCAGCGCGGTGCGCGCATCGTCACATTCAACCCGGT
TGTCGAGCAGGGGCTGGTATCATTCGTCAATCCACAAAGCCCGATTGACATGCTGACGGGACGCGAAACGCAGATTTCAG
ACGAGTATCTTCAAGTTCGGGCTGGCGGTGACATTTCCGCAATACTGGGCCTCTGCAAGGTTGTCATCGAAGCTGACGAC
GTAGCGGTGGCCAATGGACAAAAGCGCGTGCTCGATGTGGCGTTCATCGATGAGCACACGACAGGATTCGATAGTTTTAT
CGCCCTTGTCAGAACGACGAGCTGGGCCGATATCGAGCGGGAAAGCGGTCTGACTGAGGCGGCGATCCGGCGTGCCGGTG
AAATCTATATCAGCGCGGAAAGGGTCATCGGTGTCTACGGCATGGGCCTGACACAGCATTCGCAAGGCGCGATTAACGTG
GCCATGCTGGTCAATCTGCTGCTTTTGCGCGGCAATATCGGGCGCGAAGGGGCTGGATGCTGTCCGGTTCGCGGCCATTC
GAATGTCCAAGGTCAACGAACCGTCGGAATCGCCGAAAAGACCAAGCTTATTCCCATGGACACGTTGAAGGAGCTCTTCG
ATTTCGATCCTCCGACCGAGGACGGCACGACGATCGTCGATGCGGTGAAAGGGCTGATGGCTGGCAAGATCAAAGCCTTC
ATTTCGCTGGGAGGCAATCTTGTCCGCGCGGTACCAGATCAAACGGAGATGGAACGCGCCTGGGCTCGCCAGGAGCTGAC
CGTGATCGTCTCCACCAAGCTAAACCGAAGCCATCTTTTTCCTGGCAAGCAGGCCTATATTATTCCCTGCCTGTCGCGTG
CAGAGATAGATGAGCAGACCACGGGAAATCAAGCTGTATCCATCGAGGATAGCTTCTCCCATATTTCCGGATCAATCGGC
AAAAGACCTCCCGCATCCAAACATTTGAAGAGCGAACTGGCGATCGTCGCCGGCATTGCAAAGGCGACGCTCGCCGTAAG
GCCGAAACTGAAATGGGATGAATGGCAAGGTGACTACAGCCTCGTACGAGACCTGATCGAAGCGACCTATCCCGAGGACT
TCAAGGACTATAATGCGCGCATGTTCCAGCCGGGCGGGTTTTATCGCGGCAACGCAGCTCATGAGCGCCTCTGGAAAACC
GAGGAAAAGAAGGCTGTCTTCACAACGCCCACGCAATTGAACGCGCTGTCCTTCGAGGATGCCGACGGCCGCTTCCGACT
CGTAACAATGCGATCAAACGATCAGTTCAACACGACAATCTATGGTTACTCCGACCGCTTCCGCGGCATAGAGGGTACCC
GCGACGTCCTGTTGATGTGCGAAAGCGACATCGCGACATCTGGGCTTCAACCTGGGCAGGTTGTCACACTCGTCAGCGAT
TTCGGCGATGGCATTCGCCGAGCGCTCGGTGGCTTGACTGTCACCGCGCATAATCTGCCAAAAGGGACGATCGGCACTTA
TTATCCTGAAGCAAACGTGCTGATCGCCATTGACCATCATGACGAGATGTCGAAGACACCCGCATCGAAAGCAATTCCAG
TCCGGATCGAAACCTAG

Upstream 100 bases:

>100_bases
CACATATCAGCACTCGGCAGAGTTCAGGGCAAAGTTCAATGGGTGTCCGTTCCATGAGCCACGCCAGTAGCCAGCTATCG
ATGCCGAACCATTTGGAGGC

Downstream 100 bases:

>100_bases
ACTTTGCCAGGGAAAACCGGGTTCCACTTTTCCCTGATAAACTCTAACGAACCAGCATCGAAGCCCCACTGAGCCAGTCG
TCGCGCAGAAGCGCCATCAA

Product: formate dehydrogenase H alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MAVLKPPFFLFNLPSKERPAMADPIENPEAEGPAGGWGSVKSIARMLGDNKPSPAILETLYRLNKPAGLMCVSCAWPKPA
NYHPFEFCENGAKATISDLTSARCTPDFWNRHTVAELRNWKDYDLEQTGRLTHPLRYDAGTDRYVEVTWDKAFSDIGTTL
KSLPCESVVFYSSGHAGLEASYLYALLARVFGNNNLPQSSNMCHETTSVGLQKVIGSPVGTIVWEDLEKADAFFFFGQNP
GSNSPRFLHPLQEAKQRGARIVTFNPVVEQGLVSFVNPQSPIDMLTGRETQISDEYLQVRAGGDISAILGLCKVVIEADD
VAVANGQKRVLDVAFIDEHTTGFDSFIALVRTTSWADIERESGLTEAAIRRAGEIYISAERVIGVYGMGLTQHSQGAINV
AMLVNLLLLRGNIGREGAGCCPVRGHSNVQGQRTVGIAEKTKLIPMDTLKELFDFDPPTEDGTTIVDAVKGLMAGKIKAF
ISLGGNLVRAVPDQTEMERAWARQELTVIVSTKLNRSHLFPGKQAYIIPCLSRAEIDEQTTGNQAVSIEDSFSHISGSIG
KRPPASKHLKSELAIVAGIAKATLAVRPKLKWDEWQGDYSLVRDLIEATYPEDFKDYNARMFQPGGFYRGNAAHERLWKT
EEKKAVFTTPTQLNALSFEDADGRFRLVTMRSNDQFNTTIYGYSDRFRGIEGTRDVLLMCESDIATSGLQPGQVVTLVSD
FGDGIRRALGGLTVTAHNLPKGTIGTYYPEANVLIAIDHHDEMSKTPASKAIPVRIET

Sequences:

>Translated_778_residues
MAVLKPPFFLFNLPSKERPAMADPIENPEAEGPAGGWGSVKSIARMLGDNKPSPAILETLYRLNKPAGLMCVSCAWPKPA
NYHPFEFCENGAKATISDLTSARCTPDFWNRHTVAELRNWKDYDLEQTGRLTHPLRYDAGTDRYVEVTWDKAFSDIGTTL
KSLPCESVVFYSSGHAGLEASYLYALLARVFGNNNLPQSSNMCHETTSVGLQKVIGSPVGTIVWEDLEKADAFFFFGQNP
GSNSPRFLHPLQEAKQRGARIVTFNPVVEQGLVSFVNPQSPIDMLTGRETQISDEYLQVRAGGDISAILGLCKVVIEADD
VAVANGQKRVLDVAFIDEHTTGFDSFIALVRTTSWADIERESGLTEAAIRRAGEIYISAERVIGVYGMGLTQHSQGAINV
AMLVNLLLLRGNIGREGAGCCPVRGHSNVQGQRTVGIAEKTKLIPMDTLKELFDFDPPTEDGTTIVDAVKGLMAGKIKAF
ISLGGNLVRAVPDQTEMERAWARQELTVIVSTKLNRSHLFPGKQAYIIPCLSRAEIDEQTTGNQAVSIEDSFSHISGSIG
KRPPASKHLKSELAIVAGIAKATLAVRPKLKWDEWQGDYSLVRDLIEATYPEDFKDYNARMFQPGGFYRGNAAHERLWKT
EEKKAVFTTPTQLNALSFEDADGRFRLVTMRSNDQFNTTIYGYSDRFRGIEGTRDVLLMCESDIATSGLQPGQVVTLVSD
FGDGIRRALGGLTVTAHNLPKGTIGTYYPEANVLIAIDHHDEMSKTPASKAIPVRIET
>Mature_777_residues
AVLKPPFFLFNLPSKERPAMADPIENPEAEGPAGGWGSVKSIARMLGDNKPSPAILETLYRLNKPAGLMCVSCAWPKPAN
YHPFEFCENGAKATISDLTSARCTPDFWNRHTVAELRNWKDYDLEQTGRLTHPLRYDAGTDRYVEVTWDKAFSDIGTTLK
SLPCESVVFYSSGHAGLEASYLYALLARVFGNNNLPQSSNMCHETTSVGLQKVIGSPVGTIVWEDLEKADAFFFFGQNPG
SNSPRFLHPLQEAKQRGARIVTFNPVVEQGLVSFVNPQSPIDMLTGRETQISDEYLQVRAGGDISAILGLCKVVIEADDV
AVANGQKRVLDVAFIDEHTTGFDSFIALVRTTSWADIERESGLTEAAIRRAGEIYISAERVIGVYGMGLTQHSQGAINVA
MLVNLLLLRGNIGREGAGCCPVRGHSNVQGQRTVGIAEKTKLIPMDTLKELFDFDPPTEDGTTIVDAVKGLMAGKIKAFI
SLGGNLVRAVPDQTEMERAWARQELTVIVSTKLNRSHLFPGKQAYIIPCLSRAEIDEQTTGNQAVSIEDSFSHISGSIGK
RPPASKHLKSELAIVAGIAKATLAVRPKLKWDEWQGDYSLVRDLIEATYPEDFKDYNARMFQPGGFYRGNAAHERLWKTE
EKKAVFTTPTQLNALSFEDADGRFRLVTMRSNDQFNTTIYGYSDRFRGIEGTRDVLLMCESDIATSGLQPGQVVTLVSDF
GDGIRRALGGLTVTAHNLPKGTIGTYYPEANVLIAIDHHDEMSKTPASKAIPVRIET

Specific function: Probably involved in acid resistance [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787778, Length=750, Percent_Identity=44, Blast_Score=631, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=315, Percent_Identity=27.3015873015873, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR010046 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: NA

Molecular weight: Translated: 85431; Mature: 85300

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLKPPFFLFNLPSKERPAMADPIENPEAEGPAGGWGSVKSIARMLGDNKPSPAILETL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
YRLNKPAGLMCVSCAWPKPANYHPFEFCENGAKATISDLTSARCTPDFWNRHTVAELRNW
HHHCCCCCEEEEEECCCCCCCCCCHHHHCCCCCEEHHHHHCCCCCHHHHCCHHHHHHCCC
KDYDLEQTGRLTHPLRYDAGTDRYVEVTWDKAFSDIGTTLKSLPCESVVFYSSGHAGLEA
CCCCHHHCCCCCCCEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
SYLYALLARVFGNNNLPQSSNMCHETTSVGLQKVIGSPVGTIVWEDLEKADAFFFFGQNP
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCC
GSNSPRFLHPLQEAKQRGARIVTFNPVVEQGLVSFVNPQSPIDMLTGRETQISDEYLQVR
CCCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEE
AGGDISAILGLCKVVIEADDVAVANGQKRVLDVAFIDEHTTGFDSFIALVRTTSWADIER
CCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCHHHH
ESGLTEAAIRRAGEIYISAERVIGVYGMGLTQHSQGAINVAMLVNLLLLRGNIGREGAGC
HCCCHHHHHHCCCEEEEEEEHEEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCC
CPVRGHSNVQGQRTVGIAEKTKLIPMDTLKELFDFDPPTEDGTTIVDAVKGLMAGKIKAF
CCCCCCCCCCCCEEECCHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
ISLGGNLVRAVPDQTEMERAWARQELTVIVSTKLNRSHLFPGKQAYIIPCLSRAEIDEQT
HHCCCCEEECCCCHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCC
TGNQAVSIEDSFSHISGSIGKRPPASKHLKSELAIVAGIAKATLAVRPKLKWDEWQGDYS
CCCEEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHH
LVRDLIEATYPEDFKDYNARMFQPGGFYRGNAAHERLWKTEEKKAVFTTPTQLNALSFED
HHHHHHHHCCCCCHHCCCCEEECCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCEEEEEC
ADGRFRLVTMRSNDQFNTTIYGYSDRFRGIEGTRDVLLMCESDIATSGLQPGQVVTLVSD
CCCCEEEEEEECCCCCCEEEEECHHHCCCCCCCCEEEEEECCCHHHCCCCCCCEEEEHHH
FGDGIRRALGGLTVTAHNLPKGTIGTYYPEANVLIAIDHHDEMSKTPASKAIPVRIET
HHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
AVLKPPFFLFNLPSKERPAMADPIENPEAEGPAGGWGSVKSIARMLGDNKPSPAILETL
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
YRLNKPAGLMCVSCAWPKPANYHPFEFCENGAKATISDLTSARCTPDFWNRHTVAELRNW
HHHCCCCCEEEEEECCCCCCCCCCHHHHCCCCCEEHHHHHCCCCCHHHHCCHHHHHHCCC
KDYDLEQTGRLTHPLRYDAGTDRYVEVTWDKAFSDIGTTLKSLPCESVVFYSSGHAGLEA
CCCCHHHCCCCCCCEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
SYLYALLARVFGNNNLPQSSNMCHETTSVGLQKVIGSPVGTIVWEDLEKADAFFFFGQNP
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCC
GSNSPRFLHPLQEAKQRGARIVTFNPVVEQGLVSFVNPQSPIDMLTGRETQISDEYLQVR
CCCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEE
AGGDISAILGLCKVVIEADDVAVANGQKRVLDVAFIDEHTTGFDSFIALVRTTSWADIER
CCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCHHHH
ESGLTEAAIRRAGEIYISAERVIGVYGMGLTQHSQGAINVAMLVNLLLLRGNIGREGAGC
HCCCHHHHHHCCCEEEEEEEHEEEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCC
CPVRGHSNVQGQRTVGIAEKTKLIPMDTLKELFDFDPPTEDGTTIVDAVKGLMAGKIKAF
CCCCCCCCCCCCEEECCHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
ISLGGNLVRAVPDQTEMERAWARQELTVIVSTKLNRSHLFPGKQAYIIPCLSRAEIDEQT
HHCCCCEEECCCCHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCC
TGNQAVSIEDSFSHISGSIGKRPPASKHLKSELAIVAGIAKATLAVRPKLKWDEWQGDYS
CCCEEEEECCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHH
LVRDLIEATYPEDFKDYNARMFQPGGFYRGNAAHERLWKTEEKKAVFTTPTQLNALSFED
HHHHHHHHCCCCCHHCCCCEEECCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCEEEEEC
ADGRFRLVTMRSNDQFNTTIYGYSDRFRGIEGTRDVLLMCESDIATSGLQPGQVVTLVSD
CCCCEEEEEEECCCCCCEEEEECHHHCCCCCCCCEEEEEECCCHHHCCCCCCCEEEEHHH
FGDGIRRALGGLTVTAHNLPKGTIGTYYPEANVLIAIDHHDEMSKTPASKAIPVRIET
HHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]