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The map label for this gene is hutH [H]

Identifier: 222102818

GI number: 222102818

Start: 484241

End: 485854

Strand: Direct

Name: hutH [H]

Synonym: Avi_7540

Alternate gene names: 222102818

Gene position: 484241-485854 (Clockwise)

Preceding gene: 222102817

Following gene: 222102819

Centisome position: 76.65

GC content: 55.76

Gene sequence:

>1614_bases
ATGACAACGATCATACTGGACGGCGACAGCCTCACCATCAAGCAAACGGTGCAGATTGCCCGCGAAAACGCGCAGGTCGA
GATTGCAGCGGCAGCACGGGCCGAAATCATCAAAAAGCGCGCCTATATCGAAGAAAACTGGCTGACGGAAAATGCGCCAC
CGACCTACGGCTTCAACACCGGCGTCGGCAAGCTCAAGGATTACAAGATCAATCAGGCCGATAATGAGCAGTTTCAGCTC
AATATCGTGCTGTCACACTGCTCCGGCATTGGCAAACCGGCATCTGAGGAAATCGTTCGTGCCATGATGGCCGTGCGCAT
CAATGCCTTTTGTGTTGGTGTTTCGGGCCTTCGTATCGAGGTGGTTGATCGTCTGGTACAGATGCTCAACAGCGGCGTTC
ATCCGGTGGTGCCAATCCAAGGCTCTGTTGGTGCCTCCGGCGACTTGGCTCCACTCGCCCATATGGTGTCTGTGCTAATT
GGTTATGAGGATGCAGAGGCCATCTACAAGGGGGAGCGCATGTCCGCTCCAAAGGCGCTTGAACTGGCAGGCATCAGCCC
GGTATCTTTTGAGCTGAAGGCCAAGGATTGCCTGGCGCTCATCAATGGCAACAGTCTGTGTGCAGGCATGGGCGCTTTGA
CACTGCATGATGCTGAAGAGTTGATGAAAACAGCAGATGCGATTGGTGCTCTCAGCCTTGAAGCCATCCGGGGTGAACAG
GCGGCGTTTGATGCTCGTATTCACGAAGTGCGCAAACAACCGGGCCAAATCCTGACAGCTGAAAACATCCGCCGTATGGT
TGAAGGCTCACGCCGCGCCTCAGAGTCCGCCCGCGCCGTTCATCTCGAAGATGATATCCTGCACCCAACCTATCACCCAC
GCGTACAGGACCAATATTCCTTCCGCTGCCTGCCGCAAGTGCATGGCAGCTGCCGCGATCAGCTTGAACATGCCAAGACA
GTGCTGACGCGTGAATTGAATGCGGCTACCGACAATCCGCTGGTGTTCTGGAATGAAAATGGCGCACTGGAATTCCTCTC
TGGCGGCAATTTCCATTGTGAGCCGATTGCCTTTGCCATGGATCTGCTGGCCATTGCCCTAATTGAAATCGGCAATATCT
CCGAGCGGCGGTTGTTTGCCCTGTGCGACACCACGCTGAATTACGGTCTGCCGCCCAACCTTGCTGGCAAGCCCATCGGA
CTTAACTACGGCTACGGCATTATTTCCACCGCCGCCGCCGCCGTGGCGTCTGAAAACAAGACGCTGGCCTTCCCATCTGT
CGCCGATACCATCCCCACCAAGAGCAGTCAGGAAGACCATGTTTCCATGGCGGCTTGGTCGTGCCGCAAGGCGCAGCAGG
TGCTGGATAATCTGCCAAAAATCATCGGCGTTGAGTGCTTGCTGGCCACCAAGGCAATTTTCCTCACCCGCCATGCACTG
GGCAGCTTCAAACTCGGACGTGGCACACAACCACTTTATGACGCGCTGGCCGCCGTCATCCCGCTGCAGGATGGAGATGG
CTATATGCAAAAGCAGATCAAACCCGCTTTTGCCATGGTCACCGAAGGCAAGGTTCTGAATGTGGTCGAAACCGCCATTG
GCCCTCTTCGCTGA

Upstream 100 bases:

>100_bases
AGGGAAAAGTGGTCACCGGTTTTCCCGAAAAGACAAACTTAAACAAATGTCTGACGCTGCGGTGCCAGATCAATATGCAT
TTCAAATGAAGGACTGACCT

Downstream 100 bases:

>100_bases
GACGATCTGAACCATGGGCGAGGCATTTAGCCTCGCTTACGGTTCAGTTGGCCTTGTAACGTTTACCGGACGTCGATCAA
AATGAGGGATCTGGCTGCAT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTTIILDGDSLTIKQTVQIARENAQVEIAAAARAEIIKKRAYIEENWLTENAPPTYGFNTGVGKLKDYKINQADNEQFQL
NIVLSHCSGIGKPASEEIVRAMMAVRINAFCVGVSGLRIEVVDRLVQMLNSGVHPVVPIQGSVGASGDLAPLAHMVSVLI
GYEDAEAIYKGERMSAPKALELAGISPVSFELKAKDCLALINGNSLCAGMGALTLHDAEELMKTADAIGALSLEAIRGEQ
AAFDARIHEVRKQPGQILTAENIRRMVEGSRRASESARAVHLEDDILHPTYHPRVQDQYSFRCLPQVHGSCRDQLEHAKT
VLTRELNAATDNPLVFWNENGALEFLSGGNFHCEPIAFAMDLLAIALIEIGNISERRLFALCDTTLNYGLPPNLAGKPIG
LNYGYGIISTAAAAVASENKTLAFPSVADTIPTKSSQEDHVSMAAWSCRKAQQVLDNLPKIIGVECLLATKAIFLTRHAL
GSFKLGRGTQPLYDALAAVIPLQDGDGYMQKQIKPAFAMVTEGKVLNVVETAIGPLR

Sequences:

>Translated_537_residues
MTTIILDGDSLTIKQTVQIARENAQVEIAAAARAEIIKKRAYIEENWLTENAPPTYGFNTGVGKLKDYKINQADNEQFQL
NIVLSHCSGIGKPASEEIVRAMMAVRINAFCVGVSGLRIEVVDRLVQMLNSGVHPVVPIQGSVGASGDLAPLAHMVSVLI
GYEDAEAIYKGERMSAPKALELAGISPVSFELKAKDCLALINGNSLCAGMGALTLHDAEELMKTADAIGALSLEAIRGEQ
AAFDARIHEVRKQPGQILTAENIRRMVEGSRRASESARAVHLEDDILHPTYHPRVQDQYSFRCLPQVHGSCRDQLEHAKT
VLTRELNAATDNPLVFWNENGALEFLSGGNFHCEPIAFAMDLLAIALIEIGNISERRLFALCDTTLNYGLPPNLAGKPIG
LNYGYGIISTAAAAVASENKTLAFPSVADTIPTKSSQEDHVSMAAWSCRKAQQVLDNLPKIIGVECLLATKAIFLTRHAL
GSFKLGRGTQPLYDALAAVIPLQDGDGYMQKQIKPAFAMVTEGKVLNVVETAIGPLR
>Mature_536_residues
TTIILDGDSLTIKQTVQIARENAQVEIAAAARAEIIKKRAYIEENWLTENAPPTYGFNTGVGKLKDYKINQADNEQFQLN
IVLSHCSGIGKPASEEIVRAMMAVRINAFCVGVSGLRIEVVDRLVQMLNSGVHPVVPIQGSVGASGDLAPLAHMVSVLIG
YEDAEAIYKGERMSAPKALELAGISPVSFELKAKDCLALINGNSLCAGMGALTLHDAEELMKTADAIGALSLEAIRGEQA
AFDARIHEVRKQPGQILTAENIRRMVEGSRRASESARAVHLEDDILHPTYHPRVQDQYSFRCLPQVHGSCRDQLEHAKTV
LTRELNAATDNPLVFWNENGALEFLSGGNFHCEPIAFAMDLLAIALIEIGNISERRLFALCDTTLNYGLPPNLAGKPIGL
NYGYGIISTAAAAVASENKTLAFPSVADTIPTKSSQEDHVSMAAWSCRKAQQVLDNLPKIIGVECLLATKAIFLTRHALG
SFKLGRGTQPLYDALAAVIPLQDGDGYMQKQIKPAFAMVTEGKVLNVVETAIGPLR

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=534, Percent_Identity=37.2659176029963, Blast_Score=325, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI17567831, Length=536, Percent_Identity=33.955223880597, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 58015; Mature: 57884

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIILDGDSLTIKQTVQIARENAQVEIAAAARAEIIKKRAYIEENWLTENAPPTYGFNT
CEEEEECCCCEEHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GVGKLKDYKINQADNEQFQLNIVLSHCSGIGKPASEEIVRAMMAVRINAFCVGVSGLRIE
CCCCCCCEECCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHH
VVDRLVQMLNSGVHPVVPIQGSVGASGDLAPLAHMVSVLIGYEDAEAIYKGERMSAPKAL
HHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCE
ELAGISPVSFELKAKDCLALINGNSLCAGMGALTLHDAEELMKTADAIGALSLEAIRGEQ
EECCCCCCEEEEECCCEEEEECCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCH
AAFDARIHEVRKQPGQILTAENIRRMVEGSRRASESARAVHLEDDILHPTYHPRVQDQYS
HHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCC
FRCLPQVHGSCRDQLEHAKTVLTRELNAATDNPLVFWNENGALEFLSGGNFHCEPIAFAM
EEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHH
DLLAIALIEIGNISERRLFALCDTTLNYGLPPNLAGKPIGLNYGYGIISTAAAAVASENK
HHHHHHHHHHCCCCHHHEEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
TLAFPSVADTIPTKSSQEDHVSMAAWSCRKAQQVLDNLPKIIGVECLLATKAIFLTRHAL
EEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GSFKLGRGTQPLYDALAAVIPLQDGDGYMQKQIKPAFAMVTEGKVLNVVETAIGPLR
CCEECCCCCCHHHHHHHHHEECCCCCCHHHHHCCCHHEEEECCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TTIILDGDSLTIKQTVQIARENAQVEIAAAARAEIIKKRAYIEENWLTENAPPTYGFNT
EEEEECCCCEEHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GVGKLKDYKINQADNEQFQLNIVLSHCSGIGKPASEEIVRAMMAVRINAFCVGVSGLRIE
CCCCCCCEECCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHH
VVDRLVQMLNSGVHPVVPIQGSVGASGDLAPLAHMVSVLIGYEDAEAIYKGERMSAPKAL
HHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCE
ELAGISPVSFELKAKDCLALINGNSLCAGMGALTLHDAEELMKTADAIGALSLEAIRGEQ
EECCCCCCEEEEECCCEEEEECCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCH
AAFDARIHEVRKQPGQILTAENIRRMVEGSRRASESARAVHLEDDILHPTYHPRVQDQYS
HHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCC
FRCLPQVHGSCRDQLEHAKTVLTRELNAATDNPLVFWNENGALEFLSGGNFHCEPIAFAM
EEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCCCCCHHHHHHH
DLLAIALIEIGNISERRLFALCDTTLNYGLPPNLAGKPIGLNYGYGIISTAAAAVASENK
HHHHHHHHHHCCCCHHHEEEEEHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
TLAFPSVADTIPTKSSQEDHVSMAAWSCRKAQQVLDNLPKIIGVECLLATKAIFLTRHAL
EEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
GSFKLGRGTQPLYDALAAVIPLQDGDGYMQKQIKPAFAMVTEGKVLNVVETAIGPLR
CCEECCCCCCHHHHHHHHHEECCCCCCHHHHHCCCHHEEEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]