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The map label for this gene is metR [H]

Identifier: 222102755

GI number: 222102755

Start: 409990

End: 410940

Strand: Direct

Name: metR [H]

Synonym: Avi_7441

Alternate gene names: 222102755

Gene position: 409990-410940 (Clockwise)

Preceding gene: 222102747

Following gene: 222102759

Centisome position: 64.89

GC content: 59.2

Gene sequence:

>951_bases
ATGAAGATAGACAGTGAGCATCTCGAAATCCTGGCGGTCATCGTTGAAAAGGGCGGACTGACGGAGGGCGCTGAAGCGCT
TGGGAAATCGCAGCCATCAGTGTCGCGCACCATGGCGCTTTTGGAGGAGCGGATCGGCACGCCGCTGTTTGAGGCCGGGC
GTCGGCCTCTGCGCCCGACGGAGCTTGGCAATCAGCTGGCGCGGCTCGGGGCCAAAATCAGAACTCAAAACCTTGAGGCC
AGCCGTCTGGTGCAGCGCTATCGTCAGGGGCAGGCGGGCCGATTGCGTCTGGGCGGAACGCCAATTTTCTTCGATGGCGT
GGTTGCCGGAATGGTGGCGGAATTTCAAAACCGCCATTCCGATGTGCAAATCACCCAGACCTATGGCTATTTCGAGGATC
TTTCTGCCGGCCTGCGCAGCGGTGCGCTTGATCTCGCTATCCTTCCGATGCACGCCAATATGATCCCGGCTGACATGCAG
TTCACACCCTTATTGGCTGGCCGCAACGTTATTGTTGGCAGTGCCACACACCCCTTGGCGCGGCGCGGTGCGATCACGCT
GGCGGACATCGAACCCTATTCCTGGATTGCGCCGCCGCCCGACAGCCCGCTGTTTCGCGATTTGCAACGATCTTTGAAAT
CAATCGGGCTCGATGATTTCAAAGTGAGTTTTTCAGGAGGAACGCTGGCGTCTATTTTCAGCGTCGTGCTGGGGTCCGAT
TCTCTGACGGTGCTGCCCTATTCGGTTGTCTTTACCCACCAACGGGTTATCCCTCTCCAGGCGCTGCCGCTGCGCATTGA
GCATCCTGATCGCCAACTGGGATTGCTGACAGCCACGGAGCGGATGCCGCCGCCAGCGCTGGAGCGGTTTGTCGCGTTTG
TGACCGAGAAGTTCAAACATCTCAGCACCCGCATGGAGCATGAGCAGCAAGTAACCCGCCGCCGCGGCTAA

Upstream 100 bases:

>100_bases
GGGCTCCTCCTGCCGACTGTCTGGCTCCTATGAAGGCGACAATAGATCAGTGAAAGGCGGATATTGATCGGAAGGTGGCG
ATATAATATAATCTTTTGTT

Downstream 100 bases:

>100_bases
GCGCATGCTGCTATTTTAATGCGACATAGGTCACAGGGTCTAGGTGAGCGATGCGCACCGCACCATGCGCGCCTGTGGCC
GTATTCAGTAGATCACGTAG

Product: transcriptional regulator LysR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKIDSEHLEILAVIVEKGGLTEGAEALGKSQPSVSRTMALLEERIGTPLFEAGRRPLRPTELGNQLARLGAKIRTQNLEA
SRLVQRYRQGQAGRLRLGGTPIFFDGVVAGMVAEFQNRHSDVQITQTYGYFEDLSAGLRSGALDLAILPMHANMIPADMQ
FTPLLAGRNVIVGSATHPLARRGAITLADIEPYSWIAPPPDSPLFRDLQRSLKSIGLDDFKVSFSGGTLASIFSVVLGSD
SLTVLPYSVVFTHQRVIPLQALPLRIEHPDRQLGLLTATERMPPPALERFVAFVTEKFKHLSTRMEHEQQVTRRRG

Sequences:

>Translated_316_residues
MKIDSEHLEILAVIVEKGGLTEGAEALGKSQPSVSRTMALLEERIGTPLFEAGRRPLRPTELGNQLARLGAKIRTQNLEA
SRLVQRYRQGQAGRLRLGGTPIFFDGVVAGMVAEFQNRHSDVQITQTYGYFEDLSAGLRSGALDLAILPMHANMIPADMQ
FTPLLAGRNVIVGSATHPLARRGAITLADIEPYSWIAPPPDSPLFRDLQRSLKSIGLDDFKVSFSGGTLASIFSVVLGSD
SLTVLPYSVVFTHQRVIPLQALPLRIEHPDRQLGLLTATERMPPPALERFVAFVTEKFKHLSTRMEHEQQVTRRRG
>Mature_316_residues
MKIDSEHLEILAVIVEKGGLTEGAEALGKSQPSVSRTMALLEERIGTPLFEAGRRPLRPTELGNQLARLGAKIRTQNLEA
SRLVQRYRQGQAGRLRLGGTPIFFDGVVAGMVAEFQNRHSDVQITQTYGYFEDLSAGLRSGALDLAILPMHANMIPADMQ
FTPLLAGRNVIVGSATHPLARRGAITLADIEPYSWIAPPPDSPLFRDLQRSLKSIGLDDFKVSFSGGTLASIFSVVLGSD
SLTVLPYSVVFTHQRVIPLQALPLRIEHPDRQLGLLTATERMPPPALERFVAFVTEKFKHLSTRMEHEQQVTRRRG

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787601, Length=238, Percent_Identity=25.6302521008403, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI157672245, Length=251, Percent_Identity=22.3107569721116, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789204, Length=199, Percent_Identity=29.6482412060301, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789506, Length=242, Percent_Identity=21.4876033057851, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787879, Length=293, Percent_Identity=23.8907849829352, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34821; Mature: 34821

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDSEHLEILAVIVEKGGLTEGAEALGKSQPSVSRTMALLEERIGTPLFEAGRRPLRPT
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHH
ELGNQLARLGAKIRTQNLEASRLVQRYRQGQAGRLRLGGTPIFFDGVVAGMVAEFQNRHS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
DVQITQTYGYFEDLSAGLRSGALDLAILPMHANMIPADMQFTPLLAGRNVIVGSATHPLA
CEEEEEHHCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEECCCEEEEECCCCCHH
RRGAITLADIEPYSWIAPPPDSPLFRDLQRSLKSIGLDDFKVSFSGGTLASIFSVVLGSD
HCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCC
SLTVLPYSVVFTHQRVIPLQALPLRIEHPDRQLGLLTATERMPPPALERFVAFVTEKFKH
CEEEEEEHHEEECCCCCCCEECCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LSTRMEHEQQVTRRRG
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIDSEHLEILAVIVEKGGLTEGAEALGKSQPSVSRTMALLEERIGTPLFEAGRRPLRPT
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHH
ELGNQLARLGAKIRTQNLEASRLVQRYRQGQAGRLRLGGTPIFFDGVVAGMVAEFQNRHS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCC
DVQITQTYGYFEDLSAGLRSGALDLAILPMHANMIPADMQFTPLLAGRNVIVGSATHPLA
CEEEEEHHCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEECCCEEEEECCCCCHH
RRGAITLADIEPYSWIAPPPDSPLFRDLQRSLKSIGLDDFKVSFSGGTLASIFSVVLGSD
HCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCC
SLTVLPYSVVFTHQRVIPLQALPLRIEHPDRQLGLLTATERMPPPALERFVAFVTEKFKH
CEEEEEEHHEEECCCCCCCEECCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
LSTRMEHEQQVTRRRG
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]