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The map label for this gene is acd [H]

Identifier: 222102547

GI number: 222102547

Start: 144788

End: 145972

Strand: Reverse

Name: acd [H]

Synonym: Avi_7179

Alternate gene names: 222102547

Gene position: 145972-144788 (Counterclockwise)

Preceding gene: 222102548

Following gene: 222102546

Centisome position: 23.11

GC content: 60.0

Gene sequence:

>1185_bases
ATGAGTGCCACCGTTTCTGCCATCAAGCCCAATGCGGCACCAAGCCCTGATCCGGTCGAGATCGCACGGGAACTGGCGCG
CGATTTCGCAACGCGTGCCGCCGAATATGACCGCAGCGGTGATTTCCCCCATGACAACATCGCAGCGCTTCACGAAGCCG
GTTTGCTGGCTCTGTTGATTGCCAAAGACCACGGCGGTCTTGGAGCGAACCTTGAAACCGCGCAAAAGGTGGTTTCTGAA
ATCGCGGTTGGTGATCCTTCAACCGCACTTATTCTCACCATGCATTACACCATTCATGGTGTGATCAATCTGGGGCGCTG
GCCAGAGGCCTTGGCAGCGCGTGTGCTGGCAGCCAGCCGAGCCAAGCCGGTGCTGGTCAACAATGCGCAGGCCGAGCCGG
GCATGGGCTCCCCCGCCCATGGCGGATTGCCCGAAACCATCGCCCACATTGAGGGAGATCATTGGGTAATCAATGGTCAC
AAGGGCTTTGTCACCGGGCTTGCCGGGCTGACATGGGCGGTTGTGCTGGCATTGACCACGGAGGAGGTGCCGCGCCTCAT
TCAGGTGCTGGTGCCACTGGATACGCCGGGTATTCGCAAGGTGCGCACATGGGAGGCGACTGGCATGTATTCCACCGCCA
GCGATGATCTTCTGCTGGAAAACGTGCAGGTGCCGCTGTCTGACCTGATCTTTGAACAACCGGCCAGCGAGCCACTGCGC
CGCGATCCGGATTTCGGCAATATTTTCTTCACGCTGCTGTCTTCGGTCTATCACGGCGTGGCTCTATCGGCCCGGAATGA
TATTTTGAAGCACCTCACCAGCCATGCCCCCACCAGCCTAGGCGCGCCCTTGGCCTCTATTCAGCGTCTTCAGGAAGGCG
TGGGCCAAATTGAAGTGCTGCTGGCCACCAATGCCCGGCTGCTGCGCTCTTTGGCACGCGACGTTGACCAAAAAAAAGCA
GGCCCCACCGACGCGCTGGCCGTGCGCCACGTGGTGATCGACAATGCTGTCTCCGTCACCGATCTGGCCCTTGAATACGG
CGGCAACCGTGGCCTGAGGCGAGATTATCATCTGGAGCGGCATCATCGTGATGCCATTACCGCCCGTGCCCATGCCCCCC
AAAGCCACATGATCCGATCCATTTTCGGCAAGGCCGCACTGGAGCGAGCTGCCACTACGCCCTGA

Upstream 100 bases:

>100_bases
AGGATTTTCTGTATCAATGGGGCTTCTTGCAGGCTGATTTTGACCTCGAGGCCTGGGTGGATCAGCGCCCTTATGAAACG
CTGGATCGGAGGGCTGTTGC

Downstream 100 bases:

>100_bases
AACCCAACCTTTGGAAGGATATAGCCATGAGTATTTGCACCTATAGCGCAAGACTTCAGCAGCGCCGGGCCGAGCTGAGC
ACCATGATCGACATGCAGGA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSATVSAIKPNAAPSPDPVEIARELARDFATRAAEYDRSGDFPHDNIAALHEAGLLALLIAKDHGGLGANLETAQKVVSE
IAVGDPSTALILTMHYTIHGVINLGRWPEALAARVLAASRAKPVLVNNAQAEPGMGSPAHGGLPETIAHIEGDHWVINGH
KGFVTGLAGLTWAVVLALTTEEVPRLIQVLVPLDTPGIRKVRTWEATGMYSTASDDLLLENVQVPLSDLIFEQPASEPLR
RDPDFGNIFFTLLSSVYHGVALSARNDILKHLTSHAPTSLGAPLASIQRLQEGVGQIEVLLATNARLLRSLARDVDQKKA
GPTDALAVRHVVIDNAVSVTDLALEYGGNRGLRRDYHLERHHRDAITARAHAPQSHMIRSIFGKAALERAATTP

Sequences:

>Translated_394_residues
MSATVSAIKPNAAPSPDPVEIARELARDFATRAAEYDRSGDFPHDNIAALHEAGLLALLIAKDHGGLGANLETAQKVVSE
IAVGDPSTALILTMHYTIHGVINLGRWPEALAARVLAASRAKPVLVNNAQAEPGMGSPAHGGLPETIAHIEGDHWVINGH
KGFVTGLAGLTWAVVLALTTEEVPRLIQVLVPLDTPGIRKVRTWEATGMYSTASDDLLLENVQVPLSDLIFEQPASEPLR
RDPDFGNIFFTLLSSVYHGVALSARNDILKHLTSHAPTSLGAPLASIQRLQEGVGQIEVLLATNARLLRSLARDVDQKKA
GPTDALAVRHVVIDNAVSVTDLALEYGGNRGLRRDYHLERHHRDAITARAHAPQSHMIRSIFGKAALERAATTP
>Mature_393_residues
SATVSAIKPNAAPSPDPVEIARELARDFATRAAEYDRSGDFPHDNIAALHEAGLLALLIAKDHGGLGANLETAQKVVSEI
AVGDPSTALILTMHYTIHGVINLGRWPEALAARVLAASRAKPVLVNNAQAEPGMGSPAHGGLPETIAHIEGDHWVINGHK
GFVTGLAGLTWAVVLALTTEEVPRLIQVLVPLDTPGIRKVRTWEATGMYSTASDDLLLENVQVPLSDLIFEQPASEPLRR
DPDFGNIFFTLLSSVYHGVALSARNDILKHLTSHAPTSLGAPLASIQRLQEGVGQIEVLLATNARLLRSLARDVDQKKAG
PTDALAVRHVVIDNAVSVTDLALEYGGNRGLRRDYHLERHHRDAITARAHAPQSHMIRSIFGKAALERAATTP

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=25.3968253968254, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI7656849, Length=396, Percent_Identity=23.7373737373737, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI187960098, Length=222, Percent_Identity=28.3783783783784, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=23.4986945169713, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786223, Length=374, Percent_Identity=25.1336898395722, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87081958, Length=362, Percent_Identity=22.6519337016575, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=25, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=368, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17533517, Length=393, Percent_Identity=23.9185750636132, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=23.1578947368421, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24660351, Length=410, Percent_Identity=25.8536585365854, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356377, Length=387, Percent_Identity=24.5478036175711, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646207, Length=218, Percent_Identity=25.2293577981651, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666513, Length=351, Percent_Identity=21.6524216524217, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42218; Mature: 42086

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATVSAIKPNAAPSPDPVEIARELARDFATRAAEYDRSGDFPHDNIAALHEAGLLALLI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEE
AKDHGGLGANLETAQKVVSEIAVGDPSTALILTMHYTIHGVINLGRWPEALAARVLAASR
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHCCCCCHHHHHHHHHHHHC
AKPVLVNNAQAEPGMGSPAHGGLPETIAHIEGDHWVINGHKGFVTGLAGLTWAVVLALTT
CCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
EEVPRLIQVLVPLDTPGIRKVRTWEATGMYSTASDDLLLENVQVPLSDLIFEQPASEPLR
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHHCCCCCHHH
RDPDFGNIFFTLLSSVYHGVALSARNDILKHLTSHAPTSLGAPLASIQRLQEGVGQIEVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
LATNARLLRSLARDVDQKKAGPTDALAVRHVVIDNAVSVTDLALEYGGNRGLRRDYHLER
EECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHH
HHRDAITARAHAPQSHMIRSIFGKAALERAATTP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SATVSAIKPNAAPSPDPVEIARELARDFATRAAEYDRSGDFPHDNIAALHEAGLLALLI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEE
AKDHGGLGANLETAQKVVSEIAVGDPSTALILTMHYTIHGVINLGRWPEALAARVLAASR
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHCCCCCHHHHHHHHHHHHC
AKPVLVNNAQAEPGMGSPAHGGLPETIAHIEGDHWVINGHKGFVTGLAGLTWAVVLALTT
CCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHH
EEVPRLIQVLVPLDTPGIRKVRTWEATGMYSTASDDLLLENVQVPLSDLIFEQPASEPLR
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHHCCCCCHHH
RDPDFGNIFFTLLSSVYHGVALSARNDILKHLTSHAPTSLGAPLASIQRLQEGVGQIEVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
LATNARLLRSLARDVDQKKAGPTDALAVRHVVIDNAVSVTDLALEYGGNRGLRRDYHLER
EECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHH
HHRDAITARAHAPQSHMIRSIFGKAALERAATTP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]