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The map label for this gene is mprA [H]

Identifier: 221636014

GI number: 221636014

Start: 599625

End: 600302

Strand: Reverse

Name: mprA [H]

Synonym: trd_A0608

Alternate gene names: 221636014

Gene position: 600302-599625 (Counterclockwise)

Preceding gene: 221636019

Following gene: 221636013

Centisome position: 65.41

GC content: 63.86

Gene sequence:

>678_bases
ATGACGCACGTGCTGGTGGTGGATGACGACACGCGACTAGTGGAGATGCTGCGGCGAACGCTGTCGTACGAGGGTTTCAC
GGTGAGCGTTGCGCAGTCGGGCGATGAGGCGTTGCGCCTGGTGGCGGAGCGGCGACCGGATCTGATCGTGCTCGACTGGT
TATTGCCGGGAATGGACGGGTTGGCGGTAGTCCAGCGCTTGCGAGCGGCTGGTGATGGCACGCCGATCCTGATGCTGACG
GCGCGGGACGCGGTGGAAGACCGCGTTCTGGGGTTGGACAGCGGAGCCGACGACTATCTGGTCAAGCCGTTCGCACCAGC
TGAGCTTCTCGCGCGCATTCGGGCTCTTCTGCGTCGAGTCGAACCGGCTAGCGACGAGAAGCCCCTCGTCTTCGCTGATT
TGGTCTTGGACCCGGTGACGCGGGAGACGCGGCGCGGTGACCGCTCGTTCCGCTTGAGCCCGCGCGAGTTCGATCTGCTC
TCGTACTTCATGCGGCATCCTCGCCGCGTGTTGACGCGGAATCAGATCCTGCTGGCAGTGTGGGGACACGACTTCGACGG
ATACGATAGCGTGCTCGATGTCTACATCGGCTATCTCCGACAGAAGCTGGAGGCCGGTGGGGAGCCCCGACTGATCCATA
CCGTCCGGGGTGTGGGCTATGTGTTGCGGGAGTCCTGA

Upstream 100 bases:

>100_bases
GAGTGCGGTAAGAGTTCGCTGAGAATCGGGCGAGTGGACAGAACGCCGTGGTAGGATGCGAGACGAGCAATGGAGGTCGG
CTGGAAGCGGAGTCGCGGCG

Downstream 100 bases:

>100_bases
GGAGAAATGTCGATCCGGCTGCGTTTGACGCTGCTCTACAGTGGGATCCTGGTCTGCACGCTGGTGATCTTTAGCGTCGT
GCTCTACGTGCTGGTTGCCC

Product: response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTHVLVVDDDTRLVEMLRRTLSYEGFTVSVAQSGDEALRLVAERRPDLIVLDWLLPGMDGLAVVQRLRAAGDGTPILMLT
ARDAVEDRVLGLDSGADDYLVKPFAPAELLARIRALLRRVEPASDEKPLVFADLVLDPVTRETRRGDRSFRLSPREFDLL
SYFMRHPRRVLTRNQILLAVWGHDFDGYDSVLDVYIGYLRQKLEAGGEPRLIHTVRGVGYVLRES

Sequences:

>Translated_225_residues
MTHVLVVDDDTRLVEMLRRTLSYEGFTVSVAQSGDEALRLVAERRPDLIVLDWLLPGMDGLAVVQRLRAAGDGTPILMLT
ARDAVEDRVLGLDSGADDYLVKPFAPAELLARIRALLRRVEPASDEKPLVFADLVLDPVTRETRRGDRSFRLSPREFDLL
SYFMRHPRRVLTRNQILLAVWGHDFDGYDSVLDVYIGYLRQKLEAGGEPRLIHTVRGVGYVLRES
>Mature_224_residues
THVLVVDDDTRLVEMLRRTLSYEGFTVSVAQSGDEALRLVAERRPDLIVLDWLLPGMDGLAVVQRLRAAGDGTPILMLTA
RDAVEDRVLGLDSGADDYLVKPFAPAELLARIRALLRRVEPASDEKPLVFADLVLDPVTRETRRGDRSFRLSPREFDLLS
YFMRHPRRVLTRNQILLAVWGHDFDGYDSVLDVYIGYLRQKLEAGGEPRLIHTVRGVGYVLRES

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=219, Percent_Identity=43.37899543379, Blast_Score=186, Evalue=8e-49,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=45, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=40.5286343612335, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=39.9082568807339, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=40.0900900900901, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.5650224215247, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.6681614349776, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=35.8744394618834, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=38.8127853881278, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=38.961038961039, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=32.4200913242009, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=34.6153846153846, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=32.15859030837, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=31.2775330396476, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790437, Length=137, Percent_Identity=36.4963503649635, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=35.7798165137615, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790299, Length=101, Percent_Identity=36.6336633663366, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788905, Length=126, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=32.7731092436975, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=64, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=103, Percent_Identity=32.0388349514563, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25453; Mature: 25321

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHVLVVDDDTRLVEMLRRTLSYEGFTVSVAQSGDEALRLVAERRPDLIVLDWLLPGMDG
CCEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECHHCCCCH
LAVVQRLRAAGDGTPILMLTARDAVEDRVLGLDSGADDYLVKPFAPAELLARIRALLRRV
HHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHC
EPASDEKPLVFADLVLDPVTRETRRGDRSFRLSPREFDLLSYFMRHPRRVLTRNQILLAV
CCCCCCCCEEEHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHCCCCEEEEE
WGHDFDGYDSVLDVYIGYLRQKLEAGGEPRLIHTVRGVGYVLRES
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCEEEECC
>Mature Secondary Structure 
THVLVVDDDTRLVEMLRRTLSYEGFTVSVAQSGDEALRLVAERRPDLIVLDWLLPGMDG
CEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEECHHCCCCH
LAVVQRLRAAGDGTPILMLTARDAVEDRVLGLDSGADDYLVKPFAPAELLARIRALLRRV
HHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHC
EPASDEKPLVFADLVLDPVTRETRRGDRSFRLSPREFDLLSYFMRHPRRVLTRNQILLAV
CCCCCCCCEEEHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHHHHHCCCCEEEEE
WGHDFDGYDSVLDVYIGYLRQKLEAGGEPRLIHTVRGVGYVLRES
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA