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The map label for this gene is devR [H]

Identifier: 221635975

GI number: 221635975

Start: 563455

End: 564096

Strand: Reverse

Name: devR [H]

Synonym: trd_A0569

Alternate gene names: 221635975

Gene position: 564096-563455 (Counterclockwise)

Preceding gene: 221635976

Following gene: 221635974

Centisome position: 61.47

GC content: 60.28

Gene sequence:

>642_bases
GTGAGCTGGCAGCCACTGCGGGTGGCCATCATCGACGATCACGAGATCGTGCGGAACGGCCTCAAGCACATCCTCGCCGA
CGATCCGGACTTCCTGGTGGTGGGAGAGGCTGCCGATGGGCCGAGCGGAGTGGCGATGGTCGATGCGGTGCGCCCGGATG
TCGTCATCGTGGACGTGCGATTGCCTTCCATGCAGGGCGATGATGTCTGCCGGTTGATCCGGGAGCGAGTACCGGAAACG
AGGATTTTGATCCTGAGTGCGTTCGGCGAGGATGAACTGGTCTACCGGTGCGTGCTGGCTGGTGCACAGGGATACGTTCT
CAAAGACATCGTGCACTTCGACCTGAAGAAGACGCTCAAGATGATCGCGCGCGGGGAAGCAGTGCTCGACCCGCGTGTGG
CATCGGTCGTTGTGGAGCGCTTGCGGAATCGGAAGGCGATAACCGATATTCCGCTTTCACCGCACCAGCTTTCCGTTTTG
CGACTCATCGCGCAAGGGCTGTCGAACCGGGAGATTGCCGATCGTTTGTTCCTGAGCGAGAATACGGTCAAGGGGTATGT
GCAAGAAGTCTTGCGGCGGTTAGGTGCCCGCAACCGGCTCGAAGCAGTGATGATCGCGAATGAGCGGGGCTGGTTACGGT
GA

Upstream 100 bases:

>100_bases
CCGAAGCGGTCGGCGGGGAACTCTCCTGGTACAACGGCGAAGATGGTGGGTTCGTCGTGCGGGCGGTGATACCAGCTGAG
CCACGATGGGCGGAGCAGGT

Downstream 100 bases:

>100_bases
CGAGGGATAAGCGAGTCGGTGCCATCATCCTCGCGGGAGGACGCTCGGAGCGGCTGGGACGTGCGAAGCAGCTGTTGCCC
TGGAACGGCCGCACGCTCGT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MSWQPLRVAIIDDHEIVRNGLKHILADDPDFLVVGEAADGPSGVAMVDAVRPDVVIVDVRLPSMQGDDVCRLIRERVPET
RILILSAFGEDELVYRCVLAGAQGYVLKDIVHFDLKKTLKMIARGEAVLDPRVASVVVERLRNRKAITDIPLSPHQLSVL
RLIAQGLSNREIADRLFLSENTVKGYVQEVLRRLGARNRLEAVMIANERGWLR

Sequences:

>Translated_213_residues
MSWQPLRVAIIDDHEIVRNGLKHILADDPDFLVVGEAADGPSGVAMVDAVRPDVVIVDVRLPSMQGDDVCRLIRERVPET
RILILSAFGEDELVYRCVLAGAQGYVLKDIVHFDLKKTLKMIARGEAVLDPRVASVVVERLRNRKAITDIPLSPHQLSVL
RLIAQGLSNREIADRLFLSENTVKGYVQEVLRRLGARNRLEAVMIANERGWLR
>Mature_212_residues
SWQPLRVAIIDDHEIVRNGLKHILADDPDFLVVGEAADGPSGVAMVDAVRPDVVIVDVRLPSMQGDDVCRLIRERVPETR
ILILSAFGEDELVYRCVLAGAQGYVLKDIVHFDLKKTLKMIARGEAVLDPRVASVVVERLRNRKAITDIPLSPHQLSVLR
LIAQGLSNREIADRLFLSENTVKGYVQEVLRRLGARNRLEAVMIANERGWLR

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787473, Length=212, Percent_Identity=36.3207547169811, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788521, Length=210, Percent_Identity=34.2857142857143, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=27.7511961722488, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1788712, Length=201, Percent_Identity=27.8606965174129, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1786747, Length=200, Percent_Identity=26.5, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=29.0816326530612, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082052, Length=198, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788546, Length=196, Percent_Identity=28.0612244897959, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23857; Mature: 23726

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQPLRVAIIDDHEIVRNGLKHILADDPDFLVVGEAADGPSGVAMVDAVRPDVVIVDVR
CCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEEEE
LPSMQGDDVCRLIRERVPETRILILSAFGEDELVYRCVLAGAQGYVLKDIVHFDLKKTLK
CCCCCCHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MIARGEAVLDPRVASVVVERLRNRKAITDIPLSPHQLSVLRLIAQGLSNREIADRLFLSE
HHHCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC
NTVKGYVQEVLRRLGARNRLEAVMIANERGWLR
CHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
SWQPLRVAIIDDHEIVRNGLKHILADDPDFLVVGEAADGPSGVAMVDAVRPDVVIVDVR
CCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCEEEEEEE
LPSMQGDDVCRLIRERVPETRILILSAFGEDELVYRCVLAGAQGYVLKDIVHFDLKKTLK
CCCCCCHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MIARGEAVLDPRVASVVVERLRNRKAITDIPLSPHQLSVLRLIAQGLSNREIADRLFLSE
HHHCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC
NTVKGYVQEVLRRLGARNRLEAVMIANERGWLR
CHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]