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The map label for this gene is cutM [H]

Identifier: 221635972

GI number: 221635972

Start: 559655

End: 560530

Strand: Reverse

Name: cutM [H]

Synonym: trd_A0566

Alternate gene names: 221635972

Gene position: 560530-559655 (Counterclockwise)

Preceding gene: 221635973

Following gene: 221635971

Centisome position: 61.08

GC content: 61.99

Gene sequence:

>876_bases
ATGATTCCCGGGCCATTTCGCTATCGCCGGGTATCGTCCGTGGAGGAAGCAGTCTCGCTGCTCGCACAGCTCGGAAGCGA
CGCCAAGGTTCTGAGTGGCGGGCAGAGTCTCATTCCCATGATGAAGTTTCGGCTCGCTGAACCGAATTACGTGATCGACA
TCAATCGGGTACCAGGGCTTGACTTTCTCGAAGAGCGCGATGGGCTCTTGCGTATCGGCGCGCTGGTGCGCGAATCGACC
CTCGAGCGTTCGCCGCTGATCCGCGAGCGGTACCCGATCCTCCACGACACAGCACTGGTGATCGCCGATCCACTGGTCCG
TAATCTCGCCACAGTCGGGGGTAACCTGGCGCACGGCGATCCGGCCAATGACCATCCGGCAACCATGCTCGCGCTCCGTG
CACAGGTCGTCGCGAACGGCCCAAAGGGAGAACGCGTCATACCGATCGATGAGTTCTTCGTGGACACGTTCGTCACCGCG
CTGGAACCCGACGAGCTGCTCACCGAAATCCGTATCCCGGTCTCTCCACCACGCTCGGGAGGAGCATATCTCAAATTCGA
GCGTAAAGTCGGCGACTACGCAATCGCCGCTGCCGCGGCGTTTTTGGCGCTGGACGAAAGTGGGCTTATCGTCCAGGCGG
GTATCGGTTTGACCAATCTGGCCTACAAGCCGCTTCGTGCGACGGCAGCCGAGCAGGTCCTGATCGGCCAGCCGCCGAGC
GATGAGCTGTTCCGGGAAGCAGCTGAACGCGCCGCGCAGGCAACCGATCCGGTCAGCGACTTACGCGGCCCAGCGGATTA
CAAACGAGCGGTTGCCCGGACGATGGTGTTCCGTGCCTTGCGTCGAGCGCTCGAGCGAGCACAAGCCAACGGATGA

Upstream 100 bases:

>100_bases
CCTTCTGGTCAAGACGTCGTCCAGACGTTCACCGAGCGTGAGGCCCACTGGTCGACGGTCGAGCGTGCTGCGCTGGAGCA
GAGCGAAAGGAGGATCGGTG

Downstream 100 bases:

>100_bases
GGGAGGCAGAGCATGGAACGTGTGCCGATCACAGTTACCGTCAATGGGCGGACGTACACCGCCGAAGTCGAACCGCGGCT
TTTGCTCGTCCATTTCATTC

Product: nicotine dehydrogenase chain A

Products: NA

Alternate protein names: CO dehydrogenase subunit M; CO-DH M [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MIPGPFRYRRVSSVEEAVSLLAQLGSDAKVLSGGQSLIPMMKFRLAEPNYVIDINRVPGLDFLEERDGLLRIGALVREST
LERSPLIRERYPILHDTALVIADPLVRNLATVGGNLAHGDPANDHPATMLALRAQVVANGPKGERVIPIDEFFVDTFVTA
LEPDELLTEIRIPVSPPRSGGAYLKFERKVGDYAIAAAAAFLALDESGLIVQAGIGLTNLAYKPLRATAAEQVLIGQPPS
DELFREAAERAAQATDPVSDLRGPADYKRAVARTMVFRALRRALERAQANG

Sequences:

>Translated_291_residues
MIPGPFRYRRVSSVEEAVSLLAQLGSDAKVLSGGQSLIPMMKFRLAEPNYVIDINRVPGLDFLEERDGLLRIGALVREST
LERSPLIRERYPILHDTALVIADPLVRNLATVGGNLAHGDPANDHPATMLALRAQVVANGPKGERVIPIDEFFVDTFVTA
LEPDELLTEIRIPVSPPRSGGAYLKFERKVGDYAIAAAAAFLALDESGLIVQAGIGLTNLAYKPLRATAAEQVLIGQPPS
DELFREAAERAAQATDPVSDLRGPADYKRAVARTMVFRALRRALERAQANG
>Mature_291_residues
MIPGPFRYRRVSSVEEAVSLLAQLGSDAKVLSGGQSLIPMMKFRLAEPNYVIDINRVPGLDFLEERDGLLRIGALVREST
LERSPLIRERYPILHDTALVIADPLVRNLATVGGNLAHGDPANDHPATMLALRAQVVANGPKGERVIPIDEFFVDTFVTA
LEPDELLTEIRIPVSPPRSGGAYLKFERKVGDYAIAAAAAFLALDESGLIVQAGIGLTNLAYKPLRATAAEQVLIGQPPS
DELFREAAERAAQATDPVSDLRGPADYKRAVARTMVFRALRRALERAQANG

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1319

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789231, Length=285, Percent_Identity=27.719298245614, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786479, Length=296, Percent_Identity=31.4189189189189, Blast_Score=85, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 31568; Mature: 31568

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPGPFRYRRVSSVEEAVSLLAQLGSDAKVLSGGQSLIPMMKFRLAEPNYVIDINRVPGL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCC
DFLEERDGLLRIGALVRESTLERSPLIRERYPILHDTALVIADPLVRNLATVGGNLAHGD
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PANDHPATMLALRAQVVANGPKGERVIPIDEFFVDTFVTALEPDELLTEIRIPVSPPRSG
CCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
GAYLKFERKVGDYAIAAAAAFLALDESGLIVQAGIGLTNLAYKPLRATAAEQVLIGQPPS
CCEEEEECHHCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCHHHHHHHHHEEECCCCC
DELFREAAERAAQATDPVSDLRGPADYKRAVARTMVFRALRRALERAQANG
HHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPGPFRYRRVSSVEEAVSLLAQLGSDAKVLSGGQSLIPMMKFRLAEPNYVIDINRVPGL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCC
DFLEERDGLLRIGALVRESTLERSPLIRERYPILHDTALVIADPLVRNLATVGGNLAHGD
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PANDHPATMLALRAQVVANGPKGERVIPIDEFFVDTFVTALEPDELLTEIRIPVSPPRSG
CCCCCHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
GAYLKFERKVGDYAIAAAAAFLALDESGLIVQAGIGLTNLAYKPLRATAAEQVLIGQPPS
CCEEEEECHHCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCHHHHHHHHHEEECCCCC
DELFREAAERAAQATDPVSDLRGPADYKRAVARTMVFRALRRALERAQANG
HHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]