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The map label for this gene is coxL [H]

Identifier: 221635970

GI number: 221635970

Start: 556793

End: 559138

Strand: Reverse

Name: coxL [H]

Synonym: trd_A0564

Alternate gene names: 221635970

Gene position: 559138-556793 (Counterclockwise)

Preceding gene: 221635971

Following gene: 221635969

Centisome position: 60.93

GC content: 60.91

Gene sequence:

>2346_bases
ATGACAGCGACAGCTGTTCGCGGTATCGGCGTTCCAGTCAAGCGGAAGGAAGATCCGCGGTTCATTCGCGGGAAGGGAAC
CTACGTCGACGACGTCAAACTGCCCGGCATGCTCTACATGGACATCGTTCGTAGTCCATATGCCCATGCGCGCATCAAGC
GCATCGACGTGTCCAAAGCACGAGCGATGCCGGGCGTGATCGACGTGATCACTGGCGAAGAGTTGGCCAAGGCCAATCTC
GCGTGGATGCCCACGCTCATGGGCGACCGACAAATGGTCTTGCCGACTGACCGCGTGGTCTACTACGCACAGGAAGTCGC
GGCTGTCATTGCCACCGATCGCTATATTGCCGCCGATGCCGTGCTCGCAGTCGAAGTCGAGTACGAGCCGCTGCCGCCGG
TGCTGGATCCCTTCGAAGCGCTCAAGCCGGACGCACCGCTGGTACGCCCCGATCGAGACCAGAAGACGAACCACATCTGG
CATTGGGAAGCAGGGGACAAGGAGAAGACCGATCGCATCTTCCAAGAAGCGGAGGTGGTCGTCGCTCAGGATCTGTACAT
ACCGCGGATCCACGTCGCTTCGATCGAAACCTGCGGCTGCGTCGCCAACTATGACCCAGCGACTGACAAGCTGACGATTT
GGATGACCTCGCAGGCCCCACACGCGCACCGGACGGTCTTCTCGCTGGTTACAGGGATTCCGGAACACAAGATCCGAGTG
ATTTCGCCCGATATCGGAGGAGGATTCGGCGGTAAGGTGCCGGTCTACCCCGGCTACGTCATCGCGACCTACGCGACGCT
CAAACACAAGAAGCCGATCAAGTGGATCGAGGATCGCTCCGAGAACTTGCAGGCTGATTCCTTTGCCCGCGACTATCACA
TCCACGCCGAGCTCGCAGCCAATCGGGACGGCAAGATCAGGGCGCTGCGCGTCAAGGTGCTGGCCGATCACGGTGCCTTC
GATGCAGCAGCCAATCCATCGCGTTTCCCGGCTGGCCTGTTCAGCGTCTGTACGGGCTCCTACGACATGGAAGCAGCGCA
CGTCGAAGTCGACGGTGTCTACACCACGAAGCCGCCGGGAGGCGTCGCCTATCGCTGCTCGTTCCGCGTGACCGAAGCAG
TGCACACGATCGAGCGGATGGTCGATATCCTGGCTGATGAACTCGGCATGGATCCGGCAGAAATCCGCTTCAAGAATTTC
ATCCAACCGCACCAATTCCCGTACAAGTCGCCAACCGGCTGGGAGTACGACAGCGGGAATTATCCGGCAGCGCTGCAAAA
AGCGCTGGACATGATCGGGTATCGAGAACTGCGTCGCGAGCAGGCCGAGCGGCGGGCGCGCGGTGAGCTGATGGGGATCG
GCATCTCGACGTTCACCGAGATCGTGGGTGCTGGCCCCTCACACACCTTCGACATTCTCGGCATCAAGATGTTCGACAGT
GCGGAGATCCGGGTACATCCGACGGGCGCCGTGATCGTCCGGATCGGAGTCCAGACACAAGGGCAGGGACACGAGACCAC
GTTCGCCCAGATCGTCGCCGAAGAGCTCGGTATCCCGGTCGAATACATCACCGTTGAACATGGAGACACGGACACGGCAC
CGTATGGGCTCGGCACATACGCGAGCCGTAGCACGCCGACAGCCGGTGCAGCCACTGCGGTCGCTGCCCGCAAGATCCGG
GAAAAGGCGCGGCTGATCGCGGCGCACCTTTTGGAGGTGAGCCCGGACGATCTGGAATGGAAGGATTACGCCTTCCGGGT
GAAGGGAGCTCCTGATCGGTACAAGACGATGCAAGAGATCGCGTTTGCGGCCTACACGAATTTCCCGCTCGGGCTCGAAC
CAGGACTGGAAGCGGAATGCTACTACGATCCGCCCAATCTGACGTTCCCCTTCGGTGCTTACGTCTGCGTCGTGGACATC
GATCGCGGTACGGGCCAGGTCAAGATCCGAGAGTTCCTGGCGGTCGATGACTGTGGCACGATCATCAACCCGATGATCGT
CGAGGGCCAGATTCATGGTGGGCTGACGATGGGTATGGCACCGGCGCTCTTCGAGGAGATCGTCTACGACGAGAACGGAA
CCATGCTCAGCGGTACCTTCATGGACTATCTCCTGCCCACGGCAGTCGAAACACCCCACTGGAAGACGGCCAAGACGGTC
ACGCCCTCCCCCCATCATCCGCTCGGTGCCAAGGGCGTCGGTGAGAGCCCGACGATCGGCGCACCACCAGCGATCGTCAA
CGCCGTGGTCGATGCACTGAGCCATCTCGGGGTGCGCCATATCGACATCCCGATCACGCCAGCCAAGCTGTACCGGATTC
TCCAAGAGAAGGGTGTGGCGGAGTGA

Upstream 100 bases:

>100_bases
CTGCCGCTGTACCGGCTATGTCAACATCGTCAAGGCGATCCAGTACGCAGCACGCAAGATGCGCGAAAGCGCCACAGCAG
GTGTGGGAGGAGCGTGAACG

Downstream 100 bases:

>100_bases
GCGCAGCGCAGCGATCCGGTCCGTCGCGGGGGCTGGATCGCTGCGCCCTTTCTCGATGTCCGACGAGCGACGAGCGAGCG
AGATGACGAAGGCAAGTCAT

Product: carbon-monoxide dehydrogenase, large subunit

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MTATAVRGIGVPVKRKEDPRFIRGKGTYVDDVKLPGMLYMDIVRSPYAHARIKRIDVSKARAMPGVIDVITGEELAKANL
AWMPTLMGDRQMVLPTDRVVYYAQEVAAVIATDRYIAADAVLAVEVEYEPLPPVLDPFEALKPDAPLVRPDRDQKTNHIW
HWEAGDKEKTDRIFQEAEVVVAQDLYIPRIHVASIETCGCVANYDPATDKLTIWMTSQAPHAHRTVFSLVTGIPEHKIRV
ISPDIGGGFGGKVPVYPGYVIATYATLKHKKPIKWIEDRSENLQADSFARDYHIHAELAANRDGKIRALRVKVLADHGAF
DAAANPSRFPAGLFSVCTGSYDMEAAHVEVDGVYTTKPPGGVAYRCSFRVTEAVHTIERMVDILADELGMDPAEIRFKNF
IQPHQFPYKSPTGWEYDSGNYPAALQKALDMIGYRELRREQAERRARGELMGIGISTFTEIVGAGPSHTFDILGIKMFDS
AEIRVHPTGAVIVRIGVQTQGQGHETTFAQIVAEELGIPVEYITVEHGDTDTAPYGLGTYASRSTPTAGAATAVAARKIR
EKARLIAAHLLEVSPDDLEWKDYAFRVKGAPDRYKTMQEIAFAAYTNFPLGLEPGLEAECYYDPPNLTFPFGAYVCVVDI
DRGTGQVKIREFLAVDDCGTIINPMIVEGQIHGGLTMGMAPALFEEIVYDENGTMLSGTFMDYLLPTAVETPHWKTAKTV
TPSPHHPLGAKGVGESPTIGAPPAIVNAVVDALSHLGVRHIDIPITPAKLYRILQEKGVAE

Sequences:

>Translated_781_residues
MTATAVRGIGVPVKRKEDPRFIRGKGTYVDDVKLPGMLYMDIVRSPYAHARIKRIDVSKARAMPGVIDVITGEELAKANL
AWMPTLMGDRQMVLPTDRVVYYAQEVAAVIATDRYIAADAVLAVEVEYEPLPPVLDPFEALKPDAPLVRPDRDQKTNHIW
HWEAGDKEKTDRIFQEAEVVVAQDLYIPRIHVASIETCGCVANYDPATDKLTIWMTSQAPHAHRTVFSLVTGIPEHKIRV
ISPDIGGGFGGKVPVYPGYVIATYATLKHKKPIKWIEDRSENLQADSFARDYHIHAELAANRDGKIRALRVKVLADHGAF
DAAANPSRFPAGLFSVCTGSYDMEAAHVEVDGVYTTKPPGGVAYRCSFRVTEAVHTIERMVDILADELGMDPAEIRFKNF
IQPHQFPYKSPTGWEYDSGNYPAALQKALDMIGYRELRREQAERRARGELMGIGISTFTEIVGAGPSHTFDILGIKMFDS
AEIRVHPTGAVIVRIGVQTQGQGHETTFAQIVAEELGIPVEYITVEHGDTDTAPYGLGTYASRSTPTAGAATAVAARKIR
EKARLIAAHLLEVSPDDLEWKDYAFRVKGAPDRYKTMQEIAFAAYTNFPLGLEPGLEAECYYDPPNLTFPFGAYVCVVDI
DRGTGQVKIREFLAVDDCGTIINPMIVEGQIHGGLTMGMAPALFEEIVYDENGTMLSGTFMDYLLPTAVETPHWKTAKTV
TPSPHHPLGAKGVGESPTIGAPPAIVNAVVDALSHLGVRHIDIPITPAKLYRILQEKGVAE
>Mature_780_residues
TATAVRGIGVPVKRKEDPRFIRGKGTYVDDVKLPGMLYMDIVRSPYAHARIKRIDVSKARAMPGVIDVITGEELAKANLA
WMPTLMGDRQMVLPTDRVVYYAQEVAAVIATDRYIAADAVLAVEVEYEPLPPVLDPFEALKPDAPLVRPDRDQKTNHIWH
WEAGDKEKTDRIFQEAEVVVAQDLYIPRIHVASIETCGCVANYDPATDKLTIWMTSQAPHAHRTVFSLVTGIPEHKIRVI
SPDIGGGFGGKVPVYPGYVIATYATLKHKKPIKWIEDRSENLQADSFARDYHIHAELAANRDGKIRALRVKVLADHGAFD
AAANPSRFPAGLFSVCTGSYDMEAAHVEVDGVYTTKPPGGVAYRCSFRVTEAVHTIERMVDILADELGMDPAEIRFKNFI
QPHQFPYKSPTGWEYDSGNYPAALQKALDMIGYRELRREQAERRARGELMGIGISTFTEIVGAGPSHTFDILGIKMFDSA
EIRVHPTGAVIVRIGVQTQGQGHETTFAQIVAEELGIPVEYITVEHGDTDTAPYGLGTYASRSTPTAGAATAVAARKIRE
KARLIAAHLLEVSPDDLEWKDYAFRVKGAPDRYKTMQEIAFAAYTNFPLGLEPGLEAECYYDPPNLTFPFGAYVCVVDID
RGTGQVKIREFLAVDDCGTIINPMIVEGQIHGGLTMGMAPALFEEIVYDENGTMLSGTFMDYLLPTAVETPHWKTAKTVT
PSPHHPLGAKGVGESPTIGAPPAIVNAVVDALSHLGVRHIDIPITPAKLYRILQEKGVAE

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=788, Percent_Identity=24.238578680203, Blast_Score=163, Evalue=6e-40,
Organism=Homo sapiens, GI91823271, Length=783, Percent_Identity=23.4993614303959, Blast_Score=140, Evalue=6e-33,
Organism=Escherichia coli, GI1789230, Length=777, Percent_Identity=28.5714285714286, Blast_Score=265, Evalue=1e-71,
Organism=Escherichia coli, GI1789246, Length=817, Percent_Identity=27.6621787025704, Blast_Score=222, Evalue=7e-59,
Organism=Escherichia coli, GI1786478, Length=781, Percent_Identity=25.9923175416133, Blast_Score=138, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17540638, Length=769, Percent_Identity=24.1872561768531, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17737937, Length=781, Percent_Identity=24.583866837388, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647193, Length=756, Percent_Identity=21.4285714285714, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 85805; Mature: 85674

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAVRGIGVPVKRKEDPRFIRGKGTYVDDVKLPGMLYMDIVRSPYAHARIKRIDVSKA
CCCCEECCCCCCCCCCCCCCEEECCCCEECCCCCCCHHHHHHHHCCHHHHEEEEEEHHHH
RAMPGVIDVITGEELAKANLAWMPTLMGDRQMVLPTDRVVYYAQEVAAVIATDRYIAADA
HCCCCEEEEECCCHHHHCCCEEEEHHCCCCEEECCCHHHHHHHHHHHHHHHCCCEEEECE
VLAVEVEYEPLPPVLDPFEALKPDAPLVRPDRDQKTNHIWHWEAGDKEKTDRIFQEAEVV
EEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHEE
VAQDLYIPRIHVASIETCGCVANYDPATDKLTIWMTSQAPHAHRTVFSLVTGIPEHKIRV
EECCCCCCEEEEECCCCCCEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEE
ISPDIGGGFGGKVPVYPGYVIATYATLKHKKPIKWIEDRSENLQADSFARDYHIHAELAA
ECCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCHHHHCCCCCCCCCHHHCCEEEEEEEEC
NRDGKIRALRVKVLADHGAFDAAANPSRFPAGLFSVCTGSYDMEAAHVEVDGVYTTKPPG
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECEEEECCCCC
GVAYRCSFRVTEAVHTIERMVDILADELGMDPAEIRFKNFIQPHQFPYKSPTGWEYDSGN
CEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
YPAALQKALDMIGYRELRREQAERRARGELMGIGISTFTEIVGAGPSHTFDILGIKMFDS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCEEEEEEEEEECC
AEIRVHPTGAVIVRIGVQTQGQGHETTFAQIVAEELGIPVEYITVEHGDTDTAPYGLGTY
CEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCC
ASRSTPTAGAATAVAARKIREKARLIAAHLLEVSPDDLEWKDYAFRVKGAPDRYKTMQEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHH
AFAAYTNFPLGLEPGLEAECYYDPPNLTFPFGAYVCVVDIDRGTGQVKIREFLAVDDCGT
HHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCEEEEEEECCCCCCEEEEEEEEECCCCH
IINPMIVEGQIHGGLTMGMAPALFEEIVYDENGTMLSGTFMDYLLPTAVETPHWKTAKTV
HHCCEEEEEEECCCCHHCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCC
TPSPHHPLGAKGVGESPTIGAPPAIVNAVVDALSHLGVRHIDIPITPAKLYRILQEKGVA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCC
E
C
>Mature Secondary Structure 
TATAVRGIGVPVKRKEDPRFIRGKGTYVDDVKLPGMLYMDIVRSPYAHARIKRIDVSKA
CCCEECCCCCCCCCCCCCCEEECCCCEECCCCCCCHHHHHHHHCCHHHHEEEEEEHHHH
RAMPGVIDVITGEELAKANLAWMPTLMGDRQMVLPTDRVVYYAQEVAAVIATDRYIAADA
HCCCCEEEEECCCHHHHCCCEEEEHHCCCCEEECCCHHHHHHHHHHHHHHHCCCEEEECE
VLAVEVEYEPLPPVLDPFEALKPDAPLVRPDRDQKTNHIWHWEAGDKEKTDRIFQEAEVV
EEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHEE
VAQDLYIPRIHVASIETCGCVANYDPATDKLTIWMTSQAPHAHRTVFSLVTGIPEHKIRV
EECCCCCCEEEEECCCCCCEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEE
ISPDIGGGFGGKVPVYPGYVIATYATLKHKKPIKWIEDRSENLQADSFARDYHIHAELAA
ECCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCHHHHCCCCCCCCCHHHCCEEEEEEEEC
NRDGKIRALRVKVLADHGAFDAAANPSRFPAGLFSVCTGSYDMEAAHVEVDGVYTTKPPG
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECEEEECCCCC
GVAYRCSFRVTEAVHTIERMVDILADELGMDPAEIRFKNFIQPHQFPYKSPTGWEYDSGN
CEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
YPAALQKALDMIGYRELRREQAERRARGELMGIGISTFTEIVGAGPSHTFDILGIKMFDS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCEEEEEEEEEECC
AEIRVHPTGAVIVRIGVQTQGQGHETTFAQIVAEELGIPVEYITVEHGDTDTAPYGLGTY
CEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCC
ASRSTPTAGAATAVAARKIREKARLIAAHLLEVSPDDLEWKDYAFRVKGAPDRYKTMQEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHH
AFAAYTNFPLGLEPGLEAECYYDPPNLTFPFGAYVCVVDIDRGTGQVKIREFLAVDDCGT
HHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCEEEEEEECCCCCCEEEEEEEEECCCCH
IINPMIVEGQIHGGLTMGMAPALFEEIVYDENGTMLSGTFMDYLLPTAVETPHWKTAKTV
HHCCEEEEEEECCCCHHCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCC
TPSPHHPLGAKGVGESPTIGAPPAIVNAVVDALSHLGVRHIDIPITPAKLYRILQEKGVA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]