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The map label for this gene is napA [H]

Identifier: 221635891

GI number: 221635891

Start: 473384

End: 474658

Strand: Reverse

Name: napA [H]

Synonym: trd_A0485

Alternate gene names: 221635891

Gene position: 474658-473384 (Counterclockwise)

Preceding gene: 221635892

Following gene: 221635890

Centisome position: 51.72

GC content: 66.75

Gene sequence:

>1275_bases
ATGACCGCGATCGTCGAGGTCTTGAGCGAACTCCTGATCATCTTTCTCGCCGCGAAGTTCGCAGGGGAACTCTTCCTCCG
CATGCGCCAGCCTGCGGTGATCGGCGAACTGCTCGCCGGGATCCTGATCGGCCCCTTCGCGCTCGGCCTGATCGGTGTCC
CGGGTCACGAAATCCTGGAATTGTTTCATGAGGATCGCGAGGCTGCACGCGAGGGTCTCGCACTCGCCCTGGAGTCGATC
GCCGAACTGGGCGTCGTCGTACTCCTGTTCTTCGTCGGGTTGGAAACGCGCCTGAGCGATCTCCTCCGTGTCGGCATCCG
GTCGCTCGCGGTCGCTGTGCTCGGGGTACTCGGACCCTTCGCCGGCGGAACCGTGCTCATGCTGGCGTTGGGCTACCCGT
CGATCGAGTCGATCTTCATCGGCACAGTGCTGGTCGCCACCAGTGTCGGCATCACCGCTCGCGTGCTGCGCGATGTCGGC
GCCCTCGACTCGCGCGAGGCCCGCATCATCCTCGGTGCTGCTGTCTTCGACGATATCTTCGGACTCCTCATGCTCACCGT
CGTCTCGGGGATCGCGGTCTCGGGCGAACTGGAACTCGGGCGCGTGCTCTGGGTTTCGGTCCTCGCACTCGGTTTCACCG
CGCTCGTCGGTGGGCTAGGTGCGCTGGTGGTCCGGCGCCTCTTCCCCCCGCTGGTCGACCGGCTCCAGCTCGAGCATGCC
CCGCTGGTGGTCGCACTCGCGCTGATGTTGGCCCTGGCGGCGATCGCCGCGACGATCGGTCTCGCCCCGATCGTCGGTGC
CTTCCTGGCCGGTATGGCGTTGGCCGAGGTCGCCGAGCGCTACCACTTGCACGAACAAGCGCTCCCGATCTACACGTTCC
TGGTTCCCTTCTTCTTCGTCGTCACGGGTGCGCGCGTCGATCCGCGGCTCTTCCTCCAAGGCGAGACGCTCGGGCTCGCC
CTCGCGGTCACCGGAGTCGCCGTGCTCACCAAAGCGCTCGGAGCCGCGCTGGGGACGATCGGTTTTCCCTTGCGCTCGAT
GGCGGTGGTCGGCTTCGGCATGGTGCCGCGCGGCGAGGTCGGACTCATCGTCGCCTCGATCGGCCTGTCGCTCGGCGTGG
TCGAGCGTCCCCTGTTCTCGGTCGCCGTCGTCATGTCGATGCTCACCACCCTCCTGACTCCACCGCTCCTGGTTTGGTTG
CTTCGCCCGCTGATCGCCGCGCGCCGGGCTGAACTTGCCACCACCACCGGGCACGTGGAGGGAGCCACGTCATGA

Upstream 100 bases:

>100_bases
GGCCATCCACATCTGACGCACGCCTACTCGACTCGTGGCGAGCTGGCGATAAATGAGCGCGTGAAGGGGATTCGATCACC
ATGTTCGGGGAGCGACATCG

Downstream 100 bases:

>100_bases
GGGGTCTCGGTCACGCCACATTGGCTGGTTTGGCCGGTGCCGTCGCTTTCCTTTTCGCTATGGCCGTCGATCTCGCGGTC
CTGCGCCGACGGACCAACGA

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTAIVEVLSELLIIFLAAKFAGELFLRMRQPAVIGELLAGILIGPFALGLIGVPGHEILELFHEDREAAREGLALALESI
AELGVVVLLFFVGLETRLSDLLRVGIRSLAVAVLGVLGPFAGGTVLMLALGYPSIESIFIGTVLVATSVGITARVLRDVG
ALDSREARIILGAAVFDDIFGLLMLTVVSGIAVSGELELGRVLWVSVLALGFTALVGGLGALVVRRLFPPLVDRLQLEHA
PLVVALALMLALAAIAATIGLAPIVGAFLAGMALAEVAERYHLHEQALPIYTFLVPFFFVVTGARVDPRLFLQGETLGLA
LAVTGVAVLTKALGAALGTIGFPLRSMAVVGFGMVPRGEVGLIVASIGLSLGVVERPLFSVAVVMSMLTTLLTPPLLVWL
LRPLIAARRAELATTTGHVEGATS

Sequences:

>Translated_424_residues
MTAIVEVLSELLIIFLAAKFAGELFLRMRQPAVIGELLAGILIGPFALGLIGVPGHEILELFHEDREAAREGLALALESI
AELGVVVLLFFVGLETRLSDLLRVGIRSLAVAVLGVLGPFAGGTVLMLALGYPSIESIFIGTVLVATSVGITARVLRDVG
ALDSREARIILGAAVFDDIFGLLMLTVVSGIAVSGELELGRVLWVSVLALGFTALVGGLGALVVRRLFPPLVDRLQLEHA
PLVVALALMLALAAIAATIGLAPIVGAFLAGMALAEVAERYHLHEQALPIYTFLVPFFFVVTGARVDPRLFLQGETLGLA
LAVTGVAVLTKALGAALGTIGFPLRSMAVVGFGMVPRGEVGLIVASIGLSLGVVERPLFSVAVVMSMLTTLLTPPLLVWL
LRPLIAARRAELATTTGHVEGATS
>Mature_423_residues
TAIVEVLSELLIIFLAAKFAGELFLRMRQPAVIGELLAGILIGPFALGLIGVPGHEILELFHEDREAAREGLALALESIA
ELGVVVLLFFVGLETRLSDLLRVGIRSLAVAVLGVLGPFAGGTVLMLALGYPSIESIFIGTVLVATSVGITARVLRDVGA
LDSREARIILGAAVFDDIFGLLMLTVVSGIAVSGELELGRVLWVSVLALGFTALVGGLGALVVRRLFPPLVDRLQLEHAP
LVVALALMLALAAIAATIGLAPIVGAFLAGMALAEVAERYHLHEQALPIYTFLVPFFFVVTGARVDPRLFLQGETLGLAL
AVTGVAVLTKALGAALGTIGFPLRSMAVVGFGMVPRGEVGLIVASIGLSLGVVERPLFSVAVVMSMLTTLLTPPLLVWLL
RPLIAARRAELATTTGHVEGATS

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=400, Percent_Identity=28.75, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322367, Length=397, Percent_Identity=26.9521410579345, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44240; Mature: 44109

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIVEVLSELLIIFLAAKFAGELFLRMRQPAVIGELLAGILIGPFALGLIGVPGHEILE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LFHEDREAAREGLALALESIAELGVVVLLFFVGLETRLSDLLRVGIRSLAVAVLGVLGPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGGTVLMLALGYPSIESIFIGTVLVATSVGITARVLRDVGALDSREARIILGAAVFDDIF
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
GLLMLTVVSGIAVSGELELGRVLWVSVLALGFTALVGGLGALVVRRLFPPLVDRLQLEHA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLVVALALMLALAAIAATIGLAPIVGAFLAGMALAEVAERYHLHEQALPIYTFLVPFFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTGARVDPRLFLQGETLGLALAVTGVAVLTKALGAALGTIGFPLRSMAVVGFGMVPRGEV
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCH
GLIVASIGLSLGVVERPLFSVAVVMSMLTTLLTPPLLVWLLRPLIAARRAELATTTGHVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GATS
CCCC
>Mature Secondary Structure 
TAIVEVLSELLIIFLAAKFAGELFLRMRQPAVIGELLAGILIGPFALGLIGVPGHEILE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LFHEDREAAREGLALALESIAELGVVVLLFFVGLETRLSDLLRVGIRSLAVAVLGVLGPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AGGTVLMLALGYPSIESIFIGTVLVATSVGITARVLRDVGALDSREARIILGAAVFDDIF
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
GLLMLTVVSGIAVSGELELGRVLWVSVLALGFTALVGGLGALVVRRLFPPLVDRLQLEHA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLVVALALMLALAAIAATIGLAPIVGAFLAGMALAEVAERYHLHEQALPIYTFLVPFFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTGARVDPRLFLQGETLGLALAVTGVAVLTKALGAALGTIGFPLRSMAVVGFGMVPRGEV
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCH
GLIVASIGLSLGVVERPLFSVAVVMSMLTTLLTPPLLVWLLRPLIAARRAELATTTGHVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GATS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]