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The map label for this gene is htrA [H]

Identifier: 221635726

GI number: 221635726

Start: 305812

End: 306966

Strand: Reverse

Name: htrA [H]

Synonym: trd_A0320

Alternate gene names: 221635726

Gene position: 306966-305812 (Counterclockwise)

Preceding gene: 221635729

Following gene: 221635725

Centisome position: 33.45

GC content: 66.06

Gene sequence:

>1155_bases
ATGCGCCGTCTGTCCATCGCTGCCGGTATCGTCATCGCCTTCTTGGCCGGCTGGGTAGCCGGAAGTGGATGCCTGAGCGT
CCGCCTCGCCGCGACACCGACGACTCTTGCCGCACGCACACCCATCGCCACCAACACGCCATCACTGGCACCGATCGCTC
AGCTCTCTCCGCCGGCCTCCGCGAGCCCTGTCACCCTCCCCGCTCCAGCTCCGACGGGAGACTTCGCGACCGCGATCGAG
CAGGTCGCCGCTCAGGTGATACCAGCTGTCGTCTATGTGTCTGTCCGGGCCATCGTACCGGGCCTCTTCGGCTTCGGGCA
GATTCAGGAAGGAGTCGGCTCAGGAGTCATCTTCGATCCGCGCGGCTACATCCTCACCAACGACCACGTGATCGCTGGCG
CACAAGAAATCCGAGTCGTGCTCAGCGATGGTCGGCAGTTCACCGGTCGCGTGCTGGGCCGCTCCCCATCCAACGATATC
GCTGTCGTCAAGATCGACGGGGAAAACTTGCCCGTCGCTCCGCTGGGGGACAGCGATCAACTGCGCGTCGGGCAATGGGT
CGTCGCGATCGGTAACGCTCTCGGGCTGGAAGGCGGTCCCACGGTCACCGCTGGCGTAGTCAGCGCGCTCGACCGGACGA
TCGGCCCGGGCTTCGGGGAGCCAGCTATCGGTCCCCTCATCCAGACCGACGCGGCCATCAACCCTGGTAACTCCGGTGGG
CCACTCGTCGACCTCGCCGGTCGGGTCGTGGGGATCAACTCGGCCAAGATCCAGACGGCCGAGGGGATCGGCTTCGCCAT
TCCCATCAACAAGGCCAAAGAGATCGTGCAGCAACTTTTGGAGGCTCGCCCGCGCGCGTATCTCGGCATCACCTCGGTCA
GCATGACCCCTGCTCTCGCCGCAGCTTACGGGTTGCCAGTGCAGCGCGGTGTCCTCATCGTCGATGTGGCCCCGGACAGT
CCAGCCGAGCGAGCCGGACTGCAACCCGGTGACGTCATCGTCCGCGTCGACGACCGCGACGTCACGCGGAGCGACGAGCT
GCAAGCGGTCCTCGCTGCCCACCAGCCAGGCGACCAGGTCAGGATCGTGGTCAATCGCCAAGGCCGCGAGCAGACGTTCA
CGGTGACCCTCGGGAGCGCCCCGGTCATCCAGTGA

Upstream 100 bases:

>100_bases
CCACACACCAGACACCCGACCATCCCAGTGCCACTATCATACGTCCTGCCCTGGTCGTAGGATTGCAGCTGGGGCTCGGA
GATCAGGGAGGGAGTCGAGG

Downstream 100 bases:

>100_bases
GGGAGGCGATCGCGATGGCGAGTCAGAGCGACGTGCTCTTCGCTCAGCTGCTGCGCGAGTTCGGGCGACCAGTGCCGGAG
GATCCCGCTCGGCCTTGCTT

Product: protease DO family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRRLSIAAGIVIAFLAGWVAGSGCLSVRLAATPTTLAARTPIATNTPSLAPIAQLSPPASASPVTLPAPAPTGDFATAIE
QVAAQVIPAVVYVSVRAIVPGLFGFGQIQEGVGSGVIFDPRGYILTNDHVIAGAQEIRVVLSDGRQFTGRVLGRSPSNDI
AVVKIDGENLPVAPLGDSDQLRVGQWVVAIGNALGLEGGPTVTAGVVSALDRTIGPGFGEPAIGPLIQTDAAINPGNSGG
PLVDLAGRVVGINSAKIQTAEGIGFAIPINKAKEIVQQLLEARPRAYLGITSVSMTPALAAAYGLPVQRGVLIVDVAPDS
PAERAGLQPGDVIVRVDDRDVTRSDELQAVLAAHQPGDQVRIVVNRQGREQTFTVTLGSAPVIQ

Sequences:

>Translated_384_residues
MRRLSIAAGIVIAFLAGWVAGSGCLSVRLAATPTTLAARTPIATNTPSLAPIAQLSPPASASPVTLPAPAPTGDFATAIE
QVAAQVIPAVVYVSVRAIVPGLFGFGQIQEGVGSGVIFDPRGYILTNDHVIAGAQEIRVVLSDGRQFTGRVLGRSPSNDI
AVVKIDGENLPVAPLGDSDQLRVGQWVVAIGNALGLEGGPTVTAGVVSALDRTIGPGFGEPAIGPLIQTDAAINPGNSGG
PLVDLAGRVVGINSAKIQTAEGIGFAIPINKAKEIVQQLLEARPRAYLGITSVSMTPALAAAYGLPVQRGVLIVDVAPDS
PAERAGLQPGDVIVRVDDRDVTRSDELQAVLAAHQPGDQVRIVVNRQGREQTFTVTLGSAPVIQ
>Mature_384_residues
MRRLSIAAGIVIAFLAGWVAGSGCLSVRLAATPTTLAARTPIATNTPSLAPIAQLSPPASASPVTLPAPAPTGDFATAIE
QVAAQVIPAVVYVSVRAIVPGLFGFGQIQEGVGSGVIFDPRGYILTNDHVIAGAQEIRVVLSDGRQFTGRVLGRSPSNDI
AVVKIDGENLPVAPLGDSDQLRVGQWVVAIGNALGLEGGPTVTAGVVSALDRTIGPGFGEPAIGPLIQTDAAINPGNSGG
PLVDLAGRVVGINSAKIQTAEGIGFAIPINKAKEIVQQLLEARPRAYLGITSVSMTPALAAAYGLPVQRGVLIVDVAPDS
PAERAGLQPGDVIVRVDDRDVTRSDELQAVLAAHQPGDQVRIVVNRQGREQTFTVTLGSAPVIQ

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=296, Percent_Identity=37.1621621621622, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4506141, Length=312, Percent_Identity=34.9358974358974, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI7019477, Length=322, Percent_Identity=36.3354037267081, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI24308541, Length=288, Percent_Identity=34.375, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1789629, Length=316, Percent_Identity=39.873417721519, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1786356, Length=273, Percent_Identity=41.025641025641, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789630, Length=344, Percent_Identity=36.6279069767442, Blast_Score=169, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24646839, Length=344, Percent_Identity=35.4651162790698, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 39300; Mature: 39300

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ ; PS00501 SPASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLSIAAGIVIAFLAGWVAGSGCLSVRLAATPTTLAARTPIATNTPSLAPIAQLSPPAS
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCHHHCCCCCC
ASPVTLPAPAPTGDFATAIEQVAAQVIPAVVYVSVRAIVPGLFGFGQIQEGVGSGVIFDP
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECC
RGYILTNDHVIAGAQEIRVVLSDGRQFTGRVLGRSPSNDIAVVKIDGENLPVAPLGDSDQ
CCCEEECCEEEECHHHEEEEECCCCEEEHHEECCCCCCCEEEEEECCCCCCEEECCCCCC
LRVGQWVVAIGNALGLEGGPTVTAGVVSALDRTIGPGFGEPAIGPLIQTDAAINPGNSGG
EECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCC
PLVDLAGRVVGINSAKIQTAEGIGFAIPINKAKEIVQQLLEARPRAYLGITSVSMTPALA
CCEEECCEEEECCCCEEEECCCCEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
AAYGLPVQRGVLIVDVAPDSPAERAGLQPGDVIVRVDDRDVTRSDELQAVLAAHQPGDQV
HHHCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHEECCCCCCEE
RIVVNRQGREQTFTVTLGSAPVIQ
EEEEECCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MRRLSIAAGIVIAFLAGWVAGSGCLSVRLAATPTTLAARTPIATNTPSLAPIAQLSPPAS
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCHHHCCCCCC
ASPVTLPAPAPTGDFATAIEQVAAQVIPAVVYVSVRAIVPGLFGFGQIQEGVGSGVIFDP
CCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECC
RGYILTNDHVIAGAQEIRVVLSDGRQFTGRVLGRSPSNDIAVVKIDGENLPVAPLGDSDQ
CCCEEECCEEEECHHHEEEEECCCCEEEHHEECCCCCCCEEEEEECCCCCCEEECCCCCC
LRVGQWVVAIGNALGLEGGPTVTAGVVSALDRTIGPGFGEPAIGPLIQTDAAINPGNSGG
EECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCC
PLVDLAGRVVGINSAKIQTAEGIGFAIPINKAKEIVQQLLEARPRAYLGITSVSMTPALA
CCEEECCEEEECCCCEEEECCCCEEEEECHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
AAYGLPVQRGVLIVDVAPDSPAERAGLQPGDVIVRVDDRDVTRSDELQAVLAAHQPGDQV
HHHCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCHHHHHHEECCCCCCEE
RIVVNRQGREQTFTVTLGSAPVIQ
EEEEECCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]