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The map label for this gene is xdhA [H]

Identifier: 221635475

GI number: 221635475

Start: 56603

End: 58894

Strand: Reverse

Name: xdhA [H]

Synonym: trd_A0069

Alternate gene names: 221635475

Gene position: 58894-56603 (Counterclockwise)

Preceding gene: 221635476

Following gene: 221635474

Centisome position: 6.42

GC content: 65.79

Gene sequence:

>2292_bases
ATGAGTGTTGGACAGGCTGTCCCGATGATCGATGCCGTGGAGCGGGTGACTGGGCGTCTCCGCTTCTCGCAGGATGTCGC
GCTCCCCGGCATGCTGCATGCTGCACTCGTGCGCAGCACTGTTCCGCATGGGCGCATCCGCCACATCGACACCCGTGCGG
CGTGGGAGGTTCCTGGAGTCGTCGCGGTGGTCACAGCGGCCGATTTCGCCCGGATCCCTAACCTACGGCCGGTCTACGGT
CCCCAGATCGAAGACCAGCCGGTGTTGGCTATCGACCGGGTGCGCTACGTCGGGGACATGGTCGCGCTCGTCGCCGCTGA
GAATCCACACGCTGCACGCGAGGCAGCCGCCCGCGTCGCCGTCGAGTACGAGCCGCTGCCGGCAGTGTTCGATCCCATCG
AGGCGATGCAGCCCGGCGCACCGCTCGTCCACGAGCTTCGTCCCGAGGAGCCGCATCGTGGTCACGCTGTCTACTTCGGT
CTGCGTCCGCTCTTCGGTACCAACTGCTGCAACCACTTCCGCCTCTCCACCGGCGACGTCGCGCGCGGCTTCGCTGAGGC
CGATCTCGTGCTGGAAGAAACCTTCCGCACCCCGGCTGCCCAGCACGTGGCTATGGAACCTCATGCTGCCCTCGCTGTCT
GGGAGGACGGCCACCTCACCGTGTGGAGTGGGACGCAGACTCCCTTCAATACGCGGCAGATCCTCGCTCAACTCTTCGGC
ATTCCCCCGGAGCGGGTCCGGATCATCGTCCCACCGATGGGCGGATCCTTCGGCTGTAAAGTCTTTCCGCGCATCGAGCC
ACAGGTCGCTCTTCTGGCTGCCCTCACTGGCCGTCCGGTCAAGCTGGTGCTCGACCGTTACGAGGAGTTCGTCACCCTTA
CCCGGCATGCGACGGTGGTCACCATTCGCCTCGGTCTCACTCGCGATGGCCGCATCCTGGCGAAACAGGTCCAGGCGTAC
TGGAACACGGGTGCCTACGCCGACTGCGGACCGGATGTGGCTCGCAAGGGCGGGTTCGGCAGTGTCGGACCCTATCGGAT
TCCTCACGTGGCGGTCGACTCGTACTGTGTTTATACTAACCTTCCACCGGCTGGTGCCTTCCGCGGTTATGCCGTCACCG
AGATCGTCTGGGCCTCCGAGCGGATGATGGATATCGCAGCCGATGCGCTCGGTCTCGATCCTTTGGAGTTCCGTCTCCGC
AACCTCCTCCATGACGGCGACCAGTTCGCGACCGGAGAGACGCTGCACGACGTCCATTTCCAGGAGTGCCTGGAAGCAGC
TGCCCGCGCGATCGCCTGGCAGCCTGAAGCGGTCGTGCTGCCGAAGGGGCGCGTGCGTGCCAAGGGCCTGGCGGTGGTGA
TGAAAGGAATGACGACGCCGAGTCGCTCGGAAGCCCGCGTCGGCCTCGACCGCTCCGGATGCGTCACCGTCTACTCTTCG
ACCGTCGAACTCGGCCAGGGGGCGCGGACGGTCCTGGCGCAACTCGCTGCCGAACCACTCGCTCTCCCGTATACCGCCGT
TCGAGTCATCGATCCCGATACCGACCGGACGCCGTTCGATAACCGCACGACGTCCAGTCGTTCGACATACATGATGGGGA
TGGCGGTACAGCAGGCCGCGCAGCGGCTGGCCGACCGGCTGCGACAGCTGGCAGCCGATCAGCTGGAAGCTGCGCCGGAT
GATCTCGAACTCGTCCCCGGCGCCGTGCGCGTGCGTGGGGTGCCCGAGCGCGCAATCAGCTGGGGTGAACTGGTAGCGAC
GAGCGGCGTCGAGGAACTCGTCGAGCACGGTGAGTTCCGCAACGAGGGCGGGCTGGACGAGACGGGCCACGGCATCGCCT
CCTCCCACTGGCACCAAGGCGCGGCTGGAGCTGAGGTCGAAGTCGATCTGGCGACCGGACAGGTGCGGGTGCTTCGCCTG
CATGCGGCTGTCTATGCGGGGAAGGTCGTCAACGCGCTCACGGCAGCGTTGCAGAACGAGGGAAGCATGATCATGGGTCT
GGGGAGCGCGCTCTTTGAAGCGCTGGTGTACGACCAAGGGCAGCCACTGACGGCGAACCTCTCGGACTATCTCATTCCCT
CCATGCTCGATCTTCCGGAAGAGTTGACGCACGACCTGTTGGAATGCCCGGGTGCCGAGATTCACGGCGTGGGAGAGACG
GCGGTACCGCCGATTCCAGCAGCGATCGGCAATGCCGTCGCGCGGGCGACCGCTGCGCGCCTCGTCGAGCTTCCGCTCAC
GCCGGAGCGCGTTCTCGCTGCCCTGCGGTCGCAACGCGAAGGAGCAAGCTGA

Upstream 100 bases:

>100_bases
GGCAGCGATGATGGCCGCTTACCGGTGAGGGGCTGCTGCGATGAACGCAACCGACCCGTGACCCGGCGAGGTAACGACTG
GAAGCTGTGAGGGCTTTGCG

Downstream 100 bases:

>100_bases
TGGAGCAGGCGATCACGCTCCTCGTCAATGGCGAGCAGCGCCAGCTTCGTGTGCGCTGCGACGAGACATTACTCGAGACC
TTGCGCGACCGCTGCGGGCT

Product: probable xanthine dehydrogenase subunit D (XDHasesubunit D)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MSVGQAVPMIDAVERVTGRLRFSQDVALPGMLHAALVRSTVPHGRIRHIDTRAAWEVPGVVAVVTAADFARIPNLRPVYG
PQIEDQPVLAIDRVRYVGDMVALVAAENPHAAREAAARVAVEYEPLPAVFDPIEAMQPGAPLVHELRPEEPHRGHAVYFG
LRPLFGTNCCNHFRLSTGDVARGFAEADLVLEETFRTPAAQHVAMEPHAALAVWEDGHLTVWSGTQTPFNTRQILAQLFG
IPPERVRIIVPPMGGSFGCKVFPRIEPQVALLAALTGRPVKLVLDRYEEFVTLTRHATVVTIRLGLTRDGRILAKQVQAY
WNTGAYADCGPDVARKGGFGSVGPYRIPHVAVDSYCVYTNLPPAGAFRGYAVTEIVWASERMMDIAADALGLDPLEFRLR
NLLHDGDQFATGETLHDVHFQECLEAAARAIAWQPEAVVLPKGRVRAKGLAVVMKGMTTPSRSEARVGLDRSGCVTVYSS
TVELGQGARTVLAQLAAEPLALPYTAVRVIDPDTDRTPFDNRTTSSRSTYMMGMAVQQAAQRLADRLRQLAADQLEAAPD
DLELVPGAVRVRGVPERAISWGELVATSGVEELVEHGEFRNEGGLDETGHGIASSHWHQGAAGAEVEVDLATGQVRVLRL
HAAVYAGKVVNALTAALQNEGSMIMGLGSALFEALVYDQGQPLTANLSDYLIPSMLDLPEELTHDLLECPGAEIHGVGET
AVPPIPAAIGNAVARATAARLVELPLTPERVLAALRSQREGAS

Sequences:

>Translated_763_residues
MSVGQAVPMIDAVERVTGRLRFSQDVALPGMLHAALVRSTVPHGRIRHIDTRAAWEVPGVVAVVTAADFARIPNLRPVYG
PQIEDQPVLAIDRVRYVGDMVALVAAENPHAAREAAARVAVEYEPLPAVFDPIEAMQPGAPLVHELRPEEPHRGHAVYFG
LRPLFGTNCCNHFRLSTGDVARGFAEADLVLEETFRTPAAQHVAMEPHAALAVWEDGHLTVWSGTQTPFNTRQILAQLFG
IPPERVRIIVPPMGGSFGCKVFPRIEPQVALLAALTGRPVKLVLDRYEEFVTLTRHATVVTIRLGLTRDGRILAKQVQAY
WNTGAYADCGPDVARKGGFGSVGPYRIPHVAVDSYCVYTNLPPAGAFRGYAVTEIVWASERMMDIAADALGLDPLEFRLR
NLLHDGDQFATGETLHDVHFQECLEAAARAIAWQPEAVVLPKGRVRAKGLAVVMKGMTTPSRSEARVGLDRSGCVTVYSS
TVELGQGARTVLAQLAAEPLALPYTAVRVIDPDTDRTPFDNRTTSSRSTYMMGMAVQQAAQRLADRLRQLAADQLEAAPD
DLELVPGAVRVRGVPERAISWGELVATSGVEELVEHGEFRNEGGLDETGHGIASSHWHQGAAGAEVEVDLATGQVRVLRL
HAAVYAGKVVNALTAALQNEGSMIMGLGSALFEALVYDQGQPLTANLSDYLIPSMLDLPEELTHDLLECPGAEIHGVGET
AVPPIPAAIGNAVARATAARLVELPLTPERVLAALRSQREGAS
>Mature_762_residues
SVGQAVPMIDAVERVTGRLRFSQDVALPGMLHAALVRSTVPHGRIRHIDTRAAWEVPGVVAVVTAADFARIPNLRPVYGP
QIEDQPVLAIDRVRYVGDMVALVAAENPHAAREAAARVAVEYEPLPAVFDPIEAMQPGAPLVHELRPEEPHRGHAVYFGL
RPLFGTNCCNHFRLSTGDVARGFAEADLVLEETFRTPAAQHVAMEPHAALAVWEDGHLTVWSGTQTPFNTRQILAQLFGI
PPERVRIIVPPMGGSFGCKVFPRIEPQVALLAALTGRPVKLVLDRYEEFVTLTRHATVVTIRLGLTRDGRILAKQVQAYW
NTGAYADCGPDVARKGGFGSVGPYRIPHVAVDSYCVYTNLPPAGAFRGYAVTEIVWASERMMDIAADALGLDPLEFRLRN
LLHDGDQFATGETLHDVHFQECLEAAARAIAWQPEAVVLPKGRVRAKGLAVVMKGMTTPSRSEARVGLDRSGCVTVYSST
VELGQGARTVLAQLAAEPLALPYTAVRVIDPDTDRTPFDNRTTSSRSTYMMGMAVQQAAQRLADRLRQLAADQLEAAPDD
LELVPGAVRVRGVPERAISWGELVATSGVEELVEHGEFRNEGGLDETGHGIASSHWHQGAAGAEVEVDLATGQVRVLRLH
AAVYAGKVVNALTAALQNEGSMIMGLGSALFEALVYDQGQPLTANLSDYLIPSMLDLPEELTHDLLECPGAEIHGVGETA
VPPIPAAIGNAVARATAARLVELPLTPERVLAALRSQREGAS

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=792, Percent_Identity=27.3989898989899, Blast_Score=235, Evalue=1e-61,
Organism=Homo sapiens, GI71773480, Length=791, Percent_Identity=26.9279393173198, Blast_Score=219, Evalue=8e-57,
Organism=Escherichia coli, GI1789230, Length=772, Percent_Identity=33.5492227979275, Blast_Score=352, Evalue=7e-98,
Organism=Escherichia coli, GI1789246, Length=804, Percent_Identity=29.9751243781095, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1786478, Length=786, Percent_Identity=28.7531806615776, Blast_Score=199, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17540638, Length=788, Percent_Identity=23.4771573604061, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17539860, Length=740, Percent_Identity=23.9189189189189, Blast_Score=158, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI32566215, Length=590, Percent_Identity=24.406779661017, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17737937, Length=718, Percent_Identity=27.8551532033426, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24647199, Length=754, Percent_Identity=23.474801061008, Blast_Score=126, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82204; Mature: 82073

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGQAVPMIDAVERVTGRLRFSQDVALPGMLHAALVRSTVPHGRIRHIDTRAAWEVPGV
CCCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCE
VAVVTAADFARIPNLRPVYGPQIEDQPVLAIDRVRYVGDMVALVAAENPHAAREAAARVA
EEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHEE
VEYEPLPAVFDPIEAMQPGAPLVHELRPEEPHRGHAVYFGLRPLFGTNCCNHFRLSTGDV
EEECCCCHHHCCHHHCCCCCCHHHHCCCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCHH
ARGFAEADLVLEETFRTPAAQHVAMEPHAALAVWEDGHLTVWSGTQTPFNTRQILAQLFG
HHHHHHHHHHHHHHHCCCCHHHEECCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHC
IPPERVRIIVPPMGGSFGCKVFPRIEPQVALLAALTGRPVKLVLDRYEEFVTLTRHATVV
CCHHHEEEEECCCCCCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEE
TIRLGLTRDGRILAKQVQAYWNTGAYADCGPDVARKGGFGSVGPYRIPHVAVDSYCVYTN
EEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCEEEEEC
LPPAGAFRGYAVTEIVWASERMMDIAADALGLDPLEFRLRNLLHDGDQFATGETLHDVHF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
QECLEAAARAIAWQPEAVVLPKGRVRAKGLAVVMKGMTTPSRSEARVGLDRSGCVTVYSS
HHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHEEECCCCCCCCCHHCCCCCCCCEEEEEC
TVELGQGARTVLAQLAAEPLALPYTAVRVIDPDTDRTPFDNRTTSSRSTYMMGMAVQQAA
HHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QRLADRLRQLAADQLEAAPDDLELVPGAVRVRGVPERAISWGELVATSGVEELVEHGEFR
HHHHHHHHHHHHHHHHCCCCCHHHCCCCEEECCCCHHHCCHHHHHHHCCHHHHHHCCCCC
NEGGLDETGHGIASSHWHQGAAGAEVEVDLATGQVRVLRLHAAVYAGKVVNALTAALQNE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
GSMIMGLGSALFEALVYDQGQPLTANLSDYLIPSMLDLPEELTHDLLECPGAEIHGVGET
CCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEECCCCC
AVPPIPAAIGNAVARATAARLVELPLTPERVLAALRSQREGAS
CCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVGQAVPMIDAVERVTGRLRFSQDVALPGMLHAALVRSTVPHGRIRHIDTRAAWEVPGV
CCCCCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCE
VAVVTAADFARIPNLRPVYGPQIEDQPVLAIDRVRYVGDMVALVAAENPHAAREAAARVA
EEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHHEE
VEYEPLPAVFDPIEAMQPGAPLVHELRPEEPHRGHAVYFGLRPLFGTNCCNHFRLSTGDV
EEECCCCHHHCCHHHCCCCCCHHHHCCCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCHH
ARGFAEADLVLEETFRTPAAQHVAMEPHAALAVWEDGHLTVWSGTQTPFNTRQILAQLFG
HHHHHHHHHHHHHHHCCCCHHHEECCCCEEEEEEECCCEEEECCCCCCCHHHHHHHHHHC
IPPERVRIIVPPMGGSFGCKVFPRIEPQVALLAALTGRPVKLVLDRYEEFVTLTRHATVV
CCHHHEEEEECCCCCCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEE
TIRLGLTRDGRILAKQVQAYWNTGAYADCGPDVARKGGFGSVGPYRIPHVAVDSYCVYTN
EEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEECCEEEEEC
LPPAGAFRGYAVTEIVWASERMMDIAADALGLDPLEFRLRNLLHDGDQFATGETLHDVHF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
QECLEAAARAIAWQPEAVVLPKGRVRAKGLAVVMKGMTTPSRSEARVGLDRSGCVTVYSS
HHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHEEECCCCCCCCCHHCCCCCCCCEEEEEC
TVELGQGARTVLAQLAAEPLALPYTAVRVIDPDTDRTPFDNRTTSSRSTYMMGMAVQQAA
HHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QRLADRLRQLAADQLEAAPDDLELVPGAVRVRGVPERAISWGELVATSGVEELVEHGEFR
HHHHHHHHHHHHHHHHCCCCCHHHCCCCEEECCCCHHHCCHHHHHHHCCHHHHHHCCCCC
NEGGLDETGHGIASSHWHQGAAGAEVEVDLATGQVRVLRLHAAVYAGKVVNALTAALQNE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCC
GSMIMGLGSALFEALVYDQGQPLTANLSDYLIPSMLDLPEELTHDLLECPGAEIHGVGET
CCEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCEECCCCC
AVPPIPAAIGNAVARATAARLVELPLTPERVLAALRSQREGAS
CCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]