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The map label for this gene is ndhS [H]

Identifier: 221635474

GI number: 221635474

Start: 56118

End: 56603

Strand: Reverse

Name: ndhS [H]

Synonym: trd_A0068

Alternate gene names: 221635474

Gene position: 56603-56118 (Counterclockwise)

Preceding gene: 221635475

Following gene: 221635473

Centisome position: 6.17

GC content: 62.14

Gene sequence:

>486_bases
ATGGAGCAGGCGATCACGCTCCTCGTCAATGGCGAGCAGCGCCAGCTTCGTGTGCGCTGCGACGAGACATTACTCGAGAC
CTTGCGCGACCGCTGCGGGCTGACGAGCGTTCGCGAGACGTGCGGGATCGGCATTTGCGGTGCCTGTACGATTCTCGTCG
AGGGAAAGCCGACTTCGAGTTGCCTGGTTTTGTCAGCGCTCGCCGATGGCTGGTCGATCACCACGCTCGAGGGATTGACC
GGACCCGATGGAGCATTGCATCCAGTACAAGAGGCTTTTCTGGAGAAGCAAGCCTTCCAATGCAGCTACTGTACGCCTGG
CATGATCCTGACCACGGTTGCGCTGCTGGCTGAGAACCCGCACCCGACGCGCACCGAGATCGCCCAGTACCTAGCGGGGA
ACCTCTGCCGCTGCGGCTCCTATCTCCGCATCCTAGCCGCAGTCGAGGAAGCCGCGCGGAAAGTCCAGGGATCCGCACAG
GGATGA

Upstream 100 bases:

>100_bases
ATGCCGTCGCGCGGGCGACCGCTGCGCGCCTCGTCGAGCTTCCGCTCACGCCGGAGCGCGTTCTCGCTGCCCTGCGGTCG
CAACGCGAAGGAGCAAGCTG

Downstream 100 bases:

>100_bases
GCGTGAAGCAGCTCGCGGAAGGCGACGAGAGTACACTGGGTATGAGCCACACAGCGTGGCCACCAGCACGAATGAGCCCT
GTCTTCCCAAGGTACGGAGA

Product: aldehyde dehydrogenase subunit III

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MEQAITLLVNGEQRQLRVRCDETLLETLRDRCGLTSVRETCGIGICGACTILVEGKPTSSCLVLSALADGWSITTLEGLT
GPDGALHPVQEAFLEKQAFQCSYCTPGMILTTVALLAENPHPTRTEIAQYLAGNLCRCGSYLRILAAVEEAARKVQGSAQ
G

Sequences:

>Translated_161_residues
MEQAITLLVNGEQRQLRVRCDETLLETLRDRCGLTSVRETCGIGICGACTILVEGKPTSSCLVLSALADGWSITTLEGLT
GPDGALHPVQEAFLEKQAFQCSYCTPGMILTTVALLAENPHPTRTEIAQYLAGNLCRCGSYLRILAAVEEAARKVQGSAQ
G
>Mature_161_residues
MEQAITLLVNGEQRQLRVRCDETLLETLRDRCGLTSVRETCGIGICGACTILVEGKPTSSCLVLSALADGWSITTLEGLT
GPDGALHPVQEAFLEKQAFQCSYCTPGMILTTVALLAENPHPTRTEIAQYLAGNLCRCGSYLRILAAVEEAARKVQGSAQ
G

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=91, Percent_Identity=38.4615384615385, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI91823271, Length=160, Percent_Identity=33.75, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786480, Length=167, Percent_Identity=43.7125748502994, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1789232, Length=143, Percent_Identity=47.5524475524476, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17540638, Length=153, Percent_Identity=38.562091503268, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17539860, Length=151, Percent_Identity=31.7880794701987, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI32566215, Length=164, Percent_Identity=29.8780487804878, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737937, Length=153, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647199, Length=137, Percent_Identity=32.8467153284672, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24647201, Length=157, Percent_Identity=31.2101910828025, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24647195, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24647197, Length=163, Percent_Identity=31.2883435582822, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24647193, Length=160, Percent_Identity=29.375, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17213; Mature: 17213

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
6.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQAITLLVNGEQRQLRVRCDETLLETLRDRCGLTSVRETCGIGICGACTILVEGKPTSS
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHEEEEEECCCCCCH
CLVLSALADGWSITTLEGLTGPDGALHPVQEAFLEKQAFQCSYCTPGMILTTVALLAENP
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
HPTRTEIAQYLAGNLCRCGSYLRILAAVEEAARKVQGSAQG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEQAITLLVNGEQRQLRVRCDETLLETLRDRCGLTSVRETCGIGICGACTILVEGKPTSS
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHEEEEEECCCCCCH
CLVLSALADGWSITTLEGLTGPDGALHPVQEAFLEKQAFQCSYCTPGMILTTVALLAENP
HHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
HPTRTEIAQYLAGNLCRCGSYLRILAAVEEAARKVQGSAQG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA