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The map label for this gene is sucD2 [H]

Identifier: 221633776

GI number: 221633776

Start: 1807462

End: 1808337

Strand: Reverse

Name: sucD2 [H]

Synonym: trd_1803

Alternate gene names: 221633776

Gene position: 1808337-1807462 (Counterclockwise)

Preceding gene: 221633777

Following gene: 221633775

Centisome position: 90.28

GC content: 64.84

Gene sequence:

>876_bases
ATGGCGATCCTGGTCGACGAGTCGACGCGGTTGCTGGTGCAAGGAATCACCGGGAAGGAAGGCTCGTTCCACACCGGGCA
GATGATCGAGTACGGGACCAGAGTTGTAGCGGGCGTCACACCGGGAGCCGGCGGTCGAGTCGTGCACGGTGTCCCAGTGT
TCGATACGGTCACCGATGCCGTCGCTGCCACCCAACCCAATGTCTCTTTTATCGCTGTTCCGGCGCCGTTCGCTCCCGAT
GCGATCCTCGAGGCGGCCGATGCTGGCATCCCGCTCATCGTCTGCATCACCGAGGGGATTCCAGTTCTGGAAATGCTCCG
GGTTTACCACGCCGTCCGTCAGCGCGGCGTGCGGCTCATCGGCCCCAATTGCCCGGGACTGATCTCGCCGGGCAAGGCCA
AGGTGGGCATCATGCCGGGATTCATCCACACGCCCGGGCCAGTCGGTATCGTCTCGCGCAGTGGAACGCTTACGTACGAA
GTCGTCTGGGCACTGACACGCGCAGGCATCGGCCAATCGTCGGCCGTCGGCATCGGCGGCGATCCGATCATCGGGACCTC
CTTCGTTGATGTGCTCGAGCTGTTCGAGAACGATCCAGAGACACGCGCCATCGTGCTCATCGGTGAGATCGGCGGAGCCG
ACGAGGAAGCAGCCGCAGCCTATATCCGGGAGCAGGTGACCAAGCCTGTCGTCGGCTTCATCGCCGGGCGCACGGCCCCG
CCCGGTCGACGCATGGGACACGCCGGAGCGATCATCAGCGGCGGGCGGGGAACAGCTGCCGAGAAGATCGCCGCACTAGA
GGCAGCTGGCGTGCACGTCGCGGAGCGACCGGCTGAGATAGCCGACTTGATGCGCGAGATCCTCGCGAACACGTGA

Upstream 100 bases:

>100_bases
GCCTGCTCGAGGAAGCTGGTTTCACGGTCGTGGACACGATGGAAGAAGCAGCGCAGCGAGCCGTGGCACTCGCGCAAGGT
CAGTGAGGCGGGGGCGGGAG

Downstream 100 bases:

>100_bases
CGATGACAGACAGGAGAGGCGAATGCCAGTCGAGCTCGTCCCACATCAGAGTCTCATCGCACTCGGTCGGCTGGCGGGGA
GTCGCGGGTACCTGTGGGGG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha 2; SCS-alpha 2 [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MAILVDESTRLLVQGITGKEGSFHTGQMIEYGTRVVAGVTPGAGGRVVHGVPVFDTVTDAVAATQPNVSFIAVPAPFAPD
AILEAADAGIPLIVCITEGIPVLEMLRVYHAVRQRGVRLIGPNCPGLISPGKAKVGIMPGFIHTPGPVGIVSRSGTLTYE
VVWALTRAGIGQSSAVGIGGDPIIGTSFVDVLELFENDPETRAIVLIGEIGGADEEAAAAYIREQVTKPVVGFIAGRTAP
PGRRMGHAGAIISGGRGTAAEKIAALEAAGVHVAERPAEIADLMREILANT

Sequences:

>Translated_291_residues
MAILVDESTRLLVQGITGKEGSFHTGQMIEYGTRVVAGVTPGAGGRVVHGVPVFDTVTDAVAATQPNVSFIAVPAPFAPD
AILEAADAGIPLIVCITEGIPVLEMLRVYHAVRQRGVRLIGPNCPGLISPGKAKVGIMPGFIHTPGPVGIVSRSGTLTYE
VVWALTRAGIGQSSAVGIGGDPIIGTSFVDVLELFENDPETRAIVLIGEIGGADEEAAAAYIREQVTKPVVGFIAGRTAP
PGRRMGHAGAIISGGRGTAAEKIAALEAAGVHVAERPAEIADLMREILANT
>Mature_290_residues
AILVDESTRLLVQGITGKEGSFHTGQMIEYGTRVVAGVTPGAGGRVVHGVPVFDTVTDAVAATQPNVSFIAVPAPFAPDA
ILEAADAGIPLIVCITEGIPVLEMLRVYHAVRQRGVRLIGPNCPGLISPGKAKVGIMPGFIHTPGPVGIVSRSGTLTYEV
VWALTRAGIGQSSAVGIGGDPIIGTSFVDVLELFENDPETRAIVLIGEIGGADEEAAAAYIREQVTKPVVGFIAGRTAPP
GRRMGHAGAIISGGRGTAAEKIAALEAAGVHVAERPAEIADLMREILANT

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=283, Percent_Identity=58.6572438162544, Blast_Score=279, Evalue=2e-75,
Organism=Homo sapiens, GI38569423, Length=255, Percent_Identity=32.5490196078431, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI38569421, Length=255, Percent_Identity=32.5490196078431, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1786949, Length=288, Percent_Identity=62.8472222222222, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17550194, Length=287, Percent_Identity=56.794425087108, Blast_Score=298, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=52.9209621993127, Blast_Score=283, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17551266, Length=251, Percent_Identity=31.4741035856574, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557344, Length=253, Percent_Identity=30.0395256916996, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=297, Percent_Identity=44.4444444444444, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21356559, Length=289, Percent_Identity=52.9411764705882, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI28574296, Length=291, Percent_Identity=55.6701030927835, Blast_Score=284, Evalue=6e-77,
Organism=Drosophila melanogaster, GI281363477, Length=253, Percent_Identity=29.6442687747036, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281363475, Length=253, Percent_Identity=29.6442687747036, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363473, Length=253, Percent_Identity=29.6442687747036, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29901; Mature: 29770

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVDESTRLLVQGITGKEGSFHTGQMIEYGTRVVAGVTPGAGGRVVHGVPVFDTVTDA
CEEEEECCCEEEEEECCCCCCCCCCCHHHHHCCEEEEECCCCCCCEEEECCCHHHHHHHH
VAATQPNVSFIAVPAPFAPDAILEAADAGIPLIVCITEGIPVLEMLRVYHAVRQRGVRLI
HHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEE
GPNCPGLISPGKAKVGIMPGFIHTPGPVGIVSRSGTLTYEVVWALTRAGIGQSSAVGIGG
CCCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCCEECCCC
DPIIGTSFVDVLELFENDPETRAIVLIGEIGGADEEAAAAYIREQVTKPVVGFIAGRTAP
CCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PGRRMGHAGAIISGGRGTAAEKIAALEAAGVHVAERPAEIADLMREILANT
CCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AILVDESTRLLVQGITGKEGSFHTGQMIEYGTRVVAGVTPGAGGRVVHGVPVFDTVTDA
EEEEECCCEEEEEECCCCCCCCCCCHHHHHCCEEEEECCCCCCCEEEECCCHHHHHHHH
VAATQPNVSFIAVPAPFAPDAILEAADAGIPLIVCITEGIPVLEMLRVYHAVRQRGVRLI
HHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEE
GPNCPGLISPGKAKVGIMPGFIHTPGPVGIVSRSGTLTYEVVWALTRAGIGQSSAVGIGG
CCCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCCEECCCC
DPIIGTSFVDVLELFENDPETRAIVLIGEIGGADEEAAAAYIREQVTKPVVGFIAGRTAP
CCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PGRRMGHAGAIISGGRGTAAEKIAALEAAGVHVAERPAEIADLMREILANT
CCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]