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The map label for this gene is pqqL [C]

Identifier: 221633484

GI number: 221633484

Start: 1486241

End: 1487506

Strand: Reverse

Name: pqqL [C]

Synonym: trd_1505

Alternate gene names: 221633484

Gene position: 1487506-1486241 (Counterclockwise)

Preceding gene: 221633485

Following gene: 221633478

Centisome position: 74.26

GC content: 62.72

Gene sequence:

>1266_bases
ATGGATTACCAGAAGACGTGCCTGCCCAACGGGATTCGTATCGTGACCAGCCGGATGCCCCATGTGCGCTCGGCGACGGT
CATCGTGTACGTCGGGGTCGGCTCACGCTACGAAAGCGATCGCTTGGCTGGTATCTCGCATTTTCTGGAGCACATGCTGT
TCAAGGGCACCGAGCGGCGCCCGGATCCCGTGCTGATCAGCGAGGCGATCGAAGGCGTCGGCGGGATGATGAACGCGTCG
ACCGGTCGCGAGCATACGGACTACTGGGTCAAAGTGCCGAGCCGGCATCTCGAACTCGCTTTCGATGTTCTGGCTGACAT
GCTGCGCCACTCGTTGTTCGATCCAGGCGAACTCGAGAAGGAACGGCATGTCATCGTCGAAGAGATCCACGGCATCCGCG
ACACACCGGACGACTACGTGCACGATCTGGTGGATCGGGCACTCTGGAACGGGCATCCGTTGGGAAGGCCGATCATCGGC
TCGGAAGAGACAGTGGAGGCGATCACGCGCGACGAACTCATCGCCTACCTCGAGCAGCATTACCGGGCCGATCGCTTGGT
CGTGGCTGCAGCTGGAGATCTGACGCACGAGCAGGTGATCGAACTCGTGCAGCGCTATTTCGGTGATCTGGAGCCAGGGA
CACCAGCTGATCCCCACCCGGCTCGACTGAGCGATGCACGGCCGACGATCGAACTCCTCGAGCGACCGACCGAGCAGGCG
CACCTTTGCCTCGCGCTACCCGCGTTGCCGTACCGTGACGAGCGTCGCTTCGTGCAAGGTATGTTGGATTCTGTGCTCAG
TTCCGGCATGAGTTCGCGGTTATTCAAAGAGATCCGCGAGCGCCAAGGACTCGCGTACGAGGTGTACGGGTATCTCCGCG
AGTATGCCGACGTCGGGCAGGCGGTCATCTACACGGGTACCGACGTCGAGCGTGCTGAGCGCGCGCTGCGTGCGGTGCGG
GGTGAATTGGAGAAGCTGGTGCGCGAGCCGGTTCCCGATGACGAACTCGAGCGCACAAAGGAGCTGCGTGTCGGGCGGAT
CGTCATGGGCTTGGAAGACAGTCGTGCGGTGGCCAGCTGGATCGGCGGGCAGGAACTGGTGTTCGGTGAGGTGCTGACGC
CTGAGGAAGTCATCGCCCGCATTCGGGCGGTCACCAGCGAGGAGATCCAGGCGCTGGCACAGGAACTGTTCCAGCCGGAA
CGCTTCGCCCTGGCTGTGATCGGGCCGTTCGCGGATGTCGAACCCCTGGTGTGCGCCGTGCGTTAG

Upstream 100 bases:

>100_bases
TGGCAGAACATCGAGCTGTCGGCGGAAGCGGCGCTCCGGCTGCTGCTCGATCAAGTTCAGGTCGCCGATCGATCGGCGAT
GAGGTAGGAAACGGGTAAGG

Downstream 100 bases:

>100_bases
GATCCGCTGGCGACCAGCTGCTCGATCCAACCGCGCTCGCGACCGATCGTCGTCGTCGGGCCGTGACCAGGGAAGACGAT
CACGTCACCGGGCAGTTCCA

Product: processing protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDYQKTCLPNGIRIVTSRMPHVRSATVIVYVGVGSRYESDRLAGISHFLEHMLFKGTERRPDPVLISEAIEGVGGMMNAS
TGREHTDYWVKVPSRHLELAFDVLADMLRHSLFDPGELEKERHVIVEEIHGIRDTPDDYVHDLVDRALWNGHPLGRPIIG
SEETVEAITRDELIAYLEQHYRADRLVVAAAGDLTHEQVIELVQRYFGDLEPGTPADPHPARLSDARPTIELLERPTEQA
HLCLALPALPYRDERRFVQGMLDSVLSSGMSSRLFKEIRERQGLAYEVYGYLREYADVGQAVIYTGTDVERAERALRAVR
GELEKLVREPVPDDELERTKELRVGRIVMGLEDSRAVASWIGGQELVFGEVLTPEEVIARIRAVTSEEIQALAQELFQPE
RFALAVIGPFADVEPLVCAVR

Sequences:

>Translated_421_residues
MDYQKTCLPNGIRIVTSRMPHVRSATVIVYVGVGSRYESDRLAGISHFLEHMLFKGTERRPDPVLISEAIEGVGGMMNAS
TGREHTDYWVKVPSRHLELAFDVLADMLRHSLFDPGELEKERHVIVEEIHGIRDTPDDYVHDLVDRALWNGHPLGRPIIG
SEETVEAITRDELIAYLEQHYRADRLVVAAAGDLTHEQVIELVQRYFGDLEPGTPADPHPARLSDARPTIELLERPTEQA
HLCLALPALPYRDERRFVQGMLDSVLSSGMSSRLFKEIRERQGLAYEVYGYLREYADVGQAVIYTGTDVERAERALRAVR
GELEKLVREPVPDDELERTKELRVGRIVMGLEDSRAVASWIGGQELVFGEVLTPEEVIARIRAVTSEEIQALAQELFQPE
RFALAVIGPFADVEPLVCAVR
>Mature_421_residues
MDYQKTCLPNGIRIVTSRMPHVRSATVIVYVGVGSRYESDRLAGISHFLEHMLFKGTERRPDPVLISEAIEGVGGMMNAS
TGREHTDYWVKVPSRHLELAFDVLADMLRHSLFDPGELEKERHVIVEEIHGIRDTPDDYVHDLVDRALWNGHPLGRPIIG
SEETVEAITRDELIAYLEQHYRADRLVVAAAGDLTHEQVIELVQRYFGDLEPGTPADPHPARLSDARPTIELLERPTEQA
HLCLALPALPYRDERRFVQGMLDSVLSSGMSSRLFKEIRERQGLAYEVYGYLREYADVGQAVIYTGTDVERAERALRAVR
GELEKLVREPVPDDELERTKELRVGRIVMGLEDSRAVASWIGGQELVFGEVLTPEEVIARIRAVTSEEIQALAQELFQPE
RFALAVIGPFADVEPLVCAVR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=434, Percent_Identity=29.2626728110599, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI46593007, Length=420, Percent_Identity=28.0952380952381, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI24308013, Length=437, Percent_Identity=26.7734553775744, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI155969707, Length=263, Percent_Identity=26.9961977186312, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI50592988, Length=429, Percent_Identity=20.04662004662, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI156071452, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI156071450, Length=240, Percent_Identity=26.25, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787770, Length=411, Percent_Identity=22.6277372262774, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI2367164, Length=131, Percent_Identity=30.5343511450382, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71999683, Length=419, Percent_Identity=27.9236276849642, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17553678, Length=420, Percent_Identity=25.7142857142857, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17510601, Length=455, Percent_Identity=22.8571428571429, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146563, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71994338, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI32566665, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25146566, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI72001443, Length=218, Percent_Identity=25.2293577981651, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533970, Length=213, Percent_Identity=27.2300469483568, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323192, Length=424, Percent_Identity=29.9528301886792, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321813, Length=416, Percent_Identity=22.5961538461538, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325379, Length=228, Percent_Identity=27.6315789473684, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323421, Length=195, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319426, Length=421, Percent_Identity=21.6152019002375, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357875, Length=420, Percent_Identity=29.2857142857143, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24646943, Length=420, Percent_Identity=29.2857142857143, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19921772, Length=423, Percent_Identity=27.1867612293144, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI221513245, Length=233, Percent_Identity=27.8969957081545, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641429, Length=189, Percent_Identity=26.984126984127, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24667786, Length=171, Percent_Identity=29.2397660818713, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 47458; Mature: 47458

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQKTCLPNGIRIVTSRMPHVRSATVIVYVGVGSRYESDRLAGISHFLEHMLFKGTERR
CCCCCCCCCCCCEEHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
PDPVLISEAIEGVGGMMNASTGREHTDYWVKVPSRHLELAFDVLADMLRHSLFDPGELEK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCH
ERHVIVEEIHGIRDTPDDYVHDLVDRALWNGHPLGRPIIGSEETVEAITRDELIAYLEQH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YRADRLVVAAAGDLTHEQVIELVQRYFGDLEPGTPADPHPARLSDARPTIELLERPTEQA
HCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHH
HLCLALPALPYRDERRFVQGMLDSVLSSGMSSRLFKEIRERQGLAYEVYGYLREYADVGQ
HEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
AVIYTGTDVERAERALRAVRGELEKLVREPVPDDELERTKELRVGRIVMGLEDSRAVASW
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHH
IGGQELVFGEVLTPEEVIARIRAVTSEEIQALAQELFQPERFALAVIGPFADVEPLVCAV
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHEEC
R
C
>Mature Secondary Structure
MDYQKTCLPNGIRIVTSRMPHVRSATVIVYVGVGSRYESDRLAGISHFLEHMLFKGTERR
CCCCCCCCCCCCEEHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCC
PDPVLISEAIEGVGGMMNASTGREHTDYWVKVPSRHLELAFDVLADMLRHSLFDPGELEK
CCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCH
ERHVIVEEIHGIRDTPDDYVHDLVDRALWNGHPLGRPIIGSEETVEAITRDELIAYLEQH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YRADRLVVAAAGDLTHEQVIELVQRYFGDLEPGTPADPHPARLSDARPTIELLERPTEQA
HCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHH
HLCLALPALPYRDERRFVQGMLDSVLSSGMSSRLFKEIRERQGLAYEVYGYLREYADVGQ
HEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
AVIYTGTDVERAERALRAVRGELEKLVREPVPDDELERTKELRVGRIVMGLEDSRAVASW
EEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHH
IGGQELVFGEVLTPEEVIARIRAVTSEEIQALAQELFQPERFALAVIGPFADVEPLVCAV
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]