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The map label for this gene is ubiB [C]

Identifier: 221632767

GI number: 221632767

Start: 748943

End: 750613

Strand: Reverse

Name: ubiB [C]

Synonym: trd_0757

Alternate gene names: 221632767

Gene position: 750613-748943 (Counterclockwise)

Preceding gene: 221632768

Following gene: 221632752

Centisome position: 37.47

GC content: 61.52

Gene sequence:

>1671_bases
GTGGTAGCACCACGATTGCTCTTTCCGCGTCGAATGTTCGCGCATCGCCGGCGAGTACTCGAGATCGCCGGCGTCTTCTC
CAAGCATGGACTGGGGTGGCTGCTCGATCACCTCGGAGCCCCCATTCCTGCCCGACTCCGCCGCACTCCGCGAGGACCAG
AGCTCCCAACTCCAGTCCGTCTCCGCCTCGCCCTCGAGGAACTCGGGCCAACCTTCATCAAGCTCGGACAAATCTTGTCG
ACCCGCGACGATCTCTTGCCACCAGACTACATCGCTGAACTTGCCCTGCTCCGCGATCGTGTTCCCCCGATCCCCGCCGA
ACAGATCATCGCTGAGATCGAGCGAAGTTTCGGAAGACCGCTCGGCGAACTCTTCGCCACCTTCGATCCGAACCCTCTCG
CCTCGGCCTCGATCGGTCAAGTCCATGCAGCGACCTTACCGACCGGGACGAGCGTCATCGTGAAAGTCCGCAAACCGGGC
ATCGCCGACATGATCGAGGAAGACTTAGCCCTGCTCCGCGAGATCGCCGAGTTCGCCAGTCGGCACAGTCCACTCGCCCG
CGACTACGATCTCGTTGGTCTCCTCGACGAGTTCGCCTGGACCATACGCAGCGAACTCGACTACCGGCGAGAAGGACGCA
ACGCCGATCGCTTCCGGACCCTTCTCGTTGATCGGCCAGATATCGTCATTCCCCGCGTCTTTTGGCACCGCACCACCGAG
ACGGTTCTCACGCTGCGCCGAATCGATGGTATCCCTATCGATCGCATCGAGGAACTCGACCGCGCTCGCATCGATCGCCA
CGCACTCGCGCTGCAAGCGGCTCGTTTCGTCCTCGACTGTGTCCTCGTTCATGGCTTCTTTCACGCCGACCCTCATCCTG
GCAATTTCGCCGTTCTCCCCGACGGTCGGCTCGTCGTCTACGACTTCGGAATGGTCGGTCGAGTCGATACCTTCGTGCGC
GCCGAACTCGCCGATGCGCTGCTGGCCTTCATCCGTAACGACTTCGATGCGCTCATCGATAGCCTGGGGCGACTCGGGAT
CATCCGGCACGAGGCTGATCGACCAGCACTGCGCCGCGAACTCCAGCATCTCGCCGAACGATACTACGGGCTTTCGCTCG
GTGAGTATCGCTTCGGCGAAGTTATCGCCGACCTCTCTCGCTTGATGCGCCGCTGGCGTTTGACGCTTCCCCCCGAACTG
AGCCTTCTCGTCAAAACGCTCTCGATGCATGAGGGAGTCGGACAGCGGTTGGATCCCTCTTTTCAACCATTTCTTGTCGC
AGAACCGTACGTGCGCCGCTTGCTCATGCAGCGCTATCACCCCGAGTCGTGGCTCCCTCAGGTGGCCCGCATGCTCGAGG
ACAGTGCGCGCCAAGCAGTCGGATTTCCGCGCCGGATCGATCGCCTTCTTCGCCGACTCGAGCAAGCCGAACTCGAAGTG
ACCATGCACCTCGCTGAGCTGCCGGACGCGACGCAGCGCTTGAGCGCGATGGTCAACCGGCTTATCACCGCCATCTTGCT
CGCGGCAGCAGCGATCAGTTTGAGTCTCTTGCTGAACGTCTGGCATCCCGAGTGGCTCGTCCGTTGGATCGGCCCCATAC
TCTTCTTCGGTCTTCTCAGTATCGTCGGTGCGAGTCTGCTACTGGCGTGGCAATGGTGGCGGAATCGCTAA

Upstream 100 bases:

>100_bases
GAATACACCATCGTTCGCCTCCCGAGTGCTTTTCCGATCCGCGATTATACTGCCGAGAAGATGCCATACCCGGACGCGTT
CTGAGGAGGCACATCGGACA

Downstream 100 bases:

>100_bases
TCGACCTGCTCTAAAGTACTGCTTCCGTCTTCCTCGGCGGTATCCGCGAGAAGCGTCTCTTCGTCTAACCGCTCCAAGAC
GCGGTCCGGATCCTCCCCAC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MVAPRLLFPRRMFAHRRRVLEIAGVFSKHGLGWLLDHLGAPIPARLRRTPRGPELPTPVRLRLALEELGPTFIKLGQILS
TRDDLLPPDYIAELALLRDRVPPIPAEQIIAEIERSFGRPLGELFATFDPNPLASASIGQVHAATLPTGTSVIVKVRKPG
IADMIEEDLALLREIAEFASRHSPLARDYDLVGLLDEFAWTIRSELDYRREGRNADRFRTLLVDRPDIVIPRVFWHRTTE
TVLTLRRIDGIPIDRIEELDRARIDRHALALQAARFVLDCVLVHGFFHADPHPGNFAVLPDGRLVVYDFGMVGRVDTFVR
AELADALLAFIRNDFDALIDSLGRLGIIRHEADRPALRRELQHLAERYYGLSLGEYRFGEVIADLSRLMRRWRLTLPPEL
SLLVKTLSMHEGVGQRLDPSFQPFLVAEPYVRRLLMQRYHPESWLPQVARMLEDSARQAVGFPRRIDRLLRRLEQAELEV
TMHLAELPDATQRLSAMVNRLITAILLAAAAISLSLLLNVWHPEWLVRWIGPILFFGLLSIVGASLLLAWQWWRNR

Sequences:

>Translated_556_residues
MVAPRLLFPRRMFAHRRRVLEIAGVFSKHGLGWLLDHLGAPIPARLRRTPRGPELPTPVRLRLALEELGPTFIKLGQILS
TRDDLLPPDYIAELALLRDRVPPIPAEQIIAEIERSFGRPLGELFATFDPNPLASASIGQVHAATLPTGTSVIVKVRKPG
IADMIEEDLALLREIAEFASRHSPLARDYDLVGLLDEFAWTIRSELDYRREGRNADRFRTLLVDRPDIVIPRVFWHRTTE
TVLTLRRIDGIPIDRIEELDRARIDRHALALQAARFVLDCVLVHGFFHADPHPGNFAVLPDGRLVVYDFGMVGRVDTFVR
AELADALLAFIRNDFDALIDSLGRLGIIRHEADRPALRRELQHLAERYYGLSLGEYRFGEVIADLSRLMRRWRLTLPPEL
SLLVKTLSMHEGVGQRLDPSFQPFLVAEPYVRRLLMQRYHPESWLPQVARMLEDSARQAVGFPRRIDRLLRRLEQAELEV
TMHLAELPDATQRLSAMVNRLITAILLAAAAISLSLLLNVWHPEWLVRWIGPILFFGLLSIVGASLLLAWQWWRNR
>Mature_556_residues
MVAPRLLFPRRMFAHRRRVLEIAGVFSKHGLGWLLDHLGAPIPARLRRTPRGPELPTPVRLRLALEELGPTFIKLGQILS
TRDDLLPPDYIAELALLRDRVPPIPAEQIIAEIERSFGRPLGELFATFDPNPLASASIGQVHAATLPTGTSVIVKVRKPG
IADMIEEDLALLREIAEFASRHSPLARDYDLVGLLDEFAWTIRSELDYRREGRNADRFRTLLVDRPDIVIPRVFWHRTTE
TVLTLRRIDGIPIDRIEELDRARIDRHALALQAARFVLDCVLVHGFFHADPHPGNFAVLPDGRLVVYDFGMVGRVDTFVR
AELADALLAFIRNDFDALIDSLGRLGIIRHEADRPALRRELQHLAERYYGLSLGEYRFGEVIADLSRLMRRWRLTLPPEL
SLLVKTLSMHEGVGQRLDPSFQPFLVAEPYVRRLLMQRYHPESWLPQVARMLEDSARQAVGFPRRIDRLLRRLEQAELEV
TMHLAELPDATQRLSAMVNRLITAILLAAAAISLSLLLNVWHPEWLVRWIGPILFFGLLSIVGASLLLAWQWWRNR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=316, Percent_Identity=31.3291139240506, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=32.962962962963, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI217035081, Length=229, Percent_Identity=30.1310043668122, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI27363457, Length=381, Percent_Identity=28.6089238845144, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI217416386, Length=377, Percent_Identity=27.8514588859416, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI34147522, Length=246, Percent_Identity=27.6422764227642, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI2367309, Length=484, Percent_Identity=31.404958677686, Blast_Score=209, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17559152, Length=288, Percent_Identity=29.5138888888889, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32565180, Length=318, Percent_Identity=28.6163522012579, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321319, Length=243, Percent_Identity=30.8641975308642, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=243, Percent_Identity=28.3950617283951, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=433, Percent_Identity=21.2471131639723, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24662575, Length=297, Percent_Identity=29.6296296296296, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI22024280, Length=280, Percent_Identity=27.5, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18859849, Length=283, Percent_Identity=28.2685512367491, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63535; Mature: 63535

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPRLLFPRRMFAHRRRVLEIAGVFSKHGLGWLLDHLGAPIPARLRRTPRGPELPTPVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
LRLALEELGPTFIKLGQILSTRDDLLPPDYIAELALLRDRVPPIPAEQIIAEIERSFGRP
HHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
LGELFATFDPNPLASASIGQVHAATLPTGTSVIVKVRKPGIADMIEEDLALLREIAEFAS
HHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RHSPLARDYDLVGLLDEFAWTIRSELDYRREGRNADRFRTLLVDRPDIVIPRVFWHRTTE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECHHHHHHHHH
TVLTLRRIDGIPIDRIEELDRARIDRHALALQAARFVLDCVLVHGFFHADPHPGNFAVLP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGRLVVYDFGMVGRVDTFVRAELADALLAFIRNDFDALIDSLGRLGIIRHEADRPALRRE
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEHHCCCCCHHHHHH
LQHLAERYYGLSLGEYRFGEVIADLSRLMRRWRLTLPPELSLLVKTLSMHEGVGQRLDPS
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
FQPFLVAEPYVRRLLMQRYHPESWLPQVARMLEDSARQAVGFPRRIDRLLRRLEQAELEV
CCCEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TMHLAELPDATQRLSAMVNRLITAILLAAAAISLSLLLNVWHPEWLVRWIGPILFFGLLS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
IVGASLLLAWQWWRNR
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVAPRLLFPRRMFAHRRRVLEIAGVFSKHGLGWLLDHLGAPIPARLRRTPRGPELPTPVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHCCCCCCCCCCCCHH
LRLALEELGPTFIKLGQILSTRDDLLPPDYIAELALLRDRVPPIPAEQIIAEIERSFGRP
HHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
LGELFATFDPNPLASASIGQVHAATLPTGTSVIVKVRKPGIADMIEEDLALLREIAEFAS
HHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RHSPLARDYDLVGLLDEFAWTIRSELDYRREGRNADRFRTLLVDRPDIVIPRVFWHRTTE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECHHHHHHHHH
TVLTLRRIDGIPIDRIEELDRARIDRHALALQAARFVLDCVLVHGFFHADPHPGNFAVLP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
DGRLVVYDFGMVGRVDTFVRAELADALLAFIRNDFDALIDSLGRLGIIRHEADRPALRRE
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEHHCCCCCHHHHHH
LQHLAERYYGLSLGEYRFGEVIADLSRLMRRWRLTLPPELSLLVKTLSMHEGVGQRLDPS
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
FQPFLVAEPYVRRLLMQRYHPESWLPQVARMLEDSARQAVGFPRRIDRLLRRLEQAELEV
CCCEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TMHLAELPDATQRLSAMVNRLITAILLAAAAISLSLLLNVWHPEWLVRWIGPILFFGLLS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
IVGASLLLAWQWWRNR
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]