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The map label for this gene is glmS [H]

Identifier: 221632752

GI number: 221632752

Start: 732048

End: 733859

Strand: Reverse

Name: glmS [H]

Synonym: trd_0743

Alternate gene names: 221632752

Gene position: 733859-732048 (Counterclockwise)

Preceding gene: 221632767

Following gene: 221632751

Centisome position: 36.64

GC content: 61.2

Gene sequence:

>1812_bases
ATGTGCGGAATCTTCGGTTTCGTCGCTCCGCAACCGCTCCCTGCTTCGCTCGTCATCGACGCACTGCGGACGCTGGAGTA
CCGTGGGTACGACTCCTGGGGAATCGCCTTTCTGGATGGTGACCTGGCCCGAGAACGGATCGCCGTGCTCAAGCGAGCTG
GGCGTATTCCGGCGAGCACGCCAAACCTGCCCGCTACGGTGATCGCACTCGGCCACACGCGGTGGGCGACCCATGGTGGA
GTCACGGACGAGAACGCGCATCCCCACCTCGACTGCACCGGTACCCTCGCGATCGTCCATAACGGCATCATCGAAAATTA
TCTTCCGCTGCGTCGGGCACTCGAACGATCTGGTCACCGCTTTCGGAGTAGCACCGACAGCGAGATCTTCGCGCATCTCC
TCGAAGACACCATCGCCAGCATCGAGGAGCACCATCCCAGTGCATCGGACGATATCCCCACTCTGGTCGAGGCAGTTCGA
CATGCGTTCAATCAAGTCCGCGGTCTCAATGCACTCATCGCGTTGCATCGCCCGACGCGACAACTTGTTGCCGTCAAGTC
AACTTCGCCGCTCGTTCTCGGGCATGGTCCAGCCGGAACGTTCGTCGCCTCCGATGCCGTCGCTCTCGTTGGCTATACCG
ACCGGATCCATTACCTTCAGGACGACGAGATCGCTCTGCTCGATCACCAGGGTCTCCAGCTCTTCGATCGATGCACCGGA
CAGCGCCGGTCAGCCCGCTGGGAGCCGCTCACGCTCCGCCCCGCCGATACGTCACTCGGTGGCTATCCGCACTACCTGAT
CAAGGAGATTCACGAACAGCCGCGAGTCCTCGCACGGATCGCCCGGGAGCGCCTGGACGGTGCACGACAGCTAGCTGATC
TCATTCGTCATTCGTATGGGACATTCCTGGTCGGGTGCGGTACCGCTGGCTACGCCGCGCTCTGCGGGAGTTATCTCTTT
TCGCGCATCGCGCGCCGCCACGTCAATGCGGTCATTGCGTCCGAATTCAAGTATCAGGAACATTTCTTGACCGATCGATC
GCTCGTCATTGCGCTTACCCAGAGCGGTGAGACGATCGATGTGATCGAGGCGGTCCACGCCGCCAAGCGGCGTGGAGCCA
CCGTTGCCGCTCTGGTCAATGTGACCGGCTCCACTGTCGCTCGGCTCGCCGACTTCACCATTCCACTCTCGGCCGGCCCC
GAACAGAGTGTTCTGTCGACCAAAGCCTACACAGCGAAGCTCGCTATCCTGCTGCTGACCGCACACATCCTCAATGGGAG
CGAGCATGTAGGACTCGATACGCTGTGGCGCGCGATCGAGGGTATGGAGATGGCCCTCGCACCAGCGACACTGGACCGCA
TCCGGGCTGTCGCCGATCGCCTCGTTGACGCGCAACACTGCTATGTGATCGGTCGGGGACTCTCCTACCCCACCGCGCTC
GAGGCCGCACTTAAGATCAAGGAAGTGACCTACATTCATGCCGAAGGCTTTGCCGGGGGAGAACTCAAGCACGGTGTCAT
TGCGCTCATCGAGGATGGGAGTCCCTGCCTCGTCTTCTCGCCACTCGACGAAACGAGGGCAGATATTCTCTCTGGTGCGA
TGGAAGTTCGCAGTCGCGGCGGATGGGTCATCGGCATCTCTCCAGAACCTGACGAAGCTTTTCATGTCCACATTCCGGTC
GCCGATGTGGGTGATGCCTCCCCACTGGTCTCGATCGTGCCAGCACAACTCCTCGCCTACGAGCTGGCAGTGCGCCGCGG
CCTGGATCCGGATAAACCACGGAATCTCGCCAAGAGCGTGACCGTCAAGTGA

Upstream 100 bases:

>100_bases
CGCTCCCCCTGAGAATAGTCACGCGATAGGGCGCCATACCTCTCGAGATGGCGCCGCCGAGGCTTCCTTTGGGCGCTGGC
CGAAGGAGGGAAAGTCCTGC

Downstream 100 bases:

>100_bases
GGCGAGAATGATTCTGGTCGACACGCATTGCCATCTCGACCTCCCCGACTTCGACAACGATCGGCCACTCGTGATCGAGC
GGGCCCGCGATGCTGGCGTC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MCGIFGFVAPQPLPASLVIDALRTLEYRGYDSWGIAFLDGDLARERIAVLKRAGRIPASTPNLPATVIALGHTRWATHGG
VTDENAHPHLDCTGTLAIVHNGIIENYLPLRRALERSGHRFRSSTDSEIFAHLLEDTIASIEEHHPSASDDIPTLVEAVR
HAFNQVRGLNALIALHRPTRQLVAVKSTSPLVLGHGPAGTFVASDAVALVGYTDRIHYLQDDEIALLDHQGLQLFDRCTG
QRRSARWEPLTLRPADTSLGGYPHYLIKEIHEQPRVLARIARERLDGARQLADLIRHSYGTFLVGCGTAGYAALCGSYLF
SRIARRHVNAVIASEFKYQEHFLTDRSLVIALTQSGETIDVIEAVHAAKRRGATVAALVNVTGSTVARLADFTIPLSAGP
EQSVLSTKAYTAKLAILLLTAHILNGSEHVGLDTLWRAIEGMEMALAPATLDRIRAVADRLVDAQHCYVIGRGLSYPTAL
EAALKIKEVTYIHAEGFAGGELKHGVIALIEDGSPCLVFSPLDETRADILSGAMEVRSRGGWVIGISPEPDEAFHVHIPV
ADVGDASPLVSIVPAQLLAYELAVRRGLDPDKPRNLAKSVTVK

Sequences:

>Translated_603_residues
MCGIFGFVAPQPLPASLVIDALRTLEYRGYDSWGIAFLDGDLARERIAVLKRAGRIPASTPNLPATVIALGHTRWATHGG
VTDENAHPHLDCTGTLAIVHNGIIENYLPLRRALERSGHRFRSSTDSEIFAHLLEDTIASIEEHHPSASDDIPTLVEAVR
HAFNQVRGLNALIALHRPTRQLVAVKSTSPLVLGHGPAGTFVASDAVALVGYTDRIHYLQDDEIALLDHQGLQLFDRCTG
QRRSARWEPLTLRPADTSLGGYPHYLIKEIHEQPRVLARIARERLDGARQLADLIRHSYGTFLVGCGTAGYAALCGSYLF
SRIARRHVNAVIASEFKYQEHFLTDRSLVIALTQSGETIDVIEAVHAAKRRGATVAALVNVTGSTVARLADFTIPLSAGP
EQSVLSTKAYTAKLAILLLTAHILNGSEHVGLDTLWRAIEGMEMALAPATLDRIRAVADRLVDAQHCYVIGRGLSYPTAL
EAALKIKEVTYIHAEGFAGGELKHGVIALIEDGSPCLVFSPLDETRADILSGAMEVRSRGGWVIGISPEPDEAFHVHIPV
ADVGDASPLVSIVPAQLLAYELAVRRGLDPDKPRNLAKSVTVK
>Mature_603_residues
MCGIFGFVAPQPLPASLVIDALRTLEYRGYDSWGIAFLDGDLARERIAVLKRAGRIPASTPNLPATVIALGHTRWATHGG
VTDENAHPHLDCTGTLAIVHNGIIENYLPLRRALERSGHRFRSSTDSEIFAHLLEDTIASIEEHHPSASDDIPTLVEAVR
HAFNQVRGLNALIALHRPTRQLVAVKSTSPLVLGHGPAGTFVASDAVALVGYTDRIHYLQDDEIALLDHQGLQLFDRCTG
QRRSARWEPLTLRPADTSLGGYPHYLIKEIHEQPRVLARIARERLDGARQLADLIRHSYGTFLVGCGTAGYAALCGSYLF
SRIARRHVNAVIASEFKYQEHFLTDRSLVIALTQSGETIDVIEAVHAAKRRGATVAALVNVTGSTVARLADFTIPLSAGP
EQSVLSTKAYTAKLAILLLTAHILNGSEHVGLDTLWRAIEGMEMALAPATLDRIRAVADRLVDAQHCYVIGRGLSYPTAL
EAALKIKEVTYIHAEGFAGGELKHGVIALIEDGSPCLVFSPLDETRADILSGAMEVRSRGGWVIGISPEPDEAFHVHIPV
ADVGDASPLVSIVPAQLLAYELAVRRGLDPDKPRNLAKSVTVK

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=30.7803468208092, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=29.6242774566474, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI29570798, Length=187, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790167, Length=637, Percent_Identity=37.0486656200942, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI87082251, Length=296, Percent_Identity=23.3108108108108, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788651, Length=401, Percent_Identity=25.4364089775561, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=724, Percent_Identity=29.6961325966851, Blast_Score=256, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17532899, Length=721, Percent_Identity=29.126213592233, Blast_Score=238, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=31.6279069767442, Blast_Score=187, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6322745, Length=435, Percent_Identity=31.7241379310345, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=24.2990654205607, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6323730, Length=214, Percent_Identity=31.3084112149533, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357745, Length=701, Percent_Identity=30.2425106990014, Blast_Score=279, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65361; Mature: 65361

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIFGFVAPQPLPASLVIDALRTLEYRGYDSWGIAFLDGDLARERIAVLKRAGRIPAST
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCC
PNLPATVIALGHTRWATHGGVTDENAHPHLDCTGTLAIVHNGIIENYLPLRRALERSGHR
CCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCH
FRSSTDSEIFAHLLEDTIASIEEHHPSASDDIPTLVEAVRHAFNQVRGLNALIALHRPTR
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECCCCH
QLVAVKSTSPLVLGHGPAGTFVASDAVALVGYTDRIHYLQDDEIALLDHQGLQLFDRCTG
HEEEEECCCCEEEECCCCCCCHHCCCEEEEEECCCEEEECCCCEEEECCCCHHHHHHHCC
QRRSARWEPLTLRPADTSLGGYPHYLIKEIHEQPRVLARIARERLDGARQLADLIRHSYG
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TFLVGCGTAGYAALCGSYLFSRIARRHVNAVIASEFKYQEHFLTDRSLVIALTQSGETID
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHH
VIEAVHAAKRRGATVAALVNVTGSTVARLADFTIPLSAGPEQSVLSTKAYTAKLAILLLT
HHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHH
AHILNGSEHVGLDTLWRAIEGMEMALAPATLDRIRAVADRLVDAQHCYVIGRGLSYPTAL
HHHHCCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
EAALKIKEVTYIHAEGFAGGELKHGVIALIEDGSPCLVFSPLDETRADILSGAMEVRSRG
HHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCC
GWVIGISPEPDEAFHVHIPVADVGDASPLVSIVPAQLLAYELAVRRGLDPDKPRNLAKSV
CEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHC
TVK
CCC
>Mature Secondary Structure
MCGIFGFVAPQPLPASLVIDALRTLEYRGYDSWGIAFLDGDLARERIAVLKRAGRIPAST
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCC
PNLPATVIALGHTRWATHGGVTDENAHPHLDCTGTLAIVHNGIIENYLPLRRALERSGHR
CCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCH
FRSSTDSEIFAHLLEDTIASIEEHHPSASDDIPTLVEAVRHAFNQVRGLNALIALHRPTR
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECCCCH
QLVAVKSTSPLVLGHGPAGTFVASDAVALVGYTDRIHYLQDDEIALLDHQGLQLFDRCTG
HEEEEECCCCEEEECCCCCCCHHCCCEEEEEECCCEEEECCCCEEEECCCCHHHHHHHCC
QRRSARWEPLTLRPADTSLGGYPHYLIKEIHEQPRVLARIARERLDGARQLADLIRHSYG
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TFLVGCGTAGYAALCGSYLFSRIARRHVNAVIASEFKYQEHFLTDRSLVIALTQSGETID
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHH
VIEAVHAAKRRGATVAALVNVTGSTVARLADFTIPLSAGPEQSVLSTKAYTAKLAILLLT
HHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCEEECCCCCCHHHHHHHHHHHHHHHHHHH
AHILNGSEHVGLDTLWRAIEGMEMALAPATLDRIRAVADRLVDAQHCYVIGRGLSYPTAL
HHHHCCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
EAALKIKEVTYIHAEGFAGGELKHGVIALIEDGSPCLVFSPLDETRADILSGAMEVRSRG
HHHHHHHHEEEEEECCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCC
GWVIGISPEPDEAFHVHIPVADVGDASPLVSIVPAQLLAYELAVRRGLDPDKPRNLAKSV
CEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHC
TVK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA