Click here to switch to the map view.

The map label for this gene is csd [H]

Identifier: 221632406

GI number: 221632406

Start: 379472

End: 380731

Strand: Reverse

Name: csd [H]

Synonym: trd_0378

Alternate gene names: 221632406

Gene position: 380731-379472 (Counterclockwise)

Preceding gene: 221632407

Following gene: 221632405

Centisome position: 19.01

GC content: 62.94

Gene sequence:

>1260_bases
ATGACGTCGTTCACTGGAACGCAGCCACTCGACGTCGAGCGGATCCGAGGGGACTTCCCGATCTTCCAGCGGACGGTTCG
CGGCGGCAGACCCCTCGTGTATCTCGATAGCGCGGCAACCTCACAGAAGCCAGCGAGCGTCATCGAGGCGCTCGCTGGCT
TCTATCGTACGAGCAACGCCAACATTCACCGCGGCATCTACGAGTTGAGCGAGGAGGCCTCGGTCCTCTATGAGGAAGCG
CGCGCCAAAGTCGCGCGCTTCATCGGCGCTAGCCGCGCGCAAGAGGTCGTCTTCGTCCGCAATACGACGGAGGCGATCAA
CCTGGTGGCCAGAACATGGGGTACCACCGCGCTCCAGCCAGGAGACGTCGTCGTGACGACGATCCTCGAGCACCACTCGA
ATATCGTCCCCTGGCATCAGCTCGCCGTCGAGCGCGGAATCATCGTCCGCTTCGTCGATATCGACGAGCACGGCCGGCTC
CGACTCGATCAACTTGAGGAGTTACTGGACGCATATCCGGTCAAGCTGGTCGCTGTGACGCACGTTTCGAATGCACTGGG
GACCATCAATCCCATCCCGGAGATCGTTCGTCTCGCCCACCGTACCGGTGCACTCGTGCTGGTCGATGGTGCACAGAGCG
TTCCTCATCTACCGGTCAACGTCCGCGAACTCGGAGCCGATTTCCTGGCATTTTCCGGCCACAAGATGCTCGCGCCATTC
GGGATCGGCGTTCTCTGGGCCCGCTACGACTTGCTTACCAGCTTGCCACCATTCCTCGGTGGCGGTGGCATGATCCGCAC
GGTCACGACCGACGGTTTTTCACCAGGTGACGTACCAGCCCGCTTCGAGGCTGGAACACCGAGCGTGGCTGACGCGGTCG
CCCTGGGAGCCGCGATCGACTATCTGGAGTCGATCGGGATGGCAGCCATACGGCAACACGAGCGAGCTCTGCTGGCCTAC
GCTCTCCCCCGCTTGGAGGAAATTCCGGGCATCCGGCTCTATGGGCCGGTCGGTGATGATCGAAGCGGTGTCATCAGCTT
CACGATCGGCGACGTCCATCCCCATGACGTCGCCGCCGTGCTCGATCAGCACGGGATCGCTGTCCGCGCTGGCCACCATT
GCACGCAACCCTTGATGCGGCGCCTCGGCGTCGTGGCGACGACGCGCGCCAGTTTCTACCTTTACAATGCCGAGGACGAC
GTGGATCGCCTCATCGAGGCACTCCGCGAGGTACGTCGCGTTTTCGGCGTCGCGGGGTGA

Upstream 100 bases:

>100_bases
AGCTGATCGTCGATGGCTTCTTCGATGAGGTGATCGAGCGGGTGCCCGTGACGGAGGTACAGGAGACCGTACGGGCAGCG
ATTGCGCGGAAAATCGGGCT

Downstream 100 bases:

>100_bases
GCGGCTGACTGGAGGAGAGGCTGTGGCCGAACTTTACCGCGAGCACATCCTGGACCATTACCAGCATCCCCGGAACTACG
GGACCCTGGAACGACCGGAC

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTSFTGTQPLDVERIRGDFPIFQRTVRGGRPLVYLDSAATSQKPASVIEALAGFYRTSNANIHRGIYELSEEASVLYEEA
RAKVARFIGASRAQEVVFVRNTTEAINLVARTWGTTALQPGDVVVTTILEHHSNIVPWHQLAVERGIIVRFVDIDEHGRL
RLDQLEELLDAYPVKLVAVTHVSNALGTINPIPEIVRLAHRTGALVLVDGAQSVPHLPVNVRELGADFLAFSGHKMLAPF
GIGVLWARYDLLTSLPPFLGGGGMIRTVTTDGFSPGDVPARFEAGTPSVADAVALGAAIDYLESIGMAAIRQHERALLAY
ALPRLEEIPGIRLYGPVGDDRSGVISFTIGDVHPHDVAAVLDQHGIAVRAGHHCTQPLMRRLGVVATTRASFYLYNAEDD
VDRLIEALREVRRVFGVAG

Sequences:

>Translated_419_residues
MTSFTGTQPLDVERIRGDFPIFQRTVRGGRPLVYLDSAATSQKPASVIEALAGFYRTSNANIHRGIYELSEEASVLYEEA
RAKVARFIGASRAQEVVFVRNTTEAINLVARTWGTTALQPGDVVVTTILEHHSNIVPWHQLAVERGIIVRFVDIDEHGRL
RLDQLEELLDAYPVKLVAVTHVSNALGTINPIPEIVRLAHRTGALVLVDGAQSVPHLPVNVRELGADFLAFSGHKMLAPF
GIGVLWARYDLLTSLPPFLGGGGMIRTVTTDGFSPGDVPARFEAGTPSVADAVALGAAIDYLESIGMAAIRQHERALLAY
ALPRLEEIPGIRLYGPVGDDRSGVISFTIGDVHPHDVAAVLDQHGIAVRAGHHCTQPLMRRLGVVATTRASFYLYNAEDD
VDRLIEALREVRRVFGVAG
>Mature_418_residues
TSFTGTQPLDVERIRGDFPIFQRTVRGGRPLVYLDSAATSQKPASVIEALAGFYRTSNANIHRGIYELSEEASVLYEEAR
AKVARFIGASRAQEVVFVRNTTEAINLVARTWGTTALQPGDVVVTTILEHHSNIVPWHQLAVERGIIVRFVDIDEHGRLR
LDQLEELLDAYPVKLVAVTHVSNALGTINPIPEIVRLAHRTGALVLVDGAQSVPHLPVNVRELGADFLAFSGHKMLAPFG
IGVLWARYDLLTSLPPFLGGGGMIRTVTTDGFSPGDVPARFEAGTPSVADAVALGAAIDYLESIGMAAIRQHERALLAYA
LPRLEEIPGIRLYGPVGDDRSGVISFTIGDVHPHDVAAVLDQHGIAVRAGHHCTQPLMRRLGVVATTRASFYLYNAEDDV
DRLIEALREVRRVFGVAG

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=400, Percent_Identity=25.75, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156713448, Length=324, Percent_Identity=29.320987654321, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1787970, Length=408, Percent_Identity=47.3039215686275, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1789175, Length=395, Percent_Identity=38.7341772151899, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=25.3164556962025, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=375, Percent_Identity=27.4666666666667, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=268, Percent_Identity=26.1194029850746, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319831, Length=253, Percent_Identity=29.6442687747036, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129463, Length=276, Percent_Identity=32.2463768115942, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45532; Mature: 45400

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFTGTQPLDVERIRGDFPIFQRTVRGGRPLVYLDSAATSQKPASVIEALAGFYRTSNA
CCCCCCCCCCCHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCC
NIHRGIYELSEEASVLYEEARAKVARFIGASRAQEVVFVRNTTEAINLVARTWGTTALQP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCC
GDVVVTTILEHHSNIVPWHQLAVERGIIVRFVDIDEHGRLRLDQLEELLDAYPVKLVAVT
CCHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCCEEHHHHHHHHHHCCEEEEEEE
HVSNALGTINPIPEIVRLAHRTGALVLVDGAQSVPHLPVNVRELGADFLAFSGHKMLAPF
HHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCHHHHCCCCCEECHH
GIGVLWARYDLLTSLPPFLGGGGMIRTVTTDGFSPGDVPARFEAGTPSVADAVALGAAID
HHHHHHHHHHHHHHCCCHHCCCCEEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHH
YLESIGMAAIRQHERALLAYALPRLEEIPGIRLYGPVGDDRSGVISFTIGDVHPHDVAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHH
LDQHGIAVRAGHHCTQPLMRRLGVVATTRASFYLYNAEDDVDRLIEALREVRRVFGVAG
HHHCCCEEECCCHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSFTGTQPLDVERIRGDFPIFQRTVRGGRPLVYLDSAATSQKPASVIEALAGFYRTSNA
CCCCCCCCCCHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCC
NIHRGIYELSEEASVLYEEARAKVARFIGASRAQEVVFVRNTTEAINLVARTWGTTALQP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCC
GDVVVTTILEHHSNIVPWHQLAVERGIIVRFVDIDEHGRLRLDQLEELLDAYPVKLVAVT
CCHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECCCCCEEHHHHHHHHHHCCEEEEEEE
HVSNALGTINPIPEIVRLAHRTGALVLVDGAQSVPHLPVNVRELGADFLAFSGHKMLAPF
HHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCHHHHCCCCCEECHH
GIGVLWARYDLLTSLPPFLGGGGMIRTVTTDGFSPGDVPARFEAGTPSVADAVALGAAID
HHHHHHHHHHHHHHCCCHHCCCCEEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHH
YLESIGMAAIRQHERALLAYALPRLEEIPGIRLYGPVGDDRSGVISFTIGDVHPHDVAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHH
LDQHGIAVRAGHHCTQPLMRRLGVVATTRASFYLYNAEDDVDRLIEALREVRRVFGVAG
HHHCCCEEECCCHHHHHHHHHHCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]