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The map label for this gene is pyrC [H]

Identifier: 221632248

GI number: 221632248

Start: 223814

End: 225205

Strand: Reverse

Name: pyrC [H]

Synonym: trd_0214

Alternate gene names: 221632248

Gene position: 225205-223814 (Counterclockwise)

Preceding gene: 221632249

Following gene: 221632247

Centisome position: 11.24

GC content: 65.66

Gene sequence:

>1392_bases
GTGCTGCGGGGCGGTCGTCTCGTCGATCCCAGTCAAGGGATCGACGGCGAGGCAGACCTCCTCGTCGCAGATGGGCAGGT
TCGAGCGGTCGGCGGACGAGTTCCGGAACCTTCTGGAGCGACCGTGATCGATGCCGCTGGACTCGTGGTCGCGCCTGGTT
TCGTCGATGTGCACGCCCATCTGCGGGATCCCGGCTTTCCAGAAAAAGAGACGCTGGAAACGGGCAGTGTCGCGGCCGCG
GCCGGTGGCTTCACGACCATTTGTTGCATGCCGAACACGATGCCGCCGCTCGATACACCGGAACGGATCCGCGAACTGGT
CGAGCGAGCGCGCAGTCTCCCCGTACGCATCTTCCCGATCGGCACCATTTCGCGCGGCCGTCGTGGGGAGGAACTGGCCG
ACCTCGTCGGCATGGCTGAAGCCGGAGCGATCGGCTTTTCCGATGACGGTGACAGCACGCGGAGTGCTCGTGTCATGCGC
CAGGCTCTCCAGCTCAGCCGGCTACTCGGGCGACCGATCATGGTGCACTGCGAGGACCCAACGTTGTCAGCGGGCGGCGT
GATGCACGAGGGGGGAGTGTCGCAGCAGCTCGGCCTCCCTGGGATTCCAGCTGCTGCCGAGGAAATCGTCCTGGCTCGCG
ATCTCGAACTTGCTCGCCTGACCGGCGGCTGGCTCCATGTGCTCCACCTGACCACCGCTCGAGGACTGATGCTGGTGCGG
CGAGCCAAGCGCGAGGGGAACCGTGTCACCGTTGAGGTAACGCCGCATCACCTGCTCATGACTGACGAGTGGGTCGCAGG
TATTCGTCGCTTCGCCGGGGAGATGAAACCGTTTCCTGCCGGCCCCTGCCCCGATCCCAATGCGAAGGTCAACCCACCCC
TGCGGCCGGAAGCGGATGCCCTGGCCCTGCGCGCCGGGTTACGCGATGGGACGATCGATCTCATCGCCACCGACCATGCG
CCGCATCATGAGCAGGACAAGCCGCCGGTTCTCGAGCGAGCCGCGTTCGGGATGATCGGATTGGAACTCGCCCTCCCCTT
ACTCCTACGGCTGGTGCGCACCGGAGCACTCACGGTGAGCGAACTGGTCGAGTTCCTCTCCTGTCGTCCCGCCACGCTGT
TCGGCCTGCCAGGAGGGACCCTGAGGCCGGGTTCCCCGGCCGATGTCGTCGTCTTCGATCCTGAGGAACCCTGGCAGGTT
ACGCGCGCGACATTGCGCTCGCGCAGTGCCAACACACCGCTCCTCGGACTGACCCTGCGTGGGCGCGTCCGACTCACGAT
CGTTGGAGGGAAGGTAGCCTATGTCGATACAGCGTTCGCGGATCGGTGCACTCGTTCTGGAAGACGGGCGGATCTTTCCG
GGTACTCCCTTCGGAGCACGCCGCCCGGCTGA

Upstream 100 bases:

>100_bases
CGTGCACGGCAGCGGTAGCCCACAACCTCGGATCGAGCGAGCGAGCGGGCCTCTGGATTCAGCCCGAATCCAGAGGCCTT
TTTTATGGGGTTCTGCGCTG

Downstream 100 bases:

>100_bases
GGGCGAAGCGGTCTTCACCACTGTCATGACTGGTTATCAAGAGGTGGTCACTGACCCCTCTTTTTATGGGCAACTCGTCT
GCATGACATACCCACTCATC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MLRGGRLVDPSQGIDGEADLLVADGQVRAVGGRVPEPSGATVIDAAGLVVAPGFVDVHAHLRDPGFPEKETLETGSVAAA
AGGFTTICCMPNTMPPLDTPERIRELVERARSLPVRIFPIGTISRGRRGEELADLVGMAEAGAIGFSDDGDSTRSARVMR
QALQLSRLLGRPIMVHCEDPTLSAGGVMHEGGVSQQLGLPGIPAAAEEIVLARDLELARLTGGWLHVLHLTTARGLMLVR
RAKREGNRVTVEVTPHHLLMTDEWVAGIRRFAGEMKPFPAGPCPDPNAKVNPPLRPEADALALRAGLRDGTIDLIATDHA
PHHEQDKPPVLERAAFGMIGLELALPLLLRLVRTGALTVSELVEFLSCRPATLFGLPGGTLRPGSPADVVVFDPEEPWQV
TRATLRSRSANTPLLGLTLRGRVRLTIVGGKVAYVDTAFADRCTRSGRRADLSGYSLRSTPPG

Sequences:

>Translated_463_residues
MLRGGRLVDPSQGIDGEADLLVADGQVRAVGGRVPEPSGATVIDAAGLVVAPGFVDVHAHLRDPGFPEKETLETGSVAAA
AGGFTTICCMPNTMPPLDTPERIRELVERARSLPVRIFPIGTISRGRRGEELADLVGMAEAGAIGFSDDGDSTRSARVMR
QALQLSRLLGRPIMVHCEDPTLSAGGVMHEGGVSQQLGLPGIPAAAEEIVLARDLELARLTGGWLHVLHLTTARGLMLVR
RAKREGNRVTVEVTPHHLLMTDEWVAGIRRFAGEMKPFPAGPCPDPNAKVNPPLRPEADALALRAGLRDGTIDLIATDHA
PHHEQDKPPVLERAAFGMIGLELALPLLLRLVRTGALTVSELVEFLSCRPATLFGLPGGTLRPGSPADVVVFDPEEPWQV
TRATLRSRSANTPLLGLTLRGRVRLTIVGGKVAYVDTAFADRCTRSGRRADLSGYSLRSTPPG
>Mature_463_residues
MLRGGRLVDPSQGIDGEADLLVADGQVRAVGGRVPEPSGATVIDAAGLVVAPGFVDVHAHLRDPGFPEKETLETGSVAAA
AGGFTTICCMPNTMPPLDTPERIRELVERARSLPVRIFPIGTISRGRRGEELADLVGMAEAGAIGFSDDGDSTRSARVMR
QALQLSRLLGRPIMVHCEDPTLSAGGVMHEGGVSQQLGLPGIPAAAEEIVLARDLELARLTGGWLHVLHLTTARGLMLVR
RAKREGNRVTVEVTPHHLLMTDEWVAGIRRFAGEMKPFPAGPCPDPNAKVNPPLRPEADALALRAGLRDGTIDLIATDHA
PHHEQDKPPVLERAAFGMIGLELALPLLLRLVRTGALTVSELVEFLSCRPATLFGLPGGTLRPGSPADVVVFDPEEPWQV
TRATLRSRSANTPLLGLTLRGRVRLTIVGGKVAYVDTAFADRCTRSGRRADLSGYSLRSTPPG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=421, Percent_Identity=31.353919239905, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI190194363, Length=463, Percent_Identity=25.4859611231102, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786722, Length=432, Percent_Identity=28.7037037037037, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87082175, Length=475, Percent_Identity=28.2105263157895, Blast_Score=122, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI193204318, Length=414, Percent_Identity=30.1932367149758, Blast_Score=141, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322218, Length=437, Percent_Identity=26.7734553775744, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642586, Length=411, Percent_Identity=28.2238442822384, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859883, Length=428, Percent_Identity=27.5700934579439, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49282; Mature: 49282

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2 ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRGGRLVDPSQGIDGEADLLVADGQVRAVGGRVPEPSGATVIDAAGLVVAPGFVDVHAH
CCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCCCCEEEECCCEEEECCEEEEEEE
LRDPGFPEKETLETGSVAAAAGGFTTICCMPNTMPPLDTPERIRELVERARSLPVRIFPI
CCCCCCCCHHHCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEC
GTISRGRRGEELADLVGMAEAGAIGFSDDGDSTRSARVMRQALQLSRLLGRPIMVHCEDP
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
TLSAGGVMHEGGVSQQLGLPGIPAAAEEIVLARDLELARLTGGWLHVLHLTTARGLMLVR
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCEEEEEEHHHHHHHHHHH
RAKREGNRVTVEVTPHHLLMTDEWVAGIRRFAGEMKPFPAGPCPDPNAKVNPPLRPEADA
HHHCCCCEEEEEECCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHH
LALRAGLRDGTIDLIATDHAPHHEQDKPPVLERAAFGMIGLELALPLLLRLVRTGALTVS
HHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELVEFLSCRPATLFGLPGGTLRPGSPADVVVFDPEEPWQVTRATLRSRSANTPLLGLTLR
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEC
GRVRLTIVGGKVAYVDTAFADRCTRSGRRADLSGYSLRSTPPG
CEEEEEEECCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLRGGRLVDPSQGIDGEADLLVADGQVRAVGGRVPEPSGATVIDAAGLVVAPGFVDVHAH
CCCCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCCCCEEEECCCEEEECCEEEEEEE
LRDPGFPEKETLETGSVAAAAGGFTTICCMPNTMPPLDTPERIRELVERARSLPVRIFPI
CCCCCCCCHHHCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEC
GTISRGRRGEELADLVGMAEAGAIGFSDDGDSTRSARVMRQALQLSRLLGRPIMVHCEDP
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
TLSAGGVMHEGGVSQQLGLPGIPAAAEEIVLARDLELARLTGGWLHVLHLTTARGLMLVR
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCEEEEEEHHHHHHHHHHH
RAKREGNRVTVEVTPHHLLMTDEWVAGIRRFAGEMKPFPAGPCPDPNAKVNPPLRPEADA
HHHCCCCEEEEEECCCEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHH
LALRAGLRDGTIDLIATDHAPHHEQDKPPVLERAAFGMIGLELALPLLLRLVRTGALTVS
HHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELVEFLSCRPATLFGLPGGTLRPGSPADVVVFDPEEPWQVTRATLRSRSANTPLLGLTLR
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEEEC
GRVRLTIVGGKVAYVDTAFADRCTRSGRRADLSGYSLRSTPPG
CEEEEEEECCEEEEEEHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA