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The map label for this gene is drrC [H]

Identifier: 221230743

GI number: 221230743

Start: 2792130

End: 2792960

Strand: Reverse

Name: drrC [H]

Synonym: MLBr_02350

Alternate gene names: 221230743

Gene position: 2792960-2792130 (Counterclockwise)

Preceding gene: 221230744

Following gene: 221230742

Centisome position: 85.46

GC content: 53.31

Gene sequence:

>831_bases
ATGATCACTATGATAAGTCAAACAGTAGGACTGGTACCCGCGAGCTTGCAGTACCCGAACAATTCTGTTCGGGCGCTCGT
TTCGCAGACTTTGTTGCAGACCAAGCGGTTACTCACTCGGTGGGCGCGCGATTATGTCACCATCATTGGTGCGCTCGTGT
TGCCGATTTTGTTTCTGGTGGTGTTGAACATCGTGCTGGGTAATCTGGCTTACGTTGTAACTTACGACAGCGGGCTATAC
AGCTTTGTGCCACTAATCACCCTTGGCGCCGCGATCACTGGTTCAACATTCGTCGCTATCGACCTTGTGCGCGAGCGTTC
CATCGGTCTGCTTTCCCGACTATGGGTGTTGCCCATTCATCGGGCATCGGGTTTGCTTGCTCGAATCCTCGCAAACACAA
TTCGGACTTTCGTCACCACCCTTGTGATGCTGGTTACTGGGGTGATACTCGGTTTCCGGTTTCGGCAAGGTGTGATTGCA
AGCCTTATGTGGGTTAGTGTCCCGGTGATATTTGGTATTGCCATCGCCGTTATGGTGACTACCGTGGCGCTTTACACAGA
GCAAACATTCGTGGTTGAAGCGGTTGAGTTGGTGCAAGCAATCGCGGTCTTTTTGTCCACCGGTCTGGTACCACTAAACC
AGTATCCAGGATGGATTCAGCCTTTAGTCGCTCATCAACCGGTGAGCTACGCTATTGCGGCGATGCGCGGATTATCGATG
GGGGGGCCAGTCTTAGCTTCGATGGTTGCTATGCTGGTGTGGACCGCAGGCATTTGTGCCTCCTGTGCGGTACCCCTGGG
AGTCGGCTATCGACGGGCGTGTACGCATTGA

Upstream 100 bases:

>100_bases
TACCAGTGGCGTGGTCTGTTATGGTTCCGACGTTGGCGTGGCTGTTCGGTTTCCTGGTGGTTCTGGTGCCCATATGCCTC
GTCATTTTGTTTAGACGGAC

Downstream 100 bases:

>100_bases
CGCAATATGTGGTGGCCCCGCATGTGGTGACCAGTTGGGAGTCTTGAGGTGTTCGCCGGATCCGTGATCCGAAAGCTGTC
GCACAGTGAGGAAGTTTTCG

Product: putative antibiotic resistance membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MITMISQTVGLVPASLQYPNNSVRALVSQTLLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLGNLAYVVTYDSGLY
SFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLARILANTIRTFVTTLVMLVTGVILGFRFRQGVIA
SLMWVSVPVIFGIAIAVMVTTVALYTEQTFVVEAVELVQAIAVFLSTGLVPLNQYPGWIQPLVAHQPVSYAIAAMRGLSM
GGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH

Sequences:

>Translated_276_residues
MITMISQTVGLVPASLQYPNNSVRALVSQTLLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLGNLAYVVTYDSGLY
SFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLARILANTIRTFVTTLVMLVTGVILGFRFRQGVIA
SLMWVSVPVIFGIAIAVMVTTVALYTEQTFVVEAVELVQAIAVFLSTGLVPLNQYPGWIQPLVAHQPVSYAIAAMRGLSM
GGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH
>Mature_276_residues
MITMISQTVGLVPASLQYPNNSVRALVSQTLLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLGNLAYVVTYDSGLY
SFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLARILANTIRTFVTTLVMLVTGVILGFRFRQGVIA
SLMWVSVPVIFGIAIAVMVTTVALYTEQTFVVEAVELVQAIAVFLSTGLVPLNQYPGWIQPLVAHQPVSYAIAAMRGLSM
GGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH

Specific function: Probably part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525
- InterPro:   IPR004377
- InterPro:   IPR005943 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 29713; Mature: 29713

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]