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The map label for this gene is drrB [H]

Identifier: 221230744

GI number: 221230744

Start: 2792957

End: 2793823

Strand: Reverse

Name: drrB [H]

Synonym: MLBr_02351

Alternate gene names: 221230744

Gene position: 2793823-2792957 (Counterclockwise)

Preceding gene: 221230745

Following gene: 221230743

Centisome position: 85.49

GC content: 56.06

Gene sequence:

>867_bases
ATGAGCATGCCGGCACTAGCTCCGATTCCGGCCTCGAGGTGGCCAAGCACAATCATGGCAAAGCCACGTCGGTCGACGCT
CCGGCAGTGGTGGGCGCTCACTACGCGCTATTATACGGACATCAAGTTGTTTGTGTTTGAGAAAACAATCCAAATTGGCG
CACCAGTGGTATTCACGGTGGGCCTCTATCTACCGTTTGCCATACCGTGGAATCATTTTGTGGGTGGCCCTAGCTCAGGC
ATCGCCAGTAACTTAGGGCAATACGTCACTCCGTTGATCGTGCTGCAGTCTATCGCATTCGCCGCGATCGGATCAGCCTT
CCGGGCAGCAACCGATTCTCTGAGAGGCATAAGTCGACGGTTTCGTACTATGCCGATCGCTCCGGTGACGCCGGTGCTCG
CCCGTGTGACGGATGCCGTGCAGCGATGCTGTTGGGGTATGGGGGTAGCGCTGATTTGTGGACACGTGATCGGATTCCAG
TTCCATCGCGGTCCCCTCTATATCGTTGGATTTTGTGCATTGGTGCTCGCAATCGGAGCCGCGCTGTCATTCGCCGCTGA
CCTGCTTGGCACTGCGATCAGGAATCCCGACGCGATGCTGCCGCTACTGACTTTGCCGATCTTGATCTTCGGACTGTTGT
CGGTCGGTCTCATGCCAGTCAAACTGTTTCCTCGCTGGATTCACCCTTTTGTCCTTAACCAACCAGTCTCCCAGTTCGTG
GTGGCGTTACGCGCACTGGCCGGGGAGACCACTAAGACAGTCATACCAGTGGCGTGGTCTGTTATGGTTCCGACGTTGGC
GTGGCTGTTCGGTTTCCTGGTGGTTCTGGTGCCCATATGCCTCGTCATTTTGTTTAGACGGACATGA

Upstream 100 bases:

>100_bases
CTGACATTGCGCTACGCCGGCCGTCGCTCGATGACGTATTCCTTTCGATGACAACGGATCCCAGTGAGTCGCTGAGCCAT
CTAGCGGCGGGGGCGATGCG

Downstream 100 bases:

>100_bases
TCACTATGATAAGTCAAACAGTAGGACTGGTACCCGCGAGCTTGCAGTACCCGAACAATTCTGTTCGGGCGCTCGTTTCG
CAGACTTTGTTGCAGACCAA

Product: putative antibiotic resistance membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSMPALAPIPASRWPSTIMAKPRRSTLRQWWALTTRYYTDIKLFVFEKTIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSG
IASNLGQYVTPLIVLQSIAFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMGVALICGHVIGFQ
FHRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDAMLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFV
VALRALAGETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT

Sequences:

>Translated_288_residues
MSMPALAPIPASRWPSTIMAKPRRSTLRQWWALTTRYYTDIKLFVFEKTIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSG
IASNLGQYVTPLIVLQSIAFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMGVALICGHVIGFQ
FHRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDAMLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFV
VALRALAGETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT
>Mature_287_residues
SMPALAPIPASRWPSTIMAKPRRSTLRQWWALTTRYYTDIKLFVFEKTIQIGAPVVFTVGLYLPFAIPWNHFVGGPSSGI
ASNLGQYVTPLIVLQSIAFAAIGSAFRAATDSLRGISRRFRTMPIAPVTPVLARVTDAVQRCCWGMGVALICGHVIGFQF
HRGPLYIVGFCALVLAIGAALSFAADLLGTAIRNPDAMLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFVV
ALRALAGETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT

Specific function: Part of the ABC transporter complex drrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004377 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 31455; Mature: 31324

Theoretical pI: Translated: 11.39; Mature: 11.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMPALAPIPASRWPSTIMAKPRRSTLRQWWALTTRYYTDIKLFVFEKTIQIGAPVVFTV
CCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
GLYLPFAIPWNHFVGGPSSGIASNLGQYVTPLIVLQSIAFAAIGSAFRAATDSLRGISRR
HHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRTMPIAPVTPVLARVTDAVQRCCWGMGVALICGHVIGFQFHRGPLYIVGFCALVLAIGA
HHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ALSFAADLLGTAIRNPDAMLPLLTLPILIFGLLSVGLMPVKLFPRWIHPFVLNQPVSQFV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
VALRALAGETTKTVIPVAWSVMVPTLAWLFGFLVVLVPICLVILFRRT
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]