Click here to switch to the map view.

The map label for this gene is papA5

Identifier: 221230742

GI number: 221230742

Start: 2790810

End: 2792081

Strand: Reverse

Name: papA5

Synonym: MLBr_02349

Alternate gene names: 221230742

Gene position: 2792081-2790810 (Counterclockwise)

Preceding gene: 221230743

Following gene: 221230739

Centisome position: 85.44

GC content: 57.15

Gene sequence:

>1272_bases
GTGTTCGCCGGATCCGTGATCCGAAAGCTGTCGCACAGTGAGGAAGTTTTCGCGCGATACGAAGTTTTCACTTCTATGAC
GATCCAGTTGCGCGGTGTTCTAGATATTGATGCGCTGTCGGAGGCCTTCGACGCGCTCGTGCAGGCTCATCCAGTTTTGG
CCAGTCATCTTGAGACAAGCTCCGATGGCGGTTGGAACCTCGTTGCCGACGACCTGCTCCACCCTGGGATCTGTGTTGTT
GACGCTAACAACGGGGCGCAGTCGGGTTGTGGTGGAATACAGTCCGAAACGCGGCTCGACCAGAGCGTTTCCCTATTGAA
TCTGCGACTTACCCCCCGTGAGGGAGGAGGTGAGCTCGTACTCTATATTCATCACAGCATGGCTGATGGTCACCATGGGG
CCGTTTTGGTCGATGAGCTGTTCTCCCGCTACACCGACGTGGTGACTACTGGTGACCCTGGCCCGATAATCCCCCAGGCT
ACACCGCTGTCTATGGAGGCCGTGCTACAACAGCGGGGTGTCAAGAAACATGCCCTTTCGGGAGCTGAGCGCTTTATGTC
GGTGATGTATGCTTATGACCTTCCTGCCACCGGGACGCCGGCTGTCCTCGCCGAACCTGGATTGCCTCAAGCTGTTCCGG
TAACCAGACTCTGGCTCACTAAGCAGGAGACATCGGATCTCGCGGCGTTCGGTCGTGAACATCGGCTCAGCATCAACGCC
GTGGTAGCGGCGGCCATTCTGATGACCGAATGGCGACTCCGCGAAACCCCGCACGTTCCAATTCCCTATGTTTACCCCGT
CGATTTGCGATATGTTCTTGCCCCTCCTGTGGCCCCGACCGAAAGCACCAATTTACTCGGGGCGGCGGGTTACCTTGCTG
AGATCGGACAGGACACCGACATCGTTGATCTGGCAACCGATATCGTTGCCACACTTCGGGCTGACTTAGCCAACGGCGTG
GTTCAGCAGTCGGGCCTGCACTTTGGTACGGCATTCGAGGGAACTCCGCCCGGGTTGCCGCCACTTGTCTTCTGCACTGA
TGCCACTGCGTTCCCGACGATGCGTACACCACCGGATCTTGCGATTGAAGACATTCAGGGCCGGTTCTATTGTTCGATTA
GTGTCCCCCTGGATCTCTACTCCTGCGGTGTCTACGAAGGCCAACTGATCATCGAGCATCACGGACATATCGAGGAACCG
GCAAAGGCTCTCGAGGCAATACGTTCCCTGCTGTGCACTGTTCCCTCGGAGTACGGCTGGATTATGGAGTGA

Upstream 100 bases:

>100_bases
CTCCTGTGCGGTACCCCTGGGAGTCGGCTATCGACGGGCGTGTACGCATTGACGCAATATGTGGTGGCCCCGCATGTGGT
GACCAGTTGGGAGTCTTGAG

Downstream 100 bases:

>100_bases
CGTGTAGTGTCCACCGTTGTAGATAATGGCTTGCACCCGGGGGTCGGGGCCGAGGGCATCTCCGTGCGAGACGACCTGTT
GTGGTGTCATTGGAAGCCCC

Product: acyltransferase PapA5

Products: NA

Alternate protein names: Acyltransferase papA5; Phthiocerol/phthiodiolone O-acyltransferase; Polyketide synthase-associated protein A5

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MFAGSVIRKLSHSEEVFARYEVFTSMTIQLRGVLDIDALSEAFDALVQAHPVLASHLETSSDGGWNLVADDLLHPGICVV
DANNGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELVLYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQA
TPLSMEAVLQQRGVKKHALSGAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQETSDLAAFGREHRLSINA
VVAAAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTESTNLLGAAGYLAEIGQDTDIVDLATDIVATLRADLANGV
VQQSGLHFGTAFEGTPPGLPPLVFCTDATAFPTMRTPPDLAIEDIQGRFYCSISVPLDLYSCGVYEGQLIIEHHGHIEEP
AKALEAIRSLLCTVPSEYGWIME

Sequences:

>Translated_423_residues
MFAGSVIRKLSHSEEVFARYEVFTSMTIQLRGVLDIDALSEAFDALVQAHPVLASHLETSSDGGWNLVADDLLHPGICVV
DANNGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELVLYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQA
TPLSMEAVLQQRGVKKHALSGAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQETSDLAAFGREHRLSINA
VVAAAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTESTNLLGAAGYLAEIGQDTDIVDLATDIVATLRADLANGV
VQQSGLHFGTAFEGTPPGLPPLVFCTDATAFPTMRTPPDLAIEDIQGRFYCSISVPLDLYSCGVYEGQLIIEHHGHIEEP
AKALEAIRSLLCTVPSEYGWIME
>Mature_423_residues
MFAGSVIRKLSHSEEVFARYEVFTSMTIQLRGVLDIDALSEAFDALVQAHPVLASHLETSSDGGWNLVADDLLHPGICVV
DANNGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELVLYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQA
TPLSMEAVLQQRGVKKHALSGAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQETSDLAAFGREHRLSINA
VVAAAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTESTNLLGAAGYLAEIGQDTDIVDLATDIVATLRADLANGV
VQQSGLHFGTAFEGTPPGLPPLVFCTDATAFPTMRTPPDLAIEDIQGRFYCSISVPLDLYSCGVYEGQLIIEHHGHIEEP
AKALEAIRSLLCTVPSEYGWIME

Specific function: Catalyzes diesterification of phthiocerol and phthiodiolone with mycocerosic acids, the final step in the phthiocerol and phthiodiolone dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyltransferase papA5 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PAPA5_MYCLE (Q49939)

Other databases:

- EMBL:   U00023
- EMBL:   AL023596
- EMBL:   AL583925
- PIR:   S73020
- RefSeq:   NP_302528.1
- HSSP:   P96208
- ProteinModelPortal:   Q49939
- SMR:   Q49939
- EnsemblBacteria:   EBMYCT00000028091
- GeneID:   908671
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2349
- NMPDR:   fig|272631.1.peg.1400
- Leproma:   ML2349
- GeneTree:   EBGT00050000017025
- HOGENOM:   HBG568108
- OMA:   ATYLAEI
- ProtClustDB:   PRK09294
- BioCyc:   MLEP272631:ML2349-MONOMER
- InterPro:   IPR001242

Pfam domain/function: PF00668 Condensation

EC number: NA

Molecular weight: Translated: 45595; Mature: 45595

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAGSVIRKLSHSEEVFARYEVFTSMTIQLRGVLDIDALSEAFDALVQAHPVLASHLETS
CCCHHHHHHHCCHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCC
SDGGWNLVADDLLHPGICVVDANNGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELV
CCCCCEEEHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHCEEEEEEEECCCCCCCCEE
LYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQATPLSMEAVLQQRGVKKHALS
EEEEECCCCCCCCEEHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHH
GAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQETSDLAAFGREHRLSINA
HHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHCCHHHCEEHHH
VVAAAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTESTNLLGAAGYLAEIGQDTD
HHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCC
IVDLATDIVATLRADLANGVVQQSGLHFGTAFEGTPPGLPPLVFCTDATAFPTMRTPPDL
HHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
AIEDIQGRFYCSISVPLDLYSCGVYEGQLIIEHHGHIEEPAKALEAIRSLLCTVPSEYGW
HHCCCCCEEEEEEECCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
IME
CCC
>Mature Secondary Structure
MFAGSVIRKLSHSEEVFARYEVFTSMTIQLRGVLDIDALSEAFDALVQAHPVLASHLETS
CCCHHHHHHHCCHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCC
SDGGWNLVADDLLHPGICVVDANNGAQSGCGGIQSETRLDQSVSLLNLRLTPREGGGELV
CCCCCEEEHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHCEEEEEEEECCCCCCCCEE
LYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQATPLSMEAVLQQRGVKKHALS
EEEEECCCCCCCCEEHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHHHHCCCHHHHHH
GAERFMSVMYAYDLPATGTPAVLAEPGLPQAVPVTRLWLTKQETSDLAAFGREHRLSINA
HHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHCCHHHCEEHHH
VVAAAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTESTNLLGAAGYLAEIGQDTD
HHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCC
IVDLATDIVATLRADLANGVVQQSGLHFGTAFEGTPPGLPPLVFCTDATAFPTMRTPPDL
HHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCC
AIEDIQGRFYCSISVPLDLYSCGVYEGQLIIEHHGHIEEPAKALEAIRSLLCTVPSEYGW
HHCCCCCEEEEEEECCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
IME
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002