Click here to switch to the map view.

The map label for this gene is ilvG [H]

Identifier: 221230603

GI number: 221230603

Start: 2475138

End: 2476784

Strand: Reverse

Name: ilvG [H]

Synonym: MLBr_02083

Alternate gene names: 221230603

Gene position: 2476784-2475138 (Counterclockwise)

Preceding gene: 221230605

Following gene: 221230602

Centisome position: 75.79

GC content: 64.72

Gene sequence:

>1647_bases
ATGAGCACCGACCCTGTCCTGACCCACAGCATTCACGCCGGCCGGCTCGTCGTACGTCGACTCAAAGCCAGCGGTGTCGA
CACCGTCTTTACGTTGTCAGGTGGGCATCTATTTTCCATTTACGACGGTTGCCGTAGCGAGAGTATCAGGCTCATAGACA
CGCGCCACGAGCAGACAGCGGCCTTCGCCGCCGAGGGTTGGTCGAAAGTGACCAGGCAGCCAGGTGTGGCTGTACTAACC
GCGGGGCCGGGCGTCACCAACGGTATGAGCGCGATGGCGGCGGCGCAGCAGAACCAGTCGCCGCTGGTAGTGCTCGGCGG
CCGAGCACCCGCACTGCGATGGGGTATGGGCTCGTTACAGGAGATTGATCACGTGCCGTTCGTGGCTCCGCTAGCCCGTT
TCGCCGCCACCGCACAGTCGGCGGATGCCGCCGGCCGGCTTGTCGACGAAGCATTGCAGGCCGCGGTGGTTGCCCCGTCC
GGAGTGGGTTTCGTTGATTTCCCGATGGACTATGTGTTTTCCATGGCTGACGACGTTGGCGGTGGTCCTGGCGCTTTGGC
CAACTTGCCTGTGGCTCCCGCTGCCAACCCCGAAGCCCTGGACCGGGCTGCCGGCCTGTTAGCCGCGGCGCACCGGCCGG
TGATCATGGCCGGGACCAACGTCTGGTGGGGGCACGCCGAGGCCGCGCTACTACGTCTAGCCGAGGAATGCCAGATCCCT
GTGCTGATGAACGGAATGGCACGCGGCGTAGTGCCCGCCGACCACCCGTTGGCTTTCTCGCGGGCGCGGGGAAAAGCATT
GGGTGAGGCAGATGTGGCACTGGTTGTTGGGGTGCCGATGGATTTCCGGCTGGGCTTCGGCAAGGTGTTCGGGTCACAAA
CACAGCTCGTGGTGGCGGACCGTGCTGAACCCGATCGCGACTATCCGCGACCCGTCGCGGCCGGGCTCTACGGAGATTTG
CCAGCTATTCTCTCGGCGTTGGCTGGAGTCGGTGGGACCGACAGTCAGGACTGGATCCGCGCGCTGCGGACGGCCGAGAC
CGCCACGCGTGACCTTGAGAAAGCTGAACTGGACGACGACCGGCTCCCGCTGCACCCGATGCGGGTGTACGCTGAGCTCG
CGTCGCTGCTGGACCGCGACGCGATTGTCGTGATCGACGCCGGTGATTTCGGGTCTTATGCCGGCCGGGTGATCGACAGC
TATCTACCGGGTTGCTGGTTGGACAGCGGGCCGTTCGGTTGCCTGGGTTCGGGCCCTGGCTACGCTCTGGCCGCTAAACT
CGCCCGGCCCAACCGTCAAGTTGTCCTGCTGCAGGGCGACGGCGCGTTTGGCTTCAGCGGCATGGAATGGGACACTCTGG
TTCGGCACAATGTTCCCGTCGTGTCGGTGATCGGCAACAACGGGATCTGGGGCTTAGAGAAACACCCGATGGAAGCGTTG
TACGGCTACTCGGTGGTAGCGGAACTCCGCCCGGGTACTCGCTACGACGAGGTGGTTCGTGCCCTCGGCGGTCACGGCGA
GCTGGTGTCGGTGCCCGGTGAGCTTCGGCCTGCACTCGAACGTGCTTTCGTCACCGGTCTGCCGTCGGTCGTGAATGTGC
TGACCGATCCGAGTGTCGCCTACCCTCGCCGGTCCAACCTGGCTTGA

Upstream 100 bases:

>100_bases
ACTCCACGTTTGATGTCTCCTCGCGATTGAGGCGCTGAAAGCACCTCAATACAGAAATCTCTCGGCGAAGGTACCCGAAA
GTCGCGGATAGGCTGCTGAT

Downstream 100 bases:

>100_bases
TCACGCCGGCCCGGGCCGCGAATGTCCGCAGATTGCCGGGGTTAGCGGCGTGTCGGTGTACAGGCGCGCTTGCTTGAGGT
GATCGGTGGCTAGCGTACCG

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSTDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTAAFAAEGWSKVTRQPGVAVLT
AGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPS
GVGFVDFPMDYVFSMADDVGGGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIP
VLMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVADRAEPDRDYPRPVAAGLYGDL
PAILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDDRLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDS
YLPGCWLDSGPFGCLGSGPGYALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEAL
YGYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVAYPRRSNLA

Sequences:

>Translated_548_residues
MSTDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTAAFAAEGWSKVTRQPGVAVLT
AGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPS
GVGFVDFPMDYVFSMADDVGGGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIP
VLMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVADRAEPDRDYPRPVAAGLYGDL
PAILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDDRLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDS
YLPGCWLDSGPFGCLGSGPGYALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEAL
YGYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVAYPRRSNLA
>Mature_547_residues
STDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTAAFAAEGWSKVTRQPGVAVLTA
GPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPSG
VGFVDFPMDYVFSMADDVGGGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIPV
LMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVADRAEPDRDYPRPVAAGLYGDLP
AILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDDRLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDSY
LPGCWLDSGPFGCLGSGPGYALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEALY
GYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVAYPRRSNLA

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=573, Percent_Identity=33.3333333333333, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI93004078, Length=551, Percent_Identity=27.9491833030853, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1788716, Length=551, Percent_Identity=29.5825771324864, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1790104, Length=493, Percent_Identity=27.3833671399594, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI87081685, Length=532, Percent_Identity=26.5037593984962, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786717, Length=536, Percent_Identity=26.865671641791, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1787096, Length=531, Percent_Identity=24.105461393597, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17542570, Length=541, Percent_Identity=32.7171903881701, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17531299, Length=535, Percent_Identity=30.0934579439252, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17531301, Length=535, Percent_Identity=30.0934579439252, Blast_Score=191, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320816, Length=542, Percent_Identity=28.2287822878229, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323755, Length=558, Percent_Identity=23.8351254480287, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19922626, Length=559, Percent_Identity=30.7692307692308, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 57621; Mature: 57490

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTA
CCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCHHHH
AFAAEGWSKVTRQPGVAVLTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ
HHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCCCCHHCCCCCHH
EIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPSGVGFVDFPMDYVFSMADDVG
HHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEECCCCCCEEECCHHHHHHHHHHCC
GGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCHHHHHHHHHHHHCCCC
VLMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVAD
HHHCCHHCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEEC
RAEPDRDYPRPVAAGLYGDLPAILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDD
CCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDSYLPGCWLDSGPFGCLGSGPG
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCC
YALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEAL
HHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCHHHH
YGYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVA
HHHHEEEECCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHCCCCCC
YPRRSNLA
CCCCCCCC
>Mature Secondary Structure 
STDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDGCRSESIRLIDTRHEQTA
CCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCHHHH
AFAAEGWSKVTRQPGVAVLTAGPGVTNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQ
HHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEECCCCCCHHCCCCCHH
EIDHVPFVAPLARFAATAQSADAAGRLVDEALQAAVVAPSGVGFVDFPMDYVFSMADDVG
HHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEECCCCCCEEECCHHHHHHHHHHCC
GGPGALANLPVAPAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEECQIP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCEECCHHHHHHHHHHHHCCCC
VLMNGMARGVVPADHPLAFSRARGKALGEADVALVVGVPMDFRLGFGKVFGSQTQLVVAD
HHHCCHHCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEEC
RAEPDRDYPRPVAAGLYGDLPAILSALAGVGGTDSQDWIRALRTAETATRDLEKAELDDD
CCCCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
RLPLHPMRVYAELASLLDRDAIVVIDAGDFGSYAGRVIDSYLPGCWLDSGPFGCLGSGPG
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCC
YALAAKLARPNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVIGNNGIWGLEKHPMEAL
HHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCHHHH
YGYSVVAELRPGTRYDEVVRALGGHGELVSVPGELRPALERAFVTGLPSVVNVLTDPSVA
HHHHEEEECCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHCCCCCC
YPRRSNLA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]