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The map label for this gene is secA2

Identifier: 221230602

GI number: 221230602

Start: 2472694

End: 2475030

Strand: Reverse

Name: secA2

Synonym: MLBr_02082

Alternate gene names: 221230602

Gene position: 2475030-2472694 (Counterclockwise)

Preceding gene: 221230603

Following gene: 221230601

Centisome position: 75.73

GC content: 61.87

Gene sequence:

>2337_bases
GTGTCTAAGACGCCTCGCACTCAGCCTGGCCGTCTGAGTAGTCGATTTTGGCGGCTACTCGGCGCCAGCACGGACAAGAA
CCTAAACTACTCTTCCGCTGAGGTCACTGCTGCGGCGGCTTACCACAAGGAAGCTGCCGATCTGGGCGATGAGCAGTTGC
GCAAGGCGTGCGGGTTGCTCAATCTCAACGATCTCGCCGATTCTCGCGACGTCCCCCAATTCCTTGCCATCGTCCGGGAA
GCGTCTGAGCGGTCCACGGGTTTGAGGCCTTTTGATGTGCAGTTACTCGGGGCGCTACGCATGCTTGCTGGTGACGTGAT
CGAGATGGCCACCGGTGAGGGCAAAACTCTCGCCGGCGCGATTGCGGCGGCCGGATACGCCCTTGCCGGCCGGCATGTGC
ACGTCGTGACGATCAACGATTATTTGGCCCGCCGTGATGCGGAATGGATGGGCCCGCTGCTCGAGGCCATAGGCCTGACG
GTGGGCTGGATCACCGCGGAGTCAACACGCGAGGACCGTAAGGCTGCTTACGGCTGCGACGTCACCTACGCCTCGGTCAA
CGAGATCGGTTTTGATGTGCTGCGCGATCAGTTGGTGACCGACGTCGACGACCTGGTATCGCCCCATCCTGATGTGGCCC
TTATCGACGAGGCCGACTCCGTGCTGGTCGATGAGGCATTGGTGCCGCTCGTGTTAGCCGGTGCCACGCATCGGGAGACG
CCGCGGCTCGAGATCATCAAGCTGGTCGGCGAGCTGTCCGCCGAATCCGATTATGACACCGATTCCGACAGCCGCAACGT
CCACCTGACTGATGTCGGGGCGCGCAAGGTCGAAAAGGCGCTCGGTGGCATCGATCTGTACTCCGAGGAACACGTTGGCA
CCACGTTGACCGAGGTAAACGTCGCATTGCACGCCCATGTGCTGTTGCAGCGTGACGTGCACTACATTGTCCGAGACGAC
GCGGTACATCTAGTCAACGCCTCCCGCGGCCGCATCGCACAGCTGCAACGCTGGCCGGACGGCCTGCAGGCCGCGGTCGA
GGCGAAGGAGGGCATCGAGACCACCGAGACCGGCGAAGTGCTCGATACCATCACAGTGCAGGCACTGATCAATCGTTACG
CCACTGTGTGCGGTATGACCGGCACAGCGCTGGCCGCTGGTGAGCAGTTACGCCAGTTCTACAAGCTCGGTGTGTCACCG
ATACCGCCGAATACTCCCAACATTCGTGACGACGCGTCGGACCGAGTCTACATCACCGCGGCCGCCAAGAATGACGCGAT
CGTGGCGCACCTCGCTGAGGTGCACGAAACGGGTCAACCGGTGCTGGTCGGGACCCGTAACGTTGCCGAATCCGAGGAGC
TGCACGAGCGGTTGCTGCGACACGGCGTGCCCGCGGTCGTGCTCAACGCTAAAAACGATGCCGAAGAAGCGCGGTTCATC
GCGGAAGCCGGCAAATTCGGTGCGGTCACCGTGTCCACCCAGATGGCTGGGCGCGGCACCGATATCCGTCTTGGTGGATC
TGACGAATCCGACCACGACAGGGTCGTCGAGCTAGGTGGGCTGCACGTGGTCGGCACCGGGCGGCACCATACCGAGCGAT
TGGATAACCAGTTGCGTGGCCGGGCTGGGCGCCAGGGCGATCCTGGATCGTCGGTGTTCTTCTCCAGCTGGGAAGATGAT
GTCATTGCGGCCAACCTCGACCGCAACAAGTTGCCGATGCAGACCGACGAGGATGGCCGCATCATCAGCCTCAAAACCAC
CGGTTTGCTTGACCATGCCCAGCGTGTTGCGGAGGGTCGGCTGCTGGACGTGCATGCGAATACCTGGCGCTACAACCAGT
TGATAGCCCAGCAGCGCGCCATCATCGTGGATCGGCGAAACGCGTTGCTGAGTAGTGCAACCGCGCGCGAGGAGCTCGCA
GAGCTGGCGCCCAAGCGTTACGAGGAGCTGGCTCAGGCACTGCCCAAAGAGGAGGCCGAAGAACGGCTCGAGACGATCTG
CCGATTGATCATGTTGTATCACCTCGACCGTGGCTGGGCCGATCATCTGGCGTATCTGGCTGACATTCGTGAAAGTATCC
ATTTGCGCGCGCTCGGCCGGCAAAGTCCTCTGGACGAGTTTCACCGGTTGGCGGTGAACGCGTTTGCTTTGCTGGCCGCC
GACGCGATCGAGGCGGCCCAGCAGACGTTCGAAACCGCGAATATCCTTGATGGGGCGCCAGGACTGGATTTGTCCAAACT
AGCGCGGCCGACGTCGACGTGGACCTACATGGTCAATGATGCCCCGCTGTCCGATGACACGCTTTCTCCCTTGAGCCTAC
CCGGGGTTTTCCGCTGA

Upstream 100 bases:

>100_bases
GGCCCGGGCCGCGAATGTCCGCAGATTGCCGGGGTTAGCGGCGTGTCGGTGTACAGGCGCGCTTGCTTGAGGTGATCGGT
GGCTAGCGTACCGTTAACCT

Downstream 100 bases:

>100_bases
GGTCCGATTGCTTTCGGCCCGTTATCCGGACCGTCATATCGCCAGGCTAAGGTCACTGCTCATGGAGTCGGTGTGTCCGC
CCAATCGGGTGCTGACAGTG

Product: preprotein translocase subunit SecA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MSKTPRTQPGRLSSRFWRLLGASTDKNLNYSSAEVTAAAAYHKEAADLGDEQLRKACGLLNLNDLADSRDVPQFLAIVRE
ASERSTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLEAIGLT
VGWITAESTREDRKAAYGCDVTYASVNEIGFDVLRDQLVTDVDDLVSPHPDVALIDEADSVLVDEALVPLVLAGATHRET
PRLEIIKLVGELSAESDYDTDSDSRNVHLTDVGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDD
AVHLVNASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAAGEQLRQFYKLGVSP
IPPNTPNIRDDASDRVYITAAAKNDAIVAHLAEVHETGQPVLVGTRNVAESEELHERLLRHGVPAVVLNAKNDAEEARFI
AEAGKFGAVTVSTQMAGRGTDIRLGGSDESDHDRVVELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDD
VIAANLDRNKLPMQTDEDGRIISLKTTGLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVDRRNALLSSATAREELA
ELAPKRYEELAQALPKEEAEERLETICRLIMLYHLDRGWADHLAYLADIRESIHLRALGRQSPLDEFHRLAVNAFALLAA
DAIEAAQQTFETANILDGAPGLDLSKLARPTSTWTYMVNDAPLSDDTLSPLSLPGVFR

Sequences:

>Translated_778_residues
MSKTPRTQPGRLSSRFWRLLGASTDKNLNYSSAEVTAAAAYHKEAADLGDEQLRKACGLLNLNDLADSRDVPQFLAIVRE
ASERSTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLEAIGLT
VGWITAESTREDRKAAYGCDVTYASVNEIGFDVLRDQLVTDVDDLVSPHPDVALIDEADSVLVDEALVPLVLAGATHRET
PRLEIIKLVGELSAESDYDTDSDSRNVHLTDVGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDD
AVHLVNASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAAGEQLRQFYKLGVSP
IPPNTPNIRDDASDRVYITAAAKNDAIVAHLAEVHETGQPVLVGTRNVAESEELHERLLRHGVPAVVLNAKNDAEEARFI
AEAGKFGAVTVSTQMAGRGTDIRLGGSDESDHDRVVELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDD
VIAANLDRNKLPMQTDEDGRIISLKTTGLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVDRRNALLSSATAREELA
ELAPKRYEELAQALPKEEAEERLETICRLIMLYHLDRGWADHLAYLADIRESIHLRALGRQSPLDEFHRLAVNAFALLAA
DAIEAAQQTFETANILDGAPGLDLSKLARPTSTWTYMVNDAPLSDDTLSPLSLPGVFR
>Mature_777_residues
SKTPRTQPGRLSSRFWRLLGASTDKNLNYSSAEVTAAAAYHKEAADLGDEQLRKACGLLNLNDLADSRDVPQFLAIVREA
SERSTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGAIAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLEAIGLTV
GWITAESTREDRKAAYGCDVTYASVNEIGFDVLRDQLVTDVDDLVSPHPDVALIDEADSVLVDEALVPLVLAGATHRETP
RLEIIKLVGELSAESDYDTDSDSRNVHLTDVGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDA
VHLVNASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYATVCGMTGTALAAGEQLRQFYKLGVSPI
PPNTPNIRDDASDRVYITAAAKNDAIVAHLAEVHETGQPVLVGTRNVAESEELHERLLRHGVPAVVLNAKNDAEEARFIA
EAGKFGAVTVSTQMAGRGTDIRLGGSDESDHDRVVELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDV
IAANLDRNKLPMQTDEDGRIISLKTTGLLDHAQRVAEGRLLDVHANTWRYNQLIAQQRAIIVDRRNALLSSATAREELAE
LAPKRYEELAQALPKEEAEERLETICRLIMLYHLDRGWADHLAYLADIRESIHLRALGRQSPLDEFHRLAVNAFALLAAD
AIEAAQQTFETANILDGAPGLDLSKLARPTSTWTYMVNDAPLSDDTLSPLSLPGVFR

Specific function: Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular mo

COG id: COG0653

COG function: function code U; Preprotein translocase subunit SecA (ATPase, RNA helicase)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Note=Distribution is 50-50 (By similarity)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secA family

Homologues:

Organism=Escherichia coli, GI1786287, Length=819, Percent_Identity=35.5311355311355, Blast_Score=419, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECA2_MYCLE (O32922)

Other databases:

- EMBL:   AL008609
- EMBL:   AL583924
- PIR:   T44761
- RefSeq:   NP_302388.1
- ProteinModelPortal:   O32922
- SMR:   O32922
- EnsemblBacteria:   EBMYCT00000029493
- GeneID:   908485
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2082
- NMPDR:   fig|272631.1.peg.1260
- Leproma:   ML2082
- GeneTree:   EBGT00050000016775
- HOGENOM:   HBG284200
- OMA:   QRVTEGQ
- ProtClustDB:   PRK12326
- BioCyc:   MLEP272631:ML2082-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01382
- InterPro:   IPR000185
- InterPro:   IPR020937
- InterPro:   IPR011115
- InterPro:   IPR014018
- InterPro:   IPR011130
- InterPro:   IPR011116
- Gene3D:   G3DSA:1.10.3060.10
- PRINTS:   PR00906
- SMART:   SM00957
- SMART:   SM00958

Pfam domain/function: PF07517 SecA_DEAD; PF01043 SecA_PP_bind; PF07516 SecA_SW; SSF81767 SecA_PP_bd; SSF81886 SecA_SW

EC number: NA

Molecular weight: Translated: 84815; Mature: 84684

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS01312 SECA; PS51196 SECA_MOTOR_DEAD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTPRTQPGRLSSRFWRLLGASTDKNLNYSSAEVTAAAAYHKEAADLGDEQLRKACGLL
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCC
NLNDLADSRDVPQFLAIVREASERSTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGA
CCHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLEAIGLTVGWITAESTREDRKAAYGCD
HHHHHHHCCCCEEEEEEECHHHHHCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCC
VTYASVNEIGFDVLRDQLVTDVDDLVSPHPDVALIDEADSVLVDEALVPLVLAGATHRET
EEEHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCC
PRLEIIKLVGELSAESDYDTDSDSRNVHLTDVGARKVEKALGGIDLYSEEHVGTTLTEVN
CHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHH
VALHAHVLLQRDVHYIVRDDAVHLVNASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEV
HHHHHHHHHHHCCCEEEECCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHH
LDTITVQALINRYATVCGMTGTALAAGEQLRQFYKLGVSPIPPNTPNIRDDASDRVYITA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
AAKNDAIVAHLAEVHETGQPVLVGTRNVAESEELHERLLRHGVPAVVLNAKNDAEEARFI
ECCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
AEAGKFGAVTVSTQMAGRGTDIRLGGSDESDHDRVVELGGLHVVGTGRHHTERLDNQLRG
HHCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHC
RAGRQGDPGSSVFFSSWEDDVIAANLDRNKLPMQTDEDGRIISLKTTGLLDHAQRVAEGR
CCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCC
LLDVHANTWRYNQLIAQQRAIIVDRRNALLSSATAREELAELAPKRYEELAQALPKEEAE
EEEEECCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHH
ERLETICRLIMLYHLDRGWADHLAYLADIRESIHLRALGRQSPLDEFHRLAVNAFALLAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DAIEAAQQTFETANILDGAPGLDLSKLARPTSTWTYMVNDAPLSDDTLSPLSLPGVFR
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKTPRTQPGRLSSRFWRLLGASTDKNLNYSSAEVTAAAAYHKEAADLGDEQLRKACGLL
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCC
NLNDLADSRDVPQFLAIVREASERSTGLRPFDVQLLGALRMLAGDVIEMATGEGKTLAGA
CCHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IAAAGYALAGRHVHVVTINDYLARRDAEWMGPLLEAIGLTVGWITAESTREDRKAAYGCD
HHHHHHHCCCCEEEEEEECHHHHHCCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCC
VTYASVNEIGFDVLRDQLVTDVDDLVSPHPDVALIDEADSVLVDEALVPLVLAGATHRET
EEEHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCC
PRLEIIKLVGELSAESDYDTDSDSRNVHLTDVGARKVEKALGGIDLYSEEHVGTTLTEVN
CHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHH
VALHAHVLLQRDVHYIVRDDAVHLVNASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEV
HHHHHHHHHHHCCCEEEECCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHH
LDTITVQALINRYATVCGMTGTALAAGEQLRQFYKLGVSPIPPNTPNIRDDASDRVYITA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEE
AAKNDAIVAHLAEVHETGQPVLVGTRNVAESEELHERLLRHGVPAVVLNAKNDAEEARFI
ECCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
AEAGKFGAVTVSTQMAGRGTDIRLGGSDESDHDRVVELGGLHVVGTGRHHTERLDNQLRG
HHCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHC
RAGRQGDPGSSVFFSSWEDDVIAANLDRNKLPMQTDEDGRIISLKTTGLLDHAQRVAEGR
CCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCC
LLDVHANTWRYNQLIAQQRAIIVDRRNALLSSATAREELAELAPKRYEELAQALPKEEAE
EEEEECCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHH
ERLETICRLIMLYHLDRGWADHLAYLADIRESIHLRALGRQSPLDEFHRLAVNAFALLAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
DAIEAAQQTFETANILDGAPGLDLSKLARPTSTWTYMVNDAPLSDDTLSPLSLPGVFR
HHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002