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The map label for this gene is pgsA2 [H]

Identifier: 221230601

GI number: 221230601

Start: 2472012

End: 2472632

Strand: Reverse

Name: pgsA2 [H]

Synonym: MLBr_02081

Alternate gene names: 221230601

Gene position: 2472632-2472012 (Counterclockwise)

Preceding gene: 221230602

Following gene: 221230600

Centisome position: 75.66

GC content: 59.58

Gene sequence:

>621_bases
ATGGAGTCGGTGTGTCCGCCCAATCGGGTGCTGACAGTGCCCAATTTGCTCAGCGCTGTCCGCCTGGCGCTGATCCCGGC
GTTTGTCTACGTTCTGCTGGTCATGCACGCCGATGGCTGGGCGGTGGTGATTCTGGTGTTCAGCGGTGTCTCGGACTGGG
CCGACGGCAAGATTGCCCGGCTGCTGGATCAGTATTCGCGGTTGGGTGTGCTGCTTGACCCCGCTGTCGATCGGCTGTAC
ATGGTGACGATCCCCGTCGTGTTGGCGTTGAGCGGGATCGTGCCGTGGTGGTTTGTCGTCGCTCTACTGGCACGTGACGT
GCTACTGACCGCAACGCTGCCGTTGCTGTGGAGTCGCGGACTGCTGTCATTACCGGTGACCTATATCGGTAAGGCGGCGA
CGTTCAGCTTGATGGTCGGCTTTCCATTCGTTCTTCTAGGAACTTGGGACACGTTGTGGAGCCGTGTTCTGGGGGCCTGC
GGTTGGGCGTTTCTGATCTGGGGTACCTATGCGTACCTGTGGGCATTCGTGCTGTATGTGGTGCAGATGACGATGGTGGT
GCGGTGGATGCCTAAGATCAAGCACCAAGCCCATCGTCAGTTTGCGGGAAAGGCCAGATGA

Upstream 100 bases:

>100_bases
ACGCTTTCTCCCTTGAGCCTACCCGGGGTTTTCCGCTGAGGTCCGATTGCTTTCGGCCCGTTATCCGGACCGTCATATCG
CCAGGCTAAGGTCACTGCTC

Downstream 100 bases:

>100_bases
ATATGGCCGAACGTGAGCGACAGCTCAGCGGCTATGACCCGAAAGCGGGCTAGAATCTTCACGCGGAAGCCCGCCCAAGA
AGGTCCCGGTGTGCCCTCGC

Product: CDP-diacylglycerol-glycerol-3-phosphate

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIARLLDQYSRLGVLLDPAVDRLY
MVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRGLLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGAC
GWAFLIWGTYAYLWAFVLYVVQMTMVVRWMPKIKHQAHRQFAGKAR

Sequences:

>Translated_206_residues
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIARLLDQYSRLGVLLDPAVDRLY
MVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRGLLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGAC
GWAFLIWGTYAYLWAFVLYVVQMTMVVRWMPKIKHQAHRQFAGKAR
>Mature_206_residues
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIARLLDQYSRLGVLLDPAVDRLY
MVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRGLLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGAC
GWAFLIWGTYAYLWAFVLYVVQMTMVVRWMPKIKHQAHRQFAGKAR

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1788220, Length=141, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 23031; Mature: 23031

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIAR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHH
LLDQYSRLGVLLDPAVDRLYMVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGACGWAFLIWGTYAYLWAFVLYV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMTMVVRWMPKIKHQAHRQFAGKAR
HHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MESVCPPNRVLTVPNLLSAVRLALIPAFVYVLLVMHADGWAVVILVFSGVSDWADGKIAR
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHH
LLDQYSRLGVLLDPAVDRLYMVTIPVVLALSGIVPWWFVVALLARDVLLTATLPLLWSRG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LLSLPVTYIGKAATFSLMVGFPFVLLGTWDTLWSRVLGACGWAFLIWGTYAYLWAFVLYV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQMTMVVRWMPKIKHQAHRQFAGKAR
HHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]