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The map label for this gene is adk

Identifier: 221230456

GI number: 221230456

Start: 2220139

End: 2220684

Strand: Reverse

Name: adk

Synonym: MLBr_01832

Alternate gene names: 221230456

Gene position: 2220684-2220139 (Counterclockwise)

Preceding gene: 221230457

Following gene: 221230455

Centisome position: 67.95

GC content: 58.97

Gene sequence:

>546_bases
GTGAGAGTTGTTTTGCTGGGACCGCCGGGGGCAGGCAAGGGCACGCAAGCCCAAAGGCTCGCCGAGAAGCTTGGTATCCC
GCAGATCTCCACCGGTGAATTGTTCCGGCGCAACATCGAAAAAGACACCAAACTCGGGCACGAGGCCAAGAAGTACCTGG
ACGCCGGCGACTTGGTTCCTGCCGACCTGACCAATCAGCTGGTGGACGACCGTCTGAACAAATCGGACACGGTCGACGGG
TTTATCTTGGATGGGTATCCGCGCTCGCTCGAGCAAGCCAAGGCGCTGCATGAAATGCTGGAACGCCGGGGTACCGACAT
TGATGCCGTGCTGGAGTTTCGCGTGTCGCAGGCGGTGGTGCTGGAGCGGCTTAAAGGGCGGGGCCGCGCCGATGACACCG
ACGACGTCGTCATCAATCGGATGAACATCTACCGTGACGAGACTGCTTCGCTGTTGGAGTACTATAGCAGCGAATTGAAG
ACTATTGACGCCATCGGCACCATGGACGAAGTGTTTGCCCGTGCGTTGCACGCCTTGGGAAAGTAG

Upstream 100 bases:

>100_bases
TCGGGGGAACCGCTGTGTTGATCATGATCGGTGTTGGCTTGGATACGGTCAAGCAGATCGAGAGTCAGCTGATGCAACGC
AACTATGAAGGGTTCCTGAA

Downstream 100 bases:

>100_bases
GTAAAGTAGCTGTGGGCGCGTTGACACGGCTGCGCAGTCGCAGGGTTGTGCCGCAGCGCAGTGTTGGCGAACTTGACGCG
ATGGCCGCAGCCGGTGCAGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVPADLTNQLVDDRLNKSDTVDG
FILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVVLERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELK
TIDAIGTMDEVFARALHALGK

Sequences:

>Translated_181_residues
MRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVPADLTNQLVDDRLNKSDTVDG
FILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVVLERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELK
TIDAIGTMDEVFARALHALGK
>Mature_181_residues
MRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVPADLTNQLVDDRLNKSDTVDG
FILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVVLERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELK
TIDAIGTMDEVFARALHALGK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=33.6448598130841, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=33.6448598130841, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=30.5263157894737, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI19923437, Length=189, Percent_Identity=31.7460317460317, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=29.3478260869565, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI28144899, Length=185, Percent_Identity=32.4324324324324, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI28144897, Length=185, Percent_Identity=32.4324324324324, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI310110345, Length=188, Percent_Identity=30.3191489361702, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI53832003, Length=188, Percent_Identity=30.3191489361702, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI8051579, Length=188, Percent_Identity=30.3191489361702, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI53832001, Length=188, Percent_Identity=30.3191489361702, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=32.2834645669291, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786680, Length=189, Percent_Identity=39.1534391534392, Blast_Score=130, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=31.7757009345794, Blast_Score=115, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=31.3513513513514, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=176, Percent_Identity=25.5681818181818, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=156, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=26.6331658291457, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=33.4883720930233, Blast_Score=122, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=31.7204301075269, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322828, Length=169, Percent_Identity=29.585798816568, Blast_Score=82, Evalue=4e-17,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=33.6448598130841, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=29.6296296296296, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=29.6296296296296, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24663208, Length=184, Percent_Identity=28.804347826087, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17647141, Length=184, Percent_Identity=28.804347826087, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221459597, Length=179, Percent_Identity=28.4916201117318, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=179, Percent_Identity=28.4916201117318, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582962, Length=168, Percent_Identity=29.7619047619048, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MYCLB (B8ZS96)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503872.1
- ProteinModelPortal:   B8ZS96
- SMR:   B8ZS96
- EnsemblBacteria:   EBMYCT00000085238
- GeneID:   7325436
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000015504
- HOGENOM:   HBG630208
- OMA:   APLLEFY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20111; Mature: 20111

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ADLTNQLVDDRLNKSDTVDGFILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVV
HHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELKTIDAIGTMDEVFARALHALG
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MRVVLLGPPGAGKGTQAQRLAEKLGIPQISTGELFRRNIEKDTKLGHEAKKYLDAGDLVP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ADLTNQLVDDRLNKSDTVDGFILDGYPRSLEQAKALHEMLERRGTDIDAVLEFRVSQAVV
HHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LERLKGRGRADDTDDVVINRMNIYRDETASLLEYYSSELKTIDAIGTMDEVFARALHALG
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA