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The map label for this gene is mapA [H]

Identifier: 221230455

GI number: 221230455

Start: 2219327

End: 2220127

Strand: Reverse

Name: mapA [H]

Synonym: MLBr_01831

Alternate gene names: 221230455

Gene position: 2220127-2219327 (Counterclockwise)

Preceding gene: 221230456

Following gene: 221230453

Centisome position: 67.93

GC content: 62.05

Gene sequence:

>801_bases
GTGGGCGCGTTGACACGGCTGCGCAGTCGCAGGGTTGTGCCGCAGCGCAGTGTTGGCGAACTTGACGCGATGGCCGCAGC
CGGTGCAGTGGTCGCGGCAGCACTGCACGCCGTCCGGGACGCTGCAGGCCCCGGGGTGTCGAGTCTCAGCCTCGACGAAA
TTGCCGAGTCAGTGATCCGCGAAGCCGGAGCTACACCGTCATTTCTCCGTTATCACGGCTACCCCGCTACCATCTGCACA
TCGGTTAATGACCGGGTGATTCATGGAATCCCCTCTGCCGTTGAGATTCTCGCACCCGGCGACCTCGTGTCGATCGACTG
CGGCGCGGTGCTGGACGGCTGGCACGGTGATGCGGCGATAACCTTTGGTGTGGGCACCCTCACTTCCGTGGATGAAGCCT
TGTCCCAGGCGACCAGAGAATCGCTGGAAGCCGGCATTGCGGCGATGATTGTCAACAATCGTTTGACCGACGTGGCGCAT
GCCATCGAAGTGAGTACCCGTACGTCCGAGATTCGATACCGACTTACGTTTGGGATCGTGCAAGGTTACGGGGGTCATGG
CATCGGCCGGCACATGCACATGGATCCGTTTCTGCCCAACGAAGGCGCTCCTGGGCGCGGCCCGCTGCTGGTACCTGGCT
CGGTACTGGCCATCGAACCGATGTTGACGCTTGGCACCGGCAAAACGATTGTGCTCGACGACGAATGGACGGTAACGACT
GCTGACGGTTCGCGTGCGGCTCATTGGGAGCACACTGTGGCCGTCACCGAGGACGGACCTCGCGTTCTTACTCTGGCCTG
A

Upstream 100 bases:

>100_bases
AGTACTATAGCAGCGAATTGAAGACTATTGACGCCATCGGCACCATGGACGAAGTGTTTGCCCGTGCGTTGCACGCCTTG
GGAAAGTAGGTAAAGTAGCT

Downstream 100 bases:

>100_bases
CACTTCTAGCGCACACGTACTCTGGTGAATCTTCCTCTAGGGGGGCGGTGAACTAAGCATTTACTCGTATCCAGTAAGTG
GAGGTGATCAAATGACTTGC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MGALTRLRSRRVVPQRSVGELDAMAAAGAVVAAALHAVRDAAGPGVSSLSLDEIAESVIREAGATPSFLRYHGYPATICT
SVNDRVIHGIPSAVEILAPGDLVSIDCGAVLDGWHGDAAITFGVGTLTSVDEALSQATRESLEAGIAAMIVNNRLTDVAH
AIEVSTRTSEIRYRLTFGIVQGYGGHGIGRHMHMDPFLPNEGAPGRGPLLVPGSVLAIEPMLTLGTGKTIVLDDEWTVTT
ADGSRAAHWEHTVAVTEDGPRVLTLA

Sequences:

>Translated_266_residues
MGALTRLRSRRVVPQRSVGELDAMAAAGAVVAAALHAVRDAAGPGVSSLSLDEIAESVIREAGATPSFLRYHGYPATICT
SVNDRVIHGIPSAVEILAPGDLVSIDCGAVLDGWHGDAAITFGVGTLTSVDEALSQATRESLEAGIAAMIVNNRLTDVAH
AIEVSTRTSEIRYRLTFGIVQGYGGHGIGRHMHMDPFLPNEGAPGRGPLLVPGSVLAIEPMLTLGTGKTIVLDDEWTVTT
ADGSRAAHWEHTVAVTEDGPRVLTLA
>Mature_265_residues
GALTRLRSRRVVPQRSVGELDAMAAAGAVVAAALHAVRDAAGPGVSSLSLDEIAESVIREAGATPSFLRYHGYPATICTS
VNDRVIHGIPSAVEILAPGDLVSIDCGAVLDGWHGDAAITFGVGTLTSVDEALSQATRESLEAGIAAMIVNNRLTDVAHA
IEVSTRTSEIRYRLTFGIVQGYGGHGIGRHMHMDPFLPNEGAPGRGPLLVPGSVLAIEPMLTLGTGKTIVLDDEWTVTTA
DGSRAAHWEHTVAVTEDGPRVLTLA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=221, Percent_Identity=33.0316742081448, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI40385867, Length=219, Percent_Identity=33.7899543378995, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=35.6275303643725, Blast_Score=161, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71996291, Length=260, Percent_Identity=32.3076923076923, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323273, Length=224, Percent_Identity=36.1607142857143, Blast_Score=142, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24583427, Length=252, Percent_Identity=34.5238095238095, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=32.6530612244898, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27739; Mature: 27608

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGALTRLRSRRVVPQRSVGELDAMAAAGAVVAAALHAVRDAAGPGVSSLSLDEIAESVIR
CCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EAGATPSFLRYHGYPATICTSVNDRVIHGIPSAVEILAPGDLVSIDCGAVLDGWHGDAAI
HHCCCCHHEEECCCCCEEEECCCCCEEECCCCCEEEECCCCEEEECCCCEECCCCCCEEE
TFGVGTLTSVDEALSQATRESLEAGIAAMIVNNRLTDVAHAIEVSTRTSEIRYRLTFGIV
EECCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHCCCCCCEEEEEEEEEE
QGYGGHGIGRHMHMDPFLPNEGAPGRGPLLVPGSVLAIEPMLTLGTGKTIVLDDEWTVTT
ECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEECCEEEECCCCEEEECCCEEEEE
ADGSRAAHWEHTVAVTEDGPRVLTLA
CCCCCCCCCEEEEEEECCCCEEEEEC
>Mature Secondary Structure 
GALTRLRSRRVVPQRSVGELDAMAAAGAVVAAALHAVRDAAGPGVSSLSLDEIAESVIR
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EAGATPSFLRYHGYPATICTSVNDRVIHGIPSAVEILAPGDLVSIDCGAVLDGWHGDAAI
HHCCCCHHEEECCCCCEEEECCCCCEEECCCCCEEEECCCCEEEECCCCEECCCCCCEEE
TFGVGTLTSVDEALSQATRESLEAGIAAMIVNNRLTDVAHAIEVSTRTSEIRYRLTFGIV
EECCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHCCCCCCEEEEEEEEEE
QGYGGHGIGRHMHMDPFLPNEGAPGRGPLLVPGSVLAIEPMLTLGTGKTIVLDDEWTVTT
ECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEECCEEEECCCCEEEECCCEEEEE
ADGSRAAHWEHTVAVTEDGPRVLTLA
CCCCCCCCCEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]