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The map label for this gene is mtrA [H]

Identifier: 221229812

GI number: 221229812

Start: 915878

End: 916564

Strand: Direct

Name: mtrA [H]

Synonym: MLBr_00773

Alternate gene names: 221229812

Gene position: 915878-916564 (Clockwise)

Preceding gene: 221229811

Following gene: 221229813

Centisome position: 28.03

GC content: 59.24

Gene sequence:

>687_bases
ATGGACATCATGAGGCAAAGGATTTTGGTCGTCGATGACGACGCTTCGCTGGCTGAGATGCTCACTATAGTGCTGCGTGG
GGAGGGCTTCGATACCGCGGTCATCGGTGACGGTACTCAGGCCTTGACCGCGGTCCGCGAGCTACGTCCCGACTTGGTGC
TACTGGACCTTATGTTGCCTGGTATGAATGGCATCGACGTGTGCAGGGTGTTGCGCGCCGACTCCGGCGTTCCGATTGTG
ATGCTGACCGCCAAGACCGACACTGTGGACGTGGTGCTGGGCTTAGAGTCGGGTGCTGATGACTACATCATGAAGCCGTT
CAAGCCCAAGGAACTGGTTGCTCGGGTACGGGCGCGGCTACGGCGCAACGACGACGAGCCAGCCGAGATGCTGTCCATTG
CCGACGTCGACATTGACGTGCCGGCACATAAGGTCACCCGAAACGGTGAACACATCTCATTGACACCGTTGGAATTCGAC
CTGCTGGTAGCGCTTGCACGCAAGCCACGCCAGGTTTTTACTCGTGATGTGCTGCTCGAACAGGTGTGGGGCTATCGTCA
CCCAGCGGATACCCGCTTGGTTAACGTGCATGTCCAGCGGCTACGGGCCAAGGTCGAGAAAGACCCGGAGAACCCGACCG
TGGTGTTGACCGTTCGAGGAGTGGGATACAAGGCCGGACCCCCGTGA

Upstream 100 bases:

>100_bases
GCTGTTAGACTGTGTTCCGGCAGGATTTCACGGTAATTGAGCTTATCATTGTGTGAAACGCCCGTGTGGCGCCCTAGGTT
TGTCCCGATCTGGTGACACC

Downstream 100 bases:

>100_bases
CGTGCTGGCGGCGATTCGGAGCGAAGAGATACGGTAGGGTCTCTACTCGCTCGCGTTGCGATGCGGACATCGGGGCACGC
TCCCACCAATGTGAGGTATA

Product: putative two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIV
MLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFD
LLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP

Sequences:

>Translated_228_residues
MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIV
MLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFD
LLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
>Mature_228_residues
MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIV
MLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFD
LLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP

Specific function: Member of the two-component regulatory system mtrA/mtrB [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=40.990990990991, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=41.7777777777778, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=40, Blast_Score=156, Evalue=8e-40,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=41.0714285714286, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=37.6146788990826, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=35.5555555555556, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=35.6164383561644, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.0530973451327, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.4159292035398, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=34.3891402714932, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=32.5688073394495, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=33.7719298245614, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=32.8767123287671, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=33.6206896551724, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=35.1851851851852, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=37.3983739837398, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=33.0434782608696, Blast_Score=68, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=31.3725490196078, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25287; Mature: 25287

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLP
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEHHHC
GMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARL
CCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
RRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLVALARKPRQVFTRDVLLE
HCCCCCHHHHHEECCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHH
QVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
HHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MDIMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLP
CCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEHHHC
GMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARL
CCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
RRNDDEPAEMLSIADVDIDVPAHKVTRNGEHISLTPLEFDLLVALARKPRQVFTRDVLLE
HCCCCCHHHHHEECCCCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHH
QVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP
HHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]