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The map label for this gene is mtrB

Identifier: 221229813

GI number: 221229813

Start: 916692

End: 918380

Strand: Direct

Name: mtrB

Synonym: MLBr_00774

Alternate gene names: 221229813

Gene position: 916692-918380 (Clockwise)

Preceding gene: 221229812

Following gene: 221229814

Centisome position: 28.05

GC content: 62.17

Gene sequence:

>1689_bases
GTGATCTTTAGTTCGCGGCGACGGATCCGGGGTCGCTGGGGGCGTTCGGGCCCCATGATGCGTGGCATGGGCGCGTTGAC
TCGAGTCGTGGGTGTTGTCTGGCGCCGGTCGCTGCAACTGCGAGTTGTAGCACTAACATTTGGTCTTTCGTTGGCCGTGA
TTTTGGCGCTTGGCTTCGTGCTCACCAGTCAGCTCACCAGCCGTGTCCTCGACGTCAAAGTCAGGGTAGCCATCGAGCAG
ATCGAGCGGGCACGCACCACCGTCACAGGGATCGTCAACGGTGAGGAGACCCGTTCGCTGGACAGCAGTCTGCAGCTGGC
CCGCAACACGTTGACATCGAAAACTGACCCAACTTCTGGTGCTGGCCTCGTCGGTGCCTTCGATGCAGTGCTGATAGTGC
CCGGTGATGGCCCGCGCACCGCGACCACGGCCGGACCCGTCGATCAGGTGCCTAATTCGTTGCGTGGCTTTATCAAAGCC
GGGCAGGCGGCTTACCAGTACGCAACTGTACATACTGAAGGCTTCTCGGGGCCAGCGCTGATCATCGGCACGCCGACGTC
GTCGCAGGTGACCAATCTCGAGCTTTATCTGATCTTTCCGCTGAAGAACGAACAGGCGACCGTCACGCTGGTGCGTGGCA
CGATGGCCACCGGTGGCATGGTGCTGCTGGTATTGCTGTCGGGTATTGCGTTGCTGGTATCGCGCCAGGTAGTGGTACCG
GTGCGATCCGCGTCGCGGATCGCCGAACGGTTCGCCGAGGGGCACCTGTCGGAACGGATGCCGGTGCGTGGCGAGGACGA
CATGGCCCGGTTGGCGGTGTCGTTCAACGACATGGCGGAGAGCTTGTCTCGGCAGATCACCCAGCTCGAGGAATTCGGTA
ACCTACAACGCCGTTTTACGTCCGACGTCAGCCACGAACTCCGCACGCCGCTGACCACCGTGCGGATGGCCGCCGACTTG
ATCTACGACCACAGCTCCGATCTCGATCCTACGTTGCGGCGGTCCACCGAACTGATGGTCAGCGAACTCGATCGATTCGA
GACACTGCTCAACGACCTGCTCGAGATCTCGCGGCACGACGCCGGCGTGGCCGAACTCTCTGTCGAGGCGGTTGATTTGC
GCGTGATGGTGAATAACGCGCTGGGCAATGTCGGCCACTTGGCCGAGGAGGCCGGTATTGAACTGCTGGTGGACATGCCT
GTCGACGAGGTGATTGCCGAGGTTGATGCCCGCCGAGTCGAGCGGATCTTGCGCAACCTTATCGCCAACGCTATCGACCA
CTCCGAGCATAAACCGGTGAGGATTCGTATGGCCGCCGACGAAGATACTGTCGCTGTCACTGTGCGTGACTACGGGATCG
GACTGCGGCCCGGCGAAGAGAAGTTGGTGTTCAGTCGGTTTTGGCGTTCGGACCCGTCACGGGTGCGGCGCTCCGGCGGT
ACCGGCCTGGGACTGGCGATCAGCATCGAGGATGCGCGGCTGCACCAGGGTCGACTCGAAGCATGGGGCGAGCCTGGCCA
GGGCGCCTGCTTCAGACTGACGCTTCCGTTGGTTCGCGGCCACAAGGTCACCACAAGTCCGCTGCCCATGAAACCGATTC
TGCAACCAAGTCCGCAGGCCAGCACAGCTGGCCAACAACACGGCACCCAACGCCAACGCCTGCGAGAGCACGCTGAGAGG
AGCCGGTGA

Upstream 100 bases:

>100_bases
GATACGGTAGGGTCTCTACTCGCTCGCGTTGCGATGCGGACATCGGGGCACGCTCCCACCAATGTGAGGTATACCCACCC
GCGTGTGGGGGACGCCGTCT

Downstream 100 bases:

>100_bases
TGCGGGGCGTTCTAGTGATCATGCGGCTGTTGTGTCTGGGCATGTTGTTCACTGGCTGTGCCGGGGTACCCAACTCGTCG
GCTCCACAGGCGATTGGCAC

Product: putative two-component system sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVLTSQLTSRVLDVKVRVAIEQ
IERARTTVTGIVNGEETRSLDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKA
GQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVP
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADL
IYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMP
VDEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGG
TGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAER
SR

Sequences:

>Translated_562_residues
MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVLTSQLTSRVLDVKVRVAIEQ
IERARTTVTGIVNGEETRSLDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKA
GQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVP
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADL
IYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMP
VDEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGG
TGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAER
SR
>Mature_562_residues
MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFVLTSQLTSRVLDVKVRVAIEQ
IERARTTVTGIVNGEETRSLDSSLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKA
GQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVP
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADL
IYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMP
VDEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGG
TGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQHGTQRQRLREHAER
SR

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1790346, Length=330, Percent_Identity=30, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788393, Length=286, Percent_Identity=29.7202797202797, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787894, Length=270, Percent_Identity=29.2592592592593, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789149, Length=336, Percent_Identity=26.7857142857143, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786783, Length=345, Percent_Identity=26.0869565217391, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=327, Percent_Identity=27.82874617737, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=438, Percent_Identity=26.2557077625571, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786600, Length=238, Percent_Identity=27.3109243697479, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=307, Percent_Identity=25.7328990228013, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=26.8595041322314, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=25.7575757575758, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1788279, Length=301, Percent_Identity=26.9102990033223, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=25.1121076233184, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI48994928, Length=222, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=233, Percent_Identity=29.6137339055794, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=25.2707581227437, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=25.6666666666667, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTRB_MYCLE (Q9CCJ1)

Other databases:

- EMBL:   AL583919
- PIR:   G87005
- RefSeq:   NP_301598.1
- ProteinModelPortal:   Q9CCJ1
- SMR:   Q9CCJ1
- EnsemblBacteria:   EBMYCT00000028946
- GeneID:   909729
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0774
- NMPDR:   fig|272631.1.peg.470
- Leproma:   ML0774
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG428949
- OMA:   MVNELDR
- ProtClustDB:   CLSK792375
- BioCyc:   MLEP272631:ML0774-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 61507; Mature: 61507

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x23265ba0)-; HASH(0x21dad1f0)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFV
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHH
LTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDSSLQLARNTLTSKTDPTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
AGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQAAYQYATVHTEGFSGPAL
CCCEEECCEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHCHHHEEEEEEEECCCCCCEE
IIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVP
EEECCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEE
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFT
CHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHD
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRNL
CCHHHEEEEEEEEEEEEEHHCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
IANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGG
HHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCC
TGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQA
CCEEEEEEEEHHHHHCCHHHHCCCCCCCCEEEEEEEHHCCCEEECCCCCCCCCCCCCCCC
STAGQQHGTQRQRLREHAERSR
CCCCHHCCHHHHHHHHHHHHCH
>Mature Secondary Structure
MIFSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLAVILALGFV
CCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHH
LTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDSSLQLARNTLTSKTDPTSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
AGLVGAFDAVLIVPGDGPRTATTAGPVDQVPNSLRGFIKAGQAAYQYATVHTEGFSGPAL
CCCEEECCEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHCHHHEEEEEEEECCCCCCEE
IIGTPTSSQVTNLELYLIFPLKNEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVP
EEECCCCCCEEEEEEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEE
VRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQITQLEEFGNLQRRFT
CHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SDVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTELMVSELDRFETLLNDLLEISRHD
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMPVDEVIAEVDARRVERILRNL
CCHHHEEEEEEEEEEEEEHHCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
IANAIDHSEHKPVRIRMAADEDTVAVTVRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGG
HHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCC
TGLGLAISIEDARLHQGRLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQA
CCEEEEEEEEHHHHHCCHHHHCCCCCCCCEEEEEEEHHCCCEEECCCCCCCCCCCCCCCC
STAGQQHGTQRQRLREHAERSR
CCCCHHCCHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002