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The map label for this gene is tmk [H]

Identifier: 221229811

GI number: 221229811

Start: 915153

End: 915785

Strand: Direct

Name: tmk [H]

Synonym: MLBr_00772

Alternate gene names: 221229811

Gene position: 915153-915785 (Clockwise)

Preceding gene: 221229810

Following gene: 221229812

Centisome position: 28.0

GC content: 62.24

Gene sequence:

>633_bases
GTGTTGATCGCGATTGAAGGTGTTGACGGCGCTGGCAAGCGCACTTTGTCCGAGGAGTTACGCCAGGCGTTTGAGGCCAC
TGGGAAGTCGGTAGCAACGTTGGCTTTCCCGCGTTACCGGCAATCAGTAGCCGCCGACATAGCTGCAGAGGCGCTGCACG
GCCAGCACGGTGATCTCGCGTCGTCAGTGTATGCGATGGCCCTGCTGTTCGCGTTCGACCGCGCCGGGGCGGTCGAGGAC
ATCGAAGCGTTGGATCGCAACCATGACATAGTGATTCTTGATCGCTACGTCGCGTCCAATGCCGCCTACAGCGCCGCGCG
TTTGCATGAGGACTGCAGCGGGAGAGCGGTGGCCTGGGTACAGCGAATCGAATACCAGAGATTGCGGCTGCCCTCTCCCG
ATTGGCAAGTGTTGCTCGCGGTCTCTGTCGAGCTTGCTGGGAAGCGTTCCCGCTACCGGGCCCGCACTGATCCCGACCGG
CTGCGTGACAGCTACGAACGCGACGACGGCCTTCAGCAGCGCACTGGCGCGGTATACGCTGGCCTGGCTGCCGCAGATTG
GGGCGGGCGGTGGCTAGTCGTCGATGCGGATATCGATTCGGGCTGGTTGGTAGCAACTTTGATGGGCTGTTAG

Upstream 100 bases:

>100_bases
CGAATACCTCGGTGTCGACGTCGACGGCCCGTTCAAGCCGGACCACTATCGCTACTGATTCCGCTGAGCGTTCGTCAGTT
GGGCCCGATAGGCTCGCGCC

Downstream 100 bases:

>100_bases
ACTGTGTTCCGGCAGGATTTCACGGTAATTGAGCTTATCATTGTGTGAAACGCCCGTGTGGCGCCCTAGGTTTGTCCCGA
TCTGGTGACACCATGGACAT

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIAAEALHGQHGDLASSVYAMALLFAFDRAGAVED
IEALDRNHDIVILDRYVASNAAYSAARLHEDCSGRAVAWVQRIEYQRLRLPSPDWQVLLAVSVELAGKRSRYRARTDPDR
LRDSYERDDGLQQRTGAVYAGLAAADWGGRWLVVDADIDSGWLVATLMGC

Sequences:

>Translated_210_residues
MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIAAEALHGQHGDLASSVYAMALLFAFDRAGAVED
IEALDRNHDIVILDRYVASNAAYSAARLHEDCSGRAVAWVQRIEYQRLRLPSPDWQVLLAVSVELAGKRSRYRARTDPDR
LRDSYERDDGLQQRTGAVYAGLAAADWGGRWLVVDADIDSGWLVATLMGC
>Mature_210_residues
MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIAAEALHGQHGDLASSVYAMALLFAFDRAGAVED
IEALDRNHDIVILDRYVASNAAYSAARLHEDCSGRAVAWVQRIEYQRLRLPSPDWQVLLAVSVELAGKRSRYRARTDPDR
LRDSYERDDGLQQRTGAVYAGLAAADWGGRWLVVDADIDSGWLVATLMGC

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23025; Mature: 23025

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIAAEALHGQHGDLA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCHH
SSVYAMALLFAFDRAGAVEDIEALDRNHDIVILDRYVASNAAYSAARLHEDCSGRAVAWV
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHCCCCHHHHHH
QRIEYQRLRLPSPDWQVLLAVSVELAGKRSRYRARTDPDRLRDSYERDDGLQQRTGAVYA
HHHHHHHHCCCCCCCEEEEEEEEHHCCCCHHCCCCCCHHHHHHHHHCCCCHHHHCCHHHC
GLAAADWGGRWLVVDADIDSGWLVATLMGC
CEEEECCCCEEEEEECCCCCCHHHHEECCC
>Mature Secondary Structure
MLIAIEGVDGAGKRTLSEELRQAFEATGKSVATLAFPRYRQSVAADIAAEALHGQHGDLA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCHH
SSVYAMALLFAFDRAGAVEDIEALDRNHDIVILDRYVASNAAYSAARLHEDCSGRAVAWV
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHCCCCHHHHHH
QRIEYQRLRLPSPDWQVLLAVSVELAGKRSRYRARTDPDRLRDSYERDDGLQQRTGAVYA
HHHHHHHHCCCCCCCEEEEEEEEHHCCCCHHCCCCCCHHHHHHHHHCCCCHHHHCCHHHC
GLAAADWGGRWLVVDADIDSGWLVATLMGC
CEEEECCCCEEEEEECCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]