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The map label for this gene is sahH [H]

Identifier: 221229810

GI number: 221229810

Start: 913632

End: 915110

Strand: Direct

Name: sahH [H]

Synonym: MLBr_00771

Alternate gene names: 221229810

Gene position: 913632-915110 (Clockwise)

Preceding gene: 221229809

Following gene: 221229811

Centisome position: 27.96

GC content: 59.16

Gene sequence:

>1479_bases
ATGACGACGACCGAAAATTCGCTGATGCCTGATGTTCGTAACGGCATCGACTTCAAGGTTGCTGACCTGTCGCTAGCGAA
TTTCGGCCGCAAAGAACTCGACCTCGCCGAGTACGAGATGCCTGGCCTGATGTCACTGCGTCATGAGTACGCCGAAGTGC
AGCCCTTGAAAGGGGCCCGTATTTCCGGCTCGCTGCACATGACGGTGCAGACCGCGGTGCTGATCGAGACGTTAACTGCA
CTTGGCGCCGAGGTTCGCTGGGCATCGTGCAATATCTTCTCGACTCAGGACCATGCGGCAGCGGCAGTTGTCGTTGGCCC
ATACGGCACGCCCGAGGAGCCCAAGGGTGTACCGGTGTTCGCCTGGAAGGGCGAGACGCTCGAGGAGTATTGGTGGGCTG
CCGAGCAGATGCTCACCTGGCCAGATCCCGATAAGCCGGTCAACATGATCCTGGATGACGGCGGGGATGCCACCATGCTG
GTGCTGCGAGGCGTGCAGTACGAGAAAGCCGGCGTAGTGCCGCCTGCCGAGGTCGACGACTCCGCCGAGTGGAAAGTTTT
TCTGAACCTGCTGCGGAAGCGCTTCGAGACTGACAAAGGCAAATGGACCAAGATCGCCAAGTCGGTCAAGGGTGTCACCG
AGGAGACGACCACGGGCGTGCTGCGACTGTACCAATTCGCCGCGGCCGGGGATCTGGCCTTCCCCGCGATCAATGTCAAC
GACTCGGTGACCAAGTCCAAGTTCGACAACAAGTACGGCACTCGACACTCCCTGATCGACGGCATCAACCGTGGTACCGA
CTCCCTAATTGGGGGCAAGAACGTGCTCATTTGTGGCTACGGGGATGTAGGTAAGGGGTGCGCGGAGGCGGCGAAGGGTC
AGGGTGCGCGGGTCACTATCACCGAGATCGACCCGATTAACGCGCTGCAGGCGCTGATGGAGGGCTTCGACGTCAAGCGG
GTCGAGGACGTCATCGCTGATTCAGACATCGTCGTCACCGCGACCGGCAACAAGGACATCATTCTACTTGAGCACATGAA
GGCAATGAAGGATCACGCCATCCTGGGCAACATTGGCCATTTTGACAACGAAATCGACATGGCGGCGCTGGAACGTTCCG
GGGCGACGCGGCTCAACATCAAACCGCAGGTTGATCTGTGGACTTTCGGCGACAGCGGTAAGTCGATCATTGTGCTTTCC
GAAGGCCGGCTGCTGAACCTGGGCAACGCCACCGGTCATCCGTCGTTTGTGATGAGTAATAGTTTCGCTAACCAGACTAT
CGCCCAGATCGAGCTGTGGACCAAAAACGACGACTATGACAATGAGGTGTATAGGCTCCCCAAGCACCTCGACGAAAAAG
TGGCCCGCGTCCACGTCGAGGCCCTGGGCGGCCAGCTGACCAAGCTGACCAAGGACCAGGCCGAATACCTCGGTGTCGAC
GTCGACGGCCCGTTCAAGCCGGACCACTATCGCTACTGA

Upstream 100 bases:

>100_bases
GAGGATCCAGGGCCTCAGAAAGGTAAGACGACTACAGTGACTGTAAAATAGTTTATTTGCCCTTGTGAGTCTCTGAGCTC
TAGAAGGATCGAGGCACGTT

Downstream 100 bases:

>100_bases
TTCCGCTGAGCGTTCGTCAGTTGGGCCCGATAGGCTCGCGCCGTGTTGATCGCGATTGAAGGTGTTGACGGCGCTGGCAA
GCGCACTTTGTCCGAGGAGT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MTTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGARISGSLHMTVQTAVLIETLTA
LGAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATML
VLRGVQYEKAGVVPPAEVDDSAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVN
DSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTITEIDPINALQALMEGFDVKR
VEDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLS
EGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVD
VDGPFKPDHYRY

Sequences:

>Translated_492_residues
MTTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGARISGSLHMTVQTAVLIETLTA
LGAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATML
VLRGVQYEKAGVVPPAEVDDSAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVN
DSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTITEIDPINALQALMEGFDVKR
VEDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLS
EGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVD
VDGPFKPDHYRY
>Mature_491_residues
TTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGARISGSLHMTVQTAVLIETLTAL
GAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATMLV
LRGVQYEKAGVVPPAEVDDSAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVND
SVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTITEIDPINALQALMEGFDVKRV
EDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLSE
GRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVDV
DGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=477, Percent_Identity=55.7651991614256, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI239937451, Length=453, Percent_Identity=55.6291390728477, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI195539337, Length=495, Percent_Identity=44.040404040404, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI24308043, Length=495, Percent_Identity=44.040404040404, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI298286489, Length=495, Percent_Identity=44.040404040404, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI195539349, Length=495, Percent_Identity=43.8383838383838, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI21361647, Length=480, Percent_Identity=44.5833333333333, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17506425, Length=478, Percent_Identity=54.3933054393305, Blast_Score=502, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6320882, Length=490, Percent_Identity=53.8775510204082, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24642172, Length=475, Percent_Identity=56.8421052631579, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24656245, Length=483, Percent_Identity=46.3768115942029, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553387, Length=478, Percent_Identity=45.81589958159, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45553385, Length=477, Percent_Identity=45.7023060796646, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 53987; Mature: 53856

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGAR
CCCCCCCCCCHHHCCCCEEEEEEEHHHCCCHHCCHHHHCCCCHHHHHHHHHHCCCCCCCE
ISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVF
ECCEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
AWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATMLVLRGVQYEKAGVVPPAEVDD
EECCCCHHHHHHHHHHEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
SAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVN
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCC
DSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTI
CCHHHHHHCCCCCCHHHHHHHHCCCCCHHCCCCEEEEECCCCCCHHHHHHHCCCCCEEEE
TEIDPINALQALMEGFDVKRVEDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGH
EECCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCEEEHHHHHHHHHCCEECCCCC
FDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNLGNATGHPSFVMSN
CCCCHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEEEEC
SFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVD
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEC
VDGPFKPDHYRY
CCCCCCCCCCCC
>Mature Secondary Structure 
TTTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLRHEYAEVQPLKGAR
CCCCCCCCCHHHCCCCEEEEEEEHHHCCCHHCCHHHHCCCCHHHHHHHHHHCCCCCCCE
ISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPYGTPEEPKGVPVF
ECCEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
AWKGETLEEYWWAAEQMLTWPDPDKPVNMILDDGGDATMLVLRGVQYEKAGVVPPAEVDD
EECCCCHHHHHHHHHHEECCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
SAEWKVFLNLLRKRFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVN
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEECCC
DSVTKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKGQGARVTI
CCHHHHHHCCCCCCHHHHHHHHCCCCCHHCCCCEEEEECCCCCCHHHHHHHCCCCCEEEE
TEIDPINALQALMEGFDVKRVEDVIADSDIVVTATGNKDIILLEHMKAMKDHAILGNIGH
EECCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCEEEHHHHHHHHHCCEECCCCC
FDNEIDMAALERSGATRLNIKPQVDLWTFGDSGKSIIVLSEGRLLNLGNATGHPSFVMSN
CCCCHHHHHHHCCCCEEEECCCCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEEEEC
SFANQTIAQIELWTKNDDYDNEVYRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVD
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEC
VDGPFKPDHYRY
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]