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The map label for this gene is manA [H]

Identifier: 221229809

GI number: 221229809

Start: 907192

End: 908424

Strand: Direct

Name: manA [H]

Synonym: MLBr_00765

Alternate gene names: 221229809

Gene position: 907192-908424 (Clockwise)

Preceding gene: 221229808

Following gene: 221229810

Centisome position: 27.76

GC content: 61.8

Gene sequence:

>1233_bases
GTGGAACTGCTACGCGGAGCGTTGCGGACATATGCGTGGGGATCGCGGACCGCTATCGCCGAATTCACTGGAAGACCTGT
GCCGGCTGCTCACCCTGAAGCTGAGCTCTGGTTCGGTGCGCACCCCGGTGACTCGGTTTGGCTACAAGCAGCGAACGGCG
AAACTTCGCTACTGGAGGCTCTGGTCGCTGATCCGGAAGGGCAGCTTGGCTCAGTGTCCCGCGCTCGATTTGGTGACGTG
CTGCCGTTCCTGGTCAAGGTGCTGGCAGCTGACGAACCGCTGTCGCTGCAGGCCCATCCGAGCACCAAGCAGGCGGTCGA
GGGTTACCTGCGCGAAGAACGTCTGGGCATTCCGGTGTCCTCGCCGGAACGTAACTACCGGGATACCAGTCACAAGCCGG
AGTTATTGGTGGCGCTGCAGTCATTCGAGGCGTTGGCTGGATTTCGTCAGTCGTCACGCACTGCTGAGCTACTGACGGCG
TTAGCCGTCTCCGACCTCGACCCTTTCATTCATTTGCTGAGCGACCAGTCCGACGCCGACGGTCTGCGTGCGCTGTTCAC
TACCTGGATAACCGCGCCCCAGACCGACATCGACATGCTGGTACCTGCCGTGCTGGAGGGGGCGATCGCCTACGTCAGTT
CCGGAGCGACGGAGTTCCTGGCGGAAGTCAAGACGGTGATGGAACTTGGCGAGCGTTATCCCGGCGACGCCGGCGTGCTG
GCATCGTTGTTGCTTAACCGCATCAGCCTCACTCCCGGCGAGGCTATCTTCTTGCCGGCCGGCAACTTGCATGCCTATTT
GCGAGGTGTTGGGGTGGAGGTGATGGCTAACTCCGACAACGTGTTGCGAGGAGGCCTCACCCCCAAGCATGTCGATGTGC
CTGAGCTGTTGCGGGTGCTGGATTTCAACCCAACTCCCGAGGAGGCGCTGCGCCCGCCGACCCGCTGCGAGGGTTTTGCG
GTGGTTTACGAGACCCCGACCGATGAGTTCGAGGTAGCGCTATTGGCGCTCGACGGCGATTATCTGGGTCACGAGGTCGA
TGCGTCACCCCACGATGTGTCGCAAGGCCCACAGATCTTGTTGTGCACCGAGGGTGAAATTACGGTGCACGGCAAGTTCC
AGGCACTCACCGTAGAACGCGGTATGGCTGTCTGGATGGCGGCCGACGACGGCCCGATTCGGCTGGTCGCGCAGCAACCC
GCCAAGCTGTTCAGGGCAACCGTCGGTTTGTGA

Upstream 100 bases:

>100_bases
TCGGGTGGCGCCGATCGCGCTGAGCAAGAGCTGGCAATGTTAGCTGTTCGGCTTGAAATGGCCGCGGTTTATTTGCGATT
GGTACGGGGATAGATAGACA

Downstream 100 bases:

>100_bases
CGGCTTGCCTTCGCTCACGTAGCTACAACCGGAGTGTGTGAGCGCTGGTGCGACATTTATTTTATTTCGACCGGGCGGAC
CTAAGTACAGGCTGTCAAGA

Product: putative mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQAANGETSLLEALVADPEGQLGSVSRARFGDV
LPFLVKVLAADEPLSLQAHPSTKQAVEGYLREERLGIPVSSPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTA
LAVSDLDPFIHLLSDQSDADGLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVL
ASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFNPTPEEALRPPTRCEGFA
VVYETPTDEFEVALLALDGDYLGHEVDASPHDVSQGPQILLCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQP
AKLFRATVGL

Sequences:

>Translated_410_residues
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQAANGETSLLEALVADPEGQLGSVSRARFGDV
LPFLVKVLAADEPLSLQAHPSTKQAVEGYLREERLGIPVSSPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTA
LAVSDLDPFIHLLSDQSDADGLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVL
ASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFNPTPEEALRPPTRCEGFA
VVYETPTDEFEVALLALDGDYLGHEVDASPHDVSQGPQILLCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQP
AKLFRATVGL
>Mature_410_residues
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQAANGETSLLEALVADPEGQLGSVSRARFGDV
LPFLVKVLAADEPLSLQAHPSTKQAVEGYLREERLGIPVSSPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTA
LAVSDLDPFIHLLSDQSDADGLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVL
ASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFNPTPEEALRPPTRCEGFA
VVYETPTDEFEVALLALDGDYLGHEVDASPHDVSQGPQILLCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQP
AKLFRATVGL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=440, Percent_Identity=30.6818181818182, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1787899, Length=395, Percent_Identity=38.7341772151899, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71997620, Length=320, Percent_Identity=33.75, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17557650, Length=346, Percent_Identity=28.0346820809249, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320839, Length=446, Percent_Identity=30.0448430493274, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21356061, Length=406, Percent_Identity=29.5566502463054, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 44156; Mature: 44156

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQAANGETSLLEA
CHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCHHHHHH
LVADPEGQLGSVSRARFGDVLPFLVKVLAADEPLSLQAHPSTKQAVEGYLREERLGIPVS
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCC
SPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTALAVSDLDPFIHLLSDQSDAD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHH
ASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEEECCCHHHHHHCCCEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFNPTPEEALRPPTRCEGFAVVYETPTDEFEVALLALDGDYLGHEVDASPHDVSQGPQIL
CCCCCCHHHCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEE
LCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQPAKLFRATVGL
EEECCCEEEECEEEEEEEECCEEEEEECCCCCEEEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQAANGETSLLEA
CHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCEEEEECCCCHHHHHH
LVADPEGQLGSVSRARFGDVLPFLVKVLAADEPLSLQAHPSTKQAVEGYLREERLGIPVS
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCC
SPERNYRDTSHKPELLVALQSFEALAGFRQSSRTAELLTALAVSDLDPFIHLLSDQSDAD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GLRALFTTWITAPQTDIDMLVPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHH
ASLLLNRISLTPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEEECCCHHHHHHCCCEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFNPTPEEALRPPTRCEGFAVVYETPTDEFEVALLALDGDYLGHEVDASPHDVSQGPQIL
CCCCCCHHHCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEEE
LCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQPAKLFRATVGL
EEECCCEEEECEEEEEEEECCEEEEEECCCCCEEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1879695; 11677609 [H]