Click here to switch to the map view.

The map label for this gene is secF

Identifier: 221229643

GI number: 221229643

Start: 591843

End: 593258

Strand: Direct

Name: secF

Synonym: MLBr_00488

Alternate gene names: 221229643

Gene position: 591843-593258 (Clockwise)

Preceding gene: 221229642

Following gene: 221229644

Centisome position: 18.11

GC content: 59.75

Gene sequence:

>1416_bases
ATGGTCTCCAGAGCCAAAGTCGGGGCCGAGACCACCAAGGGTATCGACGAACCAGACCGAAATGACAACACCGACGACAA
TGGCGCCGGTGCGGTCGAAGTCACCGAAGCCGCCGAGGATGCCGTGGAGCTGACTAACGATATATCCACACAGCTGCCGC
AGCACGGCTTTCTTGCTCGGTTCTACACCGGCCTTTCTCGACTGTACACCGGCACCGGTGTGTTCGAGGTGGTGGGACGC
CGGCGGCTGTGGTACAGCGTGGGCGGCGTCATCGTGGCGGTTGCGGTCCTGTCCATTATCGTTCGCGGGTTTACTTTCGG
GATTGATTTCAAGGGCGGCACCACGGTGTCCATGCCTGTCTCGCCCGGAGTGGGGGGGACAGGCGCAATTGAGGTTGCGC
AGGTTGCCGATGTCTTCAAGAAGACCCTTGGCAGTGATCCGGAATCGGTGGTCGTTGTTGGTAACGGCGCGTCAGCAACG
GTGCGGATCAGTTCGAAAACGCTGTCCAATGACCAGACGTCGAAGCTGCGTAACGCCTTGTTTGACGCATTCGGACCCAA
AGGCGCCGACGCTAAGCCTAGCAAGCAGGCAATCAGCGACGCGGCGGTATCGGAGACCTGGGGCGGTCAGATCACCAAGA
AGGTGGTGATCGCTCTTGTGGTGTTTCTGGTGCTAGTCGGCCTGTACATCACTGTGCGGTACGAGCGTTATATGGCTATC
TCCGCACTGACTACCATGTGTTTTGACCTGACCGTCACAGCCGGCGTGTACTCGCTGGTGGGCTTCGAAGTCACTCCGGC
CACTGTCATCGGCTTGTTGACGATCCTCGGTTTCTCTCTCTACGACACCGTTATCGTGTTCGACAAAGTTGAGGAGAATA
CCCACGGTTTCCAGCACACCACTCGGCGCACCTTCGCTGAGCAGGCTAACTTGGCGATCAATCAGACCTTCATGCGTTCG
ATCAACACCAGCCTGATCTCGGTACTACCGGTGTTGGCGCTGATGGTGGTCGCGGTGTGGTTGCTGGGCGTCGGTACGCT
CAAGGACCTGGCATTAGTGCAGCTGGTCGGCATCATTGTCGGCACCTACTCGTCGATCTTCTTTGCAACTCCACTGTTGG
TCACGCTGCGTGAACGCACAGAGCTGGTACGCACCCACACCCGCCGGGTAGTCAAACGGCGCACCCTCGGTTCGCAAGTG
GGCAAAAAAAACGCTGACAGCCACGTTGCAGCAGGCACCCGAAAACCGCAGAATCAAGCGGAATCCTGCGCTGACGCATC
GTCGCAGGAGGGCACCGAGGTCGCCACCGCGTCCGTGCCCACGGTACTCAGCAAGCTGGCACCGGGAGTGCGTCCGGTGC
GGCCGACCGGTACCCGACGTCCTACCGGCAAGCGAAACAACGTCGGTCGGCGGTAG

Upstream 100 bases:

>100_bases
TCTCCGTTGCTGGCAAGGCCGGCATACAACGGCTTGGGCGCCGTTCAACAGGTTGCCCGCGAACGACGGGCTTCCGCCAA
GACAGGACGGGGGTAGCGCG

Downstream 100 bases:

>100_bases
TCAAGGTGGCTACCCGAGGTTGGCAAGCCGTGAGTGAGTACGATTTGCGGTCCGGCTTATTCGGGGTTTTGCGGTGGACT
GCAGTAGGCTTGGTCGCGAC

Product: preprotein translocase subunit SecF

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MVSRAKVGAETTKGIDEPDRNDNTDDNGAGAVEVTEAAEDAVELTNDISTQLPQHGFLARFYTGLSRLYTGTGVFEVVGR
RRLWYSVGGVIVAVAVLSIIVRGFTFGIDFKGGTTVSMPVSPGVGGTGAIEVAQVADVFKKTLGSDPESVVVVGNGASAT
VRISSKTLSNDQTSKLRNALFDAFGPKGADAKPSKQAISDAAVSETWGGQITKKVVIALVVFLVLVGLYITVRYERYMAI
SALTTMCFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRS
INTSLISVLPVLALMVVAVWLLGVGTLKDLALVQLVGIIVGTYSSIFFATPLLVTLRERTELVRTHTRRVVKRRTLGSQV
GKKNADSHVAAGTRKPQNQAESCADASSQEGTEVATASVPTVLSKLAPGVRPVRPTGTRRPTGKRNNVGRR

Sequences:

>Translated_471_residues
MVSRAKVGAETTKGIDEPDRNDNTDDNGAGAVEVTEAAEDAVELTNDISTQLPQHGFLARFYTGLSRLYTGTGVFEVVGR
RRLWYSVGGVIVAVAVLSIIVRGFTFGIDFKGGTTVSMPVSPGVGGTGAIEVAQVADVFKKTLGSDPESVVVVGNGASAT
VRISSKTLSNDQTSKLRNALFDAFGPKGADAKPSKQAISDAAVSETWGGQITKKVVIALVVFLVLVGLYITVRYERYMAI
SALTTMCFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRS
INTSLISVLPVLALMVVAVWLLGVGTLKDLALVQLVGIIVGTYSSIFFATPLLVTLRERTELVRTHTRRVVKRRTLGSQV
GKKNADSHVAAGTRKPQNQAESCADASSQEGTEVATASVPTVLSKLAPGVRPVRPTGTRRPTGKRNNVGRR
>Mature_471_residues
MVSRAKVGAETTKGIDEPDRNDNTDDNGAGAVEVTEAAEDAVELTNDISTQLPQHGFLARFYTGLSRLYTGTGVFEVVGR
RRLWYSVGGVIVAVAVLSIIVRGFTFGIDFKGGTTVSMPVSPGVGGTGAIEVAQVADVFKKTLGSDPESVVVVGNGASAT
VRISSKTLSNDQTSKLRNALFDAFGPKGADAKPSKQAISDAAVSETWGGQITKKVVIALVVFLVLVGLYITVRYERYMAI
SALTTMCFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHTTRRTFAEQANLAINQTFMRS
INTSLISVLPVLALMVVAVWLLGVGTLKDLALVQLVGIIVGTYSSIFFATPLLVTLRERTELVRTHTRRVVKRRTLGSQV
GKKNADSHVAAGTRKPQNQAESCADASSQEGTEVATASVPTVLSKLAPGVRPVRPTGTRRPTGKRNNVGRR

Specific function: Involved in protein export

COG id: COG0341

COG function: function code U; Preprotein translocase subunit SecF

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secD/secF family. SecF subfamily

Homologues:

Organism=Escherichia coli, GI1786610, Length=325, Percent_Identity=24.3076923076923, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECF_MYCLE (P38386)

Other databases:

- EMBL:   U00011
- EMBL:   AL023591
- EMBL:   AL583918
- PIR:   H86969
- PIR:   S72736
- RefSeq:   NP_301428.1
- ProteinModelPortal:   P38386
- EnsemblBacteria:   EBMYCT00000028929
- GeneID:   909241
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0488
- NMPDR:   fig|272631.1.peg.300
- Leproma:   ML0488
- GeneTree:   EBGT00050000016758
- HOGENOM:   HBG465293
- OMA:   MVRMPPV
- ProtClustDB:   PRK13022
- BioCyc:   MLEP272631:ML0488-MONOMER
- InterPro:   IPR022813
- InterPro:   IPR022646
- InterPro:   IPR022645
- InterPro:   IPR005665
- PRINTS:   PR01755
- TIGRFAMs:   TIGR00916
- TIGRFAMs:   TIGR00966

Pfam domain/function: PF07549 Sec_GG; PF02355 SecD_SecF

EC number: NA

Molecular weight: Translated: 50183; Mature: 50183

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x22379894)-; HASH(0x226fd854)-; HASH(0x215a93ac)-; HASH(0x21ff1e50)-; HASH(0x22fafd2c)-; HASH(0x22122848)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRAKVGAETTKGIDEPDRNDNTDDNGAGAVEVTEAAEDAVELTNDISTQLPQHGFLAR
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHH
FYTGLSRLYTGTGVFEVVGRRRLWYSVGGVIVAVAVLSIIVRGFTFGIDFKGGTTVSMPV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECC
SPGVGGTGAIEVAQVADVFKKTLGSDPESVVVVGNGASATVRISSKTLSNDQTSKLRNAL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHCCCHHHHHHHHHH
FDAFGPKGADAKPSKQAISDAAVSETWGGQITKKVVIALVVFLVLVGLYITVRYERYMAI
HHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALTTMCFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHT
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCHHHH
TRRTFAEQANLAINQTFMRSINTSLISVLPVLALMVVAVWLLGVGTLKDLALVQLVGIIV
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTYSSIFFATPLLVTLRERTELVRTHTRRVVKRRTLGSQVGKKNADSHVAAGTRKPQNQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHH
ESCADASSQEGTEVATASVPTVLSKLAPGVRPVRPTGTRRPTGKRNNVGRR
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MVSRAKVGAETTKGIDEPDRNDNTDDNGAGAVEVTEAAEDAVELTNDISTQLPQHGFLAR
CCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHH
FYTGLSRLYTGTGVFEVVGRRRLWYSVGGVIVAVAVLSIIVRGFTFGIDFKGGTTVSMPV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECC
SPGVGGTGAIEVAQVADVFKKTLGSDPESVVVVGNGASATVRISSKTLSNDQTSKLRNAL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECHHCCCHHHHHHHHHH
FDAFGPKGADAKPSKQAISDAAVSETWGGQITKKVVIALVVFLVLVGLYITVRYERYMAI
HHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALTTMCFDLTVTAGVYSLVGFEVTPATVIGLLTILGFSLYDTVIVFDKVEENTHGFQHT
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCCHHHH
TRRTFAEQANLAINQTFMRSINTSLISVLPVLALMVVAVWLLGVGTLKDLALVQLVGIIV
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTYSSIFFATPLLVTLRERTELVRTHTRRVVKRRTLGSQVGKKNADSHVAAGTRKPQNQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHH
ESCADASSQEGTEVATASVPTVLSKLAPGVRPVRPTGTRRPTGKRNNVGRR
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002