Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 221229467

GI number: 221229467

Start: 243069

End: 244217

Strand: Direct

Name: htrA [H]

Synonym: MLBr_00176

Alternate gene names: 221229467

Gene position: 243069-244217 (Clockwise)

Preceding gene: 221229466

Following gene: 221229468

Centisome position: 7.44

GC content: 63.19

Gene sequence:

>1149_bases
ATGATTCCGCCCGGTCGGGTAGCCGACAGGCGTCCTCGCGCAGGCATGTTGGCTGTTAGTGCGCTAGCGATAGCAGTGGT
GTCGGCTGGTATCGGCGGCGTGGCGGCTACGGTTGTTGCGCTGGGCACGCGCGTCGCGGGCGGCAACGGTGCTGGCCCGG
TAACCGGGCCGGCTGCCAGCGTTCCGGCGGCGAACATGCCGTCGGGCAGCGTCGAACAAGTTGCCGTTAAGGTAGTGCCC
AGTGTCGTCATGCTGGAGACCGATTTGGGTCGTCAGTCCGAGGAGGGTTCCGGCGTCATCTTGTCGGCCGATGGGTTGAT
CTTGACCAACAACCACGTCGTCGCGGTTGCCGCCAAACCAGGGGGTGGTCCTGGTGGTGGTCTGTCGCCGAAAACCACTG
TGACCTTCTTCGATGGCCGCACCGCGTCGTTCACGGTGGTCGGAGCCGATCCCACTAGCGATATTGCTGTGGTTCGGGTG
CAGAGTATTTCCGGACTGACCCCGATTACGATGGGCTCTTCCGCAGATCTGCGGGTGGGTCAGCCGGTGGTGGCTGTCGG
CTCACCGCTGGGTTTGGCGGGCACGGTGACCAGCGGGATCGTCAGTGCGCTTAACCGGCCCGTGTCGACGACCGGCGAAT
CGGGCAACCAAAATACGGTGCTGGACGCGATTCAGACCGATGCGGCTATCAACCCGGGTAATTCCGGTGGTGCGCTGGTC
AACATGGGCGGTCAGTTGGTGGGAGTCAACTCTGCTATTGCCACACTCGGCGCTGATTCGGGTGATGCACAGAGCGGCTC
GATCGGGCTTGGCTTCGCGATTCCCGTCGACCAAGCCAAGCGCATCGCTGACGAGTTAATCAGCACTGGCAAAGCGACAC
ATGCGTCGCTGGGTGTACAGGTGGCCACCGACAAAGGCACCCCGGGCGCCAAAGTTATGGACGTCGTGGCCGGTGGTGCG
GCCGCGAATGCCGCCGTTCCCAAGGGGGTCGTTCTCACTAAGGTCGACGACCGCCTGATCAGTAGCGCCGACGCGTTGGT
CGCTGCCGTGCGGTCCAAGGCACCCGGTGACAAAGTGTCGCTGACCTATCAGGATCAGTCTGGTAGCAGTCGCACGGTTC
AGGTCACACTCGGCAAGGCGGAACAGTAA

Upstream 100 bases:

>100_bases
ACAACAAGTCGATTGGTGCTATCAGCAGTCGCCCTCGTTGCAGCAGTATCACCGACCCTATGAGCCATTTGGTGGTGCGG
GTACGGTCCCGTTGCAGTCG

Downstream 100 bases:

>100_bases
CAATTAATAATCGAGAGCTACCGTGTTAGTCGATAAGCAATTGTCCGAGCTCGGATATACGGTTGCACCCATGGAGAAGG
GTGTCGAGTTGGTAGTCGGA

Product: putative secreted serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRVAGGNGAGPVTGPAASVPAANMPSGSVEQVAVKVVP
SVVMLETDLGRQSEEGSGVILSADGLILTNNHVVAVAAKPGGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRV
QSISGLTPITMGSSADLRVGQPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALV
NMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKRIADELISTGKATHASLGVQVATDKGTPGAKVMDVVAGGA
AANAAVPKGVVLTKVDDRLISSADALVAAVRSKAPGDKVSLTYQDQSGSSRTVQVTLGKAEQ

Sequences:

>Translated_382_residues
MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRVAGGNGAGPVTGPAASVPAANMPSGSVEQVAVKVVP
SVVMLETDLGRQSEEGSGVILSADGLILTNNHVVAVAAKPGGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRV
QSISGLTPITMGSSADLRVGQPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALV
NMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKRIADELISTGKATHASLGVQVATDKGTPGAKVMDVVAGGA
AANAAVPKGVVLTKVDDRLISSADALVAAVRSKAPGDKVSLTYQDQSGSSRTVQVTLGKAEQ
>Mature_382_residues
MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRVAGGNGAGPVTGPAASVPAANMPSGSVEQVAVKVVP
SVVMLETDLGRQSEEGSGVILSADGLILTNNHVVAVAAKPGGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRV
QSISGLTPITMGSSADLRVGQPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALV
NMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKRIADELISTGKATHASLGVQVATDKGTPGAKVMDVVAGGA
AANAAVPKGVVLTKVDDRLISSADALVAAVRSKAPGDKVSLTYQDQSGSSRTVQVTLGKAEQ

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=317, Percent_Identity=32.4921135646688, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI22129776, Length=333, Percent_Identity=31.8318318318318, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4506141, Length=219, Percent_Identity=36.986301369863, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI24308541, Length=375, Percent_Identity=31.4666666666667, Blast_Score=111, Evalue=9e-25,
Organism=Escherichia coli, GI1786356, Length=279, Percent_Identity=41.5770609318996, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789629, Length=299, Percent_Identity=38.7959866220736, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1789630, Length=294, Percent_Identity=32.6530612244898, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646839, Length=185, Percent_Identity=42.1621621621622, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 37084; Mature: 37084

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRVAGGNGAGPVTGPAAS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCEECCCCCCCCCCCCCCC
VPAANMPSGSVEQVAVKVVPSVVMLETDLGRQSEEGSGVILSADGLILTNNHVVAVAAKP
CCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEECCCEEEECCEEEEEEECC
GGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRVQSISGLTPITMGSSADLRVG
CCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEECCCCCCCEEECCCCCCCCC
QPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALV
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEE
NMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKRIADELISTGKATHASLGVQ
ECCCEEEECCHHHHEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEECCEE
VATDKGTPGAKVMDVVAGGAAANAAVPKGVVLTKVDDRLISSADALVAAVRSKAPGDKVS
EEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEE
LTYQDQSGSSRTVQVTLGKAEQ
EEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MIPPGRVADRRPRAGMLAVSALAIAVVSAGIGGVAATVVALGTRVAGGNGAGPVTGPAAS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCEECCCCCCCCCCCCCCC
VPAANMPSGSVEQVAVKVVPSVVMLETDLGRQSEEGSGVILSADGLILTNNHVVAVAAKP
CCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCEEEEECCCEEEECCEEEEEEECC
GGGPGGGLSPKTTVTFFDGRTASFTVVGADPTSDIAVVRVQSISGLTPITMGSSADLRVG
CCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEECCCCCCCEEECCCCCCCCC
QPVVAVGSPLGLAGTVTSGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALV
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEE
NMGGQLVGVNSAIATLGADSGDAQSGSIGLGFAIPVDQAKRIADELISTGKATHASLGVQ
ECCCEEEECCHHHHEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEECCEE
VATDKGTPGAKVMDVVAGGAAANAAVPKGVVLTKVDDRLISSADALVAAVRSKAPGDKVS
EEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEE
LTYQDQSGSSRTVQVTLGKAEQ
EEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]