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The map label for this gene is mprB

Identifier: 221229466

GI number: 221229466

Start: 241232

End: 242791

Strand: Direct

Name: mprB

Synonym: MLBr_00175

Alternate gene names: 221229466

Gene position: 241232-242791 (Clockwise)

Preceding gene: 221229465

Following gene: 221229467

Centisome position: 7.38

GC content: 61.41

Gene sequence:

>1560_bases
ATGGTTCGGTTTGCCTGGCGCCGGCGCGCATCGTTGCGAGCCACCAGTTCTTTATCCCTGCGGTGGAGGGTAATGCTCCT
GGCAATGTCCATGGTGGCGATGGTCGTCGTCTTGATGGCATTCGCTGTCTACGTTGTGATCTCGGCGGCGCTGTACAGCG
ATATCGATAATCAACTGCAGAGCAGGGCGCAGTTGCTGATCGCTAGTGGTTCGTTGGCAGCCGACCCTGGCAAGGCCATC
GAGGGCACTGCCTACTCGGATGTCAACGCCATGTTGGTGAACCCGGGCCACTCGATTTACACGGCCAATCAGCCGGGTCA
GACTCTTCCTGTCGGAACGGCAGAGAAAGCTGTCATCCGTGGTGAGCTGTTCATGTCGCAACGTACTGCATCGGACCAAC
GCATACTCGCCATCCACCTGCCCAACGACAGTTCGCTGCTGATCTCTAAGAGCTTGCGGCCAACCGAAGCTGTCATGACC
AAGCTGCGCTGGGTGCTTTTGATTGTCGGAAGCCTCGGCGTCGCGGTTGCCGCGGTGGCCGGGGGGATGGTTACTCGGGC
GGGGCTGCGTCCGGTGGGGCGTCTGACCGAAGCGGCCGAGCGAGTGGCGCGTACCGACGACCTGCGGCCCATCCCGGTGT
TCGGCAGTGACGAATTGGCCAGGCTCACTGAGGCATTCAACTTGATGTTGCGGGCATTGGCCGAATCTCGGGAACGCCAG
GCACGGCTGGTAACCGACGCCGGACATGAGTTGCGCACCCCGTTGACCTCGCTGCGCACCAACGTTGAACTGCTGATCGC
CTCGATGGCTCCCGAAGCGCCGCGGCTACCTGACCAGGAGATGGCGGATCTGCGTGCCGATGTACTCGCGCAGATTGAAG
AATTGTCCACGCTGGTAGGTGATTTGGTGGACCTCACTAGAGACGACGCTGGGCAGGTGGTGCACGAGCCGATCGACATG
TCCGAGGTCCTTTACCGCAGTCTGGAGCGGGTCAGGCGGCGGCGCAACGATATTCACTTTGACGTCCAGGCGATCGGATG
GCAGATTTATGGTGATGCCGCTGGTCTGTCGCGTGCGGTGCTGAATCTTATGGACAACGCGGCCAAGTGGAGCCCGTCGG
GTGGCCGCGTCGTCGTAACGATGCGCCAGTTCGACCCGTCGCACGTTGAGCTGGTGGTTTCCGACTACGGTCCGGGGATT
CCGCCGCAAGAACGCCGGCTGGTGTTCGAGCGCTTCTACCGATCGACGACTGCACGGTCGTTGCCGGGTTCGGGCCTTGG
GTTGGCGATCGTCAAACAGGTGGTTATCAACCACGGAGGTTTGCTTCGCGTCGAAGACACCGCGCCGGGAGTGCAACCCC
CGGGCACGTCGATTTACGTGCTTCTACCCGGACGCCCGATGCCGGTTTCAGCGTACTCCACGCTCGCGGACCAGGACATG
GGCGAAGCCAATTTCCAGGACAAGATCGGCCCAGCCGTGCAGGTTTCCGGTAAGTCGGCGAACTTTCGGGATTCAGCGCA
CGTTATCTCAGTGGACTATCAGTCCGCGCGGGCAAGGTAG

Upstream 100 bases:

>100_bases
ATGTCGGGTATTTGCGCCGCAAAACCGAGGCCGATGGTGAGTCACGGCTAATCCACACTGTACGTGGAGTGGGCTATGTA
TTAAGGGAGACGCCGCCCTG

Downstream 100 bases:

>100_bases
TTGGCAGTTACTGTATTAAAAAGTCGGCCCGCATGAAGCCGACATAGAGGAAGAGCGACTTAGCGACATGACGAATCACC
CGAGGTATTCGCCACCGCCG

Product: putative two-component system sensor kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMT
KLRWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDM
SEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGI
PPQERRLVFERFYRSTTARSLPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDM
GEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR

Sequences:

>Translated_519_residues
MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMT
KLRWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDM
SEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGI
PPQERRLVFERFYRSTTARSLPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDM
GEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR
>Mature_519_residues
MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAI
EGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIRGELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMT
KLRWVLLIVGSLGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
ARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPIDM
SEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAVLNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGI
PPQERRLVFERFYRSTTARSLPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDM
GEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786783, Length=315, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=30.5555555555556, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1788279, Length=283, Percent_Identity=28.6219081272085, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789808, Length=294, Percent_Identity=27.2108843537415, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790346, Length=283, Percent_Identity=30.0353356890459, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790861, Length=266, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=30.8695652173913, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=27.6752767527675, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789403, Length=446, Percent_Identity=23.7668161434978, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=25.1968503937008, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=228, Percent_Identity=27.1929824561404, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=25.2631578947368, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=27.4305555555556, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=356, Percent_Identity=26.123595505618, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=313, Percent_Identity=23.0031948881789, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MPRB_MYCLE (Q9Z5G7)

Other databases:

- EMBL:   AL035500
- EMBL:   AL583917
- PIR:   T45447
- RefSeq:   NP_301251.1
- HSSP:   P0A5Z8
- ProteinModelPortal:   Q9Z5G7
- EnsemblBacteria:   EBMYCT00000028804
- GeneID:   908554
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML0175
- NMPDR:   fig|272631.1.peg.123
- Leproma:   ML0175
- GeneTree:   EBGT00050000014826
- HOGENOM:   HBG334875
- OMA:   AELRTDV
- ProtClustDB:   CLSK790870
- BioCyc:   MLEP272631:ML0175-MONOMER
- BRENDA:   2.7.13.3
- GO:   GO:0009405
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 56472; Mature: 56472

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x21e9f4d0)-; HASH(0x218c8f68)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQ
CCCCHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIR
HHHHEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHH
GELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVA
HHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVG
HHHHHCCCHHHHCCHHHHHCCHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DLVDLTRDDAGQVVHEPIDMSEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAV
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECEEEEECHHHHHHHH
LNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYRSTTARS
HHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
LPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDM
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCC
GEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR
CCCCCHHHCCCEEEECCCCCCCCCCCEEEEEECHHCCCH
>Mature Secondary Structure
MVRFAWRRRASLRATSSLSLRWRVMLLAMSMVAMVVVLMAFAVYVVISAALYSDIDNQLQ
CCCCHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGHSIYTANQPGQTLPVGTAEKAVIR
HHHHEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHHH
GELFMSQRTASDQRILAIHLPNDSSLLISKSLRPTEAVMTKLRWVLLIVGSLGVAVAAVA
HHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQ
CCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARLVTDAGHELRTPLTSLRTNVELLIASMAPEAPRLPDQEMADLRADVLAQIEELSTLVG
HHHHHCCCHHHHCCHHHHHCCHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DLVDLTRDDAGQVVHEPIDMSEVLYRSLERVRRRRNDIHFDVQAIGWQIYGDAAGLSRAV
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECEEEEECHHHHHHHH
LNLMDNAAKWSPSGGRVVVTMRQFDPSHVELVVSDYGPGIPPQERRLVFERFYRSTTARS
HHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
LPGSGLGLAIVKQVVINHGGLLRVEDTAPGVQPPGTSIYVLLPGRPMPVSAYSTLADQDM
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCC
GEANFQDKIGPAVQVSGKSANFRDSAHVISVDYQSARAR
CCCCCHHHCCCEEEECCCCCCCCCCCEEEEEECHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002