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The map label for this gene is mprA [H]

Identifier: 221229465

GI number: 221229465

Start: 240546

End: 241232

Strand: Direct

Name: mprA [H]

Synonym: MLBr_00174

Alternate gene names: 221229465

Gene position: 240546-241232 (Clockwise)

Preceding gene: 221229464

Following gene: 221229466

Centisome position: 7.36

GC content: 60.7

Gene sequence:

>687_bases
GTGCGGATACTTGCCGTTGACGACGATCGGGCGGTGCGTGAGTCTCTGCGCCGGTCGTTGTCGTTCAATGGTTATTCGGT
CGAACTGGCCAACGACGGGGTCGAGGCGTTGGAGATGGTTGCCCGCGATAGGCCTGATGCTCTCGTTCTCGATGTCATGA
TGCCGCGCCTGGACGGTTTAGAGGTCTGCCGTCAGCTCCGAAGTACCGGTGACGACCTGCCGATCCTGGTGCTAACCGCC
CGCGATTCGGTCTCCGAACGGGTCGCCGGCTTGGATGCCGGTGCCGACGACTACCTGCCCAAACCGTTCGCCCTCGAAGA
ACTGTTGGCGCGGATTCGGGCGCTGCTACGCCGCACCAAGCCCGATGACGCTGCCGAGTCCGTGGCGATGAGTTTTTCCG
ACTTAACCCTGGACCCGGTGACCCGCGAAGTCGCCCGCGGACAACGCTGGATCAGTCTGACCCGTACCGAATTCGCGTTG
TTGGAAATGCTGATCGCTAATCCGCGGCGGGTACTTACACGCAGCCGCATCCTCGAAGAGGTGTGGGGATTTGATTTTCC
GACCTCCGGCAATGCACTGGAAGTCTATGTCGGGTATTTGCGCCGCAAAACCGAGGCCGATGGTGAGTCACGGCTAATCC
ACACTGTACGTGGAGTGGGCTATGTATTAAGGGAGACGCCGCCCTGA

Upstream 100 bases:

>100_bases
TGTAACGGGGTCGACGCACGCGTCGTTGACTGGAAAATTGCGATTCAACGCCAGCGATCCTTGCAAGTCGCTCTCAGGCT
CCGAGACCGAATTAGTAGCT

Downstream 100 bases:

>100_bases
TGGTTCGGTTTGCCTGGCGCCGGCGCGCATCGTTGCGAGCCACCAGTTCTTTATCCCTGCGGTGGAGGGTAATGCTCCTG
GCAATGTCCATGGTGGCGAT

Product: putative two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP

Sequences:

>Translated_228_residues
MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
>Mature_228_residues
MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=43.2314410480349, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=41.3333333333333, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.9140271493213, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.9369369369369, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.8854625550661, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=40, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=39.0134529147982, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=35.4260089686099, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=34.5291479820628, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=38.4279475982533, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.4841628959276, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.0701754385965, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=29.6137339055794, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.4372294372294, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=31.7829457364341, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=40.8695652173913, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=135, Percent_Identity=36.2962962962963, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=36.6336633663366, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=36.7924528301887, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=36.6666666666667, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788905, Length=120, Percent_Identity=30, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25600; Mature: 25600

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGL
CEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHCCCCHH
EVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTK
HHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSRILEE
CCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGL
CEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCHHHHHHHHCCCCHH
EVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTK
HHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSRILEE
CCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA