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The map label for this gene is phoR [H]

Identifier: 220932996

GI number: 220932996

Start: 2354901

End: 2356685

Strand: Reverse

Name: phoR [H]

Synonym: Hore_21630

Alternate gene names: 220932996

Gene position: 2356685-2354901 (Counterclockwise)

Preceding gene: 220932997

Following gene: 220932995

Centisome position: 91.41

GC content: 35.24

Gene sequence:

>1785_bases
TTGTTAAACTGGAATGACCTGAGTATTAAAAATCAATTTCTGGTACTATTTATTGTAACCCAGCTTATTATTATGGGGTT
GTTATTTATTTATTTTAACCATAATGAGAGGGAGTTTTACTTAGACCAGCTAAAAATTAACCTTGATCATCAGGGACAGC
TTTTATTATTAAATGAGGTTTTCATGGAAGAATATGATAATCCCCGGATACTTGATAAATGGATTAAAAGTATAGGAAGT
GATATAGATTCCAGGCTTACTGTAATCGACATGTCAGGAAAAGTACTGGCTGATTCCCATTATAACCCTGTAAAAATGGA
TAACCATTTAAACCGCCCTGAAATTATTGAATTAATAAATGGTAAGAATTCCTCATACCGAATCAGGAGAAGCAAGACCT
TACAACAGCAGATGTTTTATTATTCACTGCCGATTAAAGTCAACGGAAACTTAACAGGATTTTTAAGGTTAAGTAAATCC
CTGAATGCAATTAATGAGACCATTGAAAAAAATACCCAGAATTATTTGTTGTTTTTCTTCTTAACTGTTATTCTTTCTTT
TATTCTGGCCTGGGGTTTCAGTAACGGTCTTGTTAGACCTTTAAATAAGCTGGGGTCAATGGCCGAGAAGCTAGCCCATG
GTAATTTTAAAGAAAGAATAGTCCTCAATAGTTATAATAATGAACTGGGTACACTGGCTCATTCATTCAACTATATGGCC
AATGAGCTTGAAAGGAAAATTGAAGAAATATTCCGGGAAAAAAGCAGGACTGAAGCGGTCTTTACCAGTATTGTAGATGG
ATTAATTGTTACAGATAATGAGAAAAAAATAACCATGGTAAATCCAGCGGCCCGAAAGATACTCGGACTGAATAAAGGTG
TTCTCGGGAGAGATATTATTGAGGTTATAAGACATCATAAAGTTGATCAGCTTTTAGAAACTTCTTTAGAAAAAAAGAAA
ATATTAAAGGAGGAACTTAATTTCCAGACACCAGGGTCAAAAATAATTCGCCTCAATTTTGCTCCCATAGAAAATAAGGA
GGGCCAGGTGGCCGGGGGTTTGATAGTTTTAACAGATGTTACCGAACTCAGGCGGCTGGAACAGCTTAGAAAGGAATTTG
TTGCCAATGTGTCCCATGAACTGAAGACTCCTTTAACGTCTATTATAGGATATATTGATACCATTATTGACAATGATATA
AAGGATGATACTACAATTAAAAGATTCTTAAGTATAATTAAGGATGAAGCTGATAGACTGTATTTATTAATTAAAGATTT
ACTTGACCTCTCCAAACTGGAGGCAAAAAGGGGAGAGGTCATATTGCAGCCTGGTGACCTTAATAAGATTGTTAAAAAGA
TTTACCTTATGTTACAGGAACAGGCTGAATCCAAAGATATTGATCTGAAACTGGATATTAAGGAAAAACTACCTTTCGTT
TATCTGATTCCTGAACAGATTGAGCAGGTTTTAATTAATCTTGTTGATAATGGTATAAAGTATACTGAACCCGGTGGTCG
GGTTATTTTAAGGGCATATGAAGAAAATAATAGAGTTGTTGTTGAAGTTGAGGATAATGGAATAGGAATACCTGAGGAAG
ATCAGGGGCGTATATTTGAGCGGTTTTACAGAGTGGATAAAGCCAGGTCCCGTTCCATGGGAGGAACCGGGATAGGGTTA
TCCATCGTTAAACACATAATAAAAAATCATGATAGTGAGATAAAGGTTGAAAGTGAGCCAGGTAAAGGGAGTCTATTCAG
GTTTTATTTAAATAAAGTTAACTGA

Upstream 100 bases:

>100_bases
TATGCAGGGGATACCAGAACTGTTGATGTTCATATAAGGAGGTTAAGAAGAAAGATCGGGGATAATTATATTGTTACCGT
GAGAGGGGTGGGGTATAAAT

Downstream 100 bases:

>100_bases
TTTCTCTTAAGTCCACTCCGTGGTTTGCCGTCTTTTATATATGGTGGTCTTAACAGCTTTATTTATAAAATCTTAATATA
TTTTGTATCTGTGTTTAAAC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MLNWNDLSIKNQFLVLFIVTQLIIMGLLFIYFNHNEREFYLDQLKINLDHQGQLLLLNEVFMEEYDNPRILDKWIKSIGS
DIDSRLTVIDMSGKVLADSHYNPVKMDNHLNRPEIIELINGKNSSYRIRRSKTLQQQMFYYSLPIKVNGNLTGFLRLSKS
LNAINETIEKNTQNYLLFFFLTVILSFILAWGFSNGLVRPLNKLGSMAEKLAHGNFKERIVLNSYNNELGTLAHSFNYMA
NELERKIEEIFREKSRTEAVFTSIVDGLIVTDNEKKITMVNPAARKILGLNKGVLGRDIIEVIRHHKVDQLLETSLEKKK
ILKEELNFQTPGSKIIRLNFAPIENKEGQVAGGLIVLTDVTELRRLEQLRKEFVANVSHELKTPLTSIIGYIDTIIDNDI
KDDTTIKRFLSIIKDEADRLYLLIKDLLDLSKLEAKRGEVILQPGDLNKIVKKIYLMLQEQAESKDIDLKLDIKEKLPFV
YLIPEQIEQVLINLVDNGIKYTEPGGRVILRAYEENNRVVVEVEDNGIGIPEEDQGRIFERFYRVDKARSRSMGGTGIGL
SIVKHIIKNHDSEIKVESEPGKGSLFRFYLNKVN

Sequences:

>Translated_594_residues
MLNWNDLSIKNQFLVLFIVTQLIIMGLLFIYFNHNEREFYLDQLKINLDHQGQLLLLNEVFMEEYDNPRILDKWIKSIGS
DIDSRLTVIDMSGKVLADSHYNPVKMDNHLNRPEIIELINGKNSSYRIRRSKTLQQQMFYYSLPIKVNGNLTGFLRLSKS
LNAINETIEKNTQNYLLFFFLTVILSFILAWGFSNGLVRPLNKLGSMAEKLAHGNFKERIVLNSYNNELGTLAHSFNYMA
NELERKIEEIFREKSRTEAVFTSIVDGLIVTDNEKKITMVNPAARKILGLNKGVLGRDIIEVIRHHKVDQLLETSLEKKK
ILKEELNFQTPGSKIIRLNFAPIENKEGQVAGGLIVLTDVTELRRLEQLRKEFVANVSHELKTPLTSIIGYIDTIIDNDI
KDDTTIKRFLSIIKDEADRLYLLIKDLLDLSKLEAKRGEVILQPGDLNKIVKKIYLMLQEQAESKDIDLKLDIKEKLPFV
YLIPEQIEQVLINLVDNGIKYTEPGGRVILRAYEENNRVVVEVEDNGIGIPEEDQGRIFERFYRVDKARSRSMGGTGIGL
SIVKHIIKNHDSEIKVESEPGKGSLFRFYLNKVN
>Mature_594_residues
MLNWNDLSIKNQFLVLFIVTQLIIMGLLFIYFNHNEREFYLDQLKINLDHQGQLLLLNEVFMEEYDNPRILDKWIKSIGS
DIDSRLTVIDMSGKVLADSHYNPVKMDNHLNRPEIIELINGKNSSYRIRRSKTLQQQMFYYSLPIKVNGNLTGFLRLSKS
LNAINETIEKNTQNYLLFFFLTVILSFILAWGFSNGLVRPLNKLGSMAEKLAHGNFKERIVLNSYNNELGTLAHSFNYMA
NELERKIEEIFREKSRTEAVFTSIVDGLIVTDNEKKITMVNPAARKILGLNKGVLGRDIIEVIRHHKVDQLLETSLEKKK
ILKEELNFQTPGSKIIRLNFAPIENKEGQVAGGLIVLTDVTELRRLEQLRKEFVANVSHELKTPLTSIIGYIDTIIDNDI
KDDTTIKRFLSIIKDEADRLYLLIKDLLDLSKLEAKRGEVILQPGDLNKIVKKIYLMLQEQAESKDIDLKLDIKEKLPFV
YLIPEQIEQVLINLVDNGIKYTEPGGRVILRAYEENNRVVVEVEDNGIGIPEEDQGRIFERFYRVDKARSRSMGGTGIGL
SIVKHIIKNHDSEIKVESEPGKGSLFRFYLNKVN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=334, Percent_Identity=32.3353293413174, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=38.3620689655172, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788549, Length=463, Percent_Identity=24.4060475161987, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI48994928, Length=261, Percent_Identity=29.8850574712644, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=30.1587301587302, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=30.379746835443, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788713, Length=226, Percent_Identity=30.0884955752212, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=30.7359307359307, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788393, Length=230, Percent_Identity=27.3913043478261, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=29.0598290598291, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87082128, Length=277, Percent_Identity=27.7978339350181, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790300, Length=354, Percent_Identity=27.1186440677966, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=28, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=219, Percent_Identity=29.6803652968037, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1790861, Length=222, Percent_Identity=29.2792792792793, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1787894, Length=219, Percent_Identity=27.3972602739726, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=28.8702928870293, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1786837, Length=387, Percent_Identity=24.2894056847545, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=28.8557213930348, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788279, Length=236, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68407; Mature: 68407

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNWNDLSIKNQFLVLFIVTQLIIMGLLFIYFNHNEREFYLDQLKINLDHQGQLLLLNEV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEEHHHH
FMEEYDNPRILDKWIKSIGSDIDSRLTVIDMSGKVLADSHYNPVKMDNHLNRPEIIELIN
HHHHCCCCHHHHHHHHHHCCCHHCCEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHC
GKNSSYRIRRSKTLQQQMFYYSLPIKVNGNLTGFLRLSKSLNAINETIEKNTQNYLLFFF
CCCCCEEEHHHHHHHHHHHEEECCEEECCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHH
LTVILSFILAWGFSNGLVRPLNKLGSMAEKLAHGNFKERIVLNSYNNELGTLAHSFNYMA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHH
NELERKIEEIFREKSRTEAVFTSIVDGLIVTDNEKKITMVNPAARKILGLNKGVLGRDII
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECHHHHHHHCCCCCCCHHHHH
EVIRHHKVDQLLETSLEKKKILKEELNFQTPGSKIIRLNFAPIENKEGQVAGGLIVLTDV
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEECCEEEEECH
TELRRLEQLRKEFVANVSHELKTPLTSIIGYIDTIIDNDIKDDTTIKRFLSIIKDEADRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YLLIKDLLDLSKLEAKRGEVILQPGDLNKIVKKIYLMLQEQAESKDIDLKLDIKEKLPFV
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCEE
YLIPEQIEQVLINLVDNGIKYTEPGGRVILRAYEENNRVVVEVEDNGIGIPEEDQGRIFE
EECHHHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHH
RFYRVDKARSRSMGGTGIGLSIVKHIIKNHDSEIKVESEPGKGSLFRFYLNKVN
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEHHCC
>Mature Secondary Structure
MLNWNDLSIKNQFLVLFIVTQLIIMGLLFIYFNHNEREFYLDQLKINLDHQGQLLLLNEV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEEHHHH
FMEEYDNPRILDKWIKSIGSDIDSRLTVIDMSGKVLADSHYNPVKMDNHLNRPEIIELIN
HHHHCCCCHHHHHHHHHHCCCHHCCEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHC
GKNSSYRIRRSKTLQQQMFYYSLPIKVNGNLTGFLRLSKSLNAINETIEKNTQNYLLFFF
CCCCCEEEHHHHHHHHHHHEEECCEEECCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHH
LTVILSFILAWGFSNGLVRPLNKLGSMAEKLAHGNFKERIVLNSYNNELGTLAHSFNYMA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHH
NELERKIEEIFREKSRTEAVFTSIVDGLIVTDNEKKITMVNPAARKILGLNKGVLGRDII
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECHHHHHHHCCCCCCCHHHHH
EVIRHHKVDQLLETSLEKKKILKEELNFQTPGSKIIRLNFAPIENKEGQVAGGLIVLTDV
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEECCEEEEECH
TELRRLEQLRKEFVANVSHELKTPLTSIIGYIDTIIDNDIKDDTTIKRFLSIIKDEADRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
YLLIKDLLDLSKLEAKRGEVILQPGDLNKIVKKIYLMLQEQAESKDIDLKLDIKEKLPFV
HHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCCEE
YLIPEQIEQVLINLVDNGIKYTEPGGRVILRAYEENNRVVVEVEDNGIGIPEEDQGRIFE
EECHHHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHH
RFYRVDKARSRSMGGTGIGLSIVKHIIKNHDSEIKVESEPGKGSLFRFYLNKVN
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]