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The map label for this gene is ttcA [H]

Identifier: 220932926

GI number: 220932926

Start: 2270102

End: 2270884

Strand: Reverse

Name: ttcA [H]

Synonym: Hore_20940

Alternate gene names: 220932926

Gene position: 2270884-2270102 (Counterclockwise)

Preceding gene: 220932929

Following gene: 220932925

Centisome position: 88.08

GC content: 39.08

Gene sequence:

>783_bases
ATGAAATTAAGACTTCCTAAAAGATATGTCAGAAAGGTTTCCAGGGCTATTACAGAATTTGACATGATTGAAGAGGGGGA
TAATATTCTGGTAGGGTTATCGGGGGGCAAAGATAGTTCGTTTTTATTATATGTCCTGGCCCTGATTAACAGATATGCAT
CCCTGGACTTTCGATTAGCAGCTCTTACGGTAGATCTTGGTTTTGATGGAGGAAAGAATTATTTTGATTATCTAAAAAAT
TACTGTGATCGGCTGGGTGTTAAATACTATGTATTAGAAACTGAGATTGCCAGCTATATTCTCAGTGAGAAAACTGAAAA
ACCATGTGCCAGGTGTGCCCATTTCAGAAAAGGGGCTATTGTAGATTTTATGAAAGAAAATGGTTTTAATAAGATTGCCT
ATGGGCATCATTATGATGATGCTGTAGAAACCTTTTTGATGAGTATTCTTTATGCCGGGCAGGTAAAAACCTTTTTACCG
AAGACATATCTTTCCAGGAACGAGGTATATGTTATCAGGCCCCTTGTTTATTTACGGGAGAGTGAAATTATAAGAGCCCG
GAAGTACATGGATTATAATCCCCCGGAGAGTCCCTGTCCCTATGATGGCCAGACTACCAGGGATAAGGTTAAAAAATTGC
TCAGAGAACTGGCCAGTGATAAACAGATTTTTTACAATATTGCTGCTGCCATGAGGGAAGGTTCTGTTATTGACCTCTGG
CCGGAAAAACCCCCCCAGGAAGAAATTATTGAAAGATCTAAAAAGCTATGGACATCTAATTGA

Upstream 100 bases:

>100_bases
TTTTCTGGTAGTAAATGTGACCATGAAACTGGTTTATATACTTGTATACTAATTGACATTATTAATAATCATTGAAGCAT
TATTAACTGGAGGGCTATCA

Downstream 100 bases:

>100_bases
CTTCATTTTCATTGACACTTCTAACCTGTATATTATATACTAATATTGAATATATGAATAATTGTTCAAATATGAGATAA
AAAGGGTTGATAACTATGTT

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKLRLPKRYVRKVSRAITEFDMIEEGDNILVGLSGGKDSSFLLYVLALINRYASLDFRLAALTVDLGFDGGKNYFDYLKN
YCDRLGVKYYVLETEIASYILSEKTEKPCARCAHFRKGAIVDFMKENGFNKIAYGHHYDDAVETFLMSILYAGQVKTFLP
KTYLSRNEVYVIRPLVYLRESEIIRARKYMDYNPPESPCPYDGQTTRDKVKKLLRELASDKQIFYNIAAAMREGSVIDLW
PEKPPQEEIIERSKKLWTSN

Sequences:

>Translated_260_residues
MKLRLPKRYVRKVSRAITEFDMIEEGDNILVGLSGGKDSSFLLYVLALINRYASLDFRLAALTVDLGFDGGKNYFDYLKN
YCDRLGVKYYVLETEIASYILSEKTEKPCARCAHFRKGAIVDFMKENGFNKIAYGHHYDDAVETFLMSILYAGQVKTFLP
KTYLSRNEVYVIRPLVYLRESEIIRARKYMDYNPPESPCPYDGQTTRDKVKKLLRELASDKQIFYNIAAAMREGSVIDLW
PEKPPQEEIIERSKKLWTSN
>Mature_260_residues
MKLRLPKRYVRKVSRAITEFDMIEEGDNILVGLSGGKDSSFLLYVLALINRYASLDFRLAALTVDLGFDGGKNYFDYLKN
YCDRLGVKYYVLETEIASYILSEKTEKPCARCAHFRKGAIVDFMKENGFNKIAYGHHYDDAVETFLMSILYAGQVKTFLP
KTYLSRNEVYVIRPLVYLRESEIIRARKYMDYNPPESPCPYDGQTTRDKVKKLLRELASDKQIFYNIAAAMREGSVIDLW
PEKPPQEEIIERSKKLWTSN

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=219, Percent_Identity=36.0730593607306, Blast_Score=124, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193211090, Length=233, Percent_Identity=31.3304721030043, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24651972, Length=216, Percent_Identity=24.537037037037, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 30159; Mature: 30159

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRLPKRYVRKVSRAITEFDMIEEGDNILVGLSGGKDSSFLLYVLALINRYASLDFRLA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE
ALTVDLGFDGGKNYFDYLKNYCDRLGVKYYVLETEIASYILSEKTEKPCARCAHFRKGAI
EEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCH
VDFMKENGFNKIAYGHHYDDAVETFLMSILYAGQVKTFLPKTYLSRNEVYVIRPLVYLRE
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
SEIIRARKYMDYNPPESPCPYDGQTTRDKVKKLLRELASDKQIFYNIAAAMREGSVIDLW
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEC
PEKPPQEEIIERSKKLWTSN
CCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLRLPKRYVRKVSRAITEFDMIEEGDNILVGLSGGKDSSFLLYVLALINRYASLDFRLA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEE
ALTVDLGFDGGKNYFDYLKNYCDRLGVKYYVLETEIASYILSEKTEKPCARCAHFRKGAI
EEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCH
VDFMKENGFNKIAYGHHYDDAVETFLMSILYAGQVKTFLPKTYLSRNEVYVIRPLVYLRE
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHH
SEIIRARKYMDYNPPESPCPYDGQTTRDKVKKLLRELASDKQIFYNIAAAMREGSVIDLW
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEC
PEKPPQEEIIERSKKLWTSN
CCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA