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The map label for this gene is cadA [H]

Identifier: 220932925

GI number: 220932925

Start: 2267769

End: 2270006

Strand: Reverse

Name: cadA [H]

Synonym: Hore_20930

Alternate gene names: 220932925

Gene position: 2270006-2267769 (Counterclockwise)

Preceding gene: 220932926

Following gene: 220932920

Centisome position: 88.05

GC content: 41.2

Gene sequence:

>2238_bases
ATGTTGACTAATTTAAAAACCAGGCAGGAAACATTACCCCATAACAAAAAAGAGGGATTATCTTTCATTAAAAAAGAATA
TATGTTAGAGGGGCTTTTCTGTGCCAATTGTGCCGGCAAAATAGTACAGGAAATAAAGGAGTTGCCGGTGGTTTATGATG
CCACTTTAAACCTGTCAACGGGCCGGTTGATAGTATTTCTTAAAAAACAGGCGGATTTTGAAGCTGGTCTGCTTATAAGT
CAGGTCCAGGAAATAGCTGACAGGATAGAACCTGGTTTAACGGTAAAACCATCAGGTCAAAATGAAAATCAAAACCGGAC
AAATAAAGCTGGAGAGACCAGCACACTTAAAAATAAGATAACATCTGAAAATGAAGGGAAACATCAAAGTTATGATCTGC
TACTTATATCAGGTATACTCCTGTTTGCTTTAACCCTTTACTTTGATTACAGAGGCTTTGATTTTGTTCCCTTTGGTATA
CCTTTACTCTATTCAGTGGCCTATTTGCTGGTGGGAAGAAGTGTATTAAAGTTAACTATTTATAATATTGGAAAAAGGAA
TTTTTTTGATGAGAATTTTTTAATGACCGTAGCTACCCTGGGGGCCTTTGGTGTCGGTGAATTTGCTGAAGGTGTTTCTG
TAATGTTATTTTATAAAATAGGTGAATACCTGCAGGAAAGAGCGGTCAAGCGTTCCCGCCGTTCTATTAAAGAGATGATG
GATTTAAAACCCGATTATGCCAATCTAATTAGAGAAGGCAAAATAGTTCAGGTATCCCCCGAACAGGTAAAGCCTGGTGA
TAAAATAATAATTAAGCCCGGGGAAAGAATTCCCTTGGATGGAAGGGTTATAAAGGGAAAGTCAAGGCTGGATACTTCTT
CATTAACAGGGGAATCAGTCACCAGGGCGATTAATAAAGGTGATAAGGTTCTGGCCGGAGCTATAAATAAGAACAGTGTC
TTGACTGTTGAGGTTATTAAAGAATACCGGGAATCAACGGTTTCCAGAATCCTGAATCTGGTTGAAGAGGCGAGTAATAG
AAAAGCGGCCACAGAGAAGTTTATCACTAAATTTGCCCGTTATTATACTCCAGCAGTAGTCGGAATTGCTGCTTTTATTT
CCCTCATCCCTCCCCTGATCTTTCCCGGGAGTAGTTTTAGTAACTGGCTATACCGGGGCCTTGTGTTTCTTGTAATTTCG
TGTCCATGTGCCCTGGTTATTTCAATACCCCTGGGCTACTTTGCCGGGATTGGCCGGGCTTCACGGGATGGTATCCTGGT
AAAAGGGGGTAATTACCTGGAAGGGTTGGCCAATATAACCAGGGTTATTTTTGATAAAACAGGGACCCTTTCCCGGGGGG
TTTTCCGGGTTCAGGAGGTTTCGGCAACGGGGAATTATACCGGAGAGAAACTATTAAAACTAGCGGCCACAGCAGAGTAT
TATTCTCATCATCCTGTTGCTGATTCCATTAAGGAGGCATATGGTAAGGAACCCGATTTAGTAAATATTGAGGGGTATAA
TGAAATACCGGGACAGGGGATTGAGGCAACCATAAATGGGAAAGAGATTCTGCTCGGTAATAAGACCTTAATGGAAAGAG
AGAAGGTTATCGGATTTAAAGAGGCAAGTGGTGAAGGAAGTATTGTTTATGTTGCTGTAAATAAAGATTATGCCGGTTAT
ATTATTATTTCTGATGAATTAAAGTCAGATTCTAAAAAAGCCATCAGGTCTCTTAAAAAACTCGGTATTGAAGATATAAC
CATGTTTACAGGTGACAGGGAAAAAACAGCGGCTGCTGTCAGTAAAAGATTGGGGTTAGATAATTATGAGGCCAGTTTAT
TACCCGGTGATAAGGTGGCCAAACTTGAAGAGGTATTAAATGGGACCTATCACGGGCGGGTTGCCTTTGTGGGTGATGGT
ATTAATGATGCCCCGGTTCTGGCCCGGGCTGATATCGGTATTGCCATGGGTGGTCTTGGTTCAGATGCTGCCGTTGAGGC
TGCTGATGTGGTTATAATGACAGATGAACCATCTAAACTCGGGAAAGCAATTTTTATTGCCAGGAGGACCAGAAGCATAG
TCTGGCAAAATATTGTAATGTCGCTCGGGATAAAATTTTTAATTCTCGTAGCAGGTTTATTTGGTCTAGCTACTATGTGG
GCCGCTGTTTTTGCAGATGTCGGGGTTGCTCTGTTAGCGGTACTCAATTCTATCAGGGTTTTAACTTTAAAAAAGTAA

Upstream 100 bases:

>100_bases
ATTGACTTCATTTTCATTGACACTTCTAACCTGTATATTATATACTAATATTGAATATATGAATAATTGTTCAAATATGA
GATAAAAAGGGTTGATAACT

Downstream 100 bases:

>100_bases
CCTTAAAGTAATAACTTTAAACTAGATGAACAAATAAAATATCATCAACGTAGGTATAACGTCAAAGCACAATTTTGTGG
TTTTTATACCTTAAAGTAAC

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MLTNLKTRQETLPHNKKEGLSFIKKEYMLEGLFCANCAGKIVQEIKELPVVYDATLNLSTGRLIVFLKKQADFEAGLLIS
QVQEIADRIEPGLTVKPSGQNENQNRTNKAGETSTLKNKITSENEGKHQSYDLLLISGILLFALTLYFDYRGFDFVPFGI
PLLYSVAYLLVGRSVLKLTIYNIGKRNFFDENFLMTVATLGAFGVGEFAEGVSVMLFYKIGEYLQERAVKRSRRSIKEMM
DLKPDYANLIREGKIVQVSPEQVKPGDKIIIKPGERIPLDGRVIKGKSRLDTSSLTGESVTRAINKGDKVLAGAINKNSV
LTVEVIKEYRESTVSRILNLVEEASNRKAATEKFITKFARYYTPAVVGIAAFISLIPPLIFPGSSFSNWLYRGLVFLVIS
CPCALVISIPLGYFAGIGRASRDGILVKGGNYLEGLANITRVIFDKTGTLSRGVFRVQEVSATGNYTGEKLLKLAATAEY
YSHHPVADSIKEAYGKEPDLVNIEGYNEIPGQGIEATINGKEILLGNKTLMEREKVIGFKEASGEGSIVYVAVNKDYAGY
IIISDELKSDSKKAIRSLKKLGIEDITMFTGDREKTAAAVSKRLGLDNYEASLLPGDKVAKLEEVLNGTYHGRVAFVGDG
INDAPVLARADIGIAMGGLGSDAAVEAADVVIMTDEPSKLGKAIFIARRTRSIVWQNIVMSLGIKFLILVAGLFGLATMW
AAVFADVGVALLAVLNSIRVLTLKK

Sequences:

>Translated_745_residues
MLTNLKTRQETLPHNKKEGLSFIKKEYMLEGLFCANCAGKIVQEIKELPVVYDATLNLSTGRLIVFLKKQADFEAGLLIS
QVQEIADRIEPGLTVKPSGQNENQNRTNKAGETSTLKNKITSENEGKHQSYDLLLISGILLFALTLYFDYRGFDFVPFGI
PLLYSVAYLLVGRSVLKLTIYNIGKRNFFDENFLMTVATLGAFGVGEFAEGVSVMLFYKIGEYLQERAVKRSRRSIKEMM
DLKPDYANLIREGKIVQVSPEQVKPGDKIIIKPGERIPLDGRVIKGKSRLDTSSLTGESVTRAINKGDKVLAGAINKNSV
LTVEVIKEYRESTVSRILNLVEEASNRKAATEKFITKFARYYTPAVVGIAAFISLIPPLIFPGSSFSNWLYRGLVFLVIS
CPCALVISIPLGYFAGIGRASRDGILVKGGNYLEGLANITRVIFDKTGTLSRGVFRVQEVSATGNYTGEKLLKLAATAEY
YSHHPVADSIKEAYGKEPDLVNIEGYNEIPGQGIEATINGKEILLGNKTLMEREKVIGFKEASGEGSIVYVAVNKDYAGY
IIISDELKSDSKKAIRSLKKLGIEDITMFTGDREKTAAAVSKRLGLDNYEASLLPGDKVAKLEEVLNGTYHGRVAFVGDG
INDAPVLARADIGIAMGGLGSDAAVEAADVVIMTDEPSKLGKAIFIARRTRSIVWQNIVMSLGIKFLILVAGLFGLATMW
AAVFADVGVALLAVLNSIRVLTLKK
>Mature_745_residues
MLTNLKTRQETLPHNKKEGLSFIKKEYMLEGLFCANCAGKIVQEIKELPVVYDATLNLSTGRLIVFLKKQADFEAGLLIS
QVQEIADRIEPGLTVKPSGQNENQNRTNKAGETSTLKNKITSENEGKHQSYDLLLISGILLFALTLYFDYRGFDFVPFGI
PLLYSVAYLLVGRSVLKLTIYNIGKRNFFDENFLMTVATLGAFGVGEFAEGVSVMLFYKIGEYLQERAVKRSRRSIKEMM
DLKPDYANLIREGKIVQVSPEQVKPGDKIIIKPGERIPLDGRVIKGKSRLDTSSLTGESVTRAINKGDKVLAGAINKNSV
LTVEVIKEYRESTVSRILNLVEEASNRKAATEKFITKFARYYTPAVVGIAAFISLIPPLIFPGSSFSNWLYRGLVFLVIS
CPCALVISIPLGYFAGIGRASRDGILVKGGNYLEGLANITRVIFDKTGTLSRGVFRVQEVSATGNYTGEKLLKLAATAEY
YSHHPVADSIKEAYGKEPDLVNIEGYNEIPGQGIEATINGKEILLGNKTLMEREKVIGFKEASGEGSIVYVAVNKDYAGY
IIISDELKSDSKKAIRSLKKLGIEDITMFTGDREKTAAAVSKRLGLDNYEASLLPGDKVAKLEEVLNGTYHGRVAFVGDG
INDAPVLARADIGIAMGGLGSDAAVEAADVVIMTDEPSKLGKAIFIARRTRSIVWQNIVMSLGIKFLILVAGLFGLATMW
AAVFADVGVALLAVLNSIRVLTLKK

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=818, Percent_Identity=26.2836185819071, Blast_Score=244, Evalue=3e-64,
Organism=Homo sapiens, GI115529486, Length=610, Percent_Identity=29.5081967213115, Blast_Score=236, Evalue=7e-62,
Organism=Homo sapiens, GI55743073, Length=563, Percent_Identity=29.3072824156306, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI48762689, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI48762685, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI48762691, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI48762687, Length=156, Percent_Identity=31.4102564102564, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI118498343, Length=208, Percent_Identity=27.4038461538462, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1789879, Length=734, Percent_Identity=36.1035422343324, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1786691, Length=707, Percent_Identity=28.5714285714286, Blast_Score=245, Evalue=6e-66,
Organism=Escherichia coli, GI1786914, Length=507, Percent_Identity=27.810650887574, Blast_Score=119, Evalue=9e-28,
Organism=Escherichia coli, GI2367363, Length=183, Percent_Identity=33.879781420765, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=562, Percent_Identity=28.1138790035587, Blast_Score=204, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997262, Length=576, Percent_Identity=23.9583333333333, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71997275, Length=576, Percent_Identity=24.1319444444444, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71997269, Length=248, Percent_Identity=25, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=543, Percent_Identity=29.097605893186, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=553, Percent_Identity=26.9439421338156, Blast_Score=170, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6325221, Length=647, Percent_Identity=22.8748068006182, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221329854, Length=368, Percent_Identity=28.804347826087, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24668708, Length=160, Percent_Identity=33.125, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668704, Length=160, Percent_Identity=33.125, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366617, Length=160, Percent_Identity=33.125, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161085803, Length=160, Percent_Identity=33.125, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24668696, Length=160, Percent_Identity=33.125, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 81499; Mature: 81499

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNLKTRQETLPHNKKEGLSFIKKEYMLEGLFCANCAGKIVQEIKELPVVYDATLNLST
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECC
GRLIVFLKKQADFEAGLLISQVQEIADRIEPGLTVKPSGQNENQNRTNKAGETSTLKNKI
CEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHH
TSENEGKHQSYDLLLISGILLFALTLYFDYRGFDFVPFGIPLLYSVAYLLVGRSVLKLTI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
YNIGKRNFFDENFLMTVATLGAFGVGEFAEGVSVMLFYKIGEYLQERAVKRSRRSIKEMM
HHCCCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKPDYANLIREGKIVQVSPEQVKPGDKIIIKPGERIPLDGRVIKGKSRLDTSSLTGESV
HCCCCHHHHHHCCCEEEECHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHH
TRAINKGDKVLAGAINKNSVLTVEVIKEYRESTVSRILNLVEEASNRKAATEKFITKFAR
HHHHCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
YYTPAVVGIAAFISLIPPLIFPGSSFSNWLYRGLVFLVISCPCALVISIPLGYFAGIGRA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
SRDGILVKGGNYLEGLANITRVIFDKTGTLSRGVFRVQEVSATGNYTGEKLLKLAATAEY
CCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHCCEEEEEECCCCCCCHHHHHHHHHHHHH
YSHHPVADSIKEAYGKEPDLVNIEGYNEIPGQGIEATINGKEILLGNKTLMEREKVIGFK
HCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHCCEE
EASGEGSIVYVAVNKDYAGYIIISDELKSDSKKAIRSLKKLGIEDITMFTGDREKTAAAV
ECCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
SKRLGLDNYEASLLPGDKVAKLEEVLNGTYHGRVAFVGDGINDAPVLARADIGIAMGGLG
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCEEECCCC
SDAAVEAADVVIMTDEPSKLGKAIFIARRTRSIVWQNIVMSLGIKFLILVAGLFGLATMW
CCCCCCEEEEEEECCCCHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVFADVGVALLAVLNSIRVLTLKK
HHHHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MLTNLKTRQETLPHNKKEGLSFIKKEYMLEGLFCANCAGKIVQEIKELPVVYDATLNLST
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECC
GRLIVFLKKQADFEAGLLISQVQEIADRIEPGLTVKPSGQNENQNRTNKAGETSTLKNKI
CEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHH
TSENEGKHQSYDLLLISGILLFALTLYFDYRGFDFVPFGIPLLYSVAYLLVGRSVLKLTI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
YNIGKRNFFDENFLMTVATLGAFGVGEFAEGVSVMLFYKIGEYLQERAVKRSRRSIKEMM
HHCCCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLKPDYANLIREGKIVQVSPEQVKPGDKIIIKPGERIPLDGRVIKGKSRLDTSSLTGESV
HCCCCHHHHHHCCCEEEECHHHCCCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHH
TRAINKGDKVLAGAINKNSVLTVEVIKEYRESTVSRILNLVEEASNRKAATEKFITKFAR
HHHHCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
YYTPAVVGIAAFISLIPPLIFPGSSFSNWLYRGLVFLVISCPCALVISIPLGYFAGIGRA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
SRDGILVKGGNYLEGLANITRVIFDKTGTLSRGVFRVQEVSATGNYTGEKLLKLAATAEY
CCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHCCEEEEEECCCCCCCHHHHHHHHHHHHH
YSHHPVADSIKEAYGKEPDLVNIEGYNEIPGQGIEATINGKEILLGNKTLMEREKVIGFK
HCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHCCEE
EASGEGSIVYVAVNKDYAGYIIISDELKSDSKKAIRSLKKLGIEDITMFTGDREKTAAAV
ECCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
SKRLGLDNYEASLLPGDKVAKLEEVLNGTYHGRVAFVGDGINDAPVLARADIGIAMGGLG
HHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCCCEEECCCC
SDAAVEAADVVIMTDEPSKLGKAIFIARRTRSIVWQNIVMSLGIKFLILVAGLFGLATMW
CCCCCCEEEEEEECCCCHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVFADVGVALLAVLNSIRVLTLKK
HHHHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]