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The map label for this gene is tpiA [H]

Identifier: 220932417

GI number: 220932417

Start: 1693403

End: 1694155

Strand: Reverse

Name: tpiA [H]

Synonym: Hore_15810

Alternate gene names: 220932417

Gene position: 1694155-1693403 (Counterclockwise)

Preceding gene: 220932418

Following gene: 220932416

Centisome position: 65.71

GC content: 44.22

Gene sequence:

>753_bases
GTGAGGACACCGTTTATTGCCGGTAACTGGAAGATGAACTTGACATTGAAAGAATCGGTGGCCCTGGTAGAAGAATTAAA
AGACCTGGTTTCCGGTGTTACCGGGGTTGAGATTGCTGTCTGCCCACCGGCTGTTAACCTGACCCGTGTTCAGGAAGTGT
TAAAGGATACCAGTATTAAGGTCGGAGCCCAGAATATGCACTGGGAAGACAGTGGTGCCTTTACCGGGGAATTATCTCCG
GTTATGCTCAGGGATATAGATGTTGATTATATTATTATCGGACATTCTGAAAGAAGACAGTATTTTAATGAAACCGATCA
GATTGTTAATAGAAAGGTTCAGGCTGCCCATACCCATGGTCTGAAACCCATTATCTGTGTTGGTGAAAGCCTTGATGAGA
GGGAAGAAGGCAAAACAAGACAGGTAGTCAAAGCTCAGGTTAAATCTGCCCTGGCAGGCTTAACAAAAGACCAGGTTGCT
GATTCAGTAATTGCCTATGAACCCATCTGGGCTATTGGTACCGGAAAATCGGCTACTGCTGAAGAGGCCAATGATGTGAT
CAAATTTATCAGGGAAACAGTAAACCAGGATTTTGACGGAGCCGGGGATGCCATGAGGATACAATATGGTGGTAGTGTTA
AGCCCCATAATATTGAAGACTTTATAAAACAGAGTGATATTGATGGTGCCCTGGTCGGTGGAGCCAGTCTTAAAGCTGAG
TCTTTTGCTGAAATAGTGAAAAAGTCAGTTTAA

Upstream 100 bases:

>100_bases
TCATATTTCAACCGGTGGTGGTGCTTCCCTGATGTTCTTTGAAGGAAAGCCCTTACCCGGTGTTGAAGCATTAGATGATG
TTGAGTAAGGAGGGGATTTT

Downstream 100 bases:

>100_bases
AGTAAGTTAAAAAAATCCCCGGGGAAAGCCCCCGGGGAGCATAATGGTTAAAGCAATGTTTTTTAATAAAGCATTAAATA
TATCAACAGATATTGTATAT

Product: Triose-phosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MRTPFIAGNWKMNLTLKESVALVEELKDLVSGVTGVEIAVCPPAVNLTRVQEVLKDTSIKVGAQNMHWEDSGAFTGELSP
VMLRDIDVDYIIIGHSERRQYFNETDQIVNRKVQAAHTHGLKPIICVGESLDEREEGKTRQVVKAQVKSALAGLTKDQVA
DSVIAYEPIWAIGTGKSATAEEANDVIKFIRETVNQDFDGAGDAMRIQYGGSVKPHNIEDFIKQSDIDGALVGGASLKAE
SFAEIVKKSV

Sequences:

>Translated_250_residues
MRTPFIAGNWKMNLTLKESVALVEELKDLVSGVTGVEIAVCPPAVNLTRVQEVLKDTSIKVGAQNMHWEDSGAFTGELSP
VMLRDIDVDYIIIGHSERRQYFNETDQIVNRKVQAAHTHGLKPIICVGESLDEREEGKTRQVVKAQVKSALAGLTKDQVA
DSVIAYEPIWAIGTGKSATAEEANDVIKFIRETVNQDFDGAGDAMRIQYGGSVKPHNIEDFIKQSDIDGALVGGASLKAE
SFAEIVKKSV
>Mature_250_residues
MRTPFIAGNWKMNLTLKESVALVEELKDLVSGVTGVEIAVCPPAVNLTRVQEVLKDTSIKVGAQNMHWEDSGAFTGELSP
VMLRDIDVDYIIIGHSERRQYFNETDQIVNRKVQAAHTHGLKPIICVGESLDEREEGKTRQVVKAQVKSALAGLTKDQVA
DSVIAYEPIWAIGTGKSATAEEANDVIKFIRETVNQDFDGAGDAMRIQYGGSVKPHNIEDFIKQSDIDGALVGGASLKAE
SFAEIVKKSV

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=246, Percent_Identity=41.4634146341463, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI226529917, Length=246, Percent_Identity=41.4634146341463, Blast_Score=174, Evalue=6e-44,
Organism=Escherichia coli, GI1790353, Length=249, Percent_Identity=44.9799196787149, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=41.7004048582996, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=42.2764227642276, Blast_Score=185, Evalue=6e-48,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=43.5483870967742, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=43.5483870967742, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=43.5483870967742, Blast_Score=185, Evalue=2e-47,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27266; Mature: 27266

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPFIAGNWKMNLTLKESVALVEELKDLVSGVTGVEIAVCPPAVNLTRVQEVLKDTSIK
CCCCEECCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCEE
VGAQNMHWEDSGAFTGELSPVMLRDIDVDYIIIGHSERRQYFNETDQIVNRKVQAAHTHG
ECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
LKPIICVGESLDEREEGKTRQVVKAQVKSALAGLTKDQVADSVIAYEPIWAIGTGKSATA
CCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCH
EEANDVIKFIRETVNQDFDGAGDAMRIQYGGSVKPHNIEDFIKQSDIDGALVGGASLKAE
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCHH
SFAEIVKKSV
HHHHHHHHCC
>Mature Secondary Structure
MRTPFIAGNWKMNLTLKESVALVEELKDLVSGVTGVEIAVCPPAVNLTRVQEVLKDTSIK
CCCCEECCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCEE
VGAQNMHWEDSGAFTGELSPVMLRDIDVDYIIIGHSERRQYFNETDQIVNRKVQAAHTHG
ECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
LKPIICVGESLDEREEGKTRQVVKAQVKSALAGLTKDQVADSVIAYEPIWAIGTGKSATA
CCEEEEECCCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCH
EEANDVIKFIRETVNQDFDGAGDAMRIQYGGSVKPHNIEDFIKQSDIDGALVGGASLKAE
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCHH
SFAEIVKKSV
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA