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The map label for this gene is eno [H]

Identifier: 220932415

GI number: 220932415

Start: 1690306

End: 1691592

Strand: Reverse

Name: eno [H]

Synonym: Hore_15790

Alternate gene names: 220932415

Gene position: 1691592-1690306 (Counterclockwise)

Preceding gene: 220932416

Following gene: 220932414

Centisome position: 65.61

GC content: 43.98

Gene sequence:

>1287_bases
ATGATTGATACCAGTATTGTTGATGTTTTTGCCCGTGAAATTCTTGATTCTCGCGGTAATCCTACTGTTGAAGTTGAAGT
TGTCCTTGGTGACGGTTCCCTGGGGCGTGCTGCTGTTCCTTCTGGAGCCTCAACCGGAGCCTATGAAGCTGTTGAATTGA
GGGATGGTGAGGACCGTTACCTCGGCAAGGGTGTTCAGAAAGCTGTTAAAAATGTTAATGAAGTAATTGCTCCTGAATTA
ATTGGATATGACGCCAGGGACCAGGTTGATATTGACAGGTTAATGATTGAACTCGATGGAACCGAGAATAAGGGTAAACT
CGGGGCCAATGCTATTCTCGGAGTATCACTGGCTGTAGCCAAAGCTGCTGCCAATGCTTCAGATAGCTACTTGTTTAAAT
ACCTCGGTGGTGTCAATGCTAAAGTTTTACCTGTGCCGATGATGAATATCCTCAATGGTGGGGAGCATGCCGATAACAAT
GTTGACATTCAGGAATTTATGATTATGCCGGTAGGGGCTGTAAACTTTGCTGAAGCCATGAGGATGGGAAGCGAGGTTTA
CCACAACCTCAAAAAAGTACTTCAGGGTAGAGGCCTTAACACTGCTATCGGTGATGAAGGTGGCTTTGCCCCTGACCTGG
GTTCAAACGAAGAAGCCATTGAAGTAATTATTGAGGCTGTAGAAAAGGCCGGTTATAAACCCGGAGATGACATCATGCTG
GCCCTTGATGTAGCCGCTACCGAGCTTTATAAAGATGGTAAATATGTTCTTGAAGGTGAAGGGGTTGAAAAAACCTCTGA
AGAAATGATCGAGTTCTATGAAAAACTGGTAGATAAATATCCCATTATTTCAATTGAAGATGGTCTATCTGAAGATGACT
GGGATGGTTGGGCTAAACTTACTGAAAAACTCGGTAATAAAATCCAGCTGGTTGGGGATGACCTCTATGTAACCAATACC
GAACGTCTCTCCCGCGGTATTGAAGAAAAGAGTAGTAACTCTATTCTTATCAAGGTTAACCAGATCGGTACCCTGACTGA
AACCATTGAAGCTATTGAAATGGCTAAAAAAGCTGGTTTTACTGCTGTTGTTTCTCACCGTTCCGGTGAAACCGAGGATG
TTACCATCTCTGACCTGGTTGTTGCCATGAATACCGGACAGATTAAAACCGGTGCTCCGGCCAGGTCTGAAAGGGTTGCT
AAATACAATCAGCTCTTAAGGATTGAAGAAGTACTCGGTGAAGCCGCTGAGTATGCTGGTAAAGATGCTTTCTATAACTT
AAGGTAA

Upstream 100 bases:

>100_bases
GTTAATGGTTTTGTCTATATTTCTGCCAGTAATGTGATTGGAAGACATAATTAGAATCAAATAAAAACTTATAAACAATA
TAAATAATGGAGGGATAAAA

Downstream 100 bases:

>100_bases
GAAGTGGTAAAATACCTGTAAGCGAATAAAGTTAAAGAATATAACACTACTTGAAGCAGGGGTTATAAAAAAGCAGAAGG
CGAAGATGGTTATAGAAAAA

Product: enolase

Products: NA

Alternate protein names: 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydratase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIDTSIVDVFAREILDSRGNPTVEVEVVLGDGSLGRAAVPSGASTGAYEAVELRDGEDRYLGKGVQKAVKNVNEVIAPEL
IGYDARDQVDIDRLMIELDGTENKGKLGANAILGVSLAVAKAAANASDSYLFKYLGGVNAKVLPVPMMNILNGGEHADNN
VDIQEFMIMPVGAVNFAEAMRMGSEVYHNLKKVLQGRGLNTAIGDEGGFAPDLGSNEEAIEVIIEAVEKAGYKPGDDIML
ALDVAATELYKDGKYVLEGEGVEKTSEEMIEFYEKLVDKYPIISIEDGLSEDDWDGWAKLTEKLGNKIQLVGDDLYVTNT
ERLSRGIEEKSSNSILIKVNQIGTLTETIEAIEMAKKAGFTAVVSHRSGETEDVTISDLVVAMNTGQIKTGAPARSERVA
KYNQLLRIEEVLGEAAEYAGKDAFYNLR

Sequences:

>Translated_428_residues
MIDTSIVDVFAREILDSRGNPTVEVEVVLGDGSLGRAAVPSGASTGAYEAVELRDGEDRYLGKGVQKAVKNVNEVIAPEL
IGYDARDQVDIDRLMIELDGTENKGKLGANAILGVSLAVAKAAANASDSYLFKYLGGVNAKVLPVPMMNILNGGEHADNN
VDIQEFMIMPVGAVNFAEAMRMGSEVYHNLKKVLQGRGLNTAIGDEGGFAPDLGSNEEAIEVIIEAVEKAGYKPGDDIML
ALDVAATELYKDGKYVLEGEGVEKTSEEMIEFYEKLVDKYPIISIEDGLSEDDWDGWAKLTEKLGNKIQLVGDDLYVTNT
ERLSRGIEEKSSNSILIKVNQIGTLTETIEAIEMAKKAGFTAVVSHRSGETEDVTISDLVVAMNTGQIKTGAPARSERVA
KYNQLLRIEEVLGEAAEYAGKDAFYNLR
>Mature_428_residues
MIDTSIVDVFAREILDSRGNPTVEVEVVLGDGSLGRAAVPSGASTGAYEAVELRDGEDRYLGKGVQKAVKNVNEVIAPEL
IGYDARDQVDIDRLMIELDGTENKGKLGANAILGVSLAVAKAAANASDSYLFKYLGGVNAKVLPVPMMNILNGGEHADNN
VDIQEFMIMPVGAVNFAEAMRMGSEVYHNLKKVLQGRGLNTAIGDEGGFAPDLGSNEEAIEVIIEAVEKAGYKPGDDIML
ALDVAATELYKDGKYVLEGEGVEKTSEEMIEFYEKLVDKYPIISIEDGLSEDDWDGWAKLTEKLGNKIQLVGDDLYVTNT
ERLSRGIEEKSSNSILIKVNQIGTLTETIEAIEMAKKAGFTAVVSHRSGETEDVTISDLVVAMNTGQIKTGAPARSERVA
KYNQLLRIEEVLGEAAEYAGKDAFYNLR

Specific function: Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis [H]

COG id: COG0148

COG function: function code G; Enolase

Gene ontology:

Cell location: Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enolase family [H]

Homologues:

Organism=Homo sapiens, GI5803011, Length=437, Percent_Identity=54.9199084668192, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI4503571, Length=431, Percent_Identity=53.5962877030162, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI301897477, Length=426, Percent_Identity=53.7558685446009, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI301897469, Length=426, Percent_Identity=53.7558685446009, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI301897479, Length=424, Percent_Identity=48.8207547169811, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI169201331, Length=336, Percent_Identity=26.1904761904762, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI169201757, Length=336, Percent_Identity=26.1904761904762, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI239744207, Length=336, Percent_Identity=26.1904761904762, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1789141, Length=424, Percent_Identity=65.3301886792453, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71995829, Length=437, Percent_Identity=56.0640732265446, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17536383, Length=437, Percent_Identity=56.0640732265446, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI32563855, Length=197, Percent_Identity=52.7918781725888, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321693, Length=437, Percent_Identity=50.8009153318078, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6323985, Length=433, Percent_Identity=51.7321016166282, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324974, Length=433, Percent_Identity=51.7321016166282, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324969, Length=433, Percent_Identity=51.7321016166282, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321968, Length=437, Percent_Identity=50.1144164759725, Blast_Score=386, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24580918, Length=433, Percent_Identity=54.0415704387991, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24580916, Length=433, Percent_Identity=54.0415704387991, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24580920, Length=433, Percent_Identity=54.0415704387991, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24580914, Length=433, Percent_Identity=54.0415704387991, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281360527, Length=431, Percent_Identity=54.292343387471, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI17137654, Length=431, Percent_Identity=54.292343387471, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000941
- InterPro:   IPR020810
- InterPro:   IPR020809
- InterPro:   IPR020811 [H]

Pfam domain/function: PF00113 Enolase_C; PF03952 Enolase_N [H]

EC number: =4.2.1.11 [H]

Molecular weight: Translated: 46208; Mature: 46208

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS00164 ENOLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTSIVDVFAREILDSRGNPTVEVEVVLGDGSLGRAAVPSGASTGAYEAVELRDGEDRY
CCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHH
LGKGVQKAVKNVNEVIAPELIGYDARDQVDIDRLMIELDGTENKGKLGANAILGVSLAVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHH
KAAANASDSYLFKYLGGVNAKVLPVPMMNILNGGEHADNNVDIQEFMIMPVGAVNFAEAM
HHHCCCCHHHHHHHHCCCCCEEECCCHHHHHCCCCCCCCCCCHHHHEEECCCHHHHHHHH
RMGSEVYHNLKKVLQGRGLNTAIGDEGGFAPDLGSNEEAIEVIIEAVEKAGYKPGDDIML
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
ALDVAATELYKDGKYVLEGEGVEKTSEEMIEFYEKLVDKYPIISIEDGLSEDDWDGWAKL
EEEHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHH
TEKLGNKIQLVGDDLYVTNTERLSRGIEEKSSNSILIKVNQIGTLTETIEAIEMAKKAGF
HHHHCCEEEEEECCEEEECHHHHHCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCC
TAVVSHRSGETEDVTISDLVVAMNTGQIKTGAPARSERVAKYNQLLRIEEVLGEAAEYAG
EEEEECCCCCCCCEEHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KDAFYNLR
CCCEECCC
>Mature Secondary Structure
MIDTSIVDVFAREILDSRGNPTVEVEVVLGDGSLGRAAVPSGASTGAYEAVELRDGEDRY
CCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHH
LGKGVQKAVKNVNEVIAPELIGYDARDQVDIDRLMIELDGTENKGKLGANAILGVSLAVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCCCCCCHHHHHHHHHHH
KAAANASDSYLFKYLGGVNAKVLPVPMMNILNGGEHADNNVDIQEFMIMPVGAVNFAEAM
HHHCCCCHHHHHHHHCCCCCEEECCCHHHHHCCCCCCCCCCCHHHHEEECCCHHHHHHHH
RMGSEVYHNLKKVLQGRGLNTAIGDEGGFAPDLGSNEEAIEVIIEAVEKAGYKPGDDIML
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
ALDVAATELYKDGKYVLEGEGVEKTSEEMIEFYEKLVDKYPIISIEDGLSEDDWDGWAKL
EEEHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHH
TEKLGNKIQLVGDDLYVTNTERLSRGIEEKSSNSILIKVNQIGTLTETIEAIEMAKKAGF
HHHHCCEEEEEECCEEEECHHHHHCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCC
TAVVSHRSGETEDVTISDLVVAMNTGQIKTGAPARSERVAKYNQLLRIEEVLGEAAEYAG
EEEEECCCCCCCCEEHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KDAFYNLR
CCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA