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The map label for this gene is clpP

Identifier: 220932330

GI number: 220932330

Start: 1592901

End: 1593497

Strand: Reverse

Name: clpP

Synonym: Hore_14940

Alternate gene names: 220932330

Gene position: 1593497-1592901 (Counterclockwise)

Preceding gene: 220932331

Following gene: 220932329

Centisome position: 61.81

GC content: 41.04

Gene sequence:

>597_bases
ATGAGTTTGATACCTGTTGTTGTTGAACAGACTAACAGGGGAGAGAGATCCTATGACATCTATTCCCGCCTGTTAAAAGA
TAGGATAGTTTTTCTGGGCCATCCTATTAATGATGAGCTTTCTAATTTAATTATTGCCCAGTTATTATTCCTGGAAGCAG
AAGACCCGGATAAAGATATTCATTTGTATATAAATAGTCCAGGTGGTTCTGTTACCGCTGCTTTAGCAATGTATGATACC
ATTCAGTATATAAAACCCGATGTAGCCACAATATGTATGGGTCAAGCCGCCAGTGCCGGTGCCCTGCTGCTGGCTTCTGG
AACCAAAGGTAAGCGTTATGCCCTGCCCAATGCCAGGGTTATGATTCATCAGCCGGCCGGTGGTGTTCAGGGTAAGGCTA
CTGAGGCTGAAATTCACATTAAAGAGCTTTTAAGGTTAAGAGAAAGACTCAATGAAATTTTAAGCAAGCACACCGGGAAG
AGTGTTGAACAGATCAGTAAAGATGTTGAGCAGGATTATTTTATGACAGCAGAAGAGGCCCTTGAATATGGTATTATTGA
TGAGGTAATTACCAAGAACGAATTAAAAGATAAGTAA

Upstream 100 bases:

>100_bases
TCATAGATTTCCTGGTGGAACACAACCAGAATGACTAGAATAGAGTAGGTTTAAATTATTTATAATCGGGAATAATGAAA
TTAAGAGGAGGGATTTTACT

Downstream 100 bases:

>100_bases
CTCTTTCAAGAGGTGATATAATGTTTAAATTTGGAGATGAAAAGGGTCAGTTGAAATGTTCCTTCTGCGGGAAATCCCAG
GAACAGGTCCGTAAACTGGT

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MSLIPVVVEQTNRGERSYDIYSRLLKDRIVFLGHPINDELSNLIIAQLLFLEAEDPDKDIHLYINSPGGSVTAALAMYDT
IQYIKPDVATICMGQAASAGALLLASGTKGKRYALPNARVMIHQPAGGVQGKATEAEIHIKELLRLRERLNEILSKHTGK
SVEQISKDVEQDYFMTAEEALEYGIIDEVITKNELKDK

Sequences:

>Translated_198_residues
MSLIPVVVEQTNRGERSYDIYSRLLKDRIVFLGHPINDELSNLIIAQLLFLEAEDPDKDIHLYINSPGGSVTAALAMYDT
IQYIKPDVATICMGQAASAGALLLASGTKGKRYALPNARVMIHQPAGGVQGKATEAEIHIKELLRLRERLNEILSKHTGK
SVEQISKDVEQDYFMTAEEALEYGIIDEVITKNELKDK
>Mature_197_residues
SLIPVVVEQTNRGERSYDIYSRLLKDRIVFLGHPINDELSNLIIAQLLFLEAEDPDKDIHLYINSPGGSVTAALAMYDTI
QYIKPDVATICMGQAASAGALLLASGTKGKRYALPNARVMIHQPAGGVQGKATEAEIHIKELLRLRERLNEILSKHTGKS
VEQISKDVEQDYFMTAEEALEYGIIDEVITKNELKDK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=55.7894736842105, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=62.303664921466, Blast_Score=281, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=54.7368421052632, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=57.8947368421053, Blast_Score=241, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_HALOH (B8CY74)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509238.1
- ProteinModelPortal:   B8CY74
- SMR:   B8CY74
- MEROPS:   S14.001
- GeneID:   7313085
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_14940
- HOGENOM:   HBG558421
- OMA:   TGQPFER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21981; Mature: 21849

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIPVVVEQTNRGERSYDIYSRLLKDRIVFLGHPINDELSNLIIAQLLFLEAEDPDKDI
CCCCCEEEECCCCCCCHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGSVTAALAMYDTIQYIKPDVATICMGQAASAGALLLASGTKGKRYALPNARV
EEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCEEECCCCEE
MIHQPAGGVQGKATEAEIHIKELLRLRERLNEILSKHTGKSVEQISKDVEQDYFMTAEEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LEYGIIDEVITKNELKDK
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLIPVVVEQTNRGERSYDIYSRLLKDRIVFLGHPINDELSNLIIAQLLFLEAEDPDKDI
CCCCEEEECCCCCCCHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGSVTAALAMYDTIQYIKPDVATICMGQAASAGALLLASGTKGKRYALPNARV
EEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCEEECCCCEE
MIHQPAGGVQGKATEAEIHIKELLRLRERLNEILSKHTGKSVEQISKDVEQDYFMTAEEA
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LEYGIIDEVITKNELKDK
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA