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The map label for this gene is lon2 [H]

Identifier: 220932328

GI number: 220932328

Start: 1589869

End: 1591545

Strand: Reverse

Name: lon2 [H]

Synonym: Hore_14920

Alternate gene names: 220932328

Gene position: 1591545-1589869 (Counterclockwise)

Preceding gene: 220932329

Following gene: 220932327

Centisome position: 61.73

GC content: 45.92

Gene sequence:

>1677_bases
GTGGATCAAAATCTCTTAAATGTTTTTACGATTATTCAGTTTTTCTTTGCGGTGGTTATCGGTCTCTACTTCTGGAATAT
GCTTCGTAACCAGCAGGGTACTAAACGTGCTGTGGTTAAGGAATCAAGAAAGGAATTAAATAAATTGAGGGAGATGAGAA
GGATATCCCTCACTGAACCCCTGGCCGAAAAAACAAGGCCAACCGGGTTTGAGGACATAATAGGACAAAAAGAGGGGATT
GAGGCCCTGAAAGCAGCACTGTGTGGGCCCAATCCCCAGCATGTTATATTATATGGACCGCCAGGTGTCGGTAAAACCGC
AGCAGCCAGGCTGGTCCTGGAAACGGCCAAACGAAATCCCCTGTCACCCTTCAAACGTGATGCTAAATTTATTGAAATAG
ACGGGACTACGGCCCGTTTTGATGAAAGAAGTATTGCCGATCCCCTGATAGGTTCGGTCCATGACCCGATTTATCAGGGA
GCGGGTCCCATGGGGATGGCCGGTATACCCCAGCCGAAACCGGGGGCAGTTACCAAGGCCCACGGAGGAGTTCTTTTTAT
AGATGAAATCGGGGAACTACATCCCATTCAGATGAACAAGCTTTTAAAGGTACTTGAAGATAGAAAGGTTTTTCTTGATA
GTGCCTATTATAGTGAAGAGGATACCAATATACCTCAGTATATCCATGATATCTTTCAAAACGGTCTTCCGGCTGATTTC
AGGTTGATTGGTGCGACAACAAGACAGCCTGATGAAATTCCGCCGGCTATCAGGTCCAGGTGTCTTGAGATCTTCTTCAG
GGAACTGAGTACAGACGAAATAAGGAAGATTGCAGTGCGGGCTGTTAAAAAGATCAGGTTTAAAATTGAGGATAAGGCCC
TTGACCTTATTGAGAAATATGCCAAGAACGGGCGGGAAACGGTCAATATGGTTCAGCTGGCCGGTGGTATTGCTATTGCC
GGGCACCGTCAGGAAATAAAGGCTCATGATATTGAAAAGGTTTTAAATAACGGCCAGTATTCTCCCCGACTTATTAAAAA
GATTCATGGCTTTCCCCAGATAGGCGTTGTAAACGGCCTGGCCGTAAGGGGTCCCAATATCGGGATGTTACTGGAGATTG
AGGTTGCCGCCATAAAAAAAAGGTCTTCTCCGGGTCAGATTAAGATAACAGGTGTTATTGAGGAAGAGGAGATAGGGTCA
ATGGGGCATACGGTCCGCCGGAAAAGTATGGCCCGGGAGTCTGCCGAAAATGCCCTGACCGTGTTACGCCGGATGATGCC
GGTTGATCCCCATAATTATGATATCCATGTTAATTTCCCGGGAGGGATTCCGGTCGATGGCCCTTCAGCCGGGGTTGCCA
TGTCGGTGGCCATTTATTCAGCTATAACCAAAAAACCAGTTGATAACCATATTGCCATGACCGGTGAGGTTTCAATCAGG
GGTCTTGTTAAACCAGTTGGTGGAATCGCTGCCAAAATTGAGGCTGCCAGCAAAGCTGGAGCCAGAAAAGTGTTAATACC
CAGGGAAAACTGGCAGAACCTCTTTGAACTCAGGGATGATATTGAAATTATTCCGATAGAGACCCTGGAAGAGGCTATTG
AGAAATCGGTGGCTATAAAAGAAGATGAGAAAATAAAATTAATTAAAGCAGATAGTTTAATGACTGTTCCCCAATAA

Upstream 100 bases:

>100_bases
AGAAGAGACCGCTTAAGAAAAAAACTTGCCCCCTGAGGATAAAAATGCCAGATAAGGATATACTATTTTTTGAAGTTTAA
GTGAAAAGGGGGCAAAGTTG

Downstream 100 bases:

>100_bases
ATTTAACGAGCAGCATTGAATGTAACAGAGCGACAGGGGAAGGCTATCTGGAACTCTACATATAAATAGGCCCGGTAAAA
CTACAGGTTTGTCGCCTGTA

Product: Sporulation protease LonB

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MDQNLLNVFTIIQFFFAVVIGLYFWNMLRNQQGTKRAVVKESRKELNKLREMRRISLTEPLAEKTRPTGFEDIIGQKEGI
EALKAALCGPNPQHVILYGPPGVGKTAAARLVLETAKRNPLSPFKRDAKFIEIDGTTARFDERSIADPLIGSVHDPIYQG
AGPMGMAGIPQPKPGAVTKAHGGVLFIDEIGELHPIQMNKLLKVLEDRKVFLDSAYYSEEDTNIPQYIHDIFQNGLPADF
RLIGATTRQPDEIPPAIRSRCLEIFFRELSTDEIRKIAVRAVKKIRFKIEDKALDLIEKYAKNGRETVNMVQLAGGIAIA
GHRQEIKAHDIEKVLNNGQYSPRLIKKIHGFPQIGVVNGLAVRGPNIGMLLEIEVAAIKKRSSPGQIKITGVIEEEEIGS
MGHTVRRKSMARESAENALTVLRRMMPVDPHNYDIHVNFPGGIPVDGPSAGVAMSVAIYSAITKKPVDNHIAMTGEVSIR
GLVKPVGGIAAKIEAASKAGARKVLIPRENWQNLFELRDDIEIIPIETLEEAIEKSVAIKEDEKIKLIKADSLMTVPQ

Sequences:

>Translated_558_residues
MDQNLLNVFTIIQFFFAVVIGLYFWNMLRNQQGTKRAVVKESRKELNKLREMRRISLTEPLAEKTRPTGFEDIIGQKEGI
EALKAALCGPNPQHVILYGPPGVGKTAAARLVLETAKRNPLSPFKRDAKFIEIDGTTARFDERSIADPLIGSVHDPIYQG
AGPMGMAGIPQPKPGAVTKAHGGVLFIDEIGELHPIQMNKLLKVLEDRKVFLDSAYYSEEDTNIPQYIHDIFQNGLPADF
RLIGATTRQPDEIPPAIRSRCLEIFFRELSTDEIRKIAVRAVKKIRFKIEDKALDLIEKYAKNGRETVNMVQLAGGIAIA
GHRQEIKAHDIEKVLNNGQYSPRLIKKIHGFPQIGVVNGLAVRGPNIGMLLEIEVAAIKKRSSPGQIKITGVIEEEEIGS
MGHTVRRKSMARESAENALTVLRRMMPVDPHNYDIHVNFPGGIPVDGPSAGVAMSVAIYSAITKKPVDNHIAMTGEVSIR
GLVKPVGGIAAKIEAASKAGARKVLIPRENWQNLFELRDDIEIIPIETLEEAIEKSVAIKEDEKIKLIKADSLMTVPQ
>Mature_558_residues
MDQNLLNVFTIIQFFFAVVIGLYFWNMLRNQQGTKRAVVKESRKELNKLREMRRISLTEPLAEKTRPTGFEDIIGQKEGI
EALKAALCGPNPQHVILYGPPGVGKTAAARLVLETAKRNPLSPFKRDAKFIEIDGTTARFDERSIADPLIGSVHDPIYQG
AGPMGMAGIPQPKPGAVTKAHGGVLFIDEIGELHPIQMNKLLKVLEDRKVFLDSAYYSEEDTNIPQYIHDIFQNGLPADF
RLIGATTRQPDEIPPAIRSRCLEIFFRELSTDEIRKIAVRAVKKIRFKIEDKALDLIEKYAKNGRETVNMVQLAGGIAIA
GHRQEIKAHDIEKVLNNGQYSPRLIKKIHGFPQIGVVNGLAVRGPNIGMLLEIEVAAIKKRSSPGQIKITGVIEEEEIGS
MGHTVRRKSMARESAENALTVLRRMMPVDPHNYDIHVNFPGGIPVDGPSAGVAMSVAIYSAITKKPVDNHIAMTGEVSIR
GLVKPVGGIAAKIEAASKAGARKVLIPRENWQNLFELRDDIEIIPIETLEEAIEKSVAIKEDEKIKLIKADSLMTVPQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=215, Percent_Identity=30.6976744186047, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI21396489, Length=454, Percent_Identity=24.2290748898678, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1786643, Length=478, Percent_Identity=27.1966527196653, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17556486, Length=480, Percent_Identity=23.9583333333333, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17505831, Length=492, Percent_Identity=25.8130081300813, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319449, Length=89, Percent_Identity=39.3258426966292, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24666867, Length=503, Percent_Identity=26.2425447316103, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221513036, Length=503, Percent_Identity=26.2425447316103, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 61753; Mature: 61753

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQNLLNVFTIIQFFFAVVIGLYFWNMLRNQQGTKRAVVKESRKELNKLREMRRISLTEP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
LAEKTRPTGFEDIIGQKEGIEALKAALCGPNPQHVILYGPPGVGKTAAARLVLETAKRNP
HHHHCCCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCC
LSPFKRDAKFIEIDGTTARFDERSIADPLIGSVHDPIYQGAGPMGMAGIPQPKPGAVTKA
CCHHHCCCEEEEECCCEECCCCHHHCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEEC
HGGVLFIDEIGELHPIQMNKLLKVLEDRKVFLDSAYYSEEDTNIPQYIHDIFQNGLPADF
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCE
RLIGATTRQPDEIPPAIRSRCLEIFFRELSTDEIRKIAVRAVKKIRFKIEDKALDLIEKY
EEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKNGRETVNMVQLAGGIAIAGHRQEIKAHDIEKVLNNGQYSPRLIKKIHGFPQIGVVNGL
HHCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCE
AVRGPNIGMLLEIEVAAIKKRSSPGQIKITGVIEEEEIGSMGHTVRRKSMARESAENALT
EEECCCCCEEEEEEEHHHHCCCCCCEEEEEEEECHHHHCHHHHHHHHHHHHHHHHHHHHH
VLRRMMPVDPHNYDIHVNFPGGIPVDGPSAGVAMSVAIYSAITKKPVDNHIAMTGEVSIR
HHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCEEEH
GLVKPVGGIAAKIEAASKAGARKVLIPRENWQNLFELRDDIEIIPIETLEEAIEKSVAIK
HHHHHHCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCC
EDEKIKLIKADSLMTVPQ
CCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MDQNLLNVFTIIQFFFAVVIGLYFWNMLRNQQGTKRAVVKESRKELNKLREMRRISLTEP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
LAEKTRPTGFEDIIGQKEGIEALKAALCGPNPQHVILYGPPGVGKTAAARLVLETAKRNP
HHHHCCCCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCC
LSPFKRDAKFIEIDGTTARFDERSIADPLIGSVHDPIYQGAGPMGMAGIPQPKPGAVTKA
CCHHHCCCEEEEECCCEECCCCHHHCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEEC
HGGVLFIDEIGELHPIQMNKLLKVLEDRKVFLDSAYYSEEDTNIPQYIHDIFQNGLPADF
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCE
RLIGATTRQPDEIPPAIRSRCLEIFFRELSTDEIRKIAVRAVKKIRFKIEDKALDLIEKY
EEEECCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKNGRETVNMVQLAGGIAIAGHRQEIKAHDIEKVLNNGQYSPRLIKKIHGFPQIGVVNGL
HHCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCE
AVRGPNIGMLLEIEVAAIKKRSSPGQIKITGVIEEEEIGSMGHTVRRKSMARESAENALT
EEECCCCCEEEEEEEHHHHCCCCCCEEEEEEEECHHHHCHHHHHHHHHHHHHHHHHHHHH
VLRRMMPVDPHNYDIHVNFPGGIPVDGPSAGVAMSVAIYSAITKKPVDNHIAMTGEVSIR
HHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCEEEH
GLVKPVGGIAAKIEAASKAGARKVLIPRENWQNLFELRDDIEIIPIETLEEAIEKSVAIK
HHHHHHCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCC
EDEKIKLIKADSLMTVPQ
CCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]