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The map label for this gene is lon

Identifier: 220932327

GI number: 220932327

Start: 1587315

End: 1589666

Strand: Reverse

Name: lon

Synonym: Hore_14910

Alternate gene names: 220932327

Gene position: 1589666-1587315 (Counterclockwise)

Preceding gene: 220932328

Following gene: 220932326

Centisome position: 61.66

GC content: 43.84

Gene sequence:

>2352_bases
ATGGATCAGGAAATGGTTACAAAAGAAACAGAAAAATACATAGAGCTACCTCTACTGGCCTCACGTGGGGTTGTTGTTTT
TCCCCATATGGTTATCCCGTTACTGGTTGGGCGGGAGAAGTCCATTGAGGCCCTGGAGAAAGCCATGGTTAAAGATAAAG
AGATTATTATTTTAAGTCAGAAGGATGAAAAGATTGAAGATCCGGATCCCGAAGATTTATATACCATCGGGACTATTGCC
GAGGTAAAACAGCTGGTTAAACTCCCCAATGGAATGTTAAAGGTTGTCGTCGAGGGGATAAAGAGGGCCAGGATTATAGA
TTTCATTGAAATAGATGAATATTTTGAAGTTCGGGCTGAAATCCTGGATCAGACGGTGCCTGAAGTGGATTTAGAAATGA
AAGCTCTGATGAAGGCGGTTTTAAATAAATTTCAGGAATATATTAAATATAACCGGAATTTACCGTCAGAAACAATTATG
ACAGTTACCAATATAGAAGAGCCGGCCCGTTTCAGTGATACTATTGCCTCTCATCTGGAGTTGAAATTCAGGCAGGAACA
GGACCTGCTTGAGGCTATATCTATAAAAGAGAGGTTAAACAAGCTTCTGGAGATTATTAAAGATGAGATAGAAATTTTAA
AAGTTGAACAAAAGATTCAGAAAAAAGTAAGGAAACAGGTTGAAAAGACCCAGAAGGAATACTATCTACGGGAACAGCTT
AAAGCCATTAAAGAAGAGCTGGATGAGGATGAAGAAGATGATGAGATTGAAGAATATAGAAATAAGGCAGAAGAGCTGGA
CTTACCTGAAAAAATCAGGGAGAAAGTCGATAAAGAGATTGAGAAATTAAAAAAGACTCCCTCCATGTCTCCTGAAGCTA
CTGTTATCAGGAATTATCTTGATTGTGTCCTCGATCTTCCCTGGAATAAAGTCCGGGAAGAGAAGATTGACCTTGATGAG
GCTAAAAATGTCCTCGATAGTGAGCATTATGGTCTTGAAGATGTTAAAGAAAGGATACTGGAATACCTGGCTGTCCGGAA
GCTTGCCCCCCAGAAAAAAAGCCCTATTCTATGTTTAATCGGGGCTCCCGGGGTAGGTAAAACATCCCTGGGCCGTTCTA
TAGCCAGAGCTCTGGGCCGTGATTTTGTCAGGTTGTCCCTTGGTGGTGTCAGGGATGAAGCTGAAATCAGGGGTCACCGC
CGCACCTATATTGGTTCCCGTCCCGGACGAATTATCAATGCTATGAGAGAAGCGGGTAGCAAAAACCCCGTTTTTCTACT
GGATGAAGTTGATAAAATGTCCTCAGACTTCAGGGGTGATCCGGCTGCTGCCTTACTGGAGGTTTTAGACCCAGAGCAGA
ATAATGAATTTACAGACCATTATCTGGAATTACCTTTTGATCTATCAAAGGTATTGTTTGTGACGACTGCCAATGTTGCT
TATCCGATTCCGGCTCCATTACTGGACCGGATGGAAGTTATAGAGCTCCCCGGTTATACCGAGGATGAAAAAGTTGAAAT
TGCCTTAAGGCACCTGATTCCCAGAATATTAAATGAACATGGGTTAACTGAAGATGAGATACATTTTTCTTCTAATTCTA
TTTACCGGATTATCAGGGAGTATACCCGTGAGGCCGGGGTTAGAAATCTGGAACGGAAGCTGGCCGCTATCACCAGAAAG
GTCAGTAAAGAGATCGTGGAGGGGCGCGGCCGTCAGGCCCGGGTGACCACCCAGAGTATTGAAAAATATCTCGGGGTTCC
AAAATTTAAATATGAAAAAGCCCAGAAAAAGGACAGGGTCGGTGTAGCCACAGGGATGGCCTATACCCAGACCGGAGGAG
ATATCCTGGATATCGAAGTGGCAGTGGTCCCCGGTAAGGGGAAATTAACCTTAACCGGTTCCCTCGGTGATGTTATGAAA
GAGTCAGCCAGGGCAGCGTTAAGCTATATACGTTCCAAGCAGGAAGAGCTGGGTCTGTCTGATAACTTTCATGAAGAGTA
TGACCTCCATGTCCACGTACCCAAGGGAGCAACCCCGAAGGATGGACCCTCAGCCGGAATAACTATTGCCTCGGCTATAG
CGTCTGCCCTGACCGGGCAACCTGTCAAGGGGAAATATGCCATGACCGGTGAAGTTACCTTAAGGGGCCGGGTCCTTCCG
GTAGGTGGAATTAAGACTAAGATTATGGCAGCAAGACGGGCCGGACTTAAAGATATAATTATGCCGGAAGAGAATAAAAA
GGATTTTGAGGAAATACCGGTCAAAATAAAGAAAGATATCAGGGTTAATTTTGTTAACCATATGGATCAGGTCCTTGATC
TCATACTGGGTGGTGATGAAGATGAAAATTAA

Upstream 100 bases:

>100_bases
TTTTTTGGGATTTATACAGGGGTTATAAAAAAATAATAATGTAATATAAATGAAGGAGACAGGGGCTTTTAGGAGAATTT
ACTTATAAGGGGTGAAATAT

Downstream 100 bases:

>100_bases
AAATCCTAGGTTTGTTATCAGTGCCTATGATTTTGATGATTTTCCAACCCATAACTGGCCTGAATTTGCCTTTTCCGGAC
GTTCCAATGTCGGAAAGTCT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MDQEMVTKETEKYIELPLLASRGVVVFPHMVIPLLVGREKSIEALEKAMVKDKEIIILSQKDEKIEDPDPEDLYTIGTIA
EVKQLVKLPNGMLKVVVEGIKRARIIDFIEIDEYFEVRAEILDQTVPEVDLEMKALMKAVLNKFQEYIKYNRNLPSETIM
TVTNIEEPARFSDTIASHLELKFRQEQDLLEAISIKERLNKLLEIIKDEIEILKVEQKIQKKVRKQVEKTQKEYYLREQL
KAIKEELDEDEEDDEIEEYRNKAEELDLPEKIREKVDKEIEKLKKTPSMSPEATVIRNYLDCVLDLPWNKVREEKIDLDE
AKNVLDSEHYGLEDVKERILEYLAVRKLAPQKKSPILCLIGAPGVGKTSLGRSIARALGRDFVRLSLGGVRDEAEIRGHR
RTYIGSRPGRIINAMREAGSKNPVFLLDEVDKMSSDFRGDPAAALLEVLDPEQNNEFTDHYLELPFDLSKVLFVTTANVA
YPIPAPLLDRMEVIELPGYTEDEKVEIALRHLIPRILNEHGLTEDEIHFSSNSIYRIIREYTREAGVRNLERKLAAITRK
VSKEIVEGRGRQARVTTQSIEKYLGVPKFKYEKAQKKDRVGVATGMAYTQTGGDILDIEVAVVPGKGKLTLTGSLGDVMK
ESARAALSYIRSKQEELGLSDNFHEEYDLHVHVPKGATPKDGPSAGITIASAIASALTGQPVKGKYAMTGEVTLRGRVLP
VGGIKTKIMAARRAGLKDIIMPEENKKDFEEIPVKIKKDIRVNFVNHMDQVLDLILGGDEDEN

Sequences:

>Translated_783_residues
MDQEMVTKETEKYIELPLLASRGVVVFPHMVIPLLVGREKSIEALEKAMVKDKEIIILSQKDEKIEDPDPEDLYTIGTIA
EVKQLVKLPNGMLKVVVEGIKRARIIDFIEIDEYFEVRAEILDQTVPEVDLEMKALMKAVLNKFQEYIKYNRNLPSETIM
TVTNIEEPARFSDTIASHLELKFRQEQDLLEAISIKERLNKLLEIIKDEIEILKVEQKIQKKVRKQVEKTQKEYYLREQL
KAIKEELDEDEEDDEIEEYRNKAEELDLPEKIREKVDKEIEKLKKTPSMSPEATVIRNYLDCVLDLPWNKVREEKIDLDE
AKNVLDSEHYGLEDVKERILEYLAVRKLAPQKKSPILCLIGAPGVGKTSLGRSIARALGRDFVRLSLGGVRDEAEIRGHR
RTYIGSRPGRIINAMREAGSKNPVFLLDEVDKMSSDFRGDPAAALLEVLDPEQNNEFTDHYLELPFDLSKVLFVTTANVA
YPIPAPLLDRMEVIELPGYTEDEKVEIALRHLIPRILNEHGLTEDEIHFSSNSIYRIIREYTREAGVRNLERKLAAITRK
VSKEIVEGRGRQARVTTQSIEKYLGVPKFKYEKAQKKDRVGVATGMAYTQTGGDILDIEVAVVPGKGKLTLTGSLGDVMK
ESARAALSYIRSKQEELGLSDNFHEEYDLHVHVPKGATPKDGPSAGITIASAIASALTGQPVKGKYAMTGEVTLRGRVLP
VGGIKTKIMAARRAGLKDIIMPEENKKDFEEIPVKIKKDIRVNFVNHMDQVLDLILGGDEDEN
>Mature_783_residues
MDQEMVTKETEKYIELPLLASRGVVVFPHMVIPLLVGREKSIEALEKAMVKDKEIIILSQKDEKIEDPDPEDLYTIGTIA
EVKQLVKLPNGMLKVVVEGIKRARIIDFIEIDEYFEVRAEILDQTVPEVDLEMKALMKAVLNKFQEYIKYNRNLPSETIM
TVTNIEEPARFSDTIASHLELKFRQEQDLLEAISIKERLNKLLEIIKDEIEILKVEQKIQKKVRKQVEKTQKEYYLREQL
KAIKEELDEDEEDDEIEEYRNKAEELDLPEKIREKVDKEIEKLKKTPSMSPEATVIRNYLDCVLDLPWNKVREEKIDLDE
AKNVLDSEHYGLEDVKERILEYLAVRKLAPQKKSPILCLIGAPGVGKTSLGRSIARALGRDFVRLSLGGVRDEAEIRGHR
RTYIGSRPGRIINAMREAGSKNPVFLLDEVDKMSSDFRGDPAAALLEVLDPEQNNEFTDHYLELPFDLSKVLFVTTANVA
YPIPAPLLDRMEVIELPGYTEDEKVEIALRHLIPRILNEHGLTEDEIHFSSNSIYRIIREYTREAGVRNLERKLAAITRK
VSKEIVEGRGRQARVTTQSIEKYLGVPKFKYEKAQKKDRVGVATGMAYTQTGGDILDIEVAVVPGKGKLTLTGSLGDVMK
ESARAALSYIRSKQEELGLSDNFHEEYDLHVHVPKGATPKDGPSAGITIASAIASALTGQPVKGKYAMTGEVTLRGRVLP
VGGIKTKIMAARRAGLKDIIMPEENKKDFEEIPVKIKKDIRVNFVNHMDQVLDLILGGDEDEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=828, Percent_Identity=39.7342995169082, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI21396489, Length=835, Percent_Identity=37.9640718562874, Blast_Score=551, Evalue=1e-157,
Organism=Escherichia coli, GI1786643, Length=771, Percent_Identity=52.2697795071336, Blast_Score=822, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=716, Percent_Identity=38.268156424581, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=784, Percent_Identity=33.8010204081633, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=709, Percent_Identity=39.0691114245416, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI221513036, Length=658, Percent_Identity=43.4650455927052, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=658, Percent_Identity=43.4650455927052, Blast_Score=530, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_HALOH (B8CY71)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002509235.1
- ProteinModelPortal:   B8CY71
- MEROPS:   S16.001
- GeneID:   7313082
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_14910
- HOGENOM:   HBG566281
- OMA:   IDPDFHE
- ProtClustDB:   CLSK2806466
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 88820; Mature: 88820

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 684-684 ACT_SITE 727-727

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQEMVTKETEKYIELPLLASRGVVVFPHMVIPLLVGREKSIEALEKAMVKDKEIIILSQ
CCCHHHHHHHHHHHHCCHHHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEC
KDEKIEDPDPEDLYTIGTIAEVKQLVKLPNGMLKVVVEGIKRARIIDFIEIDEYFEVRAE
CCCCCCCCCCCHHEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILDQTVPEVDLEMKALMKAVLNKFQEYIKYNRNLPSETIMTVTNIEEPARFSDTIASHLE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCHHHHHHHHHHHH
LKFRQEQDLLEAISIKERLNKLLEIIKDEIEILKVEQKIQKKVRKQVEKTQKEYYLREQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAIKEELDEDEEDDEIEEYRNKAEELDLPEKIREKVDKEIEKLKKTPSMSPEATVIRNYL
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DCVLDLPWNKVREEKIDLDEAKNVLDSEHYGLEDVKERILEYLAVRKLAPQKKSPILCLI
HHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GAPGVGKTSLGRSIARALGRDFVRLSLGGVRDEAEIRGHRRTYIGSRPGRIINAMREAGS
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCC
KNPVFLLDEVDKMSSDFRGDPAAALLEVLDPEQNNEFTDHYLELPFDLSKVLFVTTANVA
CCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHEEECCCC
YPIPAPLLDRMEVIELPGYTEDEKVEIALRHLIPRILNEHGLTEDEIHFSSNSIYRIIRE
CCCCHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHH
YTREAGVRNLERKLAAITRKVSKEIVEGRGRQARVTTQSIEKYLGVPKFKYEKAQKKDRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHCCC
GVATGMAYTQTGGDILDIEVAVVPGKGKLTLTGSLGDVMKESARAALSYIRSKQEELGLS
CHHHCCEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
DNFHEEYDLHVHVPKGATPKDGPSAGITIASAIASALTGQPVKGKYAMTGEVTLRGRVLP
CCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEEE
VGGIKTKIMAARRAGLKDIIMPEENKKDFEEIPVKIKKDIRVNFVNHMDQVLDLILGGDE
CCCHHHHHHHHHHCCCHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEN
CCC
>Mature Secondary Structure
MDQEMVTKETEKYIELPLLASRGVVVFPHMVIPLLVGREKSIEALEKAMVKDKEIIILSQ
CCCHHHHHHHHHHHHCCHHHCCCEEEEHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEC
KDEKIEDPDPEDLYTIGTIAEVKQLVKLPNGMLKVVVEGIKRARIIDFIEIDEYFEVRAE
CCCCCCCCCCCHHEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILDQTVPEVDLEMKALMKAVLNKFQEYIKYNRNLPSETIMTVTNIEEPARFSDTIASHLE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCHHHHHHHHHHHH
LKFRQEQDLLEAISIKERLNKLLEIIKDEIEILKVEQKIQKKVRKQVEKTQKEYYLREQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAIKEELDEDEEDDEIEEYRNKAEELDLPEKIREKVDKEIEKLKKTPSMSPEATVIRNYL
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DCVLDLPWNKVREEKIDLDEAKNVLDSEHYGLEDVKERILEYLAVRKLAPQKKSPILCLI
HHHHCCCHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GAPGVGKTSLGRSIARALGRDFVRLSLGGVRDEAEIRGHRRTYIGSRPGRIINAMREAGS
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCC
KNPVFLLDEVDKMSSDFRGDPAAALLEVLDPEQNNEFTDHYLELPFDLSKVLFVTTANVA
CCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHEEECCCC
YPIPAPLLDRMEVIELPGYTEDEKVEIALRHLIPRILNEHGLTEDEIHFSSNSIYRIIRE
CCCCHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHH
YTREAGVRNLERKLAAITRKVSKEIVEGRGRQARVTTQSIEKYLGVPKFKYEKAQKKDRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHCCC
GVATGMAYTQTGGDILDIEVAVVPGKGKLTLTGSLGDVMKESARAALSYIRSKQEELGLS
CHHHCCEEECCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
DNFHEEYDLHVHVPKGATPKDGPSAGITIASAIASALTGQPVKGKYAMTGEVTLRGRVLP
CCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEEE
VGGIKTKIMAARRAGLKDIIMPEENKKDFEEIPVKIKKDIRVNFVNHMDQVLDLILGGDE
CCCHHHHHHHHHHCCCHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA