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The map label for this gene is dtd

Identifier: 220932055

GI number: 220932055

Start: 1311323

End: 1311772

Strand: Reverse

Name: dtd

Synonym: Hore_12180

Alternate gene names: 220932055

Gene position: 1311772-1311323 (Counterclockwise)

Preceding gene: 220932056

Following gene: 220932054

Centisome position: 50.88

GC content: 36.89

Gene sequence:

>450_bases
ATGAGGGCTGTTGTTCAACGGGTAAAAGAAGCCAGTGTTACTGTTGCAGGTGATATAAAAGGAAAAATAGATAAGGGTTT
ACTTGTCTTTGTGGGAATTGGAGAAGGTGATACTGAAGAAGATGTCAGATATCTGGTAGATAAAATAGTAAATCTGAGAA
TTTTTGAAGATGATACTCATAAAATGAATCTTTCTGCCCTGGACCTTAACAGGGAAATACTGGCTGTGTCCCAGTTTACC
CTGTATGGTGATTGTCGGAAAGGAAGGAGACCTAATTTTACTGGAGCTGCTAAACCCCGGTATGCTGAAAAAATGTATGA
TACTTTTGTGAAATTCCTGAAAAATACCGGTCTCAAGGTAGAAGAAGGCGTATTTCAGGCAATGATGGAAGTAAATCTAA
TAAATGATGGACCTGTAACCATTTTACTTGATAGTAATAAACAATTTTAA

Upstream 100 bases:

>100_bases
TAAGCAGTCTGGAGCATATGAGGGATATTATAAATAAACTTGAAAAAATAACTGGTGTTCTTTCTGTTAAACGGGCAAAA
CCAACCTAAGGAGTGATGTT

Downstream 100 bases:

>100_bases
GGTGGTGACCTTATTTGATTTTTAAGAGAGTACCGGTCGGGGTCAATTATACTAACTCCTATATAATAGGACAGGAAGAT
GGTAATGGAATAATAGTAGA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MRAVVQRVKEASVTVAGDIKGKIDKGLLVFVGIGEGDTEEDVRYLVDKIVNLRIFEDDTHKMNLSALDLNREILAVSQFT
LYGDCRKGRRPNFTGAAKPRYAEKMYDTFVKFLKNTGLKVEEGVFQAMMEVNLINDGPVTILLDSNKQF

Sequences:

>Translated_149_residues
MRAVVQRVKEASVTVAGDIKGKIDKGLLVFVGIGEGDTEEDVRYLVDKIVNLRIFEDDTHKMNLSALDLNREILAVSQFT
LYGDCRKGRRPNFTGAAKPRYAEKMYDTFVKFLKNTGLKVEEGVFQAMMEVNLINDGPVTILLDSNKQF
>Mature_149_residues
MRAVVQRVKEASVTVAGDIKGKIDKGLLVFVGIGEGDTEEDVRYLVDKIVNLRIFEDDTHKMNLSALDLNREILAVSQFT
LYGDCRKGRRPNFTGAAKPRYAEKMYDTFVKFLKNTGLKVEEGVFQAMMEVNLINDGPVTILLDSNKQF

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=149, Percent_Identity=44.9664429530201, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=43.3566433566434, Blast_Score=125, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=44.3708609271523, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319982, Length=150, Percent_Identity=40, Blast_Score=110, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281361569, Length=150, Percent_Identity=47.3333333333333, Blast_Score=126, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_HALOH (B8CXE9)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508963.1
- GeneID:   7313919
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_12180
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16763; Mature: 16763

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVQRVKEASVTVAGDIKGKIDKGLLVFVGIGEGDTEEDVRYLVDKIVNLRIFEDDTH
CHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEEECCCC
KMNLSALDLNREILAVSQFTLYGDCRKGRRPNFTGAAKPRYAEKMYDTFVKFLKNTGLKV
EEEEEEECCCCEEEEEEHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
EEGVFQAMMEVNLINDGPVTILLDSNKQF
HHHHHHHHHHHEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MRAVVQRVKEASVTVAGDIKGKIDKGLLVFVGIGEGDTEEDVRYLVDKIVNLRIFEDDTH
CHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEEECCCC
KMNLSALDLNREILAVSQFTLYGDCRKGRRPNFTGAAKPRYAEKMYDTFVKFLKNTGLKV
EEEEEEECCCCEEEEEEHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
EEGVFQAMMEVNLINDGPVTILLDSNKQF
HHHHHHHHHHHEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA