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The map label for this gene is pyrE [H]

Identifier: 220931786

GI number: 220931786

Start: 1015778

End: 1016359

Strand: Direct

Name: pyrE [H]

Synonym: Hore_09430

Alternate gene names: 220931786

Gene position: 1015778-1016359 (Clockwise)

Preceding gene: 220931785

Following gene: 220931787

Centisome position: 39.4

GC content: 41.92

Gene sequence:

>582_bases
ATGTTGAAACAGGACAGAATTATTGAAATTTTTAAAAAAACCGGTGTTCTCAGGGAAGGACACTTTCTACTGAGTTCGGG
AAGGCATGCTGAAAAATACCTCCAGTGTGCCCGTGTCTTGCAATACCCTGAATACGCCAATGAACTGGCAGAAGGAATTG
CTCAATTTTGGGAAGATGATAATCTTGATGTCGTTATTGGTCCAGCTATTGGGGGTATTGTTGTTTCCTATGCCGTTGGA
CAGGCTTTAGGAATCAGGGCTATTTTTGCAGAAAGGGAAAATGGTCAAATGGCATTAAGGCGTAATTTCAAAATTGAAGT
TGGTGAAAGGATACTGGTTGTTGAAGATGTGGTCACAACAGGTGGTTCGGTTAAGGAAGTACTCCAGCTACTCGAGAAAA
CAGGAGGTACCATTGTAGGCGTAAGTTCCCTTGTCGACCGGAGTGCCGGTAAGGTTGATTTTAAATACCCCTATCGTCCT
TTAATTAAACTTGATATCAAGTCATATTTACCTGAAGAATGCCCCCTTTGCCAACAGGGTTATGAGGTTGAAAAACCTGG
TAGTAGAAATATCCAGTCTTGA

Upstream 100 bases:

>100_bases
TGAGAGAATAGGGGAGTTGAAAGGAAAGGCTTTATAAATATACTCTAAACAGGTAGTCCAGAAATTATGTTTACAATTTT
ATAAAAGGAAGGTGGTATTA

Downstream 100 bases:

>100_bases
TTTACCTTATTGAGTTGTAAATGTGGTAATGTTATAATAGGAATGTTAAAAGATTATTTATTATTTCAGTACCTCTTATA
ATTTGTATTTTGTTATAATT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MLKQDRIIEIFKKTGVLREGHFLLSSGRHAEKYLQCARVLQYPEYANELAEGIAQFWEDDNLDVVIGPAIGGIVVSYAVG
QALGIRAIFAERENGQMALRRNFKIEVGERILVVEDVVTTGGSVKEVLQLLEKTGGTIVGVSSLVDRSAGKVDFKYPYRP
LIKLDIKSYLPEECPLCQQGYEVEKPGSRNIQS

Sequences:

>Translated_193_residues
MLKQDRIIEIFKKTGVLREGHFLLSSGRHAEKYLQCARVLQYPEYANELAEGIAQFWEDDNLDVVIGPAIGGIVVSYAVG
QALGIRAIFAERENGQMALRRNFKIEVGERILVVEDVVTTGGSVKEVLQLLEKTGGTIVGVSSLVDRSAGKVDFKYPYRP
LIKLDIKSYLPEECPLCQQGYEVEKPGSRNIQS
>Mature_193_residues
MLKQDRIIEIFKKTGVLREGHFLLSSGRHAEKYLQCARVLQYPEYANELAEGIAQFWEDDNLDVVIGPAIGGIVVSYAVG
QALGIRAIFAERENGQMALRRNFKIEVGERILVVEDVVTTGGSVKEVLQLLEKTGGTIVGVSSLVDRSAGKVDFKYPYRP
LIKLDIKSYLPEECPLCQQGYEVEKPGSRNIQS

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21472; Mature: 21472

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQDRIIEIFKKTGVLREGHFLLSSGRHAEKYLQCARVLQYPEYANELAEGIAQFWEDD
CCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCC
NLDVVIGPAIGGIVVSYAVGQALGIRAIFAERENGQMALRRNFKIEVGERILVVEDVVTT
CCCEEECCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCEEECCCEEEEEEHHHHC
GGSVKEVLQLLEKTGGTIVGVSSLVDRSAGKVDFKYPYRPLIKLDIKSYLPEECPLCQQG
CCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCEEEECCCCCCEEEEHHHHCCCCCCCCCCC
YEVEKPGSRNIQS
CCCCCCCCCCCCC
>Mature Secondary Structure
MLKQDRIIEIFKKTGVLREGHFLLSSGRHAEKYLQCARVLQYPEYANELAEGIAQFWEDD
CCCHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCC
NLDVVIGPAIGGIVVSYAVGQALGIRAIFAERENGQMALRRNFKIEVGERILVVEDVVTT
CCCEEECCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCEEECCCEEEEEEHHHHC
GGSVKEVLQLLEKTGGTIVGVSSLVDRSAGKVDFKYPYRPLIKLDIKSYLPEECPLCQQG
CCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCEEEECCCCCCEEEEHHHHCCCCCCCCCCC
YEVEKPGSRNIQS
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]