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The map label for this gene is pyrD [H]

Identifier: 220931785

GI number: 220931785

Start: 1014800

End: 1015714

Strand: Direct

Name: pyrD [H]

Synonym: Hore_09420

Alternate gene names: 220931785

Gene position: 1014800-1015714 (Clockwise)

Preceding gene: 220931784

Following gene: 220931786

Centisome position: 39.36

GC content: 41.09

Gene sequence:

>915_bases
ATGGACAGGATTGATCTTTCAGTTGATCTTGGTCCTTTAAGTTTAAAAAATCCAGTTATGACTGCTTCCGGTACCTGTGG
ATATGGTATTGAGTTTAAAGATTATTATGATCTCAATAAGCTCGGGGCGATTGTTATTAAAGGTTTAACTCTGAAACCAT
GTTCAGGTAATTTAAATCCAAGGATTGCAGAAACCACTGGTGGTCTTTTAAATTCAATAGGACTTGAAAACCCGGGTATA
GAGTCCTTTATTAAAAATTATATAGGGGTACTGCGGGATTTTAAAATACCGGTCATTGTTAATATTTCGGGACATGCTGT
AGAAGATTTTGCCCGCCTGGCCGATAAACTTGCTCCCTATTCTGAGATATCAGCTCTGGAAGTTAATGTCTCCTGTCCAA
ACCTGGCAGGTGGGGGAATGGCTTTTGGAACAGATAGTGAACTGGTTTATAGAGTTACAAAGAAGGTTAAAGAAAACTAC
CCGGGGTCTGTTATTGTTAAATTATCCCCCAATGTTACTGATATTGTAGAAATTGCCCGGGCTGCTGAATCAGCTGGGGC
AGATGTTTTATCCCTTATAAATACTTTACTGGGGATGGCGATAGATGTAGAAAAACAAAAGCCTGTCCTGGGAAATATTT
TCGGGGGGTTATCCGGGCCTGCCATAAAACCGGTAGCCTTAAGAATGGTTTACCAGGTGGCTCAACAGGTTGAAATTCCT
ATTATCGGAATGGGGGGGATTATGTCCGGAAAAGATGCCCTTGAATTTATTCTTGCCGGGGCCAGTGCTGTAGCAGTAGG
CACTGCAAATCTGGTTGATCCCCTGGCCGGTCAAAAGGTTTTACGTGAGATACATGACTATCTTATTAAACATAATATTG
AGAGAATAGGGGAGTTGAAAGGAAAGGCTTTATAA

Upstream 100 bases:

>100_bases
GGGTATGGTGTCTGTTTATCCTGTGTTTGCAACACTGAAAAAGGTAACCAGCGTGTCTGTAAGGAAGGGCCTGTTTTTAA
CATTAATGAGGTGATTTTTG

Downstream 100 bases:

>100_bases
ATATACTCTAAACAGGTAGTCCAGAAATTATGTTTACAATTTTATAAAAGGAAGGTGGTATTAATGTTGAAACAGGACAG
AATTATTGAAATTTTTAAAA

Product: dihydroorotate oxidase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MDRIDLSVDLGPLSLKNPVMTASGTCGYGIEFKDYYDLNKLGAIVIKGLTLKPCSGNLNPRIAETTGGLLNSIGLENPGI
ESFIKNYIGVLRDFKIPVIVNISGHAVEDFARLADKLAPYSEISALEVNVSCPNLAGGGMAFGTDSELVYRVTKKVKENY
PGSVIVKLSPNVTDIVEIARAAESAGADVLSLINTLLGMAIDVEKQKPVLGNIFGGLSGPAIKPVALRMVYQVAQQVEIP
IIGMGGIMSGKDALEFILAGASAVAVGTANLVDPLAGQKVLREIHDYLIKHNIERIGELKGKAL

Sequences:

>Translated_304_residues
MDRIDLSVDLGPLSLKNPVMTASGTCGYGIEFKDYYDLNKLGAIVIKGLTLKPCSGNLNPRIAETTGGLLNSIGLENPGI
ESFIKNYIGVLRDFKIPVIVNISGHAVEDFARLADKLAPYSEISALEVNVSCPNLAGGGMAFGTDSELVYRVTKKVKENY
PGSVIVKLSPNVTDIVEIARAAESAGADVLSLINTLLGMAIDVEKQKPVLGNIFGGLSGPAIKPVALRMVYQVAQQVEIP
IIGMGGIMSGKDALEFILAGASAVAVGTANLVDPLAGQKVLREIHDYLIKHNIERIGELKGKAL
>Mature_304_residues
MDRIDLSVDLGPLSLKNPVMTASGTCGYGIEFKDYYDLNKLGAIVIKGLTLKPCSGNLNPRIAETTGGLLNSIGLENPGI
ESFIKNYIGVLRDFKIPVIVNISGHAVEDFARLADKLAPYSEISALEVNVSCPNLAGGGMAFGTDSELVYRVTKKVKENY
PGSVIVKLSPNVTDIVEIARAAESAGADVLSLINTLLGMAIDVEKQKPVLGNIFGGLSGPAIKPVALRMVYQVAQQVEIP
IIGMGGIMSGKDALEFILAGASAVAVGTANLVDPLAGQKVLREIHDYLIKHNIERIGELKGKAL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=358, Percent_Identity=29.3296089385475, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI45006951, Length=300, Percent_Identity=31, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87082059, Length=282, Percent_Identity=29.7872340425532, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71984108, Length=300, Percent_Identity=28.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322633, Length=301, Percent_Identity=30.2325581395349, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640763, Length=293, Percent_Identity=34.1296928327645, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18858217, Length=293, Percent_Identity=34.1296928327645, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281361352, Length=277, Percent_Identity=29.6028880866426, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137316, Length=277, Percent_Identity=29.6028880866426, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32156; Mature: 32156

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIDLSVDLGPLSLKNPVMTASGTCGYGIEFKDYYDLNKLGAIVIKGLTLKPCSGNLNP
CCCEEEEEECCCCCCCCCCEECCCCCCCCCCCHHHCCHHHHHHHHEECCEECCCCCCCCC
RIAETTGGLLNSIGLENPGIESFIKNYIGVLRDFKIPVIVNISGHAVEDFARLADKLAPY
EEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCC
SEISALEVNVSCPNLAGGGMAFGTDSELVYRVTKKVKENYPGSVIVKLSPNVTDIVEIAR
HHCCEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
AAESAGADVLSLINTLLGMAIDVEKQKPVLGNIFGGLSGPAIKPVALRMVYQVAQQVEIP
HHHHCCHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
IIGMGGIMSGKDALEFILAGASAVAVGTANLVDPLAGQKVLREIHDYLIKHNIERIGELK
EEECCCCCCCHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKAL
CCCC
>Mature Secondary Structure
MDRIDLSVDLGPLSLKNPVMTASGTCGYGIEFKDYYDLNKLGAIVIKGLTLKPCSGNLNP
CCCEEEEEECCCCCCCCCCEECCCCCCCCCCCHHHCCHHHHHHHHEECCEECCCCCCCCC
RIAETTGGLLNSIGLENPGIESFIKNYIGVLRDFKIPVIVNISGHAVEDFARLADKLAPY
EEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCC
SEISALEVNVSCPNLAGGGMAFGTDSELVYRVTKKVKENYPGSVIVKLSPNVTDIVEIAR
HHCCEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
AAESAGADVLSLINTLLGMAIDVEKQKPVLGNIFGGLSGPAIKPVALRMVYQVAQQVEIP
HHHHCCHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
IIGMGGIMSGKDALEFILAGASAVAVGTANLVDPLAGQKVLREIHDYLIKHNIERIGELK
EEECCCCCCCHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKAL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA