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The map label for this gene is pheA [H]

Identifier: 220931039

GI number: 220931039

Start: 196169

End: 197080

Strand: Direct

Name: pheA [H]

Synonym: Hore_01900

Alternate gene names: 220931039

Gene position: 196169-197080 (Clockwise)

Preceding gene: 220931038

Following gene: 220931040

Centisome position: 7.61

GC content: 42.0

Gene sequence:

>912_bases
TTGTGTCCAGCGCGATACGGGTATTTAGGACCTGGAGGCACCTTCTGTGAAAAGGCAGCCCTTAAGTATTTTGGAGGGGG
TCATGAGATGATTTCTTTCCGGACGATAAAAGAAGTCGTCCGGAATGTCAAAGAAGGCTCCATTGAAAAGGGGGTTATTC
CCCTGGAAAACTCACTCGAAGGGTCGGTCAATTTAAGCCTTGACCTGCTTGTTAAGGAATCAAACATAATTATAACCGGT
GAAGTAATTATTCCGATAAACCATAATTTAATAGGCCAGAAAGGGTTGGAAGTAGGTAACATAAAGAAGGTTTTGTCCCA
TCCCCAGGCCATTGCCCAGACGGCTGATTTTATAGAAGAAAACCTACCTCAGGCCGAAATTATTTATACGGAAAGTACCG
CTGCTGCCGCAGAGTGTGCTTTAAAAAACAGGGAGTTAGCTGTTATCGGGTCAGACCAGATTGCCCATCTGTATGGATTA
AGTGTAATAGCAGAGGGTATCCAGGATGATGATGAGAACTACACACGGTTTATAATTATCTCCCGGAGTAAAGGTAAATT
CTTTTACAGTACGGGCTATAATAATTATCAGGATACAAAGAAAATGTATAAAACATCTATTGTCTGTACCCCTGAGGTAA
ATAAGCCCGGGGTTCTTTACGAAATGCTGGGTGAATTTGCAGCTCGAAAAATAAATTTGACCAGGATAGAATCACGACCG
ACCAGGAAAAAGCTGGGGGAATATCTGTTCTATATTGACCTTGAGGGTCATTACCATGACCCACTGGTGGCCGGAGCCCT
GAAAGAAGTGAGAAATATGTCCGGACTCTTTAAAATACTGGGTTGTTATTTTAAGGATAATATTAAAGAAGGGAGTAGTG
AGAAGGATGCTAAATGTAAAAAGAGGGCTTAA

Upstream 100 bases:

>100_bases
TGACCAAAAAGGATGGTACCGCGGGATAATAAACCTCGTTCCTTCATGGGAACGGGGTTTTTTGTATTTATAGTAAAAAA
TGAGTAGGGAGGAGATATTA

Downstream 100 bases:

>100_bases
AAGCTGGAAAAGAATTGTCAGGGATGAGGTTCACAATATCAAACCCTATATCCCTGGAAAACCTATCAAAGAGGTTAAAG
AAGAGCTGGGTCTGGCTGAA

Product: Prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MCPARYGYLGPGGTFCEKAALKYFGGGHEMISFRTIKEVVRNVKEGSIEKGVIPLENSLEGSVNLSLDLLVKESNIIITG
EVIIPINHNLIGQKGLEVGNIKKVLSHPQAIAQTADFIEENLPQAEIIYTESTAAAAECALKNRELAVIGSDQIAHLYGL
SVIAEGIQDDDENYTRFIIISRSKGKFFYSTGYNNYQDTKKMYKTSIVCTPEVNKPGVLYEMLGEFAARKINLTRIESRP
TRKKLGEYLFYIDLEGHYHDPLVAGALKEVRNMSGLFKILGCYFKDNIKEGSSEKDAKCKKRA

Sequences:

>Translated_303_residues
MCPARYGYLGPGGTFCEKAALKYFGGGHEMISFRTIKEVVRNVKEGSIEKGVIPLENSLEGSVNLSLDLLVKESNIIITG
EVIIPINHNLIGQKGLEVGNIKKVLSHPQAIAQTADFIEENLPQAEIIYTESTAAAAECALKNRELAVIGSDQIAHLYGL
SVIAEGIQDDDENYTRFIIISRSKGKFFYSTGYNNYQDTKKMYKTSIVCTPEVNKPGVLYEMLGEFAARKINLTRIESRP
TRKKLGEYLFYIDLEGHYHDPLVAGALKEVRNMSGLFKILGCYFKDNIKEGSSEKDAKCKKRA
>Mature_303_residues
MCPARYGYLGPGGTFCEKAALKYFGGGHEMISFRTIKEVVRNVKEGSIEKGVIPLENSLEGSVNLSLDLLVKESNIIITG
EVIIPINHNLIGQKGLEVGNIKKVLSHPQAIAQTADFIEENLPQAEIIYTESTAAAAECALKNRELAVIGSDQIAHLYGL
SVIAEGIQDDDENYTRFIIISRSKGKFFYSTGYNNYQDTKKMYKTSIVCTPEVNKPGVLYEMLGEFAARKINLTRIESRP
TRKKLGEYLFYIDLEGHYHDPLVAGALKEVRNMSGLFKILGCYFKDNIKEGSSEKDAKCKKRA

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=290, Percent_Identity=30, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324013, Length=295, Percent_Identity=27.1186440677966, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 33688; Mature: 33688

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPARYGYLGPGGTFCEKAALKYFGGGHEMISFRTIKEVVRNVKEGSIEKGVIPLENSLE
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCEECCCCCCC
GSVNLSLDLLVKESNIIITGEVIIPINHNLIGQKGLEVGNIKKVLSHPQAIAQTADFIEE
CCEEEEEEEEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHH
NLPQAEIIYTESTAAAAECALKNRELAVIGSDQIAHLYGLSVIAEGIQDDDENYTRFIII
CCCCEEEEEECCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEE
SRSKGKFFYSTGYNNYQDTKKMYKTSIVCTPEVNKPGVLYEMLGEFAARKINLTRIESRP
ECCCCCEEEECCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHEEEEEEECCCC
TRKKLGEYLFYIDLEGHYHDPLVAGALKEVRNMSGLFKILGCYFKDNIKEGSSEKDAKCK
CHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
KRA
CCC
>Mature Secondary Structure
MCPARYGYLGPGGTFCEKAALKYFGGGHEMISFRTIKEVVRNVKEGSIEKGVIPLENSLE
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCEECCCCCCC
GSVNLSLDLLVKESNIIITGEVIIPINHNLIGQKGLEVGNIKKVLSHPQAIAQTADFIEE
CCEEEEEEEEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHH
NLPQAEIIYTESTAAAAECALKNRELAVIGSDQIAHLYGLSVIAEGIQDDDENYTRFIII
CCCCEEEEEECCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEEEE
SRSKGKFFYSTGYNNYQDTKKMYKTSIVCTPEVNKPGVLYEMLGEFAARKINLTRIESRP
ECCCCCEEEECCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHEEEEEEECCCC
TRKKLGEYLFYIDLEGHYHDPLVAGALKEVRNMSGLFKILGCYFKDNIKEGSSEKDAKCK
CHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
KRA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]