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The map label for this gene is hisC [H]

Identifier: 220931040

GI number: 220931040

Start: 197055

End: 198173

Strand: Direct

Name: hisC [H]

Synonym: Hore_01910

Alternate gene names: 220931040

Gene position: 197055-198173 (Clockwise)

Preceding gene: 220931039

Following gene: 220931041

Centisome position: 7.64

GC content: 41.2

Gene sequence:

>1119_bases
ATGCTAAATGTAAAAAGAGGGCTTAAAAGCTGGAAAAGAATTGTCAGGGATGAGGTTCACAATATCAAACCCTATATCCC
TGGAAAACCTATCAAAGAGGTTAAAGAAGAGCTGGGTCTGGCTGAAGTATATAAACTGGCTTCAAATGAAAACCCACTGG
GAGTATCACCCAGGGTTAAGGAGGTTTTGACCAGAGAAACGGTAAATATCAATCGTTATCCCGATGGTGCCAGCCGGAGT
TTAAAAAGATCTTTAAGTGATAAGCTTGGTGTTAAAGAAGATATGATTGCCATCGGTAATGGTTCTGATGGATTATTAAA
AGTAATTGCGGAGGCATTCCTCGATAATAATAGTCAGGCTGTAATTTCCTATCCATCATTTGTTGAATATAAATTTGTTT
CCCAGTTAATGGGGACCCAGCTTATAAGGGTCTGGATGAAAAATTATCATCAAAACCTGGAGGCCCTTGCCCGCGGGGTG
ACCTCAAAAACAAAACTAATCTTTTTAACCAATCCCCACAATCCAGCTGGTACTATATTCAGGAAAGATGAGTTGGAACA
ATTTTTAAGCCAGATCCCCGATGATGTAATCGTTGTCCTTGATGAGGCTTATCATGAATTTGTCCAGGATGAATCCTATC
CTGACGGAATTGAGTATGTAAAACAGGGTTATCCGGTTATTGTACTCCGGACTTTTTCAAAAGCATATGGCCTGGCTGGC
TTAAGACTCGGCTATGCTATATCTGCCCCGGATATAATTGAAACTTTAATGAAGGTAAGGGATCCCTTTAATGTGAATCA
CCTCGCAGAGAAAGCAGGGCAGGCAGCCCTTGAGGATAAAGACTTCCTGGAGGCTACCATTCGTAATAACGAACAGGGTA
AAGAGTATCTATACACTGAACTTGACAAAATTGGGGTTGGTTATGTTCCTACCCAGGCCAATTTTGTGTTAATAAGGACC
GGGGTAGATTCTATAAAAATGTTTAAAGAACTCTTAAAACATGGGGTTATAGTAAGACCGGGTAAACCCCTGGGTTATCC
CCATCATCTACGGGTTAGTATTGGTCTCCCCGAAGAGAATGAGGCCTTTATCAGGGGCCTTAAATTGACTCTGGAATAA

Upstream 100 bases:

>100_bases
GTGGCCGGAGCCCTGAAAGAAGTGAGAAATATGTCCGGACTCTTTAAAATACTGGGTTGTTATTTTAAGGATAATATTAA
AGAAGGGAGTAGTGAGAAGG

Downstream 100 bases:

>100_bases
CTATTTGCTATAATTAATAAATATACAAATCAAGATATTAAGGAAATAGACCAGGGGATGATTATATGGGCAGGGGACGA
AAGAAGAAATATAACCGGGT

Product: Histidinol-phosphate transaminase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MLNVKRGLKSWKRIVRDEVHNIKPYIPGKPIKEVKEELGLAEVYKLASNENPLGVSPRVKEVLTRETVNINRYPDGASRS
LKRSLSDKLGVKEDMIAIGNGSDGLLKVIAEAFLDNNSQAVISYPSFVEYKFVSQLMGTQLIRVWMKNYHQNLEALARGV
TSKTKLIFLTNPHNPAGTIFRKDELEQFLSQIPDDVIVVLDEAYHEFVQDESYPDGIEYVKQGYPVIVLRTFSKAYGLAG
LRLGYAISAPDIIETLMKVRDPFNVNHLAEKAGQAALEDKDFLEATIRNNEQGKEYLYTELDKIGVGYVPTQANFVLIRT
GVDSIKMFKELLKHGVIVRPGKPLGYPHHLRVSIGLPEENEAFIRGLKLTLE

Sequences:

>Translated_372_residues
MLNVKRGLKSWKRIVRDEVHNIKPYIPGKPIKEVKEELGLAEVYKLASNENPLGVSPRVKEVLTRETVNINRYPDGASRS
LKRSLSDKLGVKEDMIAIGNGSDGLLKVIAEAFLDNNSQAVISYPSFVEYKFVSQLMGTQLIRVWMKNYHQNLEALARGV
TSKTKLIFLTNPHNPAGTIFRKDELEQFLSQIPDDVIVVLDEAYHEFVQDESYPDGIEYVKQGYPVIVLRTFSKAYGLAG
LRLGYAISAPDIIETLMKVRDPFNVNHLAEKAGQAALEDKDFLEATIRNNEQGKEYLYTELDKIGVGYVPTQANFVLIRT
GVDSIKMFKELLKHGVIVRPGKPLGYPHHLRVSIGLPEENEAFIRGLKLTLE
>Mature_372_residues
MLNVKRGLKSWKRIVRDEVHNIKPYIPGKPIKEVKEELGLAEVYKLASNENPLGVSPRVKEVLTRETVNINRYPDGASRS
LKRSLSDKLGVKEDMIAIGNGSDGLLKVIAEAFLDNNSQAVISYPSFVEYKFVSQLMGTQLIRVWMKNYHQNLEALARGV
TSKTKLIFLTNPHNPAGTIFRKDELEQFLSQIPDDVIVVLDEAYHEFVQDESYPDGIEYVKQGYPVIVLRTFSKAYGLAG
LRLGYAISAPDIIETLMKVRDPFNVNHLAEKAGQAALEDKDFLEATIRNNEQGKEYLYTELDKIGVGYVPTQANFVLIRT
GVDSIKMFKELLKHGVIVRPGKPLGYPHHLRVSIGLPEENEAFIRGLKLTLE

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=366, Percent_Identity=26.5027322404372, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322075, Length=395, Percent_Identity=27.5949367088608, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41908; Mature: 41908

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVKRGLKSWKRIVRDEVHNIKPYIPGKPIKEVKEELGLAEVYKLASNENPLGVSPRVK
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHH
EVLTRETVNINRYPDGASRSLKRSLSDKLGVKEDMIAIGNGSDGLLKVIAEAFLDNNSQA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCE
VISYPSFVEYKFVSQLMGTQLIRVWMKNYHQNLEALARGVTSKTKLIFLTNPHNPAGTIF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCE
RKDELEQFLSQIPDDVIVVLDEAYHEFVQDESYPDGIEYVKQGYPVIVLRTFSKAYGLAG
EHHHHHHHHHHCCHHEEEHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEEHHHHHCCCH
LRLGYAISAPDIIETLMKVRDPFNVNHLAEKAGQAALEDKDFLEATIRNNEQGKEYLYTE
HHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHH
LDKIGVGYVPTQANFVLIRTGVDSIKMFKELLKHGVIVRPGKPLGYPHHLRVSIGLPEEN
HHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCC
EAFIRGLKLTLE
HHHHHHEEEEEC
>Mature Secondary Structure
MLNVKRGLKSWKRIVRDEVHNIKPYIPGKPIKEVKEELGLAEVYKLASNENPLGVSPRVK
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCCHHHH
EVLTRETVNINRYPDGASRSLKRSLSDKLGVKEDMIAIGNGSDGLLKVIAEAFLDNNSQA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCE
VISYPSFVEYKFVSQLMGTQLIRVWMKNYHQNLEALARGVTSKTKLIFLTNPHNPAGTIF
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCE
RKDELEQFLSQIPDDVIVVLDEAYHEFVQDESYPDGIEYVKQGYPVIVLRTFSKAYGLAG
EHHHHHHHHHHCCHHEEEHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEEHHHHHCCCH
LRLGYAISAPDIIETLMKVRDPFNVNHLAEKAGQAALEDKDFLEATIRNNEQGKEYLYTE
HHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHH
LDKIGVGYVPTQANFVLIRTGVDSIKMFKELLKHGVIVRPGKPLGYPHHLRVSIGLPEEN
HHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEECCCCCC
EAFIRGLKLTLE
HHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA